Veterinary Services
Added: Jan 23, 2015 2:14 pm This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a written solicitation will not be issued. The solicitation number is HSBP1015R0014, and is issued as a request for quote (RFQ), unless otherwise indicated herein. The solicitation document and incorporated provisions and clauses are those in effect tough Federal Acquisition Circular FAC 2005-79. The associated North American Industrial Classification System (NAICS) code for this procurement is 541940. The Small Business Size Standard is $7.5 million. One contract is anticipated to be awarded as a result of this request for quote.The DHS Customs and Border Protection (CBP) requires the following items, Meet or Exceed, to the following:CLIN 001- Year 1 - Veterinary Services for Canines.CLIN 002- Year 2 - Veterinary Services for Canines.Reference the attached Statement of Work.Bid MUST be good for 30 calendar days after close of solicitation.Shipping must be free on board (FOB) destination CONUS (Continental U.S.), which means that the seller must deliver the goods on its conveyance at the destination specified by the buyer, and the seller is responsible for the cost of shipping and risk of loss prior to actual delivery at the specified destination.This solicitation requires registration with the System for Award Management (SAM), and completion of Online Representations and Certifications prior to award, pursuant to applicable regulations and guidelines. Registration information can be found at www.sam.gov .Award Criteria - An award will be made to a responsive offeror (who submits all required submissions on time), whose past performance does not pose a risk to the Government, and whose offer is the Lowest Price Technically Acceptable (LPTA). An offer is technically acceptable if its technical capabilities conform to the Government's Statement of Work.The Government may determine that an offer is unacceptable if the first and second year prices are significantly unbalanced.Offers are due January 30, 2015 by 4:00 p.m. Eastern Standard Time. Quotes/Offers to include any supporting documentation must be submitted by e-mail to: david.torres3@cbp.dhs.gov . Offers not received timely will not be considered.Vendors shall submit their bids on Standard Form 18, or a similar document that includes all the information requested in this solicitation. The bid must be signed and dated.
HSBP1015R0014 Department of Homeland Security Customs and Border Protection
1/23/15, 2:14 PM Operation and Maintenance of the Federal Chimpanzee Sanctuary System for Retired Chimpanzees
This pre-solicitation notice seeks capability statements from qualified nonprofit organizations to operate and maintain the Federally Supported Chimpanzee Sanctuary System on behalf of the National Institutes of Health. Interested parties must demonstrate experience providing lifetime care to large numbers of chimpanzees in accordance with all laws and regulations. Capability statements will be evaluated based on the respondent's experience, skills, and ability to fulfill requirements outlined in the attached statement of work. Capability statements must be submitted to the NIH by September 10, 2021 and shall not exceed 10 pages.
There is no set-aside designated for this requirement. Respondents should be able to provide care for up to 330 retired chimpanzees used in past federal research. Capability statements must include the organization's name, address, socio-economic status, point of contact, DUNS number, and evidence of relevant past performance caring for primates under federal contracts. The selected contractor will assume full responsibility for daily animal care, veterinary services, facility maintenance and regulatory compliance for the sanctuary system.
