Child Health and Human Development Extramural Research

Active

Assistance listing
93.865
Agency
Grant awards
27,075 $32,234,462,195 in federal obligations

Program facts

Also known as
Child Health and Human Development
Assistance types
  • Project Grant
  • Cooperative Agreement
  • Block Grant
Treasury account
  • 75-0844-0-1-552
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Eunice Kennedy Shriver National Institute of Child Health and Human Development awards extramural research grants under Assistance Listing 93.865 for studies investigating human development, reproductive health, child and adolescent health, and related translational research, with the most recent award issued March 1, 2027.

The program funds basic, translational, and clinical research spanning reproductive biology, maternal and perinatal health, pediatric development, and adolescent health. Recent awards exemplify the scope: maternal early-life adversity and mother-infant physiological coregulation; uterine natural killer cell function in endometrial decidualization; mesothelial development and body plan organization; totipotency-to-pluripotency transitions; preeclampsia pathophysiology; pediatric tuberculosis diagnosis and prevention; visual attention during walking in cerebral palsy; and the gut microbiome's role in reproductive and metabolic health. The program emphasizes mechanistic research connecting molecular and cellular processes to developmental and clinical outcomes.

Funding concentrates heavily within NIH. The National Institute of Child Health and Human Development administered 9,146 awards totaling $20.96 billion in federal dollars—65 percent of all federal dollars obligated under the program. Broader NIH awarded 17,158 grants totaling $8.08 billion. NIAID distributed 13 awards for $2.07 billion, while HHS and the NIH Office of the Director contributed smaller shares. Combined federal dollars obligated reached $32.23 billion across 27,075 awards since the program's inception in 1974.

The assistance-type mix is predominantly Project Grants (94 percent, 25,471 awards), with smaller shares of Block Grants (4 percent, 1,052 awards) and Cooperative Agreements (2 percent, 552 awards). Award cadence reflects declining activity: 2023 saw 759 awards; 2024, 744; 2025, 622; 2026, 534; and 2027 to date, 32. Recent awards typically range from approximately $38 thousand to $172 thousand for training fellowships (F30, F31, F32 codes), with larger research project grants reaching up to $679 thousand for R01 and cooperative agreements. The program reports significant non-federal cost-share: combined total dollars obligated reached $33.82 billion, indicating approximately $1.59 billion in recipient match.

Recent grant opportunities remain in forecast status. PAR-28-059 solicits translational research in maternal and pediatric pharmacology and therapeutics across pregnancy, lactation, and childhood to advance precision medicine and safe drug development—applications not yet being solicited. RFA-HD-28-003 and RFA-HD-28-004 target transporter elucidation and muscular dystrophy research centers respectively, also in forecast. Several other NIH-wide opportunities, including institutional career development (PA-27-030), implementation science (RFA-AI-27-018), and research education programs (PA-27-036), remain open or upcoming with extended timelines through 2029. No recent project-specific solicitations directly tied to Assistance Listing 93.865 are currently accepting applications; the program operates primarily through standing renewal cycles and parent NOFOs that accept ongoing proposals.

Objective and description

Objective

The Eunice Kennedy Shriver National Institute of Child Health and Human Development's mission is to lead research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize a

Description

This is the NICHD legacy entry which is accurate through the end of the second quarter for fiscal year 2026. Please use: 93.HDC Child Health and Human Development Research Centers 93.HDR Child Health and Human Development Extramural Research Projects 93.HDT Child Health and Human Development Other Research 93.HDN Child Health and Human Development Research Training - Institutional Awards 93.HDD Child Health and Human Development Research Training - Individual Awards 93.HDS Child Health and Human Development Small Business Innovation Research & Small Business Technology Transfer Research 93.HDM Child Health and Human Development Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE) Initiative

