NAICS Code 325414: Biological Product (except Diagnostic) Manufacturing

National industry

SBA small business size standard: 1,250 employees

Definition

This U.S. industry comprises establishments primarily engaged in manufacturing vaccines, toxoids, blood fractions, and culture media of plant or animal origin (except diagnostic).

Government contracts for this work: PSC AN42 Health R&D Services: Health Care – Other (Applied Research) and PSC 6505 Drugs and Biologicals

Code facts

Contract awards
134 In the last 12 months

NAICS codes and definitions come from the U.S. Census Bureau, size standards from the SBA and contract spending from SAM.gov/FPDS.

Business activities under NAICS 325414

  • Agar culture media manufacturing
  • Aggressins (except in-vitro) manufacturing
  • Allergenic extracts (except diagnostic substances) manufacturing
  • Allergens manufacturing
  • Antigens manufacturing
  • Antiserums manufacturing
  • Antitoxins manufacturing
  • Antivenoms manufacturing
  • Bacterial vaccines manufacturing
  • Bacterins (i.e., bacterial vaccines) manufacturing
  • Blood derivatives manufacturing
  • Blood fractions manufacturing
  • Cholera serums manufacturing
  • Culture media manufacturing
  • Gene therapy preparations manufacturing
  • Hematology products (except diagnostic substances) manufacturing
  • Plasmas manufacturing
  • Serums (except diagnostic substances) manufacturing
  • Toxoids (e.g., diphtheria, tetanus) manufacturing
  • Tuberculin (i.e., tuberculo-protein derived) manufacturing
  • Vaccines (i.e., bacterial, virus) manufacturing
  • Virus vaccines manufacturing

Looking for another activity? Search the NAICS code lookup or browse business activities from A to Z.

Contract obligations by fiscal year

Fiscal year Obligated
FY2027 To date $4,678,381
FY2026 $475,082,074
FY2025 -$51,311,978
FY2024 $989,976,660
FY2023 $165,879,879

Top contractors by obligations

Rank Contractor Obligated, FY2026–FY2027 Share
1 Advanced Technology International $224,999,997
2 Meridian Medical Technologies, LLC $72,940,000
3 Seqirus Inc. $53,644,070
4 Emergent Product Development Gaithersburg Inc. $52,780,488
5 Sanofi Vaccines US Inc. $16,316,844
6 Seqirus USA Inc. $12,217,449
7 Octapharma USA Inc. $9,720,000
8 Artemis Technologies Inc. $6,873,559
9 Versiti Blood Health, Inc. $5,396,225
10 The American National Red Cross $4,502,486

See the full FY2025 ranking of NAICS 325414 contractors, by parent company.

Top funding agencies by obligations

Rank Agency Obligated, FY2026–FY2027 Share
1 Department of Health and Human Services $348,609,925
2 Defense Logistics Agency Department of Defense $89,469,779
3 Department of Agriculture $14,583,269
4 Department of Veterans Affairs $14,344,815
5 Defense Health Agency Department of Defense $11,436,589
6 Department of the Army Department of Defense $715,500
7 Department of the Navy Department of Defense $260,400
8 Department of Commerce $239,534
9 Environmental Protection Agency $70,582
10 Department of State $18,107
Rank PSC code Obligated, FY2026–FY2027 Share
1 AN42 Health R&D Services; Health Care – Other; Applied Research $224,999,997
2 6505 Drugs and Biologicals $166,586,692
3 6515 Medical and Surgical Instruments, Equipment, and Supplies $64,910,487
4 Q999 Other Medical Services $26,612,706
5 6509 Drugs and Biologicals, Veterinary Use $3,773,397
6 6550 In Vitro Diagnostic Substances, Reagents, Test Kits and Sets $3,059,329
7 6640 Laboratory Equipment and Supplies $2,952,581
8 6545 Replenishable Field Medical Sets, Kits, and Outfits $715,500
9 AN12 Health R&D Services; Health Care Services; Applied Research $564,953
10 6506 Blood and Blood Products $246,494

Contract obligations by state

Rank Place of performance Obligated, last 12 months Share
1 South Carolina $224,999,997
2 Missouri $73,476,632
3 Maryland $57,771,207
4 North Carolina $53,048,171
5 New Jersey $18,782,336
6 Pennsylvania $16,731,011
7 California $3,852,087
8 Georgia $3,681,552
9 District of Columbia $3,155,861
10 Wisconsin $2,607,426
11 Louisiana $2,524,437
12 New Hampshire $983,614
13 Massachusetts $886,235
14 Oklahoma $785,045
15 Ohio $529,032
16 Texas $509,014
17 Colorado $505,891
18 New York $319,588
19 Mississippi $316,209
20 Kentucky $311,800
21 Indiana $296,864
22 Washington $157,684
23 Nebraska $109,301
24 Iowa $77,117
25 Alaska $47,715
26 Virginia $41,124
27 Minnesota $34,273
28 Arizona $30,240
29 Delaware $21,835
30 Tennessee $10,919
31 Michigan $1,725
Show all 31

Shares are of everything obligated under NAICS 325414 in the last 12 months before deobligations, including work performed abroad or with no place of performance on record.

