NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
Open Posted
- Opportunity number
- PA-27-102
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
-
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- 93.859 Biomedical Research and Research Training
- 93.361 Nursing Research
- 93.213 Research and Training in Complementary and Integrative Health
- 93.273 Alcohol Research Programs
- 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health
- 93.879 Medical Library Assistance
- 93.393 Cancer Cause and Prevention Research
- 93.172 Human Genome Research
- 93.394 Cancer Detection and Diagnosis Research
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Small Businesses
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health, including 24 participating institutes and centers, is inviting applications from eligible U.S. small business concerns to submit Small Business Technology Transfer (STTR) Phase I, Phase II, Direct to Phase II, and Fast-Track grant applications by April 5, 2027, under activity code R41/R42 with clinical trials optional.
Eligibility is restricted to U.S. small business concerns (independently owned and operated for profit, no more than 500 employees) that partner with nonprofit research institutions. The small business must perform at least 40 percent of the research project and the research institution at least 30 percent. Foreign organizations and foreign components of U.S. organizations are not eligible; unfunded international collaborations are permitted.
No mandatory cost share is required. Phase I budget guidelines range from $400,000 to $700,000; Phase II budgets range from $2.5 million to $3 million, with variation by participating institute. Project periods do not exceed one year for Phase I and two years for Phase II. Awards are made as grants with earliest start dates between January 5, 2027 and July 2027 depending on the submission cycle.
The STTR program supports feasibility studies and later-stage research and development needed to develop commercial products addressing the missions of 24 NIH institutes and centers including NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, ORIP, and NCI, plus the NIH Office of Research on Women's Health.
Evaluation criteria emphasize scientific merit (soundness of approach, investigator qualifications, technological innovation, commercial potential), feasibility of Phase I objectives for Phase II applications, adequacy of facilities, and appropriateness of budget. Applications undergo scientific peer review followed by advisory council review. Performance benchmarks apply: companies with more than 20 Phase I awards in the past five fiscal years must demonstrate minimum Phase I-to-Phase II transition rates of 0.25; those with more than 50 awards must achieve 0.5.
Applicants must register with SAM, complete eRA Commons registration, register in Grants.gov, and register in the SBA Company Registry before submission. All applications must comply with SBIR/STTR instructions and be submitted electronically through Grants.gov. Applications proposing clinical trials must include regulatory plans addressing FDA requirements and marketing approval pathways. Recipients must comply with NIH Grants Policy Statement requirements, cybersecurity standards under NIST frameworks, and foreign relationship disclosure during the just-in-time process. Grantees must maintain data rights for up to 20 years post-award and submit annual Research Performance Progress Reports and Final Invention Statements within 120 days of award completion.
The program operates under multiple CFDA assistance listings corresponding to participating institutes (93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.855, 93.867, and others). Three application due dates are scheduled: September 5, 2026 (earliest start January 5, 2027), January 5, 2027 (earliest start May 2027), and April 5, 2027 (earliest start July 2027).
Synopsis
The Small Business Technology Transfer (STTR) grant program helps United States small business concerns (SBCs) that partner with a nonprofit research institution bring scientific innovations to the marketplace. The STTR program supports feasibility studies to later stage research and development (R & D) needed to develop a commercial product.
Eligibility
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Files
| File | Type | Posted |
|---|---|---|
| PA-27-102-Revised-Full-Announcement.html | HTML file | |
| PKG00292978.pdf | ||
| PA-27-102-Full-Announcement.html | HTML file |
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