Elucidation and Validation of the role of Transporters in the Placenta, Lactating Mammary Gland, Developing Gut, and Blood Brain Barrier
Forecasted Federal grant Posted
- Opportunity number
- RFA-HD-28-003
- Agency
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National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
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- Other
- Higher Education Inst. (Private)
- 501(c)(3) Nonprofits
- City/Township Governments
- Independent School Districts
- Higher Education Inst. (Public)
- Special District Governments
- Non-501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Public or Indian Housing Auth.
- Tribal Organizations (Not Federally Recognized)
- State Governments
- Small Businesses
- County Governments
- For Profit Organizations
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The Eunice Kennedy Shriver National Institute of Child Health and Human Development is soliciting applications to advance understanding of maternal, fetal, and child exposure to nutrients, metabolites, medications, supplements, microbiome-derived products, and environmental chemicals through a second phase of the Transporter Elucidation Network (TEN); no specific application deadline is stated in this forecast.
Eligible applicants include higher education institutions (public and private), small businesses, for-profit and non-profit organizations, state and local governments, tribal governments (federally and non-federally recognized), special district governments, public housing authorities, faith-based and community-based organizations, regional organizations, Indian/Native American tribal governments, U.S. territories or possessions, and eligible federal agencies. Non-domestic entities are also eligible.
The initiative will establish perinatal multi-barrier transport network frameworks to clarify how transporters and local biotransformation regulate exposure processes. Work will develop standards, resources, models, and prototype multi-compartment approaches spanning maternal gut, placenta, lactating mammary epithelium, infant gut, and infant blood-brain barrier. The program emphasizes mechanistic understanding of transporter function, polarity, kinetics, and transformation capacity relevant to pregnancy, lactation, infant nutrition, pediatric pharmacology, and neurodevelopment. Deliverables will include community resources for integrated studies of perinatal exposure and risk, strengthened investigator coordination, accelerated dissemination of tools, and workforce development in human-based, developmentally relevant transporter research.
Awards are issued under CFDA 93.865 (Child Health and Human Development Extramural Research). Applications undergo dual scientific peer review by non-NIH scientists on criteria including significance, approach, innovation, investigators, and research environment. No cost share is specified. The grant authority is 42 U.S.C. 241.
Forecast synopsis
The Eunice Kennedy Shriver National Institute of Child Health and Human Development seeks to advance its mission of supporting maternal, fetal, and child health by continuing to enhance the understanding of maternal, fetal, and child exposure to nutrients, metabolites, medications, supplements, microbiome-derived products, and environmental chemicals. This will be done by supporting a second phase of the Transporter Elucidation Network (TEN). This phase of the TEN will establish perinatal multi-barrier transport network frameworks to clarify how transporters and local biotransformation regulate these processes. Building on prior organ-focused models, methods, and datasets, this initiative will develop standards, resources, models, and prototype multi-compartment approaches spanning maternal gut, placenta, lactating mammary epithelium, infant gut, and infant blood-brain barrier. The initiative is expected to support a mechanistic understanding of transporter function, polarity, kinetics, and transformation capacity relevant to pregnancy, lactation, infant nutrition, pediatric pharmacology, and neurodevelopment. By emphasizing multi-barrier perinatal transporter frameworks this phase of the TEN will provide community resources for future integrated studies of perinatal exposure, risk, and intervention across interlinked maternal, fetal, and infant systems. It will also strengthen coordination among investigators, accelerate dissemination of tools, and advance human-based, developmentally relevant transporter research and workforce development. The grant authority for this is 42 U.S.C. § 241
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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