Military Medical Research and Development

Active

Assistance listing
12.420
Agency
Grant awards
22,520 $26,539,525,644 in federal obligations

Program facts

Assistance types
  • Project Grant
  • Cooperative Agreement
  • Block Grant
  • Formula Grant
Treasury accounts
  • 21-2040-0-1-051
  • 97-0130-0-1-051
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Defense Health Agency funds biomedical research addressing military health priorities through CFDA 12.420, Military Medical Research and Development, with the most recent grant award disbursed on December 15, 2026. The program supports basic, applied, and advanced research to transform health care for Service Members and the American public and to investigate medical solutions for the battlefield; awards range from $100,000 to $20 million (consortium) depending on funding priorities and project scope, typically over 3 to 4 years. The program remains highly active, with 22,520 cumulative awards since 1997 and 412 awards disbursed in 2026 alone, though annual award volume has declined from 1,184 in 2022 to 962 in 2025.

Funded research spans cancer immunotherapy (triple-negative breast cancer, endometrial cancer, prostate cancer clinical trials), rare pediatric and adult malignancies (medulloblastoma, Wilms tumors, alveolar soft part sarcoma), neurodegenerative disease (amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis), military-relevant conditions (post-traumatic brain injury, burn care, combat casualty care), musculoskeletal and metabolic disorders (osteoporosis screening, nephrotic syndrome, bone marrow failure), and behavioral health in military families. Recent awards include $5.795 billion for a mechanistic clinical trial in nephrotic syndrome, $3.5 billion for podocyte-protective therapies in focal segmental glomerulosclerosis, and $3.347 billion for digital wrist tomosynthesis as an osteoporosis diagnostic aid.

The program distributes awards predominantly through Project Grants (88 percent of 19,850 awards) with a smaller share of Cooperative Agreements (12 percent, 2,595 awards). The Defense Health Agency leads funding with 7,451 awards totaling $12.73 billion federal dollars obligated; the Department of Defense, Department of the Army, and Department of the Army Medical Command together account for the remainder of the $26.54 billion in combined federal obligations across all funders. Multiple research program announcements remain open, including the Breast Cancer Research Program Clinical Research Extension Award and Breakthrough Award Levels 1 and 2 (due November 18, 2026), the Reconstructive Transplant Research Program Investigator-Initiated Research Award (due November 4, 2026), and Neurofibromatosis Research Program offerings including Investigator-Initiated Research, Synergistic Idea, and Academy Scholar awards (due September 22, 2026). Pre-applications are required; the program typically reviews pre-applications within 30 to 60 days and issues funding recommendations within 180 days of full application submission.

Objective and description

Objective

Through the support of basic, applied, and advanced biomedical research: (1) to transform health care for Service Members and the American public through innovative and impactful research; (2) to investigate medical solutions for the battlefield wit

Description

This Assistance Listing supports a varying number of R & D assistance sub-programs within the Defense Health Program, including congressionally-directed medical research, each year. Overall, awards are expected to range from $100,000 to $20M (consortium) depending on the funding priorities, anticipated number of awards, and project activity/scope within each sub-program for an award period, on average, of 3 to 4 years. The maximum award amount, if any, is specified in each Notice of Funding Opportunity or Broad Agency Announcement.

Eligibility

Applicant eligibility

See each NOFO for requirements specific to that announcement.

Beneficiary eligibility

Federal, State, and local governments; public, State, and private institutions of higher education, Federally Recognized Indian Tribal government, U.S. territory or possession, small business, profit organization, private nonprofit institution/organization, quasi-public nonprofit institution/organization, other private institution/organizations, and Native American organizations.

Uses of assistance

Grant and cooperative agreement awards provide funds to develop science and technology capabilities in specific areas of interest identified in each funding opportunity announcement. Notices of funding opportunity may be called Broad Agency Announcements or Program Announcements. Recipients must strictly conform to all applicable Federal, Department of War (DoD) and War Health Agency (DHA) requirements for conducting research, including regulatory requirements involving human subjects, human anatomical substances, human cadavers, and animals.

Length and time phasing of assistance

The maximum period acceptable for a research project is specified in each notice of funding opportunity. However, the maximum initial period of performance for any award is five years. The length of time for which support is requested should be consistent with the nature and complexity of the proposed research. Depending on the source of funding, some awards will be fully funded at the time of award, while others will be incrementally funded.

How to apply

Preapplication coordination

Preapplication coordination is required. Each notice of funding opportunity specifies applicable pre-application requirements. Notices of funding opportunity typically require the applicant's Principal Investigator to submit a pre-application through the Electronic Biomedical Research Application Portal (eBRAP, available at https://eBRAP.org/). Pre-applications are screened for military relevance and technical merit against criteria stated in each notice of funding opportunity. Following pre-application screening, the applicant's Authorized Organization Representative and Principal Investigator will be notified regarding whether the applicant is invited to submit a full application. Environmental impact information is not required for this program. This program is excluded from coverage under E.O. 12372.

Criteria for selecting proposals

All applications are reviewed for technical merit and relevance to the mission of the DHA and its programs. Also, additional specific evaluation criteria will be included in each funding opportunity announcement.

