Special Projects of Regional and National Significance

Active

Assistance listing
93.110
Agency
Grant awards
5,281 $5,530,921,658 in federal obligations

Program facts

Assistance types
  • Project Grant
  • Cooperative Agreement
  • Block Grant
Treasury account
  • 75-0354-0-1-550
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Health Resources and Services Administration (HRSA) runs the Special Projects of Regional and National Significance program (CFDA 93.110), which funds maternal and child health initiatives ranging from training and research to clinical service delivery, with the most recent award made in June 2026.

The program has distributed $5.53 billion in federal funds across 5,281 awards since 1954, with activity concentrated in the past several years: 147 awards in 2023, 117 in 2022, 84 in 2024, and 25 in 2025. Award volume declined sharply in 2025 and early 2026, with only one award recorded through June 2026. The portfolio is predominantly Project Grants (90%), with smaller shares of Block Grants (7%) and Cooperative Agreements (3%). HRSA's Maternal and Child Health Bureau dominates the program's funding; the portfolio block reports two HRSA entries suggesting internal program splits totaling $2.04 billion and $3.49 billion in federal dollars across 4,374 and 907 awards respectively, covering 100% of all activity.

Recent awards reflect a diverse portfolio. The State Maternal Health Innovation Program has received multiple large grants, including a $13.97 million award in February 2025 and a $21.6 million award in September 2024 supporting state-led maternal health task forces and innovation implementation. The Maternal and Child Health Research Consortium has funded multi-institution research on improving pediatric preventive care, rural maternity outcomes, and hypertensive disorders of pregnancy, with individual awards ranging from $1.97 million to $2.6 million. Smaller community-based programs include the Healthy Tomorrows Partnership for Children, which funds school-based health clinics and preventive services in rural and medically underserved areas, with awards of $150 thousand to $300 thousand. Training initiatives funded include the Pediatric Pulmonary Centers ($1.02 to $1.36 million) training interdisciplinary teams to serve children with chronic respiratory conditions, and Centers of Excellence in MCH Education programs ($1.1 to $1.61 million) training public health workforce and building academic-practice partnerships.

SPRANS funds training grants to nonprofit higher education institutions, research grants to nonprofits and higher education institutions engaged in MCH work, and special project grants (including hemophilia, genetics, and environmental health) to any public or private entity. Eligible entities for specific initiatives include tribes, tribal organizations, faith-based organizations, and community-based organizations. Competitive awards typically run two to five years with potential for noncompetitive renewal based on progress reports and fund availability; final selections are made four to six months after application receipt.

Multiple grant opportunities posted recently reflect active solicitation across SPRANS components. HRSA-27-050 (posted August 24, 2026) seeks applications for the Children and Youth with Special Health Care Needs Research Network cooperative agreement, open to domestic nonprofits and higher education institutions. HRSA-27-033 (posted August 11, 2026) funds the Healthy Tomorrows Partnership for Children Program, accepting applications from a broad range of entities including state and local governments, nonprofits, and tribes. Training-focused opportunities include HRSA-27-036 (MCH Nutrition Training Program, posted July 31, 2026) limited to domestic nonprofit higher education institutions and HRSA-27-034 (Leadership Education in Adolescent Health, posted July 31, 2026) also restricted to nonprofits and higher education. The Maternal and Child Health Research Consortium (HRSA-25-020, posted July 25, 2024, due April 23, 2025) supports institution-led consortia addressing evidence gaps in pregnancy, postpartum, and childhood populations.

