Special Projects of Regional and National Significance
Active
- Assistance listing
- 93.110
- Agency
-
Health Resources and Services Administration
Department of Health and Human Services
- Grant awards
- 5,281 $5,530,921,658 in federal obligations
Program facts
- Assistance types
-
- Project Grant
- Cooperative Agreement
- Block Grant
- Treasury account
-
- 75-0354-0-1-550
- More information
Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.
About this program
The Health Resources and Services Administration (HRSA) runs the Special Projects of Regional and National Significance program (CFDA 93.110), which funds maternal and child health initiatives ranging from training and research to clinical service delivery, with the most recent award made in June 2026.
The program has distributed $5.53 billion in federal funds across 5,281 awards since 1954, with activity concentrated in the past several years: 147 awards in 2023, 117 in 2022, 84 in 2024, and 25 in 2025. Award volume declined sharply in 2025 and early 2026, with only one award recorded through June 2026. The portfolio is predominantly Project Grants (90%), with smaller shares of Block Grants (7%) and Cooperative Agreements (3%). HRSA's Maternal and Child Health Bureau dominates the program's funding; the portfolio block reports two HRSA entries suggesting internal program splits totaling $2.04 billion and $3.49 billion in federal dollars across 4,374 and 907 awards respectively, covering 100% of all activity.
Recent awards reflect a diverse portfolio. The State Maternal Health Innovation Program has received multiple large grants, including a $13.97 million award in February 2025 and a $21.6 million award in September 2024 supporting state-led maternal health task forces and innovation implementation. The Maternal and Child Health Research Consortium has funded multi-institution research on improving pediatric preventive care, rural maternity outcomes, and hypertensive disorders of pregnancy, with individual awards ranging from $1.97 million to $2.6 million. Smaller community-based programs include the Healthy Tomorrows Partnership for Children, which funds school-based health clinics and preventive services in rural and medically underserved areas, with awards of $150 thousand to $300 thousand. Training initiatives funded include the Pediatric Pulmonary Centers ($1.02 to $1.36 million) training interdisciplinary teams to serve children with chronic respiratory conditions, and Centers of Excellence in MCH Education programs ($1.1 to $1.61 million) training public health workforce and building academic-practice partnerships.
SPRANS funds training grants to nonprofit higher education institutions, research grants to nonprofits and higher education institutions engaged in MCH work, and special project grants (including hemophilia, genetics, and environmental health) to any public or private entity. Eligible entities for specific initiatives include tribes, tribal organizations, faith-based organizations, and community-based organizations. Competitive awards typically run two to five years with potential for noncompetitive renewal based on progress reports and fund availability; final selections are made four to six months after application receipt.
Multiple grant opportunities posted recently reflect active solicitation across SPRANS components. HRSA-27-050 (posted August 24, 2026) seeks applications for the Children and Youth with Special Health Care Needs Research Network cooperative agreement, open to domestic nonprofits and higher education institutions. HRSA-27-033 (posted August 11, 2026) funds the Healthy Tomorrows Partnership for Children Program, accepting applications from a broad range of entities including state and local governments, nonprofits, and tribes. Training-focused opportunities include HRSA-27-036 (MCH Nutrition Training Program, posted July 31, 2026) limited to domestic nonprofit higher education institutions and HRSA-27-034 (Leadership Education in Adolescent Health, posted July 31, 2026) also restricted to nonprofits and higher education. The Maternal and Child Health Research Consortium (HRSA-25-020, posted July 25, 2024, due April 23, 2025) supports institution-led consortia addressing evidence gaps in pregnancy, postpartum, and childhood populations.
