Military Medical Research and Development
Active
- Assistance listing
- 12.420
- Agency
-
Defense Health Agency
Department of Defense
- Grant awards
- 22,520 $26,539,525,644 in federal obligations
Program facts
- Assistance types
-
- Project Grant
- Cooperative Agreement
- Block Grant
- Formula Grant
- Treasury accounts
-
- 21-2040-0-1-051
- 97-0130-0-1-051
- More information
Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.
About this program
The Defense Health Agency funds biomedical research addressing military health priorities through CFDA 12.420, Military Medical Research and Development, with the most recent grant award disbursed on December 15, 2026. The program supports basic, applied, and advanced research to transform health care for Service Members and the American public and to investigate medical solutions for the battlefield; awards range from $100,000 to $20 million (consortium) depending on funding priorities and project scope, typically over 3 to 4 years. The program remains highly active, with 22,520 cumulative awards since 1997 and 412 awards disbursed in 2026 alone, though annual award volume has declined from 1,184 in 2022 to 962 in 2025.
Funded research spans cancer immunotherapy (triple-negative breast cancer, endometrial cancer, prostate cancer clinical trials), rare pediatric and adult malignancies (medulloblastoma, Wilms tumors, alveolar soft part sarcoma), neurodegenerative disease (amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis), military-relevant conditions (post-traumatic brain injury, burn care, combat casualty care), musculoskeletal and metabolic disorders (osteoporosis screening, nephrotic syndrome, bone marrow failure), and behavioral health in military families. Recent awards include $5.795 billion for a mechanistic clinical trial in nephrotic syndrome, $3.5 billion for podocyte-protective therapies in focal segmental glomerulosclerosis, and $3.347 billion for digital wrist tomosynthesis as an osteoporosis diagnostic aid.
The program distributes awards predominantly through Project Grants (88 percent of 19,850 awards) with a smaller share of Cooperative Agreements (12 percent, 2,595 awards). The Defense Health Agency leads funding with 7,451 awards totaling $12.73 billion federal dollars obligated; the Department of Defense, Department of the Army, and Department of the Army Medical Command together account for the remainder of the $26.54 billion in combined federal obligations across all funders. Multiple research program announcements remain open, including the Breast Cancer Research Program Clinical Research Extension Award and Breakthrough Award Levels 1 and 2 (due November 18, 2026), the Reconstructive Transplant Research Program Investigator-Initiated Research Award (due November 4, 2026), and Neurofibromatosis Research Program offerings including Investigator-Initiated Research, Synergistic Idea, and Academy Scholar awards (due September 22, 2026). Pre-applications are required; the program typically reviews pre-applications within 30 to 60 days and issues funding recommendations within 180 days of full application submission.
Objective and description
- Objective
Through the support of basic, applied, and advanced biomedical research: (1) to transform health care for Service Members and the American public through innovative and impactful research; (2) to investigate medical solutions for the battlefield wit
- Description
This Assistance Listing supports a varying number of R & D assistance sub-programs within the Defense Health Program, including congressionally-directed medical research, each year. Overall, awards are expected to range from $100,000 to $20M (consortium) depending on the funding priorities, anticipated number of awards, and project activity/scope within each sub-program for an award period, on average, of 3 to 4 years. The maximum award amount, if any, is specified in each Notice of Funding Opportunity or Broad Agency Announcement.
Eligibility
- Applicant eligibility
See each NOFO for requirements specific to that announcement.
- Beneficiary eligibility
Federal, State, and local governments; public, State, and private institutions of higher education, Federally Recognized Indian Tribal government, U.S. territory or possession, small business, profit organization, private nonprofit institution/organization, quasi-public nonprofit institution/organization, other private institution/organizations, and Native American organizations.
- Uses of assistance
Grant and cooperative agreement awards provide funds to develop science and technology capabilities in specific areas of interest identified in each funding opportunity announcement. Notices of funding opportunity may be called Broad Agency Announcements or Program Announcements. Recipients must strictly conform to all applicable Federal, Department of War (DoD) and War Health Agency (DHA) requirements for conducting research, including regulatory requirements involving human subjects, human anatomical substances, human cadavers, and animals.
- Length and time phasing of assistance
The maximum period acceptable for a research project is specified in each notice of funding opportunity. However, the maximum initial period of performance for any award is five years. The length of time for which support is requested should be consistent with the nature and complexity of the proposed research. Depending on the source of funding, some awards will be fully funded at the time of award, while others will be incrementally funded.
How to apply
- Preapplication coordination
Preapplication coordination is required. Each notice of funding opportunity specifies applicable pre-application requirements. Notices of funding opportunity typically require the applicant's Principal Investigator to submit a pre-application through the Electronic Biomedical Research Application Portal (eBRAP, available at https://eBRAP.org/). Pre-applications are screened for military relevance and technical merit against criteria stated in each notice of funding opportunity. Following pre-application screening, the applicant's Authorized Organization Representative and Principal Investigator will be notified regarding whether the applicant is invited to submit a full application. Environmental impact information is not required for this program. This program is excluded from coverage under E.O. 12372.
- Criteria for selecting proposals
All applications are reviewed for technical merit and relevance to the mission of the DHA and its programs. Also, additional specific evaluation criteria will be included in each funding opportunity announcement.
