Project Grant R21AI199432
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University a $1,279,395 cooperative agreement on August 1, 2026, to investigate fundamental mechanisms governing the induction of antigen-specific IgA in the gastrointestinal tract under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project examines two distinct pathways generating affinity-matured gut IgA following oral immunization with protein antigens. The first pathway,...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $440,000 on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate neutrophil priming as a method of macrophage functional training to modulate inflammatory responses in autoimmune diseases such as rheumatoid arthritis. The research explores how neutrophils can instruct macrophage activity and establish innate immune memory, with the goal of developing...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $493,889 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms of food-specific antibody induction in the gut. The research will elucidate how invariant natural killer T cells, type 2 conventional dendritic cells, and T follicular helper cells work in concert to promote production of food-specific immunoglobulin E antibodies, using a mouse model...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms underlying anti-aquaporin-4 responses in neuromyelitis optica spectrum disorder (NMOSD). The research addresses the autoimmune pathogenesis of NMOSD, a severe central nervous system disease driven by T cell and autoantibody responses against aquaporin-4 on...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $206,346 on March 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on metabolic regulation of regulatory T cells through fatty acid metabolism during viral pneumonia. The research investigates how regulatory T cells (Tregs) maintain immune function during viral lung infection by examining the role of carnitine palmitoyltransferase I A (CPT1A), the...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $159,140 on August 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct molecular epidemiology research on New Delhi metallo-B-lactamase-producing Enterobacterales (NDM-E) infections. The research integrates genotype, phenotype, and patient-level outcomes to develop allele-specific therapeutic guidance for NDM-E treatment. Aim 1 defines the genetic epidemiology of...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $440,000 on February 10, 2026, for research engineering supramolecular peptide amphiphile nanofibers displaying fibroblast growth factor-2 mimetic signals to protect endothelial cell barriers and prevent allograft vasculopathy in solid organ transplantation. The award is a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research addresses long-term graft loss from...
- The National Institute of Allergy and Infectious Diseases awarded Loyola University of Chicago Health Sciences Campus $223,068 on August 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate affinity maturation mechanisms in ectopic lymphoid tissues formed in allergic lungs. The research will identify molecular features—including activation-induced cytidine deaminase (AID) expression, somatic hypermutation, and clonal selection—that drive affinity...
- The National Institute of Allergy and Infectious Diseases awarded The University of Chicago $1,177,657 on July 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the biophysical and structural basis of T cell selection at the intersection of conventional and regulatory T cell repertoires. The research addresses autoimmune disease pathogenesis by examining how CD4+ T cells recognize peptide antigens complexed with MHC class II molecules through the T...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $411,078 on April 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to model perinatal exposure to diverse pathogenic microbes and assess the functional programming of innate lymphoid cells, specifically group 1 innate lymphocytes and natural killer cells. The research addresses how early-life microbial exposure shapes immune system development and innate...
The National Institute of Allergy and Infectious Diseases awarded Northwestern University $334,649 on July 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate fetal adaptive immune responsiveness in preterm premature rupture of membranes. The research measures whether the fetal adaptive immune system, traditionally considered inert or tolerogenic, mounts a response to ascending bacterial infection following membrane rupture. The project focuses on fetal CD4+ and CD8+ T-cell release into amniotic fluid and the formation of bronchiole-associated lymphoid tissue with germinal centers in fetal lungs, which suggests adaptive immune activation and differentiation. The work addresses clinical implications of fetal immune programming, as preterm birth with chorioamnionitis represents a risk factor for childhood asthma; understanding the adaptive immune mechanism may clarify this association. The project is performed in Chicago, Illinois, with a period of performance from July 20, 2026, through June 30, 2028. Northwestern University's Sponsored Research Division serves as the recipient. The award is a Project Grant, an assistance type that supports defined research objectives through a single award rather than a cooperative agreement or training award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $334.6k | 7/20/26 |