Objective and description
- Objective
The Special Projects of Regional and National Significance Program (SPRANS) carries out maternal and child health (MCH) projects to support training and research; oral health integration; genetic disease testing, counseling, and information developme
- Description
The Special Projects of Regional and National Significance Program (SPRANS) carries out maternal and child health (MCH) projects to support training and research; oral health integration; genetic disease testing, counseling, and information development and dissemination programs; newborn screening for sickle cell anemia and other genetic disorders; and comprehensive hemophilia diagnostic and treatment centers. The Supporting Fetal Alcohol Spectrum Disorder (FASD) Screening and Intervention helps reduce alcohol use during pregnancy and improves outcomes for children with FASD nationwide, especially in communities where there is a high rate of binge drinking during pregnancy, including rural areas and medically underserved communities. The program focuses on educating primary care providers and increasing the use of screening, intervention, and referral processes for high-risk pregnancies. The State Maternal Health Innovation program creates state-led maternal health task forces to bring together the voices of key leaders, and pregnant and postpartum individuals using state-specific maternal health data to develop and implement innovative approaches to address the most pressing maternal health needs and disparities. State approaches include strengthening partnerships and collaborations, improving state-level data surveillance on maternal mortality and severe maternal morbidity, and promoting and executing innovation in maternal health service delivery. The MCH Research Portfolio includes the MCH Research Consortium, Maternal Health Research Collaborative for Minority-Serving Institutions, MCH Research Network, and MCH Field-Initiated Innovative Research Studies programs. The research portfolio advances maternal and child health by generating and testing innovative, real-world approaches to improve population-level outcomes. The program addresses critical evidence gaps through the development of research infrastructure and the conduct of rigorous, community-engaged research in close partnership with families and other stakeholders. MCH RNs focus on collaborative, interdisciplinary. The Children's Safety Network (CSN) purpose is to increase the capacity of Title V agencies to adopt and implement evidence-based child and adolescent safety programs, practices, and policies, with a specific focus on injury and violence-related to Title V performance and outcome measures, such as injury hospitalizations, bullying, safe sleep, and suicide, as well as leading causes of injury-related deaths among children and adolescents (e.g., motor vehicle crashes, firearms, and poisonings).
Eligibility
- Applicant eligibility
Training grants may be made to public or private nonprofit institutions of higher learning. Research grants may be made to public or private nonprofit institutions of higher learning and public or private nonprofit private agencies and organizations engaged in research or in MCH or Children with Special Health Care Needs (CSHCN) programs. Any public or private entity is eligible for hemophilia, genetics, and environmental health grants and other special project grants, including SPRANS and CISS. Eligible entities for the Supporting Fetal Alcohol Spectrum Disorders Screening and Intervention program are any domestic public or private entity, including Indian tribes or tribal organizations (as those terms are defined at 25 U.S.C. 450b). See 42 CFR § 51a.3(a), and domestic faith-based and community-based organizations. Eligible entities for the State Maternal Health Innovation program include any domestic public or private entity, including Indian tribes or tribal organizations, as well as domestic faith-based and community-based organizations. Eligible entities for the Integrated Maternal Health Services program include any domestic public or private entity, including Indian tribes or tribal organizations, as well as domestic faith-based and community-based organizations.
- Beneficiary eligibility
Specialized group (e.g. health professionals, students, veterans), Health Professional, Student/Trainee, Women, Infant (0-5), Child (6-15) For training grants: (1) Trainees in the health professions related to MCH; and (2) mothers and children who receive services through training programs. For research grants: public or private nonprofit agencies and organizations engaged in research in MCH or CSHCN programs. For hemophilia, sickle cell, thalassemia, genetics, newborn screening, environmental health, and other special projects: (1) Public or private agencies, organizations and institutions; and (2) mothers and children, and individuals with genetic conditions (any age) who receive services through the programs.
- Uses of assistance
Training grants are made to institutions of higher learning for training personnel for health care and related services for mothers and children. Research grants are for the purpose of research activities which show promise of a substantial contribution to the advancement of maternal and child health (MCH) services. Technical assistance grants support the effective and accurate use of data and evidence to support program development and implementation as well as performance measurement and evaluation. Genetic grants are for genetic disease testing, counseling and information development and dissemination. Hemophilia grants are for the support of centers which provide hemophilia diagnostic and treatment services. Sickle cell disease grants are made to support follow up for infants with sickle cell identified through newborn screening. Environmental health grants are made to decrease maternal and child morbidity and mortality associated with pre-and post-natal environmental exposures. Other special project grants are designed to support activities of a demonstration nature, which are designed to improve services for mothers and children.
- Use restrictions
Indirect costs that are allowed for administrative costs incurred as a result of the training grants project, are limited to 8 percent of direct costs.
- Length and time phasing of assistance
Refer to the NOFO for details. Awards are made annually, in accordance with the project period method of awarding grants.
How to apply
- Preapplication coordination
An applicant should consult the office or official designated as the single point of contact in his or her State for more information on the process the State requires to be followed in applying for assistance, if the State has selected the program for review.