Eligibility

Applicant eligibility

Universities, colleges, medical, dental and nursing schools, schools of public health, laboratories, hospitals, State and local health departments, other public or private institutions, both nonprofit and for-profit, and individuals. National Research Service Award: Support is provided for academic and research training only, in health and health-related areas that are periodically specified by the National Institutes of Health. Individuals with a professional or scientific degree are eligible (M.D., Ph.D., D.D.S., D.O., D.V.M., Sc.D., D.Eng., or equivalent domestic or foreign degree). Predoctoral research training grants to institutions are also supported. Proposed study must result in biomedical or behavioral research training in a specified shortage area and which may offer opportunity to research health scientists, research clinicians, etc., to broaden their scientific background or to extend their potential for research in health-related areas. Applicants must be citizens of the United States or be admitted to the United States for permanent residency; they also must be nominated and sponsored by a public or private institution having staff and facilities suitable to the proposed research training. Domestic nonprofit organizations may apply for the institutional NRS grant. SBIR: SBIR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees). Primary employment (more than one- half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project. In both Phase I and Phase II, the research must be performed in the U.S. or its possessions. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council. STTR grants can be awarded only to domestic small business concerns (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees) which "partner" with a research institution in cooperative research and development. At least 40 percent of the project is to be performed by the small business concern and at least 30 percent by the research institution. In both Phase I and Phase II, the research must be performed in the U.S. and its possessions. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

Beneficiary eligibility

Any nonprofit or for-profit organization, company, or institution engaged in biomedical or biobehavioral research.

Uses of assistance

Grantee agrees to administer the grant in accordance with the regulations and policies governing the research grant programs of the Public Health Service as stated in the terms and conditions on the application for the grant. National Research Service Awards: Awarded to individuals for full-time research training in specified behavioral and biomedical shortage areas. Awardees may utilize some of their time in academic and clinical duties if such work is closely related to their research training. Awards may be made to institutions to enable them to make NRS awards to individuals selected by them. Each individual awardee is obligated upon termination of the award to comply with certain service and payback provisions. SBIR Phase I grants (of approximately 6-months' duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of the research initiated in Phase I and which are likely to result in commercial products or processes. STTR Phase I grants (normally of 1- year duration) are to determine the scientific, technical, and commercial merit and feasibility of the proposed cooperative effort that has potential for commercial application. Phase II funding is based on results of research initiated in Phase I and scientific and technical merit and commercial potential on Phase II application.

Use restrictions

Please note specific restrictions which may be listed within their unique Funding Opportunities & Notices: https://www.nichd.nih.gov/grants-contracts/funding-opps-and-notices

Length and time phasing of assistance

Awards are usually made annually with no project period to exceed 5 years in length. National Research Service Awards: From 1 to 3 years. SBIR: Phase I awards are generally for 6 months; Phase II awards normally may not exceed 2 years. STTR Phase I awards are generally for 1 year; Phase II awards normally may not exceed 2 years.

How to apply

Criteria for selecting proposals

The major elements in evaluating proposals include assessments of the significance of the proposed research; approach; innovation; investigators; and environment. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the qualifications of the proposed principal investigator, supporting staff, and consultants; (4) the technological innovation originality, or societal importance of the proposed research; (5) the potential of the proposed research for commercial application; (6) the reasonableness of the budget requested for the work proposed; (7) the adequacy and suitability of the facilities and research environment; and (8) where applicable, the adequacy of (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment.

Award procedure

Each application receives a dual scientific review by non-NIH scientists. Awards are issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). National Research Service Awards: Applications are reviewed for scientific merit by an appropriate study section committee or by an institute review committee. If recommended for approval and a decision is made to make an award, a formal award notice will be sent to the applicant and sponsor. Institutional Awards are issued by the Eunice Kenney Shriver National Institute of Child Health and Human Development (NICHD). All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate scientific peer review panel and by a national advisory council or board. All applications receiving a priority score compete for the available SBIR/STTR set-aside funds on the basis of scientific and technical merit and the commercial potential of the proposed research, program relevance, and program balance among the areas of research. Contact the headquarters or regional office, as appropriate, for application deadlines, or consult the specific Funding Opportunity Announcement listed in the NIH Guide for Grants and Contracts at: https://grants.nih.gov/funding/searchGuide/nih-guide-to-grants-and-contracts.cfm. General guidance about application due dates may be found at: http://grants.nih.gov/grants/how-to-apply-application-guide/due-dates-and-submission-policies/standard-due-dates.htm

Time to approval or disapproval

From 6 to 9 months: National Research Service Awards: From 6 to 9 months. SBIR/STTR: approximately 6 months.

Renewals

Renewal applications are accepted, as described in the relevant Funding Opportunity Announcement (FOA) found at: http://grants.nih.gov/grants/guide/index.html?CFID=50541572 & CFTOKEN=87322295&jsessionid=f630f3b44e23db8088b9e5e5224596361271. National Research Service Awards: awards may be made for 1, 2, or 3 years. No individual may receive NIH fellowship support at the postdoctoral level for more than 3 years. Institutional Awards may be renewed.