- Award procedure
All invited applications are evaluated by DHA scientists, other Federal agency representatives, outside scientists with diverse expertise, clinicians, consumers, or combinations thereof, using a two-tier review process. The first tier is a peer review of applications against criteria stated in each notice of funding opportunity to determine technical merit. The second tier is a programmatic review that makes recommendations for funding based on technical merit, military relevance, the specific intent of the funding opportunity, and any other criteria specified in the notice of funding opportunity. The best-scoring applications from the first tier of review are not automatically recommended for funding. Award amount will be negotiated for those applications recommended for funding. Awards depend upon the availability of funding and priorities which DHA determines to exist at the time of award. Only the Grants Officer has the authority to issue awards and obligate funds on behalf of the Federal government.
- Deadlines
Several Program Announcements are issued through the year for this Assistance Listing. See the individual Program Announcement or Broad Agency Announcement for deadlines associated with that particular program. Current Program Announcements and Broad Agency Announcements are available at: https://cdmrp.army.mil/funding/prgdefault.
- Time to approval or disapproval
Pre-applications are normally reviewed within 30 to 60 days from submission deadline or, if no deadline, within 120 days from date of receipt. Full applications are usually reviewed and notifications whether or not applications have been recommended for funding issued within 180 days from submission deadline or, if no deadline, from date of receipt. Awards are normally made within 9-12 months from funding notification.
- Renewals
An award may be extended one time up to 12 months with no additional funds. Additional extensions may be considered. Follow on awards are treated as new awards. Once an award ends, if continued funding is desired, a new application must be submitted under an applicable funding opportunity announcement and competitively reviewed. If selected for funding, a new award will be issued.
- Appeals
If an application is not recommended for funding and the Principal Investigator believes that a factual or procedural error was made by the reviewers, (s)he can submit an inquiry. Each notice of funding opportunity will include instructions for submitting an inquiry and the timeframe for submission.
Grant opportunities
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Latest 50 listed here. See the rest on GovTribe.
Grant awards
Latest 10 of 22,520 listed here. See the rest on GovTribe.
Top recipients by federal obligations
| Rank | Recipient | Federal obligations | Share |
|---|---|---|---|
| 1 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | $4,176,446,173 | 16% |
| 2 | The Johns Hopkins University | $479,439,694 | 2% |
| 3 | The General Hospital Corporation | $419,733,067 | 2% |
| 4 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | $377,427,594 | 1% |
| 5 | The Regents Of The University Of California. San Francisco | $369,047,563 | 1% |
| 6 | Duke University | $364,137,083 | 1% |
| 7 | The Univeristy Of Texas M.d. Anderson Cancer Center | $314,272,687 | 1% |
| 8 | Wake Forest University Health Sciences | $260,500,083 | 1% |
| 9 | Regents Of The University Of Michigan | $255,523,067 | 1% |
| 10 | University Of California, LOS Angeles | $250,048,625 | 1% |
10 of 1,648 recipients listed here. See the rest on GovTribe.
Federal obligations by fiscal year
| Fiscal year | Federal obligations |
|---|---|
| FY2026 | $576,139,609 |
| FY2025 | $1,270,715,932 |
| FY2024 | $1,415,432,697 |
| FY2023 | $1,578,830,236 |
| FY2022 | $1,382,917,477 |
| FY2021 | $1,339,171,883 |
| FY2020 | $1,184,105,362 |
| FY2019 | $1,171,094,015 |
| FY2018 | $1,149,589,720 |
| FY2017 | $1,053,787,394 |
| FY2016 | $1,127,967,204 |
| FY2015 | $1,102,169,634 |
| FY2014 | $934,596,971 |
| FY2013 | $830,665,266 |
| FY2012 | $1,219,819,136 |
| FY2011 | $2,237,607,025 |
| FY2010 | $1,186,173,073 |
| FY2009 | $924,944,719 |
| FY2008 | $986,710,370 |
| FY2007 | $722,637,365 |
| FY2006 | $597,848,639 |
| FY2005 | $597,189,608 |
| FY2004 | $565,037,707 |
| FY2003 | $522,750,685 |
| FY2002 | $341,320,361 |
| FY2001 | $424,305,015 |
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Quick answers
What is Assistance Listing 12.420?
Assistance Listing 12.420 is Military Medical Research and Development, a federal grant program run by Defense Health Agency (Department of Defense).
What is the CFDA number for Military Medical Research and Development?
Its CFDA number is 12.420: Assistance Listing numbers were called CFDA numbers before 2018.
How much funding has Assistance Listing 12.420 awarded?
22,520 grant awards under 12.420 have obligated $26,539,525,644 in federal funds to 1,648 recipients.
Who receives the most funding from 12.420?
The recipients obligated the most under Military Medical Research and Development are The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. ($4,176,446,173), The Johns Hopkins University ($479,439,694) and The General Hospital Corporation ($419,733,067).
How much did 12.420 obligate in fiscal year 2025?
Grants under 12.420 obligated $1,270,715,932 in federal funds in fiscal year 2025.
Are there open grant opportunities under 12.420?
18 of the latest 50 opportunities under 12.420 are open or forecasted. The latest, DoW Breast Cancer, Clinical Research Extension Award, was posted on August 20, 2026.
On GovTribe
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