Objective and description

Objective

The Special Projects of Regional and National Significance Program (SPRANS) carries out maternal and child health (MCH) projects to support training and research; oral health integration; genetic disease testing, counseling, and information developme

Description

The Special Projects of Regional and National Significance Program (SPRANS) carries out maternal and child health (MCH) projects to support training and research; oral health integration; genetic disease testing, counseling, and information development and dissemination programs; newborn screening for sickle cell anemia and other genetic disorders; and comprehensive hemophilia diagnostic and treatment centers. The Supporting Fetal Alcohol Spectrum Disorder (FASD) Screening and Intervention helps reduce alcohol use during pregnancy and improves outcomes for children with FASD nationwide, especially in communities where there is a high rate of binge drinking during pregnancy, including rural areas and medically underserved communities. The program focuses on educating primary care providers and increasing the use of screening, intervention, and referral processes for high-risk pregnancies. The State Maternal Health Innovation program creates state-led maternal health task forces to bring together the voices of key leaders, and pregnant and postpartum individuals using state-specific maternal health data to develop and implement innovative approaches to address the most pressing maternal health needs and disparities. State approaches include strengthening partnerships and collaborations, improving state-level data surveillance on maternal mortality and severe maternal morbidity, and promoting and executing innovation in maternal health service delivery. The MCH Research Portfolio includes the MCH Research Consortium, Maternal Health Research Collaborative for Minority-Serving Institutions, MCH Research Network, and MCH Field-Initiated Innovative Research Studies programs. The research portfolio advances maternal and child health by generating and testing innovative, real-world approaches to improve population-level outcomes. The program addresses critical evidence gaps through the development of research infrastructure and the conduct of rigorous, community-engaged research in close partnership with families and other stakeholders. MCH RNs focus on collaborative, interdisciplinary. The Children's Safety Network (CSN) purpose is to increase the capacity of Title V agencies to adopt and implement evidence-based child and adolescent safety programs, practices, and policies, with a specific focus on injury and violence-related to Title V performance and outcome measures, such as injury hospitalizations, bullying, safe sleep, and suicide, as well as leading causes of injury-related deaths among children and adolescents (e.g., motor vehicle crashes, firearms, and poisonings).

Eligibility

Applicant eligibility

Training grants may be made to public or private nonprofit institutions of higher learning. Research grants may be made to public or private nonprofit institutions of higher learning and public or private nonprofit private agencies and organizations engaged in research or in MCH or Children with Special Health Care Needs (CSHCN) programs. Any public or private entity is eligible for hemophilia, genetics, and environmental health grants and other special project grants, including SPRANS and CISS. Eligible entities for the Supporting Fetal Alcohol Spectrum Disorders Screening and Intervention program are any domestic public or private entity, including Indian tribes or tribal organizations (as those terms are defined at 25 U.S.C. 450b). See 42 CFR § 51a.3(a), and domestic faith-based and community-based organizations. Eligible entities for the State Maternal Health Innovation program include any domestic public or private entity, including Indian tribes or tribal organizations, as well as domestic faith-based and community-based organizations. Eligible entities for the Integrated Maternal Health Services program include any domestic public or private entity, including Indian tribes or tribal organizations, as well as domestic faith-based and community-based organizations.

Beneficiary eligibility

Specialized group (e.g. health professionals, students, veterans), Health Professional, Student/Trainee, Women, Infant (0-5), Child (6-15) For training grants: (1) Trainees in the health professions related to MCH; and (2) mothers and children who receive services through training programs. For research grants: public or private nonprofit agencies and organizations engaged in research in MCH or CSHCN programs. For hemophilia, sickle cell, thalassemia, genetics, newborn screening, environmental health, and other special projects: (1) Public or private agencies, organizations and institutions; and (2) mothers and children, and individuals with genetic conditions (any age) who receive services through the programs.

Uses of assistance

Training grants are made to institutions of higher learning for training personnel for health care and related services for mothers and children. Research grants are for the purpose of research activities which show promise of a substantial contribution to the advancement of maternal and child health (MCH) services. Technical assistance grants support the effective and accurate use of data and evidence to support program development and implementation as well as performance measurement and evaluation. Genetic grants are for genetic disease testing, counseling and information development and dissemination. Hemophilia grants are for the support of centers which provide hemophilia diagnostic and treatment services. Sickle cell disease grants are made to support follow up for infants with sickle cell identified through newborn screening. Environmental health grants are made to decrease maternal and child morbidity and mortality associated with pre-and post-natal environmental exposures. Other special project grants are designed to support activities of a demonstration nature, which are designed to improve services for mothers and children.

