Substance Abuse and Mental Health Services Projects of Regional and National Significance
Active
- Assistance listing
- 93.243
- Agency
-
Substance Abuse and Mental Health Services Administration
Department of Health and Human Services
- Grant awards
- 14,080 $35,251,809,510 in federal obligations
Program facts
- Also known as
- (PRNS)
- Assistance types
-
- Project Grant
- Cooperative Agreement
- Block Grant
- Treasury account
-
- 75-1364-0-1-551
- More information
Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.
About this program
The Department of Health and Human Services Substance Abuse and Mental Health Services Administration (SAMHSA) funds substance abuse treatment, prevention, and mental health projects of regional and national significance through Assistance Listing 93.243, with the most recent grant award dated December 22, 2025.
SAMHSA disburses awards across a portfolio of 14,080 grants spanning substance abuse prevention and treatment, mental health services, and integrated behavioral health. Grant activity remains strong: the past five years averaged 804 awards annually, with 2022 reaching a peak of 1,004 awards before declining to 76 in 2025 (reflecting partial-year data as of the most recent award date). Combined federal dollars obligated total $35.25 billion across the portfolio.
The program funds concrete activities: hepatitis C testing and treatment integration with substance use and mental health care; evidence-based outpatient and residential substance use disorder and co-occurring disorder treatment; youth and young adult prevention services targeting underage drinking and drug initiation; suicide prevention infrastructure and training; crisis response systems; recovery housing and peer support; mobile outreach and street medicine; harm reduction services including naloxone distribution; and systems change initiatives for statewide family networks and community-based behavioral health integration in primary care. Recent awards reflect emphasis on hepatitis C elimination, treatment access expansion in rural and high-need areas, and targeted prevention in underserved communities.
The assistance-type mix is predominantly Project Grants (70 percent, 9,826 awards) with smaller shares of Cooperative Agreements (25 percent, 3,476 awards) and Block Grants (6 percent, 778 awards). SAMHSA's own centers dominate funding: SAMHSA distributed 13,600 awards totaling $32.86 billion; the Health Resources and Services Administration contributed 80 awards with a negative federal dollar obligation (a data anomaly). Recent award magnitudes range from $180 thousand to $11.4 million, with many three-year project grants in the $1 million to $3 million range.
Recent recipients include Meharry Medical College (hepatitis C elimination for people who use drugs in Nashville, $2.1 million), Henry Ford Health (hepatitis C and integrated care in Detroit, $5.1 million), University of Florida (hepatitis C same-day testing and treatment in Gainesville and Jacksonville, $3.7 million), and the Suicide Prevention Resource Center at the University of Oklahoma ($30.6 million for national training and technical assistance).
Open or recently posted opportunities include the Safety Through Recovery, Engagement, and Evidence-Based Treatment and Support program (Cooperative Agreement, due July 17, 2026) for street-based services to people experiencing homelessness with serious mental illness or substance use disorders; the FY2026 Cooperative Agreement for the 988 Suicide & Crisis Lifeline Administrator (due February 27, 2026); Implementing Zero Suicide in Health Systems (Cooperative Agreement, due April 20, 2026); and several prevention and treatment funding lines with deadlines in early 2026 (Strategic Prevention Framework - Partnerships for Success programs; Treatment and Recovery Services for Youth, Young Adults, and Families; Targeted Capacity Expansion).
Objective and description
- Objective
SAMHSA was given the authority to address priority substance abuse treatment, prevention and mental health needs of regional and national significance through assistance (grants and cooperative agreements) to States, political subdivisions of States,
- Description
rants and cooperative agreements may be for (1) knowledge and development and application projects for prevention, treatment and rehabilitation and the conduct or support of evaluations of such projects; (2) training, education, and technical assistance; (3) targeted capacity response programs (4) systems change grants including statewide family network grants and client-oriented and consumer run self-help activities; (5) programs to foster health and development of children; and (6) coordination and integration of primary care services into publicly-funded community mental health centers and other community-based behavioral health settings.
Eligibility
- Applicant eligibility
State (includes District of Columbia, U.S. Territories, and Pacific Jurisdictions, public institutions of higher education and hospitals), Local (includes State-designated Indian Tribes, excludes institutions of higher education and hospitals, Sponsored organization, Public nonprofit institution/organization (includes institutions of higher education and hospitals), Other public institution/organization, Federally Recognized Indian Tribal Governments, Private nonprofit institution/organization (includes institutions of higher education and hospitals), Quasi-public nonprofit institution/organization, Native American Organizations (includes Indian groups, cooperatives, corporations, partnerships, associations) Public organizations, such as units of State and local governments and to domestic private nonprofit organizations such as community-based organizations, universities, colleges and hospitals. State educational agencies, local educational agencies, Indian Tribes (as defined in section 4 of the Indian Self-Determination and Education Assistance Act) or their tribal educational agencies, a school operated by the Bureau of Indian Education, a Regional Corporation, or a Native Hawaiian educational organization.