Appeals

A principal investigator (P.I.) may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH web site at: http://public.csr.nih.gov/ApplicantResources/InitialReviewResultsAppeals/Pages/default.aspx

Grant opportunities

Opportunity Status Posted Applications due
Learning Disabilities Research Centers RFA-HD-28-006 Forecasted —
CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect RFA-HD-28-005 Forecasted —
Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource-Constrained Settings--Implementation Science Network (PATC3H-IN) RFA-HD-28-002 Forecasted —
Discovery Gateway to Reproductive Health Innovation RFA-HD-28-001 Forecasted —
Translational Research in Maternal and Pediatric Pharmacology and Therapeutics PAR-28-059 Forecasted —
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) RFA-HD-28-004 Forecasted —
Elucidation and Validation of the role of Transporters in the Placenta, Lactating Mammary Gland, Developing Gut, and Blood Brain Barrier RFA-HD-28-003 Forecasted —
Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional) PAR-27-040 Forecasted —
Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional) PAR-27-039 Forecasted —
Institutional Mentored Career Development Award (Parent K12) (Clinical Trials Not Allowed) PA-27-030 Open
ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV PAR-26-105 Past —
Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional) PAR-27-076 Open
NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional) PA-26-002 Open
NIH Research Education Program - Research Experiences (Parent R25 - Clinical Trial Not Allowed) PA-27-036 Open
Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional) RFA-AI-27-018 Open
Centers for AIDS Research (CFAR) and Developmental Centers for AIDS Research (D-CFAR) (P30 Clinical Trial Not Allowed) PAR-28-090 Open
Palliative Care Research Across the Lifespan: Leveraging the Palliative Care Consortium (R01 Clinical Trial Optional) PAR-27-090 Open
INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed) RFA-OD-27-003 Open
INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed) RFA-OD-27-004 Open
INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) RFA-OD-27-005 Open
Autism Centers of Excellence P50 RFA-HD-27-002 Forecasted —
Autism Centers of Excellence R01 RFA-HD-27-001 Forecasted —
Biological Testing Facility for Contraception & Reproductive Health (X01 Clinical Trial Not Allowed) PAR-27-111 Open
Data Sharing for Demographic Research Infrastructure Program RFA-HD-27-005 Past —
Maternal and Pediatric Precision in Therapeutics (MPRINT) Knowledge and Research Coordination Center RFA-HD-26-009 Past —
Maternal Medications and Human Milk Research Center (M2HMRC) RFA-HD-26-010 Past —
Bioengineering Research Grants (BRG) (R01 Clinical Trial Optional) PAR-27-072 Open
BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed) RFA-NS-27-002 Open
BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed) RFA-NS-28-010 Open
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) PA-26-001 Open
Limited Competition: Social, Behavioral, & Economic (SBE) Coordinating Center RFA-AG-26-005 Past —
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science 25-542 Closed
Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 CT Not Allowed) RFA-HD-27-007 Open
Novel Experiential Technologies Assisting Individual Learning (NExT AI) Hubs (P20 Clinical Trial Optional) RFA-HD-27-006 Closed
Notice of Intent to Publish a Funding Opportunity Announcement for HIV Pediatric, Adolescent and Maternal Clinical Trials NOT-HD-25-007 Past —
Notice of Intent to Publish a Funding Opportunity Announcement for Impact of Technology and Digital Media Exposure Usage on Child and Adolescent Development NOT-HD-25-008 Past —
Notice of Intent to Publish a Funding Opportunity Announcement for ClinGen Genomic Curation Expert Panels NOT-HD-25-006 Past —
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) PA-27-100 Open
NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional) PA-27-102 Open
NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) PA-27-101 Open
Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) PAR-27-078 Open
NIH Research Education Program - Courses, Curriculum & Methods (Parent R25 - Clinical Trial Not Allowed) PA-27-034 Open
Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed) PA-27-037 Open
SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) PAR-27-098 Open
Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed) PAR-25-450 Open
BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed) RFA-DC-27-004 Open
Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study Renewal - Data Analysis, Informatics and Resource Center, and Coordinating Center (U24 Clinical Trial Not Allowed) RFA-DA-27-003 Closed
Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed) PAR-25-442 Open
Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed) RFA-DA-27-002 Closed
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) RFA-NS-27-007 Open
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Grant awards

