Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials (R34 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-28-093
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $450,000
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Small Businesses
- 501(c)(3) Nonprofits
- Higher Education Inst. (Public)
- Tribal Organizations (Not Federally Recognized)
- County Governments
- Independent School Districts
- Higher Education Inst. (Private)
- Special District Governments
- For Profit Organizations
- Other
- Tribal Governments (Federally Recognized)
- Non-501(c)(3) Nonprofits
- State Governments
- City/Township Governments
- Public or Indian Housing Auth.
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute on Drug Abuse seeks applicants for pilot and feasibility studies preparing for efficacy, effectiveness, and services research trials in substance use prevention and HIV research, with rolling application cycles through June 16, 2029 and earliest project start dates from July 2027 onward.
Eligible applicants include small businesses, nonprofits (501(c)(3) and non-501(c)(3)), higher education institutions (public and private), tribal organizations (federally recognized and other), county and city/township governments, special district governments, independent school districts, public or Indian housing authorities, for-profit organizations, state governments, faith-based or community-based organizations, regional organizations, non-domestic entities, and eligible federal agencies. Foreign subawards or subcontracts are not permitted; however, non-domestic components of U.S. organizations, foreign components as defined in the NIH Grants Policy Statement, and unfunded international collaborations are allowed.
The award ceiling is $450,000 in direct costs over three years (maximum $225,000 per year). No cost share is required. The program funds one of three topic areas: developing interventions to prevent substance use, misuse, or progression to disorder; prevention, treatment, or recovery services research, including research addressing comorbid pain and medical and mental health disorders; or HIV eradication research, including implementation science, prevention, treatment, and recovery in substance use settings or populations.
Preliminary data is not required. Applicants must present a clearly defined theory of change, logic model, or cultural framework and demonstrate meaningful engagement of end users (individuals with lived experience, families, youth, practitioners, policymakers, state and local decision makers, community members, and relevant organizations) in study design, execution, and interpretation. Research may address information gaps, strengthen stakeholder partnerships, or pilot test interventions through intervention development or adaptation, feasibility and acceptability assessment, or development of measures, materials, and methods for future trials.
Evaluation criteria include significance and innovation; rigor and feasibility, with emphasis on end-user engagement and intervention description; and investigator expertise and resources. Applications undergo scientific merit review by peer review groups and advisory council approval. The program operates under CFDA 93.279 (Drug Use and Addiction Research Programs), 93.310 (Trans-NIH Research Support), and 93.681 (Office of Disease Prevention).
Synopsis
The purpose of this notice of funding opportunity (NOFO) is to support pilot and feasibility studies to inform the design and conduct of efficacy, effectiveness, and/or services research trials. Topics may include: 1) developing interventions to prevent substance use, misuse, or progression to substance use disorder; 2) prevention, treatment, or recovery services research, including research addressing comorbid pain and medical and mental health disorders; and 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Files
| File | Type | Posted |
|---|---|---|
| PKG00294426.pdf | ||
| PAR-28-093-Full-Announcement.html | HTML file |
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