Cancer Research Manpower

Active

Assistance listing
93.398
Agency
Grant awards
12,555 $5,392,510,120 in federal obligations

Program facts

Also known as
Cancer Manpower Grants
Assistance types
  • Project Grant
  • Block Grant
  • Cooperative Agreement
Treasury account
  • 75-0849-0-1-550
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Department of Health and Human Services National Institutes of Health administers the Cancer Research Manpower program (CFDA 93.398) to provide biomedical training opportunities for individuals pursuing careers in basic, clinical, and prevention research relevant to the National Cancer Program, with the most recent grant award on March 4, 2027.

The program funds predoctoral and postdoctoral fellowships (predominantly F31 and F30 awards), research training grants, and career development awards spanning up to five years with potential renewals. Recent awards support dissertation research in cancer biology, immunotherapy, tumor microenvironment mechanisms, and translational oncology. Representative funded projects include characterization of chemotherapy resistance in gliomas (F31CA301899, $47,383), investigation of T-cell metabolic reprogramming in leukemia (F31CA301702, $48,642), and development of HPV vaccination strategies in rural health professional shortage areas (F31CA318452, $50,114). The portfolio reflects active training in mechanism-driven cancer research across hematologic and solid tumors.

The program has maintained steady output at roughly 270–350 awards per year over the past five years. Cumulative federal dollars obligated total $5.39 billion across 12,555 awards since 1975. The National Cancer Institute dominates funding, with 4,576 awards and $3.64 billion in federal dollars, while the broader NIH system contributes an additional $1.6 billion through 7,588 awards. Assistance-type distribution is heavily skewed toward Project Grants (97% of awards), with Block Grants (3%) and Cooperative Agreements (less than 1%) comprising the remainder. Matching or cost-share contribution from recipients totals $230 million against the federal base.

No grant opportunities are currently open under this Assistance Listing. Active competing funding mechanisms for early-career researchers are available through companion programs including the Ruth L. Kirschstein NRSA predoctoral fellowship (F31, Parent PA-25-422), the predoctoral-to-postdoctoral transition award (F99/K00, Parent PA-27-037), and the Academic Career Excellence Award (K32, Parent PAR-27-062), all of which support mentored training and career development in cancer and biomedical research.

Objective and description

Objective

To make available support to nonprofit and for-profit institutions interested in providing biomedical training opportunities for individuals interested in careers in basic, clinical, and prevention research important to the National Cancer Program.

Description

To make available support to nonprofit and for-profit institutions interested in providing biomedical training opportunities for individuals interested in careers in basic, clinical, and prevention research important to the National Cancer Program.

Eligibility

Applicant eligibility

University, college, hospital, public agency, or nonprofit research institution for institutional grants and individuals for fellowships. The applicant institution must be able to provide the staff and facilities and be responsible for the selection of trainees and overall direction of the training. Selected awardees must be citizens of the United States or be admitted to the United States for permanent residency. Career and Cancer Education awards may be given to for-profit institutions.

Beneficiary eligibility

University, college, hospital, public agency, nonprofit research institution or for-profit institution.

Uses of assistance

The Research Manpower program provides support for research training in all scientific fields related to cancer. The Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Fellows, are made directly to individuals for research training in biomedical sciences areas. In addition, the National Institutes of Health (NIH) will award the Ruth L. Kirschstein NRSA Institutional Research Training grants to institutions, to enable them to make NRSA awards to individuals selected by them. Each individual who receives a postdoctoral NRSA is obligated, upon termination of the award, to comply with certain service and payback provisions. Cancer Education Grants are designed to promote education programs carried out by organizations engaged in health-related education, research, or training, located in the United States, its possessions, or territories. Various Career awards are designed to sponsor the development of independent scientists. Individual short-term support for students is available under the Cancer Education Program.

Length and time phasing of assistance

Up to 5 years.

How to apply

Criteria for selecting proposals

The major elements in evaluating proposals include the assessment of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.

Award procedure

All applications are evaluated by scientific authorities for scientific and technical merit. Applications must also be reviewed by the National Cancer Advisory Board. All competitive applications compete for available funds on the basis of scientific and technical merit, program relevance, and program balance, consistent with NCI and NIH priorities and strategic plans.