Use restrictions

Indirect costs that are allowed for administrative costs incurred as a result of the training grants project, are limited to 8 percent of direct costs.

Length and time phasing of assistance

Refer to the NOFO for details. Awards are made annually, in accordance with the project period method of awarding grants.

How to apply

Preapplication coordination

An applicant should consult the office or official designated as the single point of contact in his or her State for more information on the process the State requires to be followed in applying for assistance, if the State has selected the program for review.

Criteria for selecting proposals

Evaluation criteria vary based on the grant/cooperative agreement program. Refer to criteria included in the notice of funding opportunity for each specific program.

Award procedure

All qualified applications will be forwarded to an objective review committee. Based on the recommendations of the objective review committee, the HRSA program official with delegated authority is responsible for final selection and funding decisions. Notification is made in writing by a Notice of Award.

Time to approval or disapproval

Final decisions are made 4 to 6 months after receipt of applications.

Renewals

Competitive awards are typically made for up to 2 to 5 years, subject to the availability of funds. After initial awards, annual noncompetitive awards may be made contingent upon the submission of noncompetitive applications/progress reports and availability of funds and a determination that continued funding would be in the best interest of the federal government.

Grant opportunities

Opportunity Status Posted Applications due
Children and Youth with Special Health Care Needs Research Network HRSA-27-050 Forecasted —
Regional Excellence for Access to Comprehensive Care for Hemophilia Networks (REACH Networks) HRSA-27-037 Forecasted —
Women's Initiative for Screening and Health (WISH) HRSA-27-072 Past —
Healthy Tomorrows Partnership for Children Program (HTPCP) HRSA-27-033 Forecasted —
Infant-Toddler Court Program-State Awards HRSA-27-021 Forecasted —
Infant-Toddler Court Program-National Resource Center HRSA-27-020 Forecasted —
Maternal and Child Health (MCH) Nutrition Training Program HRSA-27-036 Forecasted —
Leadership Education in Adolescent Health (LEAH) HRSA-27-034 Forecasted —
Maternal and Child Health Encounters Networks (MCHEK) HRSA-27-038 Forecasted —
Fetal, Infant, and Child Death Review Program HRSA-27-031 Forecasted —
MCH Workforce Development and Training Center HRSA-26-041 Closed
​​Maternal and Child Health (MCH) Leadership, Education, and Advancement in Undergraduate Pathways (LEAP) Training Program​​ HRSA-26-018 Closed
Regional Pediatric Prevention Network HRSA-26-070 Closed
Hereditary Hemorrhagic Telangiectasia (HHT) Center HRSA-26-092 Closed
Transforming Pediatrics for Early Childhood (TPEC) Program HRSA-26-104 Closed
Maternal Produce Prescription Program (MP3) HRSA-26-103 Closed
Partnership for National Maternal and Child Health (MCH) Leadership HRSA-25-028 Closed
Maternal and Child Health Public Health Catalyst Program HRSA-25-025 Closed
Centers of Excellence in Maternal and Child Health Education, Science, and Practice HRSA-25-027 Closed
Pediatric Pulmonary Centers Program HRSA-25-026 Closed
Maternal and Child Health Secondary Data Analysis Research (MCH SDAR) HRSA-25-023 Closed
Healthy Tomorrows Partnership for Children Program (HTPCP) HRSA-25-019 Closed
Maternal and Child Health Research Consortium (MCH RC) HRSA-25-020 Closed
Center for Maternal and Child Health Medicaid Partnerships HRSA-24-105 Closed
Building Optimal Outcomes for Moms (BLOOM) HRSA-24-084 Past —
Growing and Diversifying the Doula Workforce Program - Consortium Award HRSA-24-086 Past —
Growing and Diversifying the Doula Workforce Program - Community Awards HRSA-24-085 Past —
Training for Health Care Providers HRSA-24-091 Past —
Behavioral Health Integration Into Community Settings HRSA-24-089 Past —
Maternal and Child Health Policy Innovation Program HRSA-24-037 Closed
Maternal and Child Health - Improving Oral Health Integration Demonstration Projects (MCH-IOHI Projects) HRSA-24-039 Closed
Supporting Fetal Alcohol Spectrum Disorders Screening and Intervention HRSA-24-046 Closed
State Maternal Health Innovation HRSA-24-047 Closed
National Coordinating Center on Transition HRSA-24-041 Closed
Maternal and Child Health - Improving Oral Health Integration National Consortium (MCH-IOHI Consortium) HRSA-24-040 Closed
Transition for Youth with Autism and/or Epilepsy Demonstration Projects HRSA-24-042 Closed
Cooperative Newborn Screening System Priorities Program (NBS Co-Propel) HRSA-24-052 Closed
Maternal Health Training and Resource Center (MHTRC) HRSA-24-050 Closed
State Maternal Health Innovation Program HRSA-23-108 Closed
Integrated Maternal Health Services HRSA-23-106 Closed
Maternal Health Research Collaborative for Minority-Serving Institutions (MH-RC-MSI) Coordinating Center (CC) HRSA-23-113 Closed
Maternal Health Research Collaborative for Minority-Serving Institutions (MH-RC-MSI) Research Centers (RCs) HRSA-23-112 Closed
Addressing Implicit Bias through Training for Maternal Health Providers HRSA-23-104 Past —
Alliance for Innovation on Maternal Health (AIM) Capacity HRSA-23-066 Closed
Alliance for Innovation on Maternal Health (AIM) Technical Assistance Center HRSA-23-084 Closed
Screening and Treatment for Maternal Mental Health and Substance Use Disorders HRSA-23-085 Closed
Maternal and Child Health Policy Innovation HRSA-23-076 Past —
State Newborn Screening System Priorities Program (NBS Propel) HRSA-23-065 Closed
Life Course Translational Research Network (LCT-RN) HRSA-23-083 Closed
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Latest 49 listed here. See the rest on GovTribe.