Contract opportunities

Notice Posted Due
Injectable Egg-Free Influenza Vaccine 2027 Solicitation · Medical Supply Chain (DLA) · SPE2DP26R0004
Injectable Influenza Vaccine 2027 Solicitation · Medical Supply Chain (DLA) · SPE2DP26R0003
iPSC Culture and Differentiation Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Tau radiotracers for Baltimore Longitudinal Study of Aging Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH) · 75N98027Q00047
Tau radiotracers for Baltimore Longitudinal Study of Aging Pre-Solicitation · National Institute on Drug Abuse (NIH) · 75N98027Q00029
Brand Name - Dectomax (Doramectin) 500mL Injectable Solution Solicitation · Marketing and Regulatory Programs Business Services (APHIS)
PANDHA-26-P-0000 046638 Defibrinated Rabbit Blood Special Notice · Defense Health Agency
Foot and Mouth Disease (FMD) Vaccine Antigen Concentrate (VAC) Solicitation · Marketing and Regulatory Programs Business Services (APHIS)
6505--Blood Contract - Madison POP: 10/1/26 - 9/30/31 Award Notice · Veterans Integrated Service Network 12 (VHA) —
6505--Blood Contract - Milwaukee/Tomah POP: 10/1/26 - 9/30/2031 Award Notice · Veterans Integrated Service Network 12 (VHA) —
6505--Blood Contract - Jesse Brown/FHCC/Hines POP: 10/1/26 - 9/30/31 Award Notice · Veterans Integrated Service Network 12 (VHA) —
2027 Southern Hemisphere Influenza Vaccine Solicitation · Medical Supply Chain (DLA) · SPE2DP26R0002
Injectable Influenza Vaccine 2027 Pre-Solicitation · Medical Supply Chain (DLA) · SPE2DP26R0003
Injectable Egg-Free Influenza Vaccine 2027 Pre-Solicitation · Medical Supply Chain (DLA) · SPE2DP26R0004
Atnaa Pre-Solicitation · Medical Supply Chain (DLA)
Lonza – Cryopreserved Primary Human Hepatocytes (spheroid-qualified) Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Animal Blood Solicitation · FDA Office of Acquisition and Grant Services
2027 Southern Hemisphere Influenza Vaccine Pre-Solicitation · Medical Supply Chain (DLA) · SPE2DP26R0002
Methylation Sequencing Library Preparation Kits fo Pre-Solicitation · National Heart Lung and Blood Institute (NIH)
​Vivo Efficacy of Blood stable Thiobenzamides​ ​ Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Notice of Intent: Chromium GEM-X sequencing reagents Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Acquisition of an Agilent-BioTek Multimode Plate Reader Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Amyloid radiotracers for Baltimore Longitudinal Study of Aging Solicitation · National Institute on Drug Abuse (NIH)
Methylation Sequencing Library Preparation Kits f Solicitation · National Heart Lung and Blood Institute (NIH)
Injectable Egg-Free Influenza Vaccine 2027 Pre-Solicitation · Medical Supply Chain (DLA) · SPE2DP26R0004
Injectable Influenza Vaccine Pre-Solicitation · Medical Supply Chain (DLA)
30 vials of cryopreserved HepaRG cells (Catalog Number: HPRGC10) Solicitation · Office of Logisitics and Acquisition Operations (NIH)
2027 Southern Hemisphere Influenza Vaccine Pre-Solicitation · Medical Supply Chain (DLA) · SPE2DP26R0002
Leptin Protein (26-006897) Special Notice · Office of Logisitics and Acquisition Operations (NIH)
Human Kinase LentiArray CRISPR Library Solicitation · Office of Logisitics and Acquisition Operations (NIH)
custom HuCAL recombinant Fab antibody Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Notice of Intent to Sole Source: NAIHS OEHE - Rabies Vaccination Purchase Special Notice · Indian Health Service
Intent to Sole Source - Endotoxin Detection System Cartridges Special Notice · National Institutes of Health
Notice of Intent to Sole Source the Procurement of Weekly Delivery of Turkey, Chicken, Guinea Pig, and Horse Red Blood Cells Solicitation · CDC Office of Acquisition Services
Purchase of new ChemiDoc™ MP Imaging system from BioRad Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
6505--VISN 12 New Blood and Blood Products Contract Solicitation · Veterans Integrated Service Network 12 (VHA) · 36C25226Q0606
6505--VISN 12 New Blood and Blood Products Contract Pre-Solicitation · Veterans Integrated Service Network 12 (VHA) · 36C25226Q0606
(Presolicitation Notice) Intent to Sole Source - BioRad Antibodies Pre-Solicitation · CDC Office of Acquisition Services
Reconstructed Human Small Intestine and Human Skin Models Microtissue Samples and Culture Media Solicitation · FDA Office of Acquisition and Grant Services
synthesis of prodrug analogs and cyclopentane peptide nucleic acid (PNA) precursors Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
NIST Human Serum Standard Reference Material (SRM) Solicitation · National Institute of Standards and Technology
GMP Grade Human Interleukin-2 (IL-2) from ACROBiosystems Inc. Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
36C255-26-AP-2749 CTL ImmunoSpot S6 Ultra M2 Analyzer - Kansas City VAMC Special Notice · Veterans Integrated Service Network 15 (VHA)
FMD Vaccine Sources Sought Pre-Solicitation · Marketing and Regulatory Programs Business Services (APHIS)
PacBio sequencing reagents Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Whole Exome Analysis of NIAAA Clinical Center pATIENTS Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Proteomics study using Olink Reveal Kits Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Ion AmpliSeq reagents Pre-Solicitation · Office of Logisitics and Acquisition Operations (NIH)
Intent to Sole Source - Olink Reagents Special Notice · National Institutes of Health
iNDI FA13. 1J Cell Lines Expansion and Distribution for the iPSC Neurodegenerative Disease Initiative (iNDI) Project Special Notice · Office of Logisitics and Acquisition Operations (NIH)
Show 40 more