75N97021R00016 Department of Health and Human Services National Institutes of Health National Institute of Environmental Health Sciences
8/27/21, 8:06 AM Combinatorial approach for identification of MicroRNA signatures as biodosimetry biomarkers
Added: May 05, 2014 9:28 am General InformationTitle: Combinatorial approach for identification of MicroRNA signatures as biodosimetry biomarkersDocument Type: Presolicitation NoticeSolicitation Number: N02RC44416-11Posted Date: 05/05/2014Response Date: 05/20/2014Classification Code: Q301 Laboratory Testing ServicesNAICS Code: 541940 Veterinary ServicesContracting Office AddressDepartment of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, Riverside Five, Suite 400, Room 4032, 8490 Progress Drive, Frederick, MD 21701, UNITED STATES.DescriptionNCI, Center for Cancer Research (CCR), is anticipating to award a cost-reimbursement non-competitive purchase order New York University School of Medicine in New York, New York for the collection of blood and tissue/organ specimens from the in vivo radiation experiments similar to those being done on the related collaborative effort.The services herein are being procured in accordance with the simplified acquisition procedures as authorized by FAR Part 13.106-1 (b)(1). The North American Industry Classification System code is 541940 and the business size standard is $7 million.Only one award will be made as a result of this solicitation. This will be awarded as a cost-reimbursement type purchase order.It is anticipated that completion of this project as described below will take two years with work ongoing for the duration. The estimated period of performance is June 3, 2014 to June 2, 2016.Background:Circulating and functional micro RNAs (miRNAs) in plasma, serum or other body fluids represent a promising potential source of non-invasive biomarkers and are actively being investigated for various diseases and different kinds of stresses including low and high doses of radiation. The current study is to investigate radiation dose dependence of the expression of miRNAs in mice exposed to whole body irradiation.As a follow on to collaborative in vivo experiments in mouse models including both single does and multi-fraction radiation in Dr. Demaria's laboratory at New York University School of Medicine, the National Cancer Institute plans to have New York University School of Medicine perform in vivo radiation experiments using mice and collect blood and tissue specimens that will be sent to our lab for analysis. Mice will receive 2, 4, 8, 12 & 15 Gy total body radiation at a dose rate of 1-2Gy/min (Xstrahl RS320 radiator, Xstrahl, Suwanee, GA). Two groups of eight age-matched sham irradiated mice will be used as controls. Mice will be euthanized at various times post-radiation up to 7 days. Dr. Demaria's lab at NYU has extensive expertise with mice irradiation, and they have a protocol approved by Institutional Animal Care and Use Committee (IACUC) to perform these radiation experiments. Utilizing the same laboratory for this work will provide time and cost savings to the Government as well as comparable results.Contractor Requirements:The contractor will provide processed blood samples, urine and tissue/organ samples after whole body irradiation for microarray and protein experiments as well as exosomal analysis services. The deliverables may include any combination of tumor samples, plasma, serum, urine samples or any other biological samples.It is anticipated that completion of this project as described below and in the attached Statement of Work (SOW) will take two years with work ongoing for the duration. The estimated period of performance is June 3, 2014 to June 2, 2016.In vivo studies will be conducted in collaboration with New York University (NYU) Langone Medical Center (NY).6-12-week old C57/BL6 mice will be purchased from Taconic Animal Laboratory (Germantown, NY). Experiments will be performed according to the protocols approved by the Institutional Animal Care and use committee of NYU. Each group will contain eight mice.Mice will be exposed to 2, 4, 8, 12 and 15 Gy whole body radiation respectively, at a dose rate of 1-2 Gy/min (Xstrahl RS320 radiator, Xstrahl, Suwanee, GA). Each group will also have appropriate age-matched unirradiated controls and kept under similar conditions. 2-3ml of blood will be collected 3h, 6h, 12h, 24h, 48h and 7 days after radiation by cardiac puncture. Blood samples and harvested tissues/organs will be processed for various analysis using appropriate protocols and stored separately under appropriate conditions for RNA isolation, protein and exosomal analysis. • 1st batch of 3 mice/ each group needed for RNA samples• 2nd batch of 3 mice /group needed for protein samples• 3rd batch of 2 mice /group needed for exosomal isolation for looking the biomarkers.Number of mice/group: 8 (3+3+2)Number of radiation dose groups: 5Number of time points: 6Number of irradiated mice = 8 x 5 x 6 = 240Number of unirradiated control mice/group: 8 Number unirradiated control mice for 6 time points: 8 x 6 = 48*Number of extra mice: 12Total number of mice per experiment: 240 + 48 + 12 = 300*If the mice die due to higher radiation OR due to any other reason if we need to repeat the experiment we put 12 extra mice. This is standard procedure for animal experiments.Experiment will be repeated 3 times. This has to be done in as different biological triplicates to see the reproducibility and integrity of the data and reduces the probability of the false positives. This is standard scientific protocol.The delivery package includes the following:* Processed and preserved blood samples at various time points * Urine and tissue/organ samples * Summary of