Time to approval or disapproval

Approximately 10 months.

Renewals

Cancer Education Grants may be made for periods of up to 5 years and renewals may be submitted when appropriate. Research training grants may be renewed for additional project periods of 5 years. Only the following Career awards are renewable: K05 and K24 only a one-time renewal after a 5-year project period, and the K12 up to 5 years (Trainees 2-7 years).

Appeals

A principal investigator (P.I.) may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available under the Review Criteria section of the NIH Office of Extramural Research website at http://grants2.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part3.htm.

Grant opportunities

Opportunity Status Posted Applications due
Investigator-Focused Award (Parent R35) PAR-28-037 Forecasted —
Academic Career Excellence (ACE) Award (K32 Independent Clinical Trial Not Allowed) PAR-27-062 Open
NCI Research Specialist (Clinician Scientist) Award (R50 Clinical Trial Not Allowed) PAR-27-089 Forecasted —
NCI Research Specialist Award for Core and Laboratory-based Scientists (R50 Clinical Trial Not Allowed) PAR-27-088 Forecasted —
NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed) RFA-LM-28-001 Open
Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional) PAR-27-076 Open
NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional) PA-26-002 Open
NIH Research Education Program - Research Experiences (Parent R25 - Clinical Trial Not Allowed) PA-27-036 Open
NIH Research Educational Program - Mentoring Activities & Networks (Parent R25/UE5 - Clinical Trial Not Allowed) PA-27-035 Open
Limited Competition: Stimulating Access to Research in Residency Transition Scholar (StARRTS) (K38 Clinical Trial Not Allowed) RFA-HL-27-010 Open
Forecast to Publish a Notice of Funding Opportunity for Academic Career Excellence (ACE) Award (K32 - Clinical Trial Required) NOT-CA-25-102 Past —
Forecast to Publish a Notice of Funding Opportunity for Paul Calabresi Career Development Award in Clinical Oncology (K12 Clinical Trial Optional) NOT-CA-25-105 Past —
NIH Research Education Program - Courses, Curriculum & Methods (Parent R25 - Clinical Trial Not Allowed) PA-27-034 Open
Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed) PA-27-037 Open
Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed) PAR-25-415 Open
Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) PAR-25-322 Open
Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required) PAR-25-323 Closed
Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed) PAR-25-414 Open
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) PA-25-425 Open
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) PA-25-422 Open
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) PA-25-426 Open
Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Clinical Trials Not Allowed) RFA-OD-25-003 Open
NCI Pathway to Independence Award (K99/R00 Clinical Trial Required) PAR-25-313 Open
NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award (K08 Clinical Trial Required) PAR-24-319 Closed
NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22 Independent Clinical Trial Not Allowed) PAR-24-317 Closed
NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22 Clinical Trial Required) PAR-24-318 Closed
NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award (K08 Clinical Trial Not Allowed) PAR-24-320 Closed
NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed) PAR-25-135 Open
NCI Mentored Research Scientist Development Award to Promote Diversity (K01 Independent Clinical Trial Not Allowed) PAR-24-316 Closed
Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) PA-25-168 Open
Emerging Global Leader Award (K43 Independent Clinical Trial Required) PAR-24-295 Open
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed) PAR-24-296 Open
Paul Calabresi Career Development Award for Clinical Oncology (K12 Clinical Trial Not Allowed) PAR-27-025 Open
NCI Research Specialist (Clinician Scientist) Award (R50 Clinical Trial Not Allowed) PAR-24-274 Closed
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed) RFA-OD-24-011 Open
Successor-in-Interest (Type 6 Parent Clinical Trial Optional) PA-24-253 Open
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional) PA-24-254 Open
National Cancer Institute Youth Enjoy Science Research Education Program (R25 Clinical Trial Not Allowed) RFA-CA-24-026 Closed
NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Basic Experimental Studies with Humans (BESH) Required) PAR-24-218 Closed
NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Not Allowed) PAR-24-219 Closed
NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Required) PAR-24-217 Closed
Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional) PAR-24-202 Closed
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) PA-24-175 Open
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) PA-24-176 Open
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required) PA-24-181 Open
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required) PA-24-183 Closed
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed) PA-24-182 Open
Mentored Research Scientist Development Award (Parent K01 Independent Basic Experimental Studies with Humans Required) PA-24-177 Closed
NIH Pathway to Independence Award (Parent K99/R00 Independent Basic Experimental Studies with Humans Required) PA-24-195 Closed
NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required) PA-24-193 Open
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Grant awards

