NIH Director's Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)
Closed Posted
- Opportunity number
- RFA-RM-27-003
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
-
- 93.310 Trans-NIH Research Support
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Tribal Organizations (Not Federally Recognized)
- Independent School Districts
- Higher Education Inst. (Private)
- Non-501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- County Governments
- For Profit Organizations
- City/Township Governments
- Small Businesses
- 501(c)(3) Nonprofits
- Public or Indian Housing Auth.
- Higher Education Inst. (Public)
- Other
- Special District Governments
- State Governments
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health seeks applicants for the NIH Director's Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional), with applications due September 3, 2026. The program supports bold, groundbreaking, exceptionally innovative, original, or unconventional research across any area within the biomedical sciences—including basic, translational, or clinical research—with potential to create new scientific paradigms, establish entirely new clinical approaches, or develop transformative technologies. No preliminary data are required; projects must demonstrate compelling potential for major impact in a broad area of relevance to NIH based on the strength of logic.
Eligible applicants include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, small businesses, for-profit organizations, tribal governments (federally recognized and not federally recognized), state governments, city/township governments, county governments, special district governments, independent school districts, and public or Indian housing authorities.
The award is funded under CFDA 93.310 (Trans-NIH Research Support) as a component of the NIH Common Fund's High-Risk, High-Reward Research Program. Awards are made for at least one year, with up to four additional years of support depending on scientific review group recommendation, national advisory council approval, successful annual performance, and fund availability. Scientific merit review encompasses peer review criteria specific to the funding announcement, significance, approach, innovation, principal investigator competency, resource adequacy, budget appropriateness, and where applicable, protective measures for humans, animals, or the environment. Funding decisions are based on scientific merit and program relevance.
Synopsis
The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.
Files
| File | Type | Posted |
|---|---|---|
| RFA-RM-27-003-Full-Announcement.html | HTML file |
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