Human Genome Research

As a leading authority in the field of genomics, the mission of the National Human Genome Research Institute (NHGRI) is to accelerate scientific and medical breakthroughs that improve human health by driving cutting-edge research, developing new tech

The National Human Genome Research Institute supports: (1) the training and career development of the genomics workforce; (2) the development of genomic resources, technologies, and methods in basic genomics, functional genomics, and genomic computational and data science research that are generally applicable to biomedical research; (3) efforts to advance the application of genomics to medical science and clinical care; and (3) studies to understand the ethical, legal, social implications of genomics research for individuals and populations.

Awards can be made to any public or private, for-profit or nonprofit university; college; medical, dental, nursing school; school of public health; hospital; laboratory; or other institution; state and local health departments; other public or private institutions, both for-profit and non-profit; and/or to individuals. National Research Service Award, Institutional Awards: Non-federal public and private domestic organizations may apply. All awardees must be citizens or have been admitted to the United States for permanent residence. Predoctoral awardees must have completed the baccalaureate degree, and postdoctoral awardees must have a professional or scientific degree (M.D., Ph.D., D.O., D.V.M., Sc.D., E.Eng., or equivalent domestic or foreign degree). National Research Service Award. Individual Awardees must be nominated and sponsored by a public or nonprofit private institution having staff and facilities appropriate to the proposed research training program. The applicant's academic record, research experience, citizenship, and institution sponsorship should be documented in the application. All awardees must be citizens or have been admitted to the United States for permanent residence. Predoctoral awardees must have completed the baccalaureate degree, and postdoctoral awardees must have a professional or scientific degree (M.D., Ph.D., D.O., D.V.M., Sc.D., E.Eng., or equivalent domestic or foreign degree). Universities, colleges, medical, dental and nursing schools, schools of public health, laboratories, hospitals, State and local health departments, other public or private institutions, both nonprofit and for-profit, and/or individuals. SBIR/SBIR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees). Primary employment (more than one- half time) of the principal investigator must be with the small business Designations State (includes District of Columbia, public institutions of higher education and hospitals), Local (includes State-designated lndian Tribes, excludes institutions of higher education and hospitals, Public nonprofit institution/organization (includes institutions of higher education and hospitals), Individual/Family, Private nonprofit institution/organization (includes institutions of higher education and hospitals) at the time of award and during the conduct of the proposed project. Small Business Innovation Research (SBIR) Program: SBIR Phase I grants (of approximately 6 months' duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of research initiated in Phase I and which are likely to result in commercial products or processes. Only Phase I awardees are eligible to apply for Phase II support. STTR Phase I grants (normally of 1-year duration) are to determine the scientific, technical, and commercial merit and feasibility of the proposed cooperative effort that has potential for commercial application. Phase II funding is based on results of research initiated in Phase I and scientific and technical merit and commercial potential of Phase II application. In both Phase I and Phase II, the research must be performed in the U.S. or its possessions. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council. STTR grants can be awarded only to domestic small business concerns (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees) which "partner" with a research institution in cooperative research and development. At least 40 percent of the project is to be performed by the small business concern and at least 30 percent by the research institution. In both Phase I and Phase II, the research must be performed in the U.S. and its possessions. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council. Any additional eligibility requirements are described at the NOFO level.

Any nonprofit or for-profit organization, company, or institution engaged in biomedical research can apply for research support.

Grants are awarded to an eligible institution in the name of a principal investigator for a discrete project or group of related projects representing the investigator's interest and competence. Funds may be used for salaries and wages, equipment, supplies, travel and other allowable costs required to carry out the research project. Awardees agree to administer awards in accordance with the regulations and policies governing research assistance programs in the Public Health Service Act, as stated in the NIH Grants Policy Statement and the terms and conditions in the notice of award. Institutional Training Grants are awarded to an eligible institution in the name of a principal investigator for a discrete project or group of related projects representing the investigator's interest and competence. Funds may be used for salaries and wages, equipment, supplies, travel and other allowable costs required to carry out the research project. Awardees agree to administer awards in accordance with the regulations and policies governing research assistance programs in the Public Health Service Act, as stated in the NIH Grants Policy Statement and the terms and conditions in the notice of award. National Research Service Awards institutional training grants may be made to institutions to enable them to select individuals for National Research Service Awards. Each individual who receives a National Research Service Award is responsible for certain service and payback provisions. Individual Training Awards: National Research Service Awards are made directly to individuals for research training in disciplines supporting the research areas. Each individual who receives a National Research Service Award is responsible for certain service and payback provisions. Funds may be used for salaries and wages, equipment, supplies, travel and other costs required to carry out the research project. Awardees agree to administer awards in accordance with the regulations and policies governing research assistance programs in the Public Health Service Act, as stated in the NIH Grants Policy Statement and terms and conditions in the notice of award. Small Business Innovation Research (SBIR) Program: SBIR Phase I grants (of approximately 6 months' duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of research initiated in Phase I and which are likely to result in commercial products or processes. Only Phase I awardees are eligible to apply for Phase II support. STTR Phase I grants (normally of 1-year duration) are to determine the scientific, technical, and commercial merit and feasibility of the proposed cooperative effort that has potential for commercial application. Phase II funding is based on results of research initiated in Phase I and scientific and technical merit and commercial potential of Phase II application. Any additional information is described at the NOFO level.

Awardees agree to administer awards in accordance with the regulations and policies governing research assistance programs in the Public Health Service Act, as stated in NIH Grants Policy Statement and the terms and conditions, in the notice of award. National Research Service Awards are made directly to individuals for research training in disciplines supporting the research areas. Each individual who receives a National Research Service Award is responsible for certain service and payback provisions. Awardees agree to administer awards in accordance with the regulations and policies governing research assistance programs in the Public Health Service Act, as stated in the terms and conditions in the NIH Grants Policy Statement and in the notice of award. Any additional information is described at the NOFO level.

Research and program projects are awarded for 2-5 years. Institutional training grants are awarded for 5 years. Individual fellowships and career development awards are from 2-5 years. For SBIR and STTR applications, normally Phase I awards are for 6 months and Phase II awards are or 2 years.

Criteria for selecting proposals is described at the NOFO level.

Only applications submitted in response to a Notice of Funding Opportunity (NOFO) will be considered for funding. Each application is scientifically reviewed by subject matter experts, with competing applications going through initial peer review and secondary review by an advisory council. All scored applications compete for available funds on the basis of scientific and technical merit, program relevance, program balance among aras of research, and availability of funds. Awards are issued throughout the year by the National Human Genome Research Institute (NHGRI).

Requests for Applications and Program Announcements for Special Review or Set Aside are not necessarily submitted on standard due dates. The submission dates of these funding opportunity announcements can be found at: https://grants.nih.gov/funding/nih-guide-for-grants-and-contracts

From submission to award of funds: Individual, project and institutional grants about 9 months; SBIR/STTR and AIDS projects about 6 months.

Renewal applications are competitively awarded. The applicant must submit an application in response to a NOFO. The application must undergo scientific and technical merit review and must be considered by a national advisory council before an award is made.

The NIH Grants Policy Statement describes appeals: https://grants.nih.gov/policy-and-compliance/nihgps Appeals of initial scientific review are described here: https://grants.nih.gov/grants/policy/nihgps/html5/section_2/2.4.2_appeals_of_initial_scientific_review.htm