- Beneficiary eligibility
Private nonprofit institution/organization, Quasi-public nonprofit organization, State, Local, Sponsored organization, Public nonprofit institution/organization, Other public institution/organization, Federally Recognized Indian Tribal Governments other non-profits
- Uses of assistance
Funds (including direct costs and indirect costs) may be used only for expenses clearly related and necessary to carry out approved activities that will provide immediately useful, practical knowledge that service providers need as they wrestle with the rapidly changing health care environment.
- Length and time phasing of assistance
Applications will be accepted for a project period of 1 to 5 years with 12 month budget periods. Annual awards will be made subject to continued availability of funds and progress achieved.
How to apply
- Preapplication coordination
Applicants must comply with the Executive Order (E.O.) 12372 if their state(s) participates. Review process recommendations from the state Single Point of Contact (SPOC) are due no later than 60 days after application deadline.
- Criteria for selecting proposals
A merit review is conducted on the applications submitted, which includes a description of the proposed project.
- Award procedure
Applications are awarded directly by SAMHSA to the applicant organization after a number of considerations, including but not limited to merit review, program analysis, and appropriate Center National Advisory Council concurrence.
Grant opportunities
Show 40 more
Latest 50 listed here. See the rest on GovTribe.
Grant awards
Latest 10 of 14,080 listed here. See the rest on GovTribe.
Top recipients by federal obligations
| Rank | Recipient | Federal obligations | Share |
|---|---|---|---|
| 1 | The Mental Health Association Of New York City, Inc. | $5,108,672,584 | 14% |
| 2 | Health & Human SVC Commn TX | $541,861,164 | 2% |
| 3 | Ohio Department Mental Health | $528,786,411 | 2% |
| 4 | California Department Of Health Care Services | $456,995,779 | 1% |
| 5 | Florida Department Of Children And Families | $455,198,819 | 1% |
| 6 | Department Of Behavioral Health & Developmental Services | $349,760,995 | 1% |
| 7 | Department Of Human Services Colorado | $265,601,926 | 1% |
| 8 | Oklahoma Department Of Mental Health And Substance Abuse Services | $254,384,165 | 1% |
| 9 | Tennessee Department Of Mental Health & Substance Abuse Services | $213,310,401 | 1% |
| 10 | Illinois Department Of Human Service | $203,187,882 | 1% |
10 of 4,545 recipients listed here. See the rest on GovTribe.
Federal obligations by fiscal year
| Fiscal year | Federal obligations |
|---|---|
| FY2026 | $640,580,324 |
| FY2025 | $7,930,422,014 |
| FY2024 | $4,397,634,708 |
| FY2023 | $10,680,850,434 |
| FY2022 | $7,019,015,064 |
| FY2021 | $5,192,575,371 |
| FY2020 | $1,181,067,203 |
| FY2019 | $1,121,394,437 |
| FY2018 | $979,888,405 |
| FY2017 | $759,431,369 |
| FY2016 | $836,918,090 |
| FY2015 | $829,521,806 |
| FY2014 | $837,169,977 |
| FY2013 | $667,202,552 |
| FY2012 | $714,806,161 |
| FY2011 | $679,658,015 |
| FY2010 | $630,175,865 |
| FY2009 | $565,168,672 |
| FY2008 | $377,153,369 |
| FY2007 | $245,270,738 |
Show all 20
Quick answers
What is Assistance Listing 93.243?
Assistance Listing 93.243 is Substance Abuse and Mental Health Services Projects of Regional and National Significance, a federal grant program run by Substance Abuse and Mental Health Services Administration (Department of Health and Human Services).
What is the CFDA number for Substance Abuse and Mental Health Services Projects of Regional and National Significance?
Its CFDA number is 93.243: Assistance Listing numbers were called CFDA numbers before 2018.
How much funding has Assistance Listing 93.243 awarded?
14,080 grant awards under 93.243 have obligated $35,251,809,510 in federal funds to 4,545 recipients.
Who receives the most funding from 93.243?
The recipients obligated the most under Substance Abuse and Mental Health Services Projects of Regional and National Significance are The Mental Health Association Of New York City, Inc. ($5,108,672,584), Health & Human SVC Commn TX ($541,861,164) and Ohio Department Mental Health ($528,786,411).
How much did 93.243 obligate in fiscal year 2025?
Grants under 93.243 obligated $7,930,422,014 in federal funds in fiscal year 2025.
Are there open grant opportunities under 93.243?
None of the latest 50 opportunities under 93.243 is open now. The latest, Safety Through Recovery, Engagement, and Evidence-Based Treatment and Support, was posted on March 20, 2026.
On GovTribe
See this program's full record
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