significant biochemical changesSamples will be delivered periodically over the course of the 2 year project, as experiments are performed at different times toughout the study and this would be based on initial experimental data and animal survival. Until experiments are actually in progress and health of animals is assessed, precise deliverable schedule cannot be predicted. This is typical of radiation experiments.To be deemed capable of satisfying these requirements, offerors must submit a written capability statement that demonstrates experience and expertise in the following technical areas:1. Personnel/Experience:a. The contractor will provide processed blood samples and tissue samples after whole body irradiation for microarray experiments as well as exosomal analysis services. The starting materials can be tissue/organs, whole blood, plasma, serum, urine samples or any other biological samples. b. The offeror shall demonstrate that the proposed team and staff have previous successful experience in carrying out the requirements of the services stated herein.c. In vivo studies will be 6-12-week old C57/BL6 mice according to the protocols approved by the Institutional Animal Care and use committee. Each group will contain eight mice. Mice will be exposed to 2, 4, 8, 12 and 15 Gy whole body radiation respectively, at a dose rate of 1-2 Gy/min (Xstrahl RS320 radiator, Xstrahl, Suwanee, GA). Two groups of six age-matched un-irradiated mice will be used as control and kept under similar conditions; Control-1 for 0-48h and Control-2 for 7 days post-radiation. d. 2-3ml of blood will be collected 3h, 6h, 12h, 24h, 48h and 7 days after radiation by cardiac puncture. Blood sample will be processed for various analysis using appropriate protocols and stored separately under appropriate conditions for RNA isolation and protein analysis. e. Experiments will be repeated 3 times.2. Facilities: Adequacy of facilities for performing the above mentioned experiments.The New York University School of Medicine is uniquely qualified to provide this service as it already has a current ongoing in vivo radiation experiments with mice related to its collaborative efforts using an approved protocol.This notice is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Capability statements must be received in the contracting office by 12:00 PM EST, on May 20, 2014. For further information, please contact Brenda Oberholzer, Contracting Officer via electronic mail at oberholzerb@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. No faxed or emailed capability statements will be accepted. In order to receive an award, contractors must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA) tu sam.gov. Reference: N02RC44416-11 on all correspondence.
N02RC44416-11 Department of Health and Human Services National Institutes of Health
5/5/14, 9:28 AM 537-14-1-041-0001 Research Veterinary Support and Supervision of the Animal Unit
Added: Dec 13, 2013 3:25 pm This is a sources sought announcement only. The purpose of this notice is to conduct market research and obtain information from qualified potential offerors. No formal solicitation document exists at this time. The Government is not obligated to nor will it pay for or reimburse any costs associated with responding to this sources sought synopsis request. This notice shall not be construed as a commitment by the Government to issue a solicitation or ultimately award a contract, nor does it restrict the Government to a particular acquisition approach. The Government will in no way be bound to this information if any solicitation is issued. The Great Lakes Acquisition Center (GLAC) is seeking potential sources capable of providing veterinarian oversight at the Jesse Brown VA Medical Center (JBVAMC). The contractor must possess a Doctor of Veterinary Medicine, be licensed to practice veterinary medicine in the state of Illinois and be certified by the American College of Laboratory Animal Medicine (ACLAM). In addition, the contractor must have experience in a biomedical research setting in which Public Health Service Policy and U.S. Department of Agriculture Animal Welfare Act Regulations were applied under the jurisdiction of the Institutional Animal Care and Use Committee. Duties shall include, at a minimum, weekly site visit to assess the health of all animals in the facility; overseeing and coordinating the management of all JBVAMC disease outbreaks; coordinating the JBVAMC sentinel program; coordinating the quarantine and/or re-derivation of all animals from non-approved vendors; reviewing and advising on all JBVAMC colony health reports both internal and external (reports from non-approved vendors); providing after hours, weekend and holiday emergency veterinary coverage. The veterinarian also serves as a member of the Institutional Animal Care and Use Committee (IACUC). The applicable NAICS Code is 541940 with a size standard $7 million. Responses to this sources sought notice should include the following: name and address of company; business size (large or small); identify whether or not firm falls into any of the following socioeconomic categories - 8(a), HUBZone, Service Disabled Veteran-Owned; brief capability statement of qualifications and any other pertinent information, which demonstrates ability to meet the above requirements. All responses shall be submitted in writing no later than 4:00PM CST, 23 December 2013. Capability statements shall be submitted by email only as a MS Word or Adobe PDF attachment to Arleen Reid at Arleen.Reid@va.gov. TELEPHONIC INQUIRIES WILL NOT BE ACCEPTED.
VA69D14Q0242 Department of Veterans Affairs Veterans Health Administration Veterans Integrated Service Network 12
12/13/13, 3:25 PM