Award procedure

All invited applications are evaluated by DHA scientists, other Federal agency representatives, outside scientists with diverse expertise, clinicians, consumers, or combinations thereof, using a two-tier review process. The first tier is a peer review of applications against criteria stated in each notice of funding opportunity to determine technical merit. The second tier is a programmatic review that makes recommendations for funding based on technical merit, military relevance, the specific intent of the funding opportunity, and any other criteria specified in the notice of funding opportunity. The best-scoring applications from the first tier of review are not automatically recommended for funding. Award amount will be negotiated for those applications recommended for funding. Awards depend upon the availability of funding and priorities which DHA determines to exist at the time of award. Only the Grants Officer has the authority to issue awards and obligate funds on behalf of the Federal government.

Deadlines

Several Program Announcements are issued through the year for this Assistance Listing. See the individual Program Announcement or Broad Agency Announcement for deadlines associated with that particular program. Current Program Announcements and Broad Agency Announcements are available at: https://cdmrp.army.mil/funding/prgdefault.

Time to approval or disapproval

Pre-applications are normally reviewed within 30 to 60 days from submission deadline or, if no deadline, within 120 days from date of receipt. Full applications are usually reviewed and notifications whether or not applications have been recommended for funding issued within 180 days from submission deadline or, if no deadline, from date of receipt. Awards are normally made within 9-12 months from funding notification.

Renewals

An award may be extended one time up to 12 months with no additional funds. Additional extensions may be considered. Follow on awards are treated as new awards. Once an award ends, if continued funding is desired, a new application must be submitted under an applicable funding opportunity announcement and competitively reviewed. If selected for funding, a new award will be issued.

Appeals

If an application is not recommended for funding and the Principal Investigator believes that a factual or procedural error was made by the reviewers, (s)he can submit an inquiry. Each notice of funding opportunity will include instructions for submitting an inquiry and the timeframe for submission.

Grant opportunities

Opportunity Status Posted Applications due
DoW Breast Cancer, Clinical Research Extension Award HT942526BCRPCREA2 Open
DoW Breast Cancer, Breakthrough Award Levels 1 and 2 HT942526BCRPBTA122 Open
DoW Reconstructive Transplant, Investigator-Initiated Research Award HT942526RTRPIIRA Open
DoW Neurofibromatosis Synergistic Idea Award HT942526NFRPSIA Closed
DoW Neurofibromatosis Investigator-Initiated Research Award HT942526NFRPIIRA Closed
DoW Neurofibromatosis Research Academy - Scholar Award HT942526NFRPNFRASA Closed
DoW Neurofibromatosis Exploration-Hypothesis Development Award HT942526NFRPEHDA Closed
DOW Combat Readiness - Medical Research Program Translational Research Award HT942526CRRPTRA Open
DoW Neurofibromatosis Research Academy - Leadership Award HT942526NFRPNFRALA Closed
DoW Kidney Cancer, Academy of Kidney Cancer Investigators - Early-Career Scholar Award HT942526KCRPAKCIECSA Closed
DoW Parkinson's, Investigator-Initiated Research Award HT942526PRPIIRA Open
DoW Kidney Cancer, Idea Development Award HT942526KCRPIDA Closed
DoW Parkinson's, Early Investigator Research Award HT942526PRPEIRA Open
DoW Rare Cancers Concept Award HT942526RCRPCA Closed
DoW Kidney Cancer, Concept Award HT942526KCRPCA Closed
DoW Bone Marrow Failure, Investigator-Initiated Research Award HT942526BMFRPIIRA Open
DoW Bone Marrow Failure, Idea Development Award HT942526BMFRPIDA Open
DoW Rare Cancers Idea Development Award HT942526RCRPIDA Open
DoW Duchenne Muscular Dystrophy, Idea Development Award HT942526DMDRPIDA Closed
DoW Duchenne Muscular Dystrophy, Clinical/Translational Research Award HT942526DMDRPCTRA Closed
DoW Rare Cancers Resource and Community Development Award HT942526RCRPRCDA Open
DoW Joint Warfighter Medical, Military Medical Research and Development Award HT942526JWMRPMMRDA Open
DoW Bone Marrow Failure, Resource Development Award HT942526BMFRPRDA Open
DoW Reconstructive Transplant, Concept Award HT942526RTRPCA Open
DoW Epilepsy Idea Development Award HT942526ERPIDA Closed
DoW Epilepsy Leveraging Research Award HT942526ERPLRA Closed
DoW Epilepsy Virtual Post-Traumatic Epilepsy Research Center - Leadership Award HT942526ERPVPTERCL Closed
DoW Epilepsy Research Partnership Award HT942526ERPRPA Closed
DoW Epilepsy Virtual Post-Traumatic Epilepsy Research Center - Faculty Award HT942526ERPVPTERCF Closed
DoW Autism Career Development Award HT942526ARPCDA Closed
DoW Autism Idea Development Award HT942526ARPIDA Closed
DoW Autism Clinical Trial Award HT942526ARPCTA Closed
DoW Orthopaedic, Clinical Research Award HT942526ORPCRA Open
DoW Orthopaedic, Applied Research Award HT942526ORPARA Open
DoW Peer Reviewed Medical, Lifestyle and Applied Health Research Award HT942526PRMRPLAHRA Closed
DoW Peer Reviewed Medical, Impact Award HT942526PRMRPIPA Closed
DoW Peer Reviewed Medical, Clinical Trial Award HT942526PRMRPCTA Closed
DoW Peer Reviewed Medical, Discovery Award HT942526PRMRPDA Closed
DoW Peer Reviewed Medical, Platform Clinical Translation Award HT942526PRMRPPCTA Closed
DoW Peer Reviewed Medical, Research Advancement Award HT942526PRMRPRAA Closed
DoW Peer Reviewed Medical, Technology/Therapeutic Development Award HT942526PRMRPTTDA Closed
DoW Toxic Exposures Clinical Trial Award HT942526TERPCTA Open
DoW Toxic Exposures Translational Research Award HT942526TERPTRA Open
DoW Toxic Exposures Investigator Initiated Research Award HT942526TERPIIRA Open
DoW Peer Reviewed Cancer, Clinical Trial Award HT942526PRCRPCTA Closed
DoW Peer Reviewed Cancer, Idea Award HT942526PRCRPIA Closed
DoW, Peer Reviewed Cancer, Impact Award HT942526PRCRPIPA Closed
DoW Traumatic Brain Injury and Psychological Health, Clinical Trial Award HT942526TBIPHRPCTA Closed
DoW Traumatic Brain Injury and Psychological Health, Health Services Research Award HT942526TBIPHRPHSRA Closed
DoW Traumatic Brain Injury and Psychological Health, Translational Research Award HT942526TBIPHRPTRA Closed
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Grant awards

