Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
Open Posted
- Opportunity number
- RFA-HG-27-009
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $1,500,000
Opportunity facts
- Assistance listings
-
- 93.172 Human Genome Research
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- State Governments
- Independent School Districts
- County Governments
- 501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Small Businesses
- Higher Education Inst. (Private)
- For Profit Organizations
- Public or Indian Housing Auth.
- City/Township Governments
- Special District Governments
- Tribal Organizations (Not Federally Recognized)
- Higher Education Inst. (Public)
- Other
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Human Genome Research Institute is soliciting applications to establish interaction centers investigating how genetic or environmental interactions modify genomic variant impact, with a cooperative agreement due December 14, 2026. Clinical trials using the UM1 activity code are not allowed.
Eligible applicants include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, state and tribal governments, county and city governments, small businesses, for-profit organizations, independent school districts, special district governments, public or Indian housing authorities, and tribal organizations (federally and non-federally recognized). Non-domestic entities and foreign components of U.S. organizations may apply; however, applications involving foreign subawards or subcontracts will be deemed noncompliant and ineligible for funding. Unfunded international collaborations and procurement of unique equipment or supplies from foreign vendors do not trigger this restriction.
Centers will propose a research framework to investigate whether interactions with effects beyond additive are important modifiers of genomic variant impact, then experimentally test combinations for interactions. Centers must share data and analyses through the Impact of Genomic Variation on Function (IGVF) portal and catalog, and share their methods for predicting important combinations for future testing. As IGVF Consortium members, centers will collaborate to ensure consortium resources are accessible to users, coordinate assays, variants, and cell types, and develop shared analysis strategies.
The funding instrument is a cooperative agreement under CFDA 93.172 (Human Genome Research). From submission to award, the typical processing timeline is approximately nine months. All applications undergo peer-reviewed merit evaluation and advisory council consideration before award issuance. Financial records must be retained for three years from submission of the final expenditure report.
Synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, interaction centers will first propose a research framework to investigate whether interactions with effects beyond additive are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions and share their data as well as analyses through the Impact of Genomic Variation on Function (IGVF) portal and catalog. Centers will share their method for predicting the most important combinations for future testing. The rationale for this combination of research and resource work is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding of genome-wide association studies (GWAS), and improved polygenic scores. As IGVF Consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Files
| File | Type | Posted |
|---|---|---|
| PKG00294349.pdf | ||
| RFA-HG-27-009-Full-Announcement.html | HTML file |
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