Pilot Projects to Enhance the Human Virome Program (R03 Clinical Trials Not Allowed)

Open Posted

Opportunity number
RFA-RM-27-024
Agency
Applications due
Award size
$50,000 to $100,000

Opportunity facts

Assistance listings
Funding instrument
Grant
Category
  • Health
Eligible applicants
  • Special District Governments
  • Non-501(c)(3) Nonprofits
  • State Governments
  • 501(c)(3) Nonprofits
  • Higher Education Inst. (Private)
  • Small Businesses
  • County Governments
  • Independent School Districts
  • Higher Education Inst. (Public)
  • City/Township Governments
  • Public or Indian Housing Auth.
  • Other
  • Tribal Governments (Federally Recognized)
  • Tribal Organizations (Not Federally Recognized)
  • For Profit Organizations
Points of contact

Opportunity details come from Grants.gov. Updated .

About this opportunity

The National Institutes of Health seeks applications for small pilot projects to enhance the Human Virome Program under the R03 mechanism, with applications due November 10, 2026; clinical trials are not allowed. Eligible applicants include higher education institutions (public and private), small businesses, for-profit and nonprofit organizations (501(c)(3) and non-501(c)(3)), city and county governments, state and tribal governments (federally recognized and non-federally recognized), special district governments, independent school districts, public or Indian housing authorities, faith-based and community-based organizations, regional organizations, U.S. territories and possessions, and eligible federal agencies. Non-domestic entities and foreign organizations are not eligible; however, foreign components and unfunded international collaborations are permitted, and NIH will not issue awards involving foreign subawards or subcontracts unless the NOFO is specifically designated for international collaborations.

Pilot projects should extend the goals of the Human Virome Program by validating and improving existing tools using human specimens from program cohorts; leveraging animal samples to refine and translate tools; expanding existing cohorts or biospecimen sampling sites for virome characterization; developing new tools, assays, and methods to study the human virome; and defining functional interactions between the human virome and host. Applicants are encouraged to collaborate across the Human Virome Program and expand the consortium while avoiding overlap with existing funded efforts.

The R03 mechanism is designed for small research projects with limited resources carried out in a short period. Scientific review encompasses significance, approach, innovation, investigator competency, resource adequacy, and budget justification. Awards are made under CFDA 93.310 (Trans-NIH Research Support), with a typical review cycle of four to nine months conducted through peer review and national advisory council assessment.

Synopsis

The Common Fund Human Virome Program (HVP) aims to extensively and comprehensively characterize the "healthy" human virome (the collection of viruses that normally reside inside the human body without evidence of disease) and create tools, models, and methods that will enable an in-depth study of its variation and composition in relation to host factors and its influence on health and disease.

The purpose of this NOFO is to support small pilot projects that extend the goals of the HVP, including further validating, improving, and complementing existing and newly developed tools from the HVP program by leveraging human specimens collected from the cohorts under the program; samples from animals to promote the refinement, utilization, and translation of these tools to better serve the goals of the HVP program; expanding existing cohorts and/or biospecimen sampling sites for virome characterization; developing tools, assays, and methods to study the human virome; and defining functional interactions between the human virome and host. These pilot projects will expand the HVP consortium, and collaboration across the HVP is expected. Applicants outside the current HVP are encouraged to apply and pilot projects should not overlap with existing HVP efforts (visit the Common Fund website for a list of funded research).

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.Regional Organizations;

Files

File Type Posted
PKG00294332.pdf PDF
RFA-RM-27-024-Full-Announcement.html HTML file

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