INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

Open Posted

Opportunity number
RFA-OD-27-003
Agency
Applications due
Award size
Up to $200,000

Opportunity facts

Funding instrument
Grant
Category
  • Health
Eligible applicants
  • Special District Governments
  • Tribal Organizations (Not Federally Recognized)
  • State Governments
  • For Profit Organizations
  • City/Township Governments
  • Non-501(c)(3) Nonprofits
  • Other
  • Independent School Districts
  • 501(c)(3) Nonprofits
  • County Governments
  • Public or Indian Housing Auth.
  • Higher Education Inst. (Private)
  • Small Businesses
  • Tribal Governments (Federally Recognized)
  • Higher Education Inst. (Public)

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institutes of Health seeks applications for exploratory and developmental research projects addressing Down syndrome through the INCLUDE Project, with applications due June 15, 2028. Clinical trials are explicitly not allowed under this R21 mechanism. The opportunity is open to higher education institutions, nonprofits (with and without 501(c)(3) status), for-profit organizations, state and local governments, tribal organizations, and foreign organizations. Cost share is not required. NIH intends to commit approximately $1 million to fund up to five awards per year across fiscal years 2027–2029, with maximum direct costs of $275,000 over a two-year project period and no more than $200,000 in any single year. The earliest project start date is October 15, 2026. Projects may assess feasibility of novel investigation areas, new experimental systems with potential to enhance health-related research, or unique and innovative applications of existing methodologies to explore new scientific areas. Participating institutes and centers include the Office of the Director, National Eye Institute, National Heart, Lung, and Blood Institute, National Institute on Aging, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Library of Medicine, and National Cancer Institute. The R21 mechanism does not require preliminary data. Applications are evaluated on conceptual framework, innovation, and potential impact using criteria emphasizing significance, innovation, rigor, feasibility, investigator expertise, and institutional resources. Applicants must maintain eRA Commons accounts and link ORCID registration to their profiles. All Program Directors and Principal Investigators must complete required registrations including SAM, UEI, eRA Commons, and Grants.gov prior to submission. Projects recruiting individuals with Down syndrome are encouraged to enroll subjects in the NIH-supported DS-Connect registry. Funding Opportunity Announcement RFA-OD-27-003 covers CFDA numbers 93.310 (Trans-NIH Research Support), 93.865 (Child Health and Human Development Extramural Research), and related parent programs.

Synopsis

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Files

File Type Posted
PKG00292761.pdf PDF
RFA-OD-27-003-Full-Announcement.html HTML file

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