Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
Open Posted
- Opportunity number
- RFA-HG-27-007
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $2,000,000
Opportunity facts
- Assistance listings
-
- 93.172 Human Genome Research
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Higher Education Inst. (Public)
- Non-501(c)(3) Nonprofits
- Higher Education Inst. (Private)
- Tribal Organizations (Not Federally Recognized)
- Small Businesses
- State Governments
- 501(c)(3) Nonprofits
- For Profit Organizations
- Public or Indian Housing Auth.
- Independent School Districts
- Other
- County Governments
- City/Township Governments
- Tribal Governments (Federally Recognized)
- Special District Governments
- Points of contact
-
- nhgri-igvf@mail.nih.gov
- Stephanie A. Morris morriss2@mail.nih.gov (301) 435-5738
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health National Human Genome Research Institute is soliciting cooperative agreement applications to establish research centers that characterize genomic variation and assess the effects of individual variants on genome function and phenotype, with applications due December 14, 2026. Clinical trials are not permitted under this activity code. Funded centers will join the Impact of Genomic Variation on Function (IGVF) Consortium and must work collaboratively to ensure consortium resources are accessible to diverse users, coordinate assays and cell types, and develop shared analysis strategies.
Eligible applicants include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, small businesses, for-profit organizations, tribal organizations and federally recognized tribal governments, state and local governments, county governments, cities and townships, special district governments, public or Indian housing authorities, and independent school districts. Non-domestic entities and foreign components of U.S. organizations are eligible to apply. However, NIH will not issue awards involving foreign subawards or subcontracts unless the NOFO is specifically designated for funded international collaborations; applications with such arrangements will be deemed noncompliant and not considered for funding. Unfunded international collaborations, foreign consultants, and procurement of unique equipment or supplies from foreign vendors remain permissible.
Centers must systematically perturb variants or elements using high-throughput methods, collect data on molecular, cellular, or organismal phenotypic effects of variants in DNA, RNA, or protein-coding elements, and develop robust, reproducible, and portable data processing pipelines. Applications will be evaluated through scientific merit review by subject matter experts and secondary review by a national advisory council, competing on scientific and technical merit, program relevance, program balance across research areas, and fund availability. Standard processing time from submission to award is approximately nine months. The opportunity is funded under Assistance Listing 93.172 (Human Genome Research).
Synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Files
| File | Type | Posted |
|---|---|---|
| PKG00294347.pdf | ||
| RFA-HG-27-007-Full-Announcement.html | HTML file |
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