Grant awards

Latest 10 of 5,281 listed here. See the rest on GovTribe.

Top recipients by federal obligations

10 of 827 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $164,459,553
FY2025 $661,047,807
FY2024 $799,017,966
FY2023 $1,039,504,112
FY2022 $674,505,538
FY2021 $223,461,963
FY2020 $213,851,844
FY2019 $193,764,254
FY2018 $160,978,338
FY2017 $159,376,792
FY2016 $142,082,436
FY2015 $137,852,966
FY2014 $135,409,346
FY2013 $128,040,375
FY2012 $131,117,664
FY2011 $146,176,784
FY2010 $150,468,278
FY2009 $144,132,213
FY2008 $87,884,114
FY2007 $80,320,341
FY2006 $39,816,944
FY2005 $61,256,967
FY2004 $36,211,345
FY2003 $69,573,829
FY2002 $138,389,571
FY2001 $94,914,647
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Quick answers

What is Assistance Listing 93.110?

Assistance Listing 93.110 is Special Projects of Regional and National Significance, a federal grant program run by Health Resources and Services Administration (Department of Health and Human Services).

What is the CFDA number for Special Projects of Regional and National Significance?

Its CFDA number is 93.110: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 93.110 awarded?

5,281 grant awards under 93.110 have obligated $5,530,921,658 in federal funds to 827 recipients.

Who receives the most funding from 93.110?

The recipients obligated the most under Special Projects of Regional and National Significance are University Hospitals Cleveland Medical Center ($165,307,888), Zero To Three National Center For Infants, Toddlers & Families ($136,606,256) and Children's National Medical Center ($122,398,806).

How much did 93.110 obligate in fiscal year 2025?

Grants under 93.110 obligated $661,047,807 in federal funds in fiscal year 2025.

Are there open grant opportunities under 93.110?

9 of the latest 49 opportunities under 93.110 are open or forecasted. The latest, Children and Youth with Special Health Care Needs Research Network, was posted on August 24, 2026.

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