Mayo Clinic Arizona

Mayo Clinic Arizona, doing business as Mayo Foundation, operates as a recipient of federal research grants and a prime contractor on clinical research and service delivery contracts, with no federal contract vehicle holdings. The organization is a nonprofit tax-exempt entity and child subsidiary of Mayo Clinic, headquartered in Scottsdale, Arizona, competing in full-and-open procurements without set-aside designations across its federal footprint.

Mayo Clinic Arizona's federal work centers on biomedical research and medical services delivery. On the contract side, the organization holds two prime awards: a $252,134 firm fixed-price purchase order from the National Cancer Institute (awarded November 1, 2024) for medical record abstraction services supporting the Pediatric Proton and Photon Therapy Comparison Cohort study, with performance through June 30, 2026; and a $638,583 purchase order from the Indian Health Service (awarded August 1, 2022) for hematology and oncology services and 24/7 on-call consultations at Phoenix Indian Medical Center, extending through August 1, 2027. Mayo Clinic Arizona also holds a Defense Advanced Research Projects Agency Other Transaction IDV with a ceiling of $1,288,748 awarded March 19, 2026, for the Network of Optimal Dynamic Energy Signatures (NODES) program.

The organization's federal footprint is predominantly grant-driven, with 71 percent of recent awards (217 of 306) structured as prime grants or grant subcontracts. Mayo Clinic Arizona acts as recipient on NIH project grants spanning cancer immunotherapy, cardiovascular disease, infectious disease mechanisms, and neurodegenerative conditions. Representative recent awards include a $657,698 five-year National Cancer Institute project grant on TRPS1-mediated regulatory T cell function in tumors (June 1, 2026 to May 31, 2031); a $209,765 National Institute of Allergy and Infectious Diseases project grant on TIGIT+ B cell therapy for transplant tolerance (May 20, 2026 to April 30, 2028); a $18.9 million Health Resources and Services Administration grant as national administrator for the Living Organ Donation Reimbursement Program (September 1, 2025 to August 31, 2028), with sub-grantee partnerships including the University of Kansas Medical Center Research Institute and Arbor Research Collaborative for Health; and a $1,409,244 National Cancer Institute cooperative agreement on immunoprevention strategies for multiple myeloma (August 15, 2025 to May 31, 2027). Defense Health Agency grants include $3,291,419 for a Phase 1 clinical trial of MUC1-activated T cells in ovarian cancer (September 1, 2024 to August 31, 2028) and $1,665,000 for cardiovascular failure pathogenesis and treatment research in acute pancreatitis (January 1, 2025 to December 31, 2028).

Customer concentration sits heavily with the NIH, which accounts for substantially more than half of recent awards. The National Cancer Institute, National Heart Lung and Blood Institute, and National Institute of Allergy and Infectious Diseases together dominate the volume of recent awards, while the Indian Health Service anchors the largest potential-value concentration at $1.6 million across 14 awards. The source data spans 34 distinct federal agencies, with remaining volume distributed across the National Institute of Diabetes and Digestive and Kidney Diseases, Department of Veterans Affairs, National Institute of Neurological Disorders and Stroke, and smaller allocations to the National Institute of Justice, National Institute on Aging, National Institute of General Medical Sciences, and others. Activity has grown sharply: from 15 awards in 2022 to 41 in both 2024 and 2025. Forty awards with combined potential value of $639,000 reach ultimate completion within the next twenty-four months, representing near-term recompete exposure.

Mayo Clinic Arizona engages subcontractors and subgrantees across a diverse research ecosystem. As a subcontractor, Mayo partners with Hennepin Healthcare Research Institute on the Scientific Registry of Transplant Recipients (operating and providing statistical support to the Organ Procurement and Transplantation Network) and with Luna Labs USA LLC on vestibular stimulator technology validation. As a sub-recipient, the organization collaborates with Arizona State University on developmental programming in stem cells and cancer, Northwestern University on achalasia precision medicine and kidney transplant biomarkers, Columbia University on eosinophil biology in lung allograft tolerance, Duke University on B cell-mediated antibody rejection, and numerous other academic and research institutions on grant aims spanning cardiovascular engineering, infectious disease, oncology, and gerontology. These collaborations are characterized by expertise-sharing arrangements—particularly in eosinophil immunology through partnerships with Elizabeth Jacobsen's lab—and joint clinical trial execution across NIH-funded multicenter studies.

Mayo Clinic Arizona's capability portfolio, grounded in award history, encompasses medical research and translational medicine in oncology immunotherapy (CAR-T cells, anti-BCMA therapies, tumor microenvironment biology), cardiovascular engineering (cardiac regeneration, engineered heart tissues, vascular intervention), infectious disease and immunology (food allergy mechanisms, transplant tolerance, viral immunity), and neurodegenerative disease biomarkers (Alzheimer's disease genetics, dementia imaging, movement disorder phenotyping). The organization performs medical record abstraction, clinical trial enrollment and patient evaluation, biospecimen acquisition and analysis, advanced imaging research including MRI and PET imaging analysis, and provision of clinical hematology-oncology services. Work is performed at Mayo Clinic Arizona's Scottsdale facility and subordinate locations, with remote performance on select grants and collaborations spanning multiple sites (Mayo Clinic Jacksonville, academic health systems nationwide, and international research partners in some grant projects).

Awards have obligated $540.7 million against combined potential value of $12.9 million—a 4,201 percent ratio reflecting Mayo's role as recipient of multi-year federal grant funding where annual obligations significantly exceed initial maximum grant authority. The organization competes exclusively in full-and-open, non-set-aside procurements and grants, with no minority, veteran, small-business, or disadvantaged-business designations present in the source data. As a nonprofit academic medical center and component of the Mayo Clinic health system, Mayo Clinic Arizona derives federal work from competitive peer-reviewed mechanisms (NIH study sections, NSF panels) and direct medical services procurement (Indian Health Service), positioning the organization as a research institution and clinical provider rather than a commercial defense or federal IT contractor.