Substance Abuse and Mental Health Services Projects of Regional and National Significance

Active

Assistance listing
93.243
Agency
Grant awards
14,080 $35,251,809,510 in federal obligations

Program facts

Also known as
(PRNS)
Assistance types
  • Project Grant
  • Cooperative Agreement
  • Block Grant
Treasury account
  • 75-1364-0-1-551
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Department of Health and Human Services Substance Abuse and Mental Health Services Administration (SAMHSA) funds substance abuse treatment, prevention, and mental health projects of regional and national significance through Assistance Listing 93.243, with the most recent grant award dated December 22, 2025.

SAMHSA disburses awards across a portfolio of 14,080 grants spanning substance abuse prevention and treatment, mental health services, and integrated behavioral health. Grant activity remains strong: the past five years averaged 804 awards annually, with 2022 reaching a peak of 1,004 awards before declining to 76 in 2025 (reflecting partial-year data as of the most recent award date). Combined federal dollars obligated total $35.25 billion across the portfolio.

The program funds concrete activities: hepatitis C testing and treatment integration with substance use and mental health care; evidence-based outpatient and residential substance use disorder and co-occurring disorder treatment; youth and young adult prevention services targeting underage drinking and drug initiation; suicide prevention infrastructure and training; crisis response systems; recovery housing and peer support; mobile outreach and street medicine; harm reduction services including naloxone distribution; and systems change initiatives for statewide family networks and community-based behavioral health integration in primary care. Recent awards reflect emphasis on hepatitis C elimination, treatment access expansion in rural and high-need areas, and targeted prevention in underserved communities.

The assistance-type mix is predominantly Project Grants (70 percent, 9,826 awards) with smaller shares of Cooperative Agreements (25 percent, 3,476 awards) and Block Grants (6 percent, 778 awards). SAMHSA's own centers dominate funding: SAMHSA distributed 13,600 awards totaling $32.86 billion; the Health Resources and Services Administration contributed 80 awards with a negative federal dollar obligation (a data anomaly). Recent award magnitudes range from $180 thousand to $11.4 million, with many three-year project grants in the $1 million to $3 million range.

Recent recipients include Meharry Medical College (hepatitis C elimination for people who use drugs in Nashville, $2.1 million), Henry Ford Health (hepatitis C and integrated care in Detroit, $5.1 million), University of Florida (hepatitis C same-day testing and treatment in Gainesville and Jacksonville, $3.7 million), and the Suicide Prevention Resource Center at the University of Oklahoma ($30.6 million for national training and technical assistance).

Open or recently posted opportunities include the Safety Through Recovery, Engagement, and Evidence-Based Treatment and Support program (Cooperative Agreement, due July 17, 2026) for street-based services to people experiencing homelessness with serious mental illness or substance use disorders; the FY2026 Cooperative Agreement for the 988 Suicide & Crisis Lifeline Administrator (due February 27, 2026); Implementing Zero Suicide in Health Systems (Cooperative Agreement, due April 20, 2026); and several prevention and treatment funding lines with deadlines in early 2026 (Strategic Prevention Framework - Partnerships for Success programs; Treatment and Recovery Services for Youth, Young Adults, and Families; Targeted Capacity Expansion).

Objective and description

Objective

SAMHSA was given the authority to address priority substance abuse treatment, prevention and mental health needs of regional and national significance through assistance (grants and cooperative agreements) to States, political subdivisions of States,

Description

rants and cooperative agreements may be for (1) knowledge and development and application projects for prevention, treatment and rehabilitation and the conduct or support of evaluations of such projects; (2) training, education, and technical assistance; (3) targeted capacity response programs (4) systems change grants including statewide family network grants and client-oriented and consumer run self-help activities; (5) programs to foster health and development of children; and (6) coordination and integration of primary care services into publicly-funded community mental health centers and other community-based behavioral health settings.

Eligibility

Applicant eligibility

State (includes District of Columbia, U.S. Territories, and Pacific Jurisdictions, public institutions of higher education and hospitals), Local (includes State-designated Indian Tribes, excludes institutions of higher education and hospitals, Sponsored organization, Public nonprofit institution/organization (includes institutions of higher education and hospitals), Other public institution/organization, Federally Recognized Indian Tribal Governments, Private nonprofit institution/organization (includes institutions of higher education and hospitals), Quasi-public nonprofit institution/organization, Native American Organizations (includes Indian groups, cooperatives, corporations, partnerships, associations) Public organizations, such as units of State and local governments and to domestic private nonprofit organizations such as community-based organizations, universities, colleges and hospitals. State educational agencies, local educational agencies, Indian Tribes (as defined in section 4 of the Indian Self-Determination and Education Assistance Act) or their tribal educational agencies, a school operated by the Bureau of Indian Education, a Regional Corporation, or a Native Hawaiian educational organization.