Award Recipient Federal obligations Awarded
Characterizing and targeting membrane properties tied to chemotherapeutic resistance in gliomas F31CA301899 University Of California Irvine $47,383
MTORC2 metabolic reprogramming in t cell lymphoma F31CA301702 Rutgers The State University Of New Jersey $48,642
Deciphering the regulatory mechanism and therapeutic targeting of EYA3/PP2A-B55A in NF-KB signaling F31CA306106 The Regents Of The University Of Colorado $39,431
TAZ-tead signaling in the immune microenvironment of cutaneous melanoma F31CA318736 Thomas Jefferson University $50,114
Overcoming adenosine-mediated suppression to enhance the antitumor efficacy of engineered t cell therapy F31CA310473 Rector & Visitors Of The University Of Virginia $39,684
Improving efficacy of tshr-cart by targeting suppressive myeloid cells F31CA310302 Mayo Clinic $50,114
The role of the mammary FAT PAT in obesity-linked breast cancer metastasis - breast cancer (BC) is the most common… F31CA301931 University Of Utah $37,417
Overcoming CD4 t cell dysfunction in acute lymphoblastic leukemia F31CA306005 Regents Of The University Of Minnesota $38,277
Implications of coagulation and fibrinolytic cascade activation in osteosarcoma angiogenesis and metastasis F30CA318159 Vanderbilt University $35,490
FOXM1-mediated regulation of anti-tumor immune memory and its potential as a target for therapeutic vaccination in… F30CA310537 The University Of Texas Health Science Center At San Antonio $55,114

Latest 10 of 12,555 listed here. See the rest on GovTribe.

Top recipients by federal obligations

10 of 378 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $206,050,438
FY2025 $321,773,135
FY2024 $374,221,901
FY2023 $422,775,812
FY2022 $461,947,837
FY2021 $408,290,284
FY2020 $202,589,207
FY2019 $187,893,650
FY2018 $177,814,764
FY2017 $164,557,124
FY2016 $163,719,523
FY2015 $161,404,868
FY2014 $162,552,855
FY2013 $163,703,415
FY2012 $168,195,717
FY2011 $182,748,387
FY2010 $188,537,068
FY2009 $195,469,546
FY2008 $81,001,875
FY2007 $139,591,003
FY2006 $175,930,440
FY2005 $174,125,926
FY2004 $170,133,871
FY2003 $158,732,830
FY2002 $137,562,638
FY2001 $77,814,717
Show all 26

Quick answers

What is Assistance Listing 93.398?

Assistance Listing 93.398 is Cancer Research Manpower, a federal grant program run by National Institutes of Health (Department of Health and Human Services).

What is the CFDA number for Cancer Research Manpower?

Its CFDA number is 93.398: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 93.398 awarded?

12,555 grant awards under 93.398 have obligated $5,392,510,120 in federal funds to 378 recipients.

Who receives the most funding from 93.398?

The recipients obligated the most under Cancer Research Manpower are Sloan-Kettering Institute For Cancer Research ($194,311,988), The Univeristy Of Texas M.d. Anderson Cancer Center ($160,684,591) and Dana-Farber Cancer Institute, Inc. ($148,436,677).

How much did 93.398 obligate in fiscal year 2025?

Grants under 93.398 obligated $321,773,135 in federal funds in fiscal year 2025.

Are there open grant opportunities under 93.398?

33 of the latest 50 opportunities under 93.398 are open or forecasted. The latest, Investigator-Focused Award (Parent R35), was posted on July 30, 2026.

On GovTribe

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