Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)

Open Posted

Opportunity number
PAR-27-021
Agency
Applications due
Award size
$50,000 to $400,000

Opportunity facts

Funding instrument
Grant
Category
  • Health
Eligible applicants
  • City/Township Governments
  • Small Businesses
  • Non-501(c)(3) Nonprofits
  • Higher Education Inst. (Private)
  • Independent School Districts
  • Tribal Organizations (Not Federally Recognized)
  • County Governments
  • Higher Education Inst. (Public)
  • Public or Indian Housing Auth.
  • For Profit Organizations
  • Other
  • Tribal Governments (Federally Recognized)
  • State Governments
  • 501(c)(3) Nonprofits
  • Special District Governments

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institutes of Health seeks applicants for the Seed Instrumentation Support (SIS) Program to fund purchase of a single commercially available biomedical research instrument currently unavailable at the applicant institution, with applications due July 1, 2028. No indirect costs are allowed, and the program does not require cost sharing.

Eligible applicants include higher education institutions (public and private), nonprofits (including 501(c)(3) and non-501(c)(3)), for-profit organizations, state and local governments, tribal organizations (federally and non-federally recognized), special district governments, and independent school districts. Foreign organizations and non-domestic components of U.S. organizations are ineligible. The program provides preference to low-resource institutions (R15-eligible institutions receiving less than $6 million annually in NIH funding).

Award ceiling is $400,000; minimum award is $50,000. The program makes one-year awards for instrument purchase only. Eligible instruments include mass spectrometers, cell sorters, bioimagers, DNA and protein sequencers, microscopes, 3D printers, and high-performance computers dedicated solely to biomedical research. Instruments must be placed in shared-access core or shared resource facilities with an Advisory Committee governing operations, access, and maintenance planning.

Applications must demonstrate at least two NIH-funded users, with at least one from the applicant institution, whose research projects will collectively represent preponderant use of the instrument. The Instrumentation Plan must address justification of need, technical expertise, research projects, administration and management, institutional commitment, financial planning for five-year maintenance and operations, letters of support, and an itemized vendor quote with academic discounts. Institutions must commit to long-term operational and maintenance support consistent with the instrument's expected useful lifetime.

Evaluation addresses need for the instrument, technical expertise in the requested technology, advancements to research projects when novel technology is available, administration of instrument usage, and institutional support for long-term maintenance. Applications receive peer review followed by advisory council review.

The program operates under CFDA 93.310 (Trans-NIH Research Support) and CFDA 93.351 (Research Infrastructure Programs), with participation from the Office of Research Infrastructure Programs, National Institute on Aging, National Institute of Allergy and Infectious Diseases, and Office of Data Science Strategy. Subsequent application deadlines are July 1, 2027, and July 1, 2029, with earliest start dates of September 25, 2026, September 25, 2027, and September 25, 2028.

Synopsis

This Notice of Funding Opportunity (NOFO) aims to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution. Instruments funded through this program must be shared among the users to create new research opportunities, enable reproducible data generation, encourage collaborative research and training, and strengthen long-term research capabilities. The minimum award is $50,000. While there is no limit on the total cost of the instrument, the maximum award is $400,000.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Files

File Type Posted
PKG00293469.pdf PDF
PAR-27-021-Full-Announcement.html HTML file

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