Beneficiary eligibility

Private nonprofit institution/organization, Quasi-public nonprofit organization, State, Local, Sponsored organization, Public nonprofit institution/organization, Other public institution/organization, Federally Recognized Indian Tribal Governments other non-profits

Uses of assistance

Funds (including direct costs and indirect costs) may be used only for expenses clearly related and necessary to carry out approved activities that will provide immediately useful, practical knowledge that service providers need as they wrestle with the rapidly changing health care environment.

Length and time phasing of assistance

Applications will be accepted for a project period of 1 to 5 years with 12 month budget periods. Annual awards will be made subject to continued availability of funds and progress achieved.

How to apply

Preapplication coordination

Applicants must comply with the Executive Order (E.O.) 12372 if their state(s) participates. Review process recommendations from the state Single Point of Contact (SPOC) are due no later than 60 days after application deadline.

Criteria for selecting proposals

A merit review is conducted on the applications submitted, which includes a description of the proposed project.

Award procedure

Applications are awarded directly by SAMHSA to the applicant organization after a number of considerations, including but not limited to merit review, program analysis, and appropriate Center National Advisory Council concurrence.

Grant opportunities

Opportunity Status Posted Applications due
Safety Through Recovery, Engagement, and Evidence-Based Treatment and Support SM-26-019 Closed
FY2026 Cooperative Agreement for 988 Suicide & Crisis Lifeline Administrator FG-26-001 Closed
Implementing Zero Suicide in Health Systems SM-26-008 Closed
Hepatitis C Elimination Initiative Pilot TI-25-005 Closed
National Women's Mental Health and Substance Use Technical Assistance Center SM-25-014 Closed
Circles of Care for American Indian/Alaska Natives (AI/AN) SM-25-016 Closed
National Technical Assistance Center for Child, Youth and Family Mental Health SM-25-020 Closed
Statewide Family Network SM-25-004 Closed
Sober Truth on Preventing Underage Drinking Act (STOP Act) Grant Program SP-25-001 Closed
Strategic Prevention Framework - Partnerships for Success for Communities and Tribes SP-25-002 Closed
Strategic Prevention Framework - Partnerships for Success for States SP-25-003 Closed
First Responders - Comprehensive Addiction and Recovery Act TI-25-001 Closed
Suicide Prevention Resource Center SM-25-012 Closed
Treatment and Recovery Services for Youth, Young Adults, and Families TI-25-003 Closed
Targeted Capacity Expansion - Special Projects TI-25-002 Closed
Community-Based Maternal Behavioral Health Services Program SM-24-013 Closed
Women's Behavioral Health Technical Assistance Center SM-24-012 Closed
National Anti-Drug Coalitions Training and Workforce Development Cooperative Agreement SP-24-003 Closed
Addiction Technology Transfer Centers Cooperative Agreements TI-24-011 Closed
Minority Fellowship Program SM-24-009 Closed
State Opioid Response (SOR)/Tribal Opioid Response (TOR) Technical Assistance TI-24-012 Closed
Prevention Technology Transfer Centers Cooperative Agreements SP-24-002 Closed
Promoting the Integration of Primary and Behavioral Health Care: Collaborative Care Model SM-24-011 Closed
The National Center for Mental Health Dissemination, Implementation and Sustainment Cooperative Agreement SM-24-010 Closed
Minority AIDS Initiative: Integrated Behavioral Health and HIV Care for Unsheltered Populations Pilot Project TI-24-013 Closed
Minority AIDS Initiative: Substance Use Disorder (SUD) Prevention and Treatment Pilot Program TI-24-005 Closed
National Peer-Run Training and Technical Assistance Center for Addiction Recovery Support TI-24-014 Closed
Screening, Brief Intervention, and Referral to Treatment (SBIRT) TI-24-010 Closed
Statewide Consumer Network Program SM-24-002 Closed
GLS Campus Suicide Prevention Grant Program SM-24-004 Closed
Promoting the Integration of Primary and Behavioral Health Care: States SM-24-003 Closed
Cooperative Agreements for the Garrett Lee Smith State/Tribal Youth Suicide Prevention and Early Intervention Program SM-24-005 Closed
Statewide Family Network Program SM-24-001 Closed
National Center of Excellence for Integrated Health Solutions SM-24-008 Closed
Rural Opioid Technical Assistance Regional Centers TI-24-007 Past —
First Responders - Comprehensive Addiction and Recovery Act TI-24-006 Closed
State Pilot Program for Treatment for Pregnant and Postpartum Women (PPW-PLT) TI-24-002 Closed
Provider's Clinical Support System Universities (PCSS-U) TI-24-001 Closed
Grants to Expand Substance Use Disorder Treatment Capacity in Adult and Family Treatment Drug Courts TI-24-004 Closed
Building Communities of Recovery TI-24-003 Closed
Sober Truth on Preventing Underage Drinking Act Grants SP-24-001 Closed
Cooperative Agreement for the Refugee and Migrant Behavioral Health Technical Assistance Center SM-23-023 Closed
Family Counseling and Support for Lesbian, Gay, Bisexual, Transgender, Queer/Questioning, Intersex+ Youth and their Families FG-23-004 Closed
Support for 988 Tribal Response Cooperative Agreements FG-23-005 Closed
Cooperative Agreements for 988 Suicide and Crisis Lifeline Crisis Center Follow-Up Programs FG-23-003 Closed
Cooperative Agreements for States and Territories to Improve Local 988 Capacity FG-23-006 Closed
FY 2023 Hurricanes Fiona and Ian Behavioral Health Recovery Program TI-23-023 Closed
Preventing Youth Overdose: Treatment, Recovery, Education, Awareness and Training TI-23-022 Closed
Minority AIDS Initiative: The Substance Use and Human Immunodeficiency Virus Prevention Navigator Program for Racial/Ethnic Minorities SP-23-005 Closed
Strategic Prevention Framework - Partnerships for Success for States SP-23-003 Closed
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Grant awards

