Limited Competition: The NHGRI Analysis, Visualization, and Informatics Lab-space (AnVIL) (U54 Clinical Trial Not Allowed)
Forecasted Federal grant Posted
- Opportunity number
- RFA-HG-28-005
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
-
- 93.172 Human Genome Research
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- State Governments
- Other
- Tribal Organizations (Not Federally Recognized)
- Higher Education Inst. (Public)
- City/Township Governments
- Tribal Governments (Federally Recognized)
- For Profit Organizations
- Small Businesses
- Special District Governments
- County Governments
- Higher Education Inst. (Private)
- Public or Indian Housing Auth.
- Independent School Districts
- 501(c)(3) Nonprofits
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Human Genome Research Institute (NHGRI) is forecasting a Notice of Funding Opportunity for a limited competition renewal of the Analysis, Visualization, and Informatics Lab-space (AnVIL) program, with an anticipated application due date in 2027. This is a cooperative agreement opportunity open to a broad range of applicants including higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), state and local governments, tribal organizations, for-profit companies, small businesses, and eligible federal agencies, as well as faith-based organizations, regional organizations, and non-domestic entities.
AnVIL is a secure, cloud-based platform hosting more than 5 petabytes of genomic data from nearly 300,000 research participants. The renewal will advance AnVIL as a community resource grounded in FAIR (Findable, Accessible, Interoperable, and Reusable) principles, with key priorities including enhanced scalability, strengthened interoperability across the federated NIH data ecosystem, and security compliance with Research Authentication Service (RAS) and NIH controlled-access data repositories requirements. The program will support integration of emerging data types and computational tools, including infrastructure for AI-based methods and complex analysis workflows, alongside expanded training and outreach to strengthen the genomics research community's capacity for clinical and translational science.
The opportunity is assigned CFDA 93.172 (Human Genome Research) and will utilize the U54 activity code. The NOFO is expected to be published in 2027. Clinical trial applications are not allowed under this activity code.
Forecast synopsis
The National Human Genome Research Institute (NHGRI) intends to issue a Notice of Funding Opportunity (NOFO) to support a limited competition renewal of the Analysis, Visualization, and Informatics Lab-space (AnVIL) program. AnVIL is a secure, cloud-based platform that enables researchers to access, share, and analyze large-scale genomic datasets without relying on local infrastructure. Currently, AnVIL hosts more than 5 petabytes of data from nearly 300,000 research participants, providing a robust environment for reproducible, cloud-native genomic research.
The renewed program will continue to advance AnVIL as a community resource grounded in FAIR (Findable, Accessible, Interoperable, and Reusable) principles. Key priorities include enhancing scalability; strengthening interoperability across a federated NIH data ecosystem; and maintaining rigorous security aligned with the Research Authentication Service (RAS) and NIH controlled-access data repositories and access management systems (CADR) requirements (see NOT‑OD‑25‑159). The renewal will also support integration of emerging data types and computational tools, including infrastructure for developing and running AI-based methods and complex analysis workflows.
In addition to platform development, the program will expand training and outreach to help researchers effectively use AnVIL's multimodal datasets and reproducible analysis capabilities. By connecting secure data access, analytical tools, and workforce development, the renewed AnVIL program aims to accelerate discovery across the research lifecycle and strengthen the genomics community's capacity for clinical and translational science.
This Notice is being provided to allow potential applicants sufficient time to develop responsive applications. The NOFO is expected to be published in 2027 with an anticipated application due date in 2027. This NOFO will utilize the U54 activity code.
This is a Forecast for a limited competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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