Mayo Clinic

Mayo Clinic, doing business as Mayo Clinic Specialty Pharmacy, a tax-exempt nonprofit academic medical center headquartered in Rochester, Minnesota, delivers comprehensive medical services and biomedical research support to the federal government as a prime contractor and recipient on the National Institutes of Health grant portfolio. The organization competes full-and-open with no SBA certifications; it is classified under primary NAICS 622110 (General Medical and Surgical Hospitals).

Mayo Clinic's federal footprint concentrates heavily in two distinct sectors: direct clinical healthcare delivery to the Federal Bureau of Prisons, and biomedical research funding through NIH institutes. The top five funding agencies account for 53% of all awards. The Department of Justice Bureau of Prisons Federal Medical Center Rochester anchors the contract portfolio with 593 awards totaling $342.3 million in combined potential value—a concentrated relationship driven by recurring monthly purchase orders for comprehensive medical services, including specialist physician coverage, telehealth, radiology, after-hours staffing, and medical transportation. The National Cancer Institute, part of the NIH, holds the second-largest potential value position at $227.7 million across 509 awards, followed by the broader National Institutes of Health (671 awards, $81.8 million). The National Institute on Aging (323 awards) and the National Institute of Diabetes and Digestive and Kidney Diseases (251 awards) round out the active research funding base.

Mayo Clinic holds active positions on five indefinite delivery contracts managed by the Department of Justice Bureau of Prisons, with the largest vehicle (DJBP041200000042) carrying 145 task orders valued at $90.1 million combined potential value and supporting ongoing medical services for federal correctional facilities. An Army Reserve Medical Command single-award indefinite delivery contract for medical simulation training services carries a ceiling of $1.13 million through September 2030.

Recent representative contract work spans clinical delivery and research. For the Federal Bureau of Prisons, Mayo Clinic received recurring purchase orders totaling hundreds of thousands of dollars monthly for comprehensive medical services at Federal Medical Center Rochester and Federal Correctional Institution Waseca, designated mission-critical under Executive Order 14398 and covering physician staffing, telehealth, radiology, and medical transportation. For the National Cancer Institute, Mayo Clinic received a $215,604 delivery order for pharmacokinetic and bioavailability studies in rats with investigational cancer chemotherapeutic agents, and a $100,228 project grant to explore LMTK2 as a mediator of endocrine sensitivity in estrogen receptor-positive breast cancer. On the clinical research side, the Defense Health Agency awarded Mayo Clinic $1.14 million for CAR-monocyte and CAR-macrophage development targeting GD2+ pediatric solid cancers, and the National Institute on Aging awarded a $4.5 million cooperative agreement to establish the Mayo Clinic Study of Aging multi-site platform for validating blood-based biomarkers in cognitive aging.

Activity has grown unevenly across the past five years. Awards per year peaked at 473 in 2024 (largely driven by the Federal Bureau of Prisons' recurring monthly purchase orders), fell to 363 in 2025, and dropped to 236 in 2026, with only three awards recorded in 2027 year-to-date. This pattern reflects the volatility of Federal Bureau of Prisons contracting cycles rather than declining portfolio strength. Within the next twenty-four months, 290 awards with combined potential value of $20.9 million face ultimate completion dates and therefore recompete exposure.

As prime contractor, Mayo Clinic performs 80% of its recent awards, subcontracting on the remaining 20%. Across SCI-reportable federal service contracts (above $150,000 threshold) during FY2022–FY2025, Mayo Clinic invoiced $3.7 million as a prime contractor, with peak FTE activity of 27.6 in FY2023 and more recent FY2024 activity of 9.2 FTEs. Government-paid hourly rates on federal services contracts show median pricing around $85.49/hour, with senior labor and specialized research roles commanding rates through $231/hour and entry-level positions running as low as $13.46/hour. On prime SCI-reportable contracts, subcontractors account for approximately 6% of total contractor hours; Mayo Clinic names eleven subcontractors across its service contract engagements, including Arizona State University on cancer systems modeling and a range of university partners on collaborative research initiatives.

Mayo Clinic's grant footprint encompasses multiple NIH institutes and external agencies including the Defense Health Agency, which funds translational oncology and cancer biology research; the National Heart, Lung, and Blood Institute, which supports cardiovascular disease and respiratory pathology research; and the National Institute of Neurological Disorders and Stroke, which funds neurodegenerative and neuroimaging research. As grant recipient, Mayo Clinic typically performs as the prime research organization, though it serves as sub-recipient on collaborative awards led by institutions including Vanderbilt University Medical Center, Johns Hopkins University, Columbia University, Duke University, and the University of Pennsylvania. Representative grant work includes a $729,906 National Institute on Aging award investigating neurobiological substrates of falls in cognitively unimpaired older adults using dual-task paradigms and plasma biomarkers, a $685,116 National Cancer Institute award examining interleukin-5's role in CAR T cell immunotherapy toxicity and efficacy, and a $1.56 million National Heart, Lung, and Blood Institute award conducting mechanistic analysis of propofol-associated hypertriglyceridemia in critically ill patients.

Mayo Clinic's corporate structure includes six named subsidiaries: Mayo Clinic Health System–Southeast Minnesota Region, Mayo Clinic Jacksonville, Mayo Foundation for Medical Education and Research, Mayo Clinic Arizona, Mayo Collaborative Services Inc., Mayo Clinic Health System–Lake City, and Mayo Clinic Health System–Southwest Minnesota Region. These subsidiaries extend Mayo's operational footprint across multiple geographic regions and healthcare delivery models while supporting the parent organization's federal mission.