- Criteria for selecting proposals
Evaluation criteria vary based on the grant/cooperative agreement program. Refer to criteria included in the notice of funding opportunity for each specific program.
- Award procedure
All qualified applications will be forwarded to an objective review committee. Based on the recommendations of the objective review committee, the HRSA program official with delegated authority is responsible for final selection and funding decisions. Notification is made in writing by a Notice of Award.
- Time to approval or disapproval
Final decisions are made 4 to 6 months after receipt of applications.
- Renewals
Competitive awards are typically made for up to 2 to 5 years, subject to the availability of funds. After initial awards, annual noncompetitive awards may be made contingent upon the submission of noncompetitive applications/progress reports and availability of funds and a determination that continued funding would be in the best interest of the federal government.
Grant opportunities
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Latest 49 listed here. See the rest on GovTribe.
Grant awards
Latest 10 of 5,281 listed here. See the rest on GovTribe.
Top recipients by federal obligations
| Rank | Recipient | Federal obligations | Share |
|---|---|---|---|
| 1 | University Hospitals Cleveland Medical Center | $165,307,888 | 3% |
| 2 | Zero To Three National Center For Infants, Toddlers & Families | $136,606,256 | 2% |
| 3 | Children's National Medical Center | $122,398,806 | 2% |
| 4 | American Academy Of Pediatrics | $113,599,486 | 2% |
| 5 | University Of North Carolina At Chapel Hill | $109,166,609 | 2% |
| 6 | The Johns Hopkins University | $81,769,471 | 1% |
| 7 | Georgetown University | $65,910,898 | 1% |
| 8 | The Regents Of The University Of California. San Francisco | $65,469,660 | 1% |
| 9 | Association Of Public Health Laboratories, Inc. (The) | $65,468,160 | 1% |
| 10 | University Of Alabama At Birmingham | $63,969,663 | 1% |
10 of 827 recipients listed here. See the rest on GovTribe.
Federal obligations by fiscal year
| Fiscal year | Federal obligations |
|---|---|
| FY2026 | $164,459,553 |
| FY2025 | $661,047,807 |
| FY2024 | $799,017,966 |
| FY2023 | $1,039,504,112 |
| FY2022 | $674,505,538 |
| FY2021 | $223,461,963 |
| FY2020 | $213,851,844 |
| FY2019 | $193,764,254 |
| FY2018 | $160,978,338 |
| FY2017 | $159,376,792 |
| FY2016 | $142,082,436 |
| FY2015 | $137,852,966 |
| FY2014 | $135,409,346 |
| FY2013 | $128,040,375 |
| FY2012 | $131,117,664 |
| FY2011 | $146,176,784 |
| FY2010 | $150,468,278 |
| FY2009 | $144,132,213 |
| FY2008 | $87,884,114 |
| FY2007 | $80,320,341 |
| FY2006 | $39,816,944 |
| FY2005 | $61,256,967 |
| FY2004 | $36,211,345 |
| FY2003 | $69,573,829 |
| FY2002 | $138,389,571 |
| FY2001 | $94,914,647 |
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Quick answers
What is Assistance Listing 93.110?
Assistance Listing 93.110 is Special Projects of Regional and National Significance, a federal grant program run by Health Resources and Services Administration (Department of Health and Human Services).
What is the CFDA number for Special Projects of Regional and National Significance?
Its CFDA number is 93.110: Assistance Listing numbers were called CFDA numbers before 2018.
How much funding has Assistance Listing 93.110 awarded?
5,281 grant awards under 93.110 have obligated $5,530,921,658 in federal funds to 827 recipients.
Who receives the most funding from 93.110?
The recipients obligated the most under Special Projects of Regional and National Significance are University Hospitals Cleveland Medical Center ($165,307,888), Zero To Three National Center For Infants, Toddlers & Families ($136,606,256) and Children's National Medical Center ($122,398,806).
How much did 93.110 obligate in fiscal year 2025?
Grants under 93.110 obligated $661,047,807 in federal funds in fiscal year 2025.
Are there open grant opportunities under 93.110?
9 of the latest 49 opportunities under 93.110 are open or forecasted. The latest, Children and Youth with Special Health Care Needs Research Network, was posted on August 24, 2026.
On GovTribe
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