Centers for Disease Control and Prevention

The Centers for Disease Control and Prevention is an independent civilian federal agency under the Department of Health and Human Services that funds disease surveillance, prevention research, occupational health and safety, and infectious disease control programs through both contracts and grants. CDC's contract and grant portfolios demonstrate sustained federal investment in public health infrastructure and applied research.

CDC has awarded 104,614 federal contracts cumulatively since 1950, with combined potential value of $2.171 billion and combined dollars obligated of $88.27 billion. Contract activity has declined in recent years: 2,116 awards in 2023, 1,705 in 2024, 408 in 2025, 979 in 2026, and 1 recorded award in 2027. The agency transacts with 12,591 distinct prime contractors across its portfolio. Competitive concentration is highly fragmented by award count; the top five primes by recent award count—MCP Computer Products Inc. (187 awards), Fisher Scientific Company L.L.C. (117 awards), Illumina, Inc. (99 awards), New TECH Solutions, Inc. (91 awards), and Carahsoft Technology Corp (68 awards)—hold only 7 percent of recent awards. By potential value, however, the picture shifts: Synergy America, Inc. leads with $2.92 billion combined potential value across 56 awards, followed by Deloitte Consulting LLP ($592.7 million, 59 awards), Research Triangle Institute ($280.5 million, 53 awards), and others, though these top-five primes by value hold 0 percent of combined potential value due to the agency's high volume of low-dollar awards with unreported values (likely Schedule task orders, BPA calls, and below-threshold purchases). Approximately 90 percent of awards carry no set-aside designation; small-business set-asides (including 8(a) sole source, competitive 8(a), reserved, and service-disabled veteran-owned small business) account for about 9 percent of awards, with remaining awards scattered across HUBZone, woman-owned small business, and other designations.

CDC has issued 31,476 federal grants cumulatively since 1981, obligating $231.46 billion in federal dollars. Recent grant activity shows: 897 awards in 2022, 1,213 in 2023, 1,115 in 2024, 373 in 2025, and 259 year-to-date in 2026. The agency funds 5,293 distinct grant recipients. Grant recipient concentration is highly fragmented; the top five recipients by recent award count—Minnesota Department of Health (42 awards, $708.6 million federal dollars), Michigan Department of Health and Human Services (41 awards, $933.3 million), Florida Department of Health (37 awards, $2.17 billion), Utah Department of Health and Human Services (33 awards, $450.6 million), and Massachusetts Department of Public Health (33 awards, $1.09 billion)—hold 5 percent of recent awards. By federal dollars obligated, the top five—Department of State Health Services ($2.27 billion, 28 awards), Florida Department of Health ($2.17 billion, 37 awards), Pennsylvania Department of Health ($1.4 billion, 28 awards), State of Georgia Department of Public Health ($1.12 billion, 31 awards), and Massachusetts Department of Public Health ($1.09 billion, 33 awards)—hold 3 percent of federal dollars. Grant assistance is predominantly cooperative agreements (56 percent of awards) and project grants (36 percent), with smaller shares of block grants (8 percent) and formula grants (less than 1 percent).

Recent contract opportunities reflect CDC's operational and research priorities. A Special Notice posted October 16, 2026 (due October 31) announces a sole-source award to Mathematica Inc. for Medicaid data analysis supporting bacterial respiratory pathogen surveillance and information systems for the National Center for Immunization and Respiratory Diseases. A pre-solicitation (due October 22) from the National Center for Health Statistics seeks market research for information management services to code vital statistics data for the National Vital Statistics System. The National Institute for Occupational Safety and Health issued a pre-solicitation (due October 30) for dose reconstruction and related activities supporting EEOICPA claims and Special Exposure Cohort petitions. Another pre-solicitation (due November 8) announces an Indefinite-Delivery/Indefinite-Quantity contract titled Safety, Prevention, Epidemiology, and Education Development for Health Care and Antimicrobial Resistance (SPEED) with partial small-business set-asides by domain and 100 percent set-aside for one domain. Additional recent solicitations target laboratory equipment, software maintenance, and data analysis services across CDC and NIOSH divisions.

Recent grant opportunities span disease surveillance, occupational health, cancer prevention, and community health. A Cooperative Agreement posted October 9, 2026 (Chronic Disease Education and Awareness, CDC-RFA-DP-27-0068) supports organizations strengthening education and awareness for non-disease-specific chronic diseases with a ceiling of $375,000 and floor of $325,000. A September 28 Cooperative Agreement (Promoting Cancer Surveillance Workforce, Education, and Data Use, CDC-RFA-DP-27-0076) funds workforce development and data use for the National Program of Cancer Registries. A Cooperative Agreement posted September 1, 2026 (Supporting Community Application of Life-Saving Evidence to Prevent Injury and Violence, CDC-RFA-CE-27-0062) addresses injury, violence, overdose, and suicide prevention across populations including tribal communities. The National Institute for Occupational Safety and Health posted a K01 mentored research development award (RFA-OH-27-078, September 1, 2026) supporting junior investigators in occupational health research. A multi-component Cooperative Agreement (Improving Protection against Influenza and Other Respiratory Pathogens: the US Flu VE Network, RFA-IP-27-026, July 28, 2026) funds vaccine effectiveness surveillance and related research across five designated sites. Grant opportunities are open to unrestricted or specified applicant types (state health departments, nonprofits, higher-education institutions, tribal governments, and others depending on the program) with varying award ceilings and eligibility constraints.

CDC collaborates to create the expertise, information, and tools that people and communities need to protect their health through health promotion, prevention of disease, injury and disability, and preparedness for new health threats.