The Johns Hopkins University

The Johns Hopkins University is a prominent private research institution registered to receive federal contract and grant awards through SAM.gov, maintaining active federal contractor status with authorization to serve as both a prime and subcontractor to the federal government. The institution operates through multiple entities, including the highly specialized Johns Hopkins University Applied Physics Laboratory LLC, and serves as a comprehensive source of advanced biomedical research, clinical services, medical innovation, and scientific expertise across numerous federal agencies. As a premier research university with extensive experience supporting critical federal initiatives, Johns Hopkins provides sophisticated services spanning biomedical research, public health, engineering, technological development, space exploration, defense applications, and specialized consultation that directly advance national scientific and defense priorities.

Through federal contract awards, The Johns Hopkins University has delivered an exceptionally diverse portfolio of services to federal agencies without small business set-aside designations, indicating full and open competition based on technical merit and demonstrated capabilities. Contract awards have included clinical services and resources for the National Institute on Drug Abuse's Intramural Research Program valued at approximately $849,575 across multiple performance periods, high-throughput genotyping and DNA sequencing services for studying genetic contributions to human health and disease through the National Heart Lung and Blood Institute, rheumatologist services, and laboratory and testing services for consensus conference research on cognitive impairment and dementia for the National Institute on Aging. The Johns Hopkins Applied Physics Laboratory has secured significant defense contracts, including a $17.4 million delivery order from the U.S. Air Force for the Advanced Common Electromagnetic Spectrum Development Environment program, $6 million and $6.3 million cost-plus-fixed-fee contracts from the Space and Missile Systems Center for critical technology solutions and Navy Joint Radiant Touchstone program support, and a $5.6 million contract with the U.S. Secret Service to provide academic medical support services. Additional contract work has encompassed educational services through delivery orders from the Bureau of Medicine and Surgery and Naval Education and Training Command for tuition and fees, macaque acquisition for the National Institute of Allergy and Infectious Diseases, FDA Center for Biologics Evaluation and Research support for the BEST IM vaccine safety program valued at $1.1 million, genetic counseling training services, and provision of specialized resources including biospecimens for collaborative research projects through the National Heart Lung and Blood Institute. Johns Hopkins serves as a prime contractor under multiple indefinite delivery vehicles and frequently partners with technology firms and specialized subcontractors, demonstrating versatility in delivering complex services across healthcare, defense, space, and scientific research domains.

Through federal grant awards, The Johns Hopkins University has established itself as a major research partner conducting cutting-edge investigations across the National Institutes of Health, National Science Foundation, NASA, Defense Health Agency, and other federal agencies, with recent awards spanning biomedical research, clinical investigations, and translational science initiatives. Recent research grants have focused on diverse areas including palliative care needs in foster children through the National Institute of Nursing Research, characterization of PR3 epitopes for precision targeting of autoreactive B cells in ANCA-associated vasculitis through the National Institute of Allergy and Infectious Diseases, severe acute respiratory failure after immune checkpoint inhibitor therapy through the National Heart Lung and Blood Institute, T cell adaptation to metabolic stress in tumor microenvironments through the National Cancer Institute, and investigations into macrophage senescence as a driver of granuloma failure in tuberculosis through a $3.1 million cooperative agreement with NIAID. Additional grant funding has supported research on hepatitis B and HIV cure consortium development ($11 million cooperative agreement), imaging of B cell infiltration in tumor microenvironments, genome editing for rare disease-causing variants, evaluation of kratom safety and abuse potential through the National Institute on Drug Abuse, multi-level stigma mitigation interventions for women living with HIV in Malawi, and health-related quality of life among adolescents with chronic hepatitis B. Johns Hopkins also received substantial funding for space science research including investigations of isotope ratios in Comet 67P/Churyumov-Gerasimenko through NASA, research on orbital events shaping Ceres through a $702,744 grant, and multiple balanced science program grants supporting exploration initiatives focused on lunar, Martian, and Earth science applications through NASA's Shared Services Center with awards ranging from $90,000 to $1.4 million. The university frequently serves as a sub-grantee on multi-institutional research collaborations and maintains active partnerships with institutions such as the University of Texas Health Science Center at San Antonio, Rutgers University, University of Connecticut Health Center, Jackson Laboratory, Children's Hospital of Philadelphia, Duke University, and numerous other academic and research organizations, reflecting its role as both an independent investigator and collaborative research partner across the federal research landscape.

The Johns Hopkins University holds a $90 million Indefinite Delivery Contract with the Agency for Healthcare Research and Quality effective from July 1, 2025 through June 30, 2030 to serve as Evidence-based Practice Center VII, under which the institution provides comprehensive evidence synthesis products and services including systematic reviews, scoping reviews, living reviews, rapid reviews, and qualitative evidence syntheses across multiple medical specialties to support federal agencies, guideline developers, clinicians, and policymakers in making evidence-informed healthcare decisions. Under this IDC vehicle, Johns Hopkins has executed task orders such as the $450,000 "EPC VII Methods and Dissemination" delivery order awarded September 30, 2025, structured on a time-and-materials pricing basis and focused on establishing methodological frameworks and dissemination strategies for evidence synthesis products. The IDC operates through a task order structure whereby AHRQ and partner federal agencies submit specific requests for evidence reports, with individual task orders defining scope, timeline, and pricing for each deliverable produced throughout the performance period, enabling flexible procurement of Johns Hopkins' evidence synthesis capabilities across diverse healthcare topics and research domains without requiring repeated full and open competition.