NIH Research Program Projects (Parent P01 Clinical Trial Optional)
Open Posted
- Opportunity number
- PA-27-061
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
-
- 93.395 Cancer Treatment Research
- 93.279 Drug Use and Addiction Research Programs
- 93.840 Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
- 93.855 Allergy and Infectious Diseases Research
- 93.399 Cancer Control
- 93.839 Blood Diseases and Resources Research
- 93.233 National Center on Sleep Disorders Research
- 93.307 Minority Health and Health Disparities Research
- 93.394 Cancer Detection and Diagnosis Research
- 93.866 Aging Research
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Tribal Organizations (Not Federally Recognized)
- Non-501(c)(3) Nonprofits
- Public or Indian Housing Auth.
- Small Businesses
- Special District Governments
- Tribal Governments (Federally Recognized)
- State Governments
- Higher Education Inst. (Private)
- Independent School Districts
- 501(c)(3) Nonprofits
- County Governments
- Other
- City/Township Governments
- Higher Education Inst. (Public)
- For Profit Organizations
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health invites applications for investigator-initiated Program Project (P01) grants supporting broadly based, multidisciplinary research programs with a specific major scientific objective or theme aligned with one or more participating NIH Institutes, Centers, and Offices, with applications due May 25, 2029. Each P01 must include at least two research projects and one required Administrative Core, with optional shared resource cores (maximum five) if needed for the proposed research. No cost-sharing requirement applies.
Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), state and local governments, tribal governments (federally recognized and other), small businesses, for-profit organizations, independent school districts, faith-based and community-based organizations, regional organizations, U.S. territories and possessions, eligible federal agencies, and foreign organizations (without foreign subawards or subcontracts).
Participating NIH Institutes, Centers, and Offices include the National Heart, Lung, and Blood Institute; National Human Genome Research Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Institute of Environmental Health Sciences; National Institute on Minority Health and Health Disparities; National Library of Medicine; and National Cancer Institute. Applicants are strongly encouraged to contact awarding ICOs at least 60 days before the receipt date to discuss ICO-specific scientific core requirements and programmatic fit.
The maximum project period is five years. All Program Directors/Principal Investigators must commit a minimum of 1.8 person-months per year; Administrative Core leads must commit 1.2 person-months minimum; and shared resource core leads must commit 0.6 person-months minimum. Budget limits are not specified; applications must reflect actual project needs. Applications are reviewed for scientific merit, synergy among projects and cores, significance, investigator qualifications, innovation, and approach. Scientific merit review is conducted by study sections convened by the Center for Scientific Review, followed by secondary review by appropriate advisory councils. Estimated earliest start dates follow each review cycle, ranging from July through December. Program Directors and Principal Investigators must have eRA Commons accounts and valid ORCID IDs; all applicants must register with the System for Award Management (SAM), obtain a Unique Entity Identifier (UEI), and complete Grants.gov registration prior to submission. The application opens October 20, 2026, with standard due dates January 25, 2027; May 25, 2027; September 25, 2027; and continuing quarterly through September 25, 2029.
Synopsis
Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and Offices (ICOs) invite applications for the investigator-initiated Program Project (P01). A P01 supports a broadly based, multidisciplinary research program with a specific major scientific objective or theme. The proposed Program Projects are focused on the programmatic interests of one or more of the participating ICOs based on their scientific missions. A program project utilizes research projects with a common central scientific theme, an administrative core, and optional shared resource core(s) to accomplish ICOs' programmatic objectives.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Files
| File | Type | Posted |
|---|---|---|
| PKG00294376.pdf | ||
| PA-27-061-Full-Announcement.html | HTML file |
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