Award Recipient Federal obligations Awarded
Inducing ferroptosis through GPX4 inhibition as a novel therapeutic approach for esophageal cancer HT9425261E381 Wayne State University $140,000
A transformative preclinical model for advancing precision immunotherapy in mismatch repair-deficient endometrial cancer HT9425261E469 University Of Oklahoma $557,612
Enhancing immunotherapy treatment response with a novel molecular glue degrader of the corest complex in… HT9425261E465 University Of Florida $996,470
Enhancing immunotherapy treatment response with a novel molecular glue degrader of the corest complex in… HT9425261E464 University Of Florida $1,499,999
Grant/investigating metabolic control of immune cold CCNE1-driven ovarian cancers HT9425261E462 The Wistar Institute Of Anatomy And Biology $1,050,000
Exploiting epigenetic dysregulation for sarcoma treatment HT9425261E461 University Of Wisconsin System $560,000
Targeted disruption of translation for nut carcinoma HT9425261E456 Mayo Clinic $140,000
Modeling BRAFV600E-driven hepatic langerhans cell histiocytosis using human ipsc-derived in vitro and in vivo platforms… HT9425261E455 The Medical University Of South Carolina $140,000
From waste to UV armor: development and optimization of cost-effective biocompatible graphene quantum dots for melanoma… HT9425261E454 The Cleveland Clinic Foundation $1,118,013
From waste to UV armor: development and optimization of cost-effective HT9425261E453 Texas Christian University $633,788

Latest 10 of 22,520 listed here. See the rest on GovTribe.

Top recipients by federal obligations

10 of 1,648 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $576,139,609
FY2025 $1,270,715,932
FY2024 $1,415,432,697
FY2023 $1,578,830,236
FY2022 $1,382,917,477
FY2021 $1,339,171,883
FY2020 $1,184,105,362
FY2019 $1,171,094,015
FY2018 $1,149,589,720
FY2017 $1,053,787,394
FY2016 $1,127,967,204
FY2015 $1,102,169,634
FY2014 $934,596,971
FY2013 $830,665,266
FY2012 $1,219,819,136
FY2011 $2,237,607,025
FY2010 $1,186,173,073
FY2009 $924,944,719
FY2008 $986,710,370
FY2007 $722,637,365
FY2006 $597,848,639
FY2005 $597,189,608
FY2004 $565,037,707
FY2003 $522,750,685
FY2002 $341,320,361
FY2001 $424,305,015
Show all 26

Quick answers

What is Assistance Listing 12.420?

Assistance Listing 12.420 is Military Medical Research and Development, a federal grant program run by Defense Health Agency (Department of Defense).

What is the CFDA number for Military Medical Research and Development?

Its CFDA number is 12.420: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 12.420 awarded?

22,520 grant awards under 12.420 have obligated $26,539,525,644 in federal funds to 1,648 recipients.

Who receives the most funding from 12.420?

The recipients obligated the most under Military Medical Research and Development are The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. ($4,176,446,173), The Johns Hopkins University ($479,439,694) and The General Hospital Corporation ($419,733,067).

How much did 12.420 obligate in fiscal year 2025?

Grants under 12.420 obligated $1,270,715,932 in federal funds in fiscal year 2025.

Are there open grant opportunities under 12.420?

18 of the latest 50 opportunities under 12.420 are open or forecasted. The latest, DoW Breast Cancer, Clinical Research Extension Award, was posted on August 20, 2026.

On GovTribe

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