Trans-NIH Research Support
Active
- Assistance listing
- 93.310
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Grant awards
- 5,283 $22,381,696,201 in federal obligations
Program facts
- Also known as
- NIH-wide Research Support
- Assistance types
-
- Cooperative Agreement
- Project Grant
- Block Grant
- Treasury account
-
- 75-0846-0-1-552
Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.
About this program
The National Institutes of Health Office of the Director administers Trans-NIH Research Support (CFDA 93.310), which awards assistance to biomedical and behavioral research projects across multiple NIH offices. The most recent grant award under this program was made on March 1, 2027.
The program funds a broad portfolio of research: recent awards support investigations into leukemia resistance mechanisms, cell-fate decision recording through molecular biology, glucagon-like peptide-1 receptor agonist effects on cognitive aging, consultant impacts on healthcare delivery, immune checkpoint inhibitor-induced arthritis, enzyme evolution platforms, G-protein-coupled receptor signaling, chronic pain modulation via engineered T cells, and dozens of other projects spanning basic science, translational research, and clinical investigation. Scope spans molecular mechanisms, therapeutic development, software tools, educational initiatives, and health services research.
The award portfolio is predominantly Project Grants (72 percent of 5,283 awards, $22.38 billion federal dollars obligated), with substantial shares of Cooperative Agreements (24 percent) and Block Grants (3 percent). The NIH Office of the Director dominates funding concentration, accounting for 3,365 awards and $18.37 billion federal dollars obligated (82 percent of the portfolio by federal dollars). The broader NIH institution supplied an additional 1,595 awards and $2.27 billion, while 26 distinct federal agencies fund under this listing.
Recent award magnitudes range from $50 thousand to $2.02 million, with many awards in the $300 thousand to $800 thousand range. Recent examples include a $843 thousand grant for single-molecule gene regulation imaging technology, a $1.7 million grant investigating glucagon-like peptide-1 receptor agonist effects on cognitive aging in a nationally representative cohort, and a $2.02 million grant testing firearm safety interventions in primary care.
Multiple grant opportunities are currently open or recently posted. The NIH Director's Pioneer Award (DP1), New Innovator Award (DP2), Early Independence Award (DP5), and Transformative Research Award (R01) were posted September 3, 2026. The Somatic Mosaicism across Human Tissues (SMaHT) program includes four Stage 2 opportunities posted September 14, 2026, for genome characterization centers, tissue procurement, data coordination, and experimental technology development. The R3PEATS program (Rigor, Replicability & Reproducibility) posted three opportunities September 11, 2026, supporting metascience projects, laboratory capacity-building, and scholar cohorts. The RNomics program supports RNA characterization technologies through five opportunities posted August 5–6, 2026. The program remains highly active with consistent annual award volume averaging 230–417 awards per year over the past five years and open solicitations spanning multiple research priorities.
Objective and description
- Objective
This listing covers multiple offices in the NIH Office of the Director that offer assistance awards or supplements to assistance awards.
- Description
This listing covers multiple offices in the NIH Office of the Director that offer assistance awards or supplements to assistance awards.
Eligibility
- Applicant eligibility
Awards can be made to domestic, public or private, for-profit or nonprofit organization, university, college, hospital, laboratory, or other institution, including State and local units of government, and individuals. Some initiatives will accept applications from foreign organizations. Additional details on eligibility are specified in each Funding Opportunity Announcement.
- Beneficiary eligibility
Institutions as described above.
- Uses of assistance
To support research and other projects that will accelerate fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments.
- Length and time phasing of assistance
Almost all awards are made for at least one year, with additional support (up to four more years) depending on the recommendation of the scientific review group, the national advisory council, successful annual performance, and availability of funds.
How to apply
- Criteria for selecting proposals
Funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment.
- Award procedure
Applications are reviewed for scientific and technical merit by a scientific review group and for program relevance by a national advisory council/board.
- Time to approval or disapproval
The length of the review cycle is four to nine months.
- Appeals
A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the NIH Scientific/Research contact, as provided on an initiative. A description of the NIH Peer Review Appeal procedures is available on the NIH Web site at http://grants.nih.gov/grants/guide/notice-files/not97-232.html .
Grant opportunities
Show 40 more
Latest 50 listed here. See the rest on GovTribe.
Grant awards
Latest 10 of 5,283 listed here. See the rest on GovTribe.
Top recipients by federal obligations
| Rank | Recipient | Federal obligations | Share |
|---|---|---|---|
| 1 | Duke University | $811,382,472 | 4% |
| 2 | University Of California, San Diego | $720,557,824 | 3% |
| 3 | The Leland Stanford Junior University | $672,715,519 | 3% |
| 4 | Scripps Research Institute | $589,126,079 | 3% |
| 5 | The Johns Hopkins University | $529,980,401 | 2% |
| 6 | The Broad Institute, Inc. | $491,948,724 | 2% |
| 7 | University Of Wisconsin System | $490,554,454 | 2% |
| 8 | The Trustees Of Columbia University In The City Of New York | $458,711,393 | 2% |
| 9 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | $391,290,398 | 2% |
| 10 | The Children's Hospital Of Philadelphia | $374,059,497 | 2% |
10 of 587 recipients listed here. See the rest on GovTribe.
Federal obligations by fiscal year
| Fiscal year | Federal obligations |
|---|---|
| FY2026 | $974,451,660 |
| FY2025 | $1,793,996,566 |
| FY2024 | $2,207,353,506 |
| FY2023 | $2,706,483,251 |
| FY2022 | $3,055,785,632 |
| FY2021 | $2,617,745,518 |
| FY2020 | $876,842,792 |
| FY2019 | $754,729,884 |
| FY2018 | $814,920,772 |
| FY2017 | $681,785,957 |
| FY2016 | $568,761,649 |
| FY2015 | $440,985,541 |
| FY2014 | $335,119,030 |
| FY2013 | $327,993,657 |
| FY2012 | $358,322,277 |
| FY2011 | $379,422,927 |
| FY2010 | $381,934,219 |
| FY2009 | $354,289,046 |
| FY2008 | $135,847,722 |
| FY2007 | $178,691,592 |
| FY2006 | $310,925,021 |
Show all 21
Quick answers
What is Assistance Listing 93.310?
Assistance Listing 93.310 is Trans-NIH Research Support, a federal grant program run by National Institutes of Health (Department of Health and Human Services).
What is the CFDA number for Trans-NIH Research Support?
Its CFDA number is 93.310: Assistance Listing numbers were called CFDA numbers before 2018.
How much funding has Assistance Listing 93.310 awarded?
5,283 grant awards under 93.310 have obligated $22,381,696,201 in federal funds to 587 recipients.
Who receives the most funding from 93.310?
The recipients obligated the most under Trans-NIH Research Support are Duke University ($811,382,472), University Of California, San Diego ($720,557,824) and The Leland Stanford Junior University ($672,715,519).
How much did 93.310 obligate in fiscal year 2025?
Grants under 93.310 obligated $1,793,996,566 in federal funds in fiscal year 2025.
Are there open grant opportunities under 93.310?
42 of the latest 50 opportunities under 93.310 are open or forecasted. The latest, Somatic Mosaicism across Human Tissues (SMaHT) Program: National Somatic Mosaicism Commons Data Analysis & Organizational Center (UM1 Clinical Trial Not Allowed), was posted on September 14, 2026.
On GovTribe
See this program's full record
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