Evidence-based Practice Centers VI (EPC VI)

The Evidence-based Practice Centers (EPC) VI is a multiple-award Indefinite Delivery/Indefinite Quantity (IDIQ) contract vehicle established by the Agency for Healthcare Research and Quality (AHRQ) to support systematic evidence reviews, technical assessments, and research synthesis across diverse healthcare topics. The primary objective of this contract is to generate high-quality, comprehensive evidence reports that can directly inform clinical decision-making, health policy development, and healthcare quality improvement. These evidence reports are designed to support various stakeholders, including clinicians, patients, policymakers, and payers, by providing rigorous, scientifically-grounded insights into medical treatments, interventions, and healthcare practices.

The task orders under this IDIQ consistently focus on conducting systematic literature reviews, evidence mapping, and technical briefs across a wide range of healthcare domains, including preventive services, clinical treatments, mental health, pain management, and healthcare delivery models. Typical contract values range from $215,000 to $4,663,654, with performance periods generally spanning 12 to 36 months. Frequent prime contractors include Oregon Health & Science University, Kaiser Foundation Hospitals, Research Triangle Institute (RTI) International, The Johns Hopkins University, Mayo Clinic, and Emergency Care Research Institute (Ecri). Most task orders are firm fixed-price contracts without small business set-asides, predominantly performed in locations such as Rockville, Maryland, Portland, Oregon, and Research Triangle Park, North Carolina. The U.S. Preventive Services Task Force (USPSTF) is a common end-user of these evidence reviews, with many task orders specifically designed to support their work in developing clinical guidelines and preventive service recommendations.