Latest 50 of 2,696 listed here. See the rest on GovTribe.

Size standard history

Federal Register rules that named this code

Final rule Published Effective
Small Business Size Standards for Manufacturing 81 FR 4469 · 3245-AG50
Small Business Size Standards; Adoption of Size Standards by 2002 North American Industry Classification System for Size Standards 67 FR 56905 · 3245-AF00
Small Business Size Regulations; Size Standards and the North American Industry Classification System 65 FR 30836

From the NAICS codes each rule's amendments to 13 CFR 121.201 name. Rules that print their size standard tables as images aren't listed.

Quick answers

What is NAICS 325414?

NAICS 325414 is Biological Product (except Diagnostic) Manufacturing, a national industry in NAICS 31-33, Manufacturing.

What is the NAICS code for plasmas manufacturing?

The NAICS code for plasmas manufacturing is 325414, Biological Product (except Diagnostic) Manufacturing.

What is the NAICS code for antigens manufacturing?

The NAICS code for antigens manufacturing is 325414, Biological Product (except Diagnostic) Manufacturing.

What is the NAICS code for allergens manufacturing?

The NAICS code for allergens manufacturing is 325414, Biological Product (except Diagnostic) Manufacturing.

When did the size standard for NAICS 325414 last change?

The most recent Federal Register rule on record that names NAICS 325414 in the SBA's size standards is "Small Business Size Standards for Manufacturing" (81 FR 4469), published Jan 26, 2016 and effective Feb 26, 2016.

How much do federal agencies spend under NAICS 325414?

Federal contracts under NAICS 325414 obligated $1,584,305,015 in fiscal years 2023 through 2027.

Who are the largest contractors under NAICS 325414?

The contractors with the most obligated under NAICS 325414 in fiscal years 2026 and 2027 are Advanced Technology International ($224,999,997); Meridian Medical Technologies, LLC ($72,940,000); and Seqirus Inc. ($53,644,070).

Which agencies buy the most under NAICS 325414?

The agencies that obligated the most under NAICS 325414 in fiscal years 2026 and 2027 are Department of Health and Human Services ($348,609,925), Defense Logistics Agency ($89,469,779) and Department of Agriculture ($14,583,269).

Which PSC codes are used with NAICS 325414?

The PSC codes with the most obligated under NAICS 325414 in fiscal years 2026 and 2027 are AN42 Health R&D Services; Health Care – Other; Applied Research; 6505 Drugs and Biologicals; and 6515 Medical and Surgical Instruments, Equipment, and Supplies.

Where is the work under NAICS 325414 performed?

By place of performance, the states with the most contract obligations under NAICS 325414 over the last 12 months are South Carolina ($224,999,997), Missouri ($73,476,632) and Maryland ($57,771,207).

What is the latest contract opportunity under NAICS 325414?

The latest contract opportunity under NAICS 325414 is Injectable Egg-Free Influenza Vaccine 2027, solicitation from Medical Supply Chain (DLA), posted November 4, 2026.

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