Center for State, Tribal, Local, and Territorial Support

The Centers for Disease Control and Prevention, a civilian sub-agency of the Department of Health and Human Services, administers federal grants for infectious-disease surveillance, prevention, and response activities nationwide and at territorial jurisdictions. CDC's grant portfolio funds state and local health departments, tribal organizations, academic institutions, and nonprofit health organizations to conduct epidemiological research, disease-control programs, and emergency preparedness operations.

CDC has obligated $10.11 billion across 1,753 grant awards since 2009, with combined federal and non-federal dollars reaching $10.15 billion. Award volume has declined significantly: CDC funded 225 awards in 2021, 127 in 2022, 71 in 2023, 37 in 2024, and 19 in 2025. The most recent recorded grant award closed on 30 September 2025. This downward trend suggests portfolio consolidation, longer award cycles, or reduced grant-making activity in recent years compared to the early 2020s peak.

Grant recipients are highly fragmented. The top five recipients by award count account for only 9 percent of awards over the last five years, with Massachusetts Department of Public Health leading by count at five awards. By federal dollars obligated over the same window, the top five recipients represent 8 percent of federal grant dollars, with Massachusetts again dominating at $612.7 million across five awards. Florida Department of Health, Minnesota Department of Health, Mississippi State Department of Health, and Michigan Department of Health and Human Services round out the top five by-value recipients. The remaining 710 distinct recipients hold the substantial majority of awards and funding, indicating a broad distribution across state, tribal, local, and organizational partners.

CDC's assistance-type mix skews toward Cooperative Agreements and Project Grants. Cooperative Agreements comprise 770 awards (44 percent of the portfolio), Project Grants account for 561 awards (32 percent), Block Grants represent 329 awards (19 percent), and Formula Grants comprise 93 awards (5 percent). The cooperative-agreement dominance reflects CDC's emphasis on collaborative, multi-year efforts with state and local health agencies in disease surveillance and prevention programming.

No recent contract activity is recorded against CDC or its descendant offices. No recent federal grant opportunities are present in available source data.