Mayo Clinic

Mayo Clinic, operating as Mayo Clinic Specialty Pharmacy, is a tax-exempt nonprofit academic medical center headquartered in Rochester, Minnesota, that delivers comprehensive healthcare and medical services to federal agencies as a prime contractor (80% of recent awards) and as a subcontractor on multi-institutional research projects. The organization holds no SBA set-aside certifications and competes full-and-open across federal contracting vehicles; its award footprint is concentrated in medical services delivery, biomedical research, and clinical trial participation.

Mayo Clinic's federal customer base reflects a dual emphasis on healthcare delivery and research. The Federal Bureau of Prisons' Federal Medical Center Rochester dominates by dollar volume—587 purchase orders worth $340.2 million combined potential value—procuring comprehensive medical services including after-hours physician coverage, telehealth consultations, radiology services, medical trips, and specialized clinical support. These awards are structured as monthly or quarterly purchase orders, firm fixed-price, with no set-aside designations, reflecting Mayo Clinic's unique geographic positioning in Rochester and established provider relationship. The National Institutes of Health leads by award count, with the National Cancer Institute (492 awards, $227.6 million), the National Institute on Aging, the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Heart, Lung, and Blood Institute collectively representing the largest research funding stream. These two customer segments—correctional healthcare and NIH-funded biomedical research—account for approximately 60% of combined potential value.

As a prime recipient on federal grants, Mayo Clinic receives project awards across the NIH institutes and the Defense Health Agency, primarily in cancer research, aging biology, metabolic disorders, immunology, and cardiovascular disease. Recent grant examples include a $2.84 million NIDDK award for genetic regulation of epithelial injury in ulcerative colitis, a $2.46 million DHA award for NKG7-armed tumor-infiltrating lymphocyte therapy for metastatic uveal melanoma, and a $3.38 million NIA award for women-specific care in Alzheimer's disease using electronic health records analysis. Mayo Clinic also operates as a research core and sub-recipient on multi-institutional consortia, including a $1.3 million NCI Cooperative Agreement for the Lymphoma Epidemiology of Outcomes cohort study and core laboratory roles on several other federally funded research networks. The organization's grant portfolio emphasizes translational oncology, neurodegenerative disease, and precision medicine methodologies.

Mayo Clinic holds a single-award Indefinite Delivery/Indefinite Quantity contract with the Army Reserve Medical Command valued at $1.13 million through September 2030, procuring medical simulation training services. The contract's initial delivery order ($28,272, September 2026 completion) indicates active task order placement. Mayo Clinic also sits as a named subcontractor on an Indefinite Delivery contract with the University of Georgia Research Foundation under the Collaborative Influenza Vaccine Innovation Centers program.

Activity has remained relatively stable, with 263–473 awards per year from 2022 to 2024, declining to 362 in 2025 and 138 in the partial 2026 data (January through August). This reflects the recency of the source snapshot rather than trend decline. Eleven awards reaching completion within the next 24 months carry combined potential value of $7.9 million, representing modest recompete exposure. The combined dollars obligated across all awards ($7.37 billion) substantially exceed combined potential value ($1.13 billion), indicating heavy delivery on indefinite vehicles and multi-year commitments.

SCI reporting captures only federal service contracts above the $150,000 threshold and excludes goods, products, and classified work; the $3.7 million in SCI-reportable invoicing (FY2022–FY2024) represents a strict subset of Mayo Clinic's total federal revenue. Across SCI-reportable prime contracts, Mayo Clinic invoiced $839 thousand in FY2022 across approximately 6.7 FTEs, $1.3 million in FY2023 across 27.6 FTEs, and $1.5 million in FY2024 across 9.2 FTEs. Government-paid hourly rates on these service contracts range from a 10th percentile of $13.46/hr to a median of $85.49/hr and a 90th percentile of $231.03/hr, reflecting a mix of administrative, clinical, and specialized research labor. Across SCI-reportable prime contracts, subcontractors performed approximately 7% of total contractor hours, with 11 named subcontractors appearing in the records—indicating Mayo Clinic predominantly delivers services with its own workforce rather than through heavy sub-reliance.

Mayo Clinic's corporate structure includes seven named subsidiaries: Mayo Clinic Jacksonville, the Mayo Foundation for Medical Education and Research, Mayo Clinic Health System regions (Southeast Minnesota, Lake City, Southwest Minnesota), Mayo Collaborative Services (a for-profit subsidiary), and Mayo Clinic Arizona. The organization's federal footprint reflects its status as a premier academic medical center with established research infrastructure, clinical trial enrollment capacity, and biomedical expertise spanning oncology, neurology, infectious disease, and precision medicine.