Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)
Forecasted Federal grant Posted
- Opportunity number
- RFA-RM-28-015
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
-
- 93.310 Trans-NIH Research Support
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- 501(c)(3) Nonprofits
- City/Township Governments
- Higher Education Inst. (Private)
- Independent School Districts
- For Profit Organizations
- State Governments
- County Governments
- Other
- Small Businesses
- Tribal Organizations (Not Federally Recognized)
- Non-501(c)(3) Nonprofits
- Higher Education Inst. (Public)
- Special District Governments
- Public or Indian Housing Auth.
- Tribal Governments (Federally Recognized)
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is forecasting a Notice of Funding Opportunity for Stage 2 of the Somatic Mosaicism across Human Tissues (SMaHT) Genome Characterization Centers initiative, with no application deadline specified in this forecast announcement.
Eligible applicants include 501(c)(3) and non-501(c)(3) nonprofits, public and private higher education institutions, for-profit organizations, small businesses, state and county governments, city and township governments, tribal governments (federally and non-federally recognized), special district governments, public or Indian housing authorities, independent school districts, faith-based or community-based organizations, regional organizations, eligible federal agencies, U.S. territories or possessions, and non-domestic entities.
The SMaHT Network's Stage 2 GCCs will determine functional consequences of somatic mutations in healthy tissue samples and in clinically relevant samples from patients whose phenotype is suspected to be driven by somatic mutations. This work extends the Stage 1 foundation, which generated multi-omic somatic mutation datasets from standardized human tissues spanning all three germ layers since 2023. The initiative supports characterization of somatic mosaicism and its role in human biology and disease.
The funding vehicle is a cooperative agreement. No cost share requirement, award ceiling, award floor, or expected number of awards is specified in this forecast. The opportunity falls under Trans-NIH Research Support (CFDA 93.310), which funds biomedical and behavioral research across NIH's mission. The typical NIH review cycle runs four to nine months, with peer review assessing scientific and technical merit and program relevance. Grantees must retain financial and programmatic records for three years from the date of final FSR submission.
Forecast synopsis
The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 of the SMaHT Genome Characterization Centers (GCCs) initiative.
The SMaHT Stage 2 GCCs will determine the functional consequences of somatic mutations in healthy and clinically relevant tissue samples, the latter comprising patients whose phenotype is suspected to be driven by somatic mutations. This work will support the SMaHT Network's efforts to characterize somatic mosaicism and its role in human biology and disease.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
On GovTribe
Work this opportunity
- Track it in your pipeline
- Find teaming partners
- Similar grant opportunities
- Ask GovTribe AI about this opportunity