Advancing Global Health

Open Posted

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Opportunity number
DFOP0017890
Agency
Applications due
Award size
$500,000 to $250,000,000

Opportunity facts

Funding instrument
Grant
Category
  • Health
Eligible applicants
  • Unrestricted
Points of contact

Opportunity details come from Grants.gov. Updated .

About this opportunity

The Department of State seeks applicants to advance the America First Global Health Strategy through grants supporting projects that complement bilateral health memoranda of understanding, with a Statement of Interest due by February 14, 2027. Applicant eligibility is unrestricted. Awards will be issued under the U.S. President's Emergency Plan for AIDS Relief Programs (CFDA 19.029), with funding priorities and geographic scope to be signaled through specific Addenda to this Annual Program Statement; Addendum D addresses Nigeria and Addendum E addresses Uganda. The Department of State's Global Health Security and Diplomacy bureau will collaborate with Embassies and other State Department bureaus and offices to post supplemental funding opportunities through Addenda that address health challenges and priorities in partner countries.

The program targets health system strengthening, outbreak response, and related activities that enhance efficiency, foster self-reliance, and ensure U.S. investments benefit American safety, strength, and prosperity. Applicants should submit Statements of Interest in response to specific Addenda as posted; standard application instructions are provided in the base APS. Recent awards under the parent PEPFAR program have ranged from approximately $20,000 to $250 million, with performance periods typically spanning 11 months to five years across Sub-Saharan African countries. Questions regarding the opportunity were addressed in an amended Q&A document posted June 3, 2026.

Synopsis

The Department of State invites eligible applicants to advance the America First Global Health Strategy, which aims to save lives, strengthen health systems, enhance efficiency, foster self-reliance, and ensure U.S. investments benefit American safety, strength, and prosperity. This Annual Program Statement (APS) establishes a supplemental framework through which the Department of State may identify and support projects that complement, extend, and/or fill identified gaps in the implementation of these bilateral MOUs. Through specific Addenda, the Department will signal priorities and needs. This APS provides the standard application instructions for the submission of all Statements of Interest (SOIs) to these specific Addenda. GHSD will collaborate with Embassies and other Department of State Bureaus and Offices to post specific funding opportunities through Addenda to this APS that address health challenges and priorities of importance.

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