Award Recipient Federal obligations Awarded
Maternal early life adversity, mother-infant physiological coregulation, and infant socioemotional development F32HD123894 Colorado State University $80,716
Uterine natural killer cell-mediated clearance of senescent cells: a novel mechanism in endometrial decidualization and… F32HD121269 Baylor College Of Medicine $79,780
Mechanisms of HAND2-mediated cell migration in mesothelia F31HD123273 The Regents Of The University Of Colorado $38,044
Integrating novel transcriptional and adhesive networks to build a functional gonad in c. Elegans. F31HD123506 Rector & Visitors Of The University Of Virginia $41,870
Vasculature-associated neural crest-derived progenitor cell contributions to zebrafish development F31HD123661 Rector & Visitors Of The University Of Virginia $41,870
Environmental and developmental regulation of primordial germ cell proliferation in the c. Elegans larval gonad F32HD123658 University Of Wisconsin System $79,000
High resolution analyses of FAM205C and FAM227A in sperm perinuclear theca and mitochondrial formation and function F32HD123515 Yale Univ $79,348
Mitochondrial origins of preeclampsia F32HD123271 The Regents Of The University Of Colorado $79,278
Visual attention during walking in children with and without cerebral palsy F32HD122482 University Of Southern California $76,300
A bioactive milk component promotes cognition through the GUT microbiome-brain axis. F32HD118812 University Of California, Davis $86,824

Latest 10 of 27,075 listed here. See the rest on GovTribe.

Top recipients by federal obligations

Rank Recipient Federal obligations Share
1 Fred Hutchinson Cancer Center $1,988,432,985 6%
2 The Johns Hopkins University $944,858,207 3%
3 Regents Of The University Of Michigan $781,032,098 2%
4 University Of North Carolina At Chapel Hill $604,899,856 2%
5 University Of Washington $536,568,377 2%
6 Baylor College Of Medicine $489,832,518 2%
7 Research Triangle Institute $488,736,764 2%
8 University Of California, LOS Angeles $478,418,768 1%
9 The Regents Of The University Of California. San Francisco $464,476,832 1%
10 University Of California, San Diego $462,891,886 1%

10 of 1,420 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $1,267,009,285
FY2025 $2,028,363,753
FY2024 $2,532,145,300
FY2023 $2,827,495,080
FY2022 $2,579,273,778
FY2021 $2,208,715,617
FY2020 $1,154,007,894
FY2019 $1,113,076,608
FY2018 $1,039,508,644
FY2017 $971,798,080
FY2016 $1,042,887,643
FY2015 $946,614,075
FY2014 $933,055,750
FY2013 $899,229,236
FY2012 $968,794,732
FY2011 $924,872,214
FY2010 $921,380,958
FY2009 $790,419,979
FY2008 $370,587,456
FY2007 $570,236,973
FY2006 $831,749,525
FY2005 $840,180,286
FY2004 $833,895,716
FY2003 $510,699,104
FY2002 $531,957,282
FY2001 $199,854,708
Show all 26

Quick answers

What is Assistance Listing 93.865?

Assistance Listing 93.865 is Child Health and Human Development Extramural Research, a federal grant program run by National Institutes of Health (Department of Health and Human Services).

What is the CFDA number for Child Health and Human Development Extramural Research?

Its CFDA number is 93.865: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 93.865 awarded?

27,075 grant awards under 93.865 have obligated $32,234,462,195 in federal funds to 1,420 recipients.

Who receives the most funding from 93.865?

The recipients obligated the most under Child Health and Human Development Extramural Research are Fred Hutchinson Cancer Center ($1,988,432,985), The Johns Hopkins University ($944,858,207) and Regents Of The University Of Michigan ($781,032,098).

How much did 93.865 obligate in fiscal year 2025?

Grants under 93.865 obligated $2,028,363,753 in federal funds in fiscal year 2025.

Are there open grant opportunities under 93.865?

38 of the latest 50 opportunities under 93.865 are open or forecasted. The latest, Learning Disabilities Research Centers, was posted on October 20, 2026.

On GovTribe

See this program's full record

  • Every grant award and opportunity under it
  • Funding by recipient, agency and assistance type
  • Alerts for new opportunities
  • Ask GovTribe AI about this program