Award Recipient Federal obligations Awarded
2025 central texas floods supplemental samhsa emergency response grant H07SM090700 Health & Human SVC Commn TX $9,996,648
Hepatitis C elimination for greater detroit - "rise: regional initiative to suppress and eliminate HCV" will expand… H79TI088437 Arab Community Center For Economic And Social Services (Access) $1,393,218
HCV elimination and integrated care for high-need communities in LOS angeles county - project title: HCV elimination… H79TI088435 Bienestar Human Services, Inc. $8,000,000
Hillcrest family services hepatitis C elimination initiative pilot - hillcrest family services will implement a… H79TI088432 Hillcrest Family Services $2,500,000
Hepc free: CORRIDOR of care - US helping US, people into living, INC. Proposes the hepc free: CORRIDOR of care, a… H79TI088430 US Helping Us-People Into Living, Inc. $3,000,000
HEP C free - communicare will implement HEP C free, an integrated care pilot targeting individuals with substance use… H79TI088414 North Mississippi Commission On Mental Illness & Retardation $2,697,500
Cherokee nation strategic tribal initiative to treat and cure hepatitis C virus (STITCH) program - using a same-day… H79TI088404 Cherokee Nation $2,092,456
Community-based unified response to eliminate hepatitis C (CURE) - project title: community-based unified response to… H79TI088392 Meharry Medical College $2,092,500
Rocky BOY health center hepatitis C elimination initiative pilot H79TI088381 Rocky Boy Health Center $686,868
Rosebud sioux tribe health administration hepatitis C elimination initiative pilot - the rosebud sioux tribe (RST)… H79TI088370 Rosebud Sioux Tribe $3,802,500

Latest 10 of 14,080 listed here. See the rest on GovTribe.

Top recipients by federal obligations

10 of 4,545 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $640,580,324
FY2025 $7,930,422,014
FY2024 $4,397,634,708
FY2023 $10,680,850,434
FY2022 $7,019,015,064
FY2021 $5,192,575,371
FY2020 $1,181,067,203
FY2019 $1,121,394,437
FY2018 $979,888,405
FY2017 $759,431,369
FY2016 $836,918,090
FY2015 $829,521,806
FY2014 $837,169,977
FY2013 $667,202,552
FY2012 $714,806,161
FY2011 $679,658,015
FY2010 $630,175,865
FY2009 $565,168,672
FY2008 $377,153,369
FY2007 $245,270,738
Show all 20

Quick answers

What is Assistance Listing 93.243?

Assistance Listing 93.243 is Substance Abuse and Mental Health Services Projects of Regional and National Significance, a federal grant program run by Substance Abuse and Mental Health Services Administration (Department of Health and Human Services).

What is the CFDA number for Substance Abuse and Mental Health Services Projects of Regional and National Significance?

Its CFDA number is 93.243: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 93.243 awarded?

14,080 grant awards under 93.243 have obligated $35,251,809,510 in federal funds to 4,545 recipients.

Who receives the most funding from 93.243?

The recipients obligated the most under Substance Abuse and Mental Health Services Projects of Regional and National Significance are The Mental Health Association Of New York City, Inc. ($5,108,672,584), Health & Human SVC Commn TX ($541,861,164) and Ohio Department Mental Health ($528,786,411).

How much did 93.243 obligate in fiscal year 2025?

Grants under 93.243 obligated $7,930,422,014 in federal funds in fiscal year 2025.

Are there open grant opportunities under 93.243?

None of the latest 50 opportunities under 93.243 is open now. The latest, Safety Through Recovery, Engagement, and Evidence-Based Treatment and Support, was posted on March 20, 2026.

On GovTribe

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