Cancer Centers Support Grants
Active
- Assistance listing
- 93.397
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Grant awards
- 1,707 $18,466,139,389 in federal obligations
Program facts
- Also known as
- Cancer Centers
- Assistance types
-
- Project Grant
- Cooperative Agreement
- Block Grant
- Treasury account
-
- 75-0849-0-1-550
- More information
Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.
About this program
The National Institutes of Health National Cancer Institute funds Cancer Centers Support Grants (CCSG, CFDA 93.397) to provide organizational infrastructure and resources enabling interdisciplinary cancer research spanning basic laboratory, clinical, and population science. The program awarded its most recent grant on August 18, 2026, and has distributed $18.47 billion in federal funding across 1,707 awards dating back to 1976.
The program funds salaries for scientific leadership, shared research resources, administrative costs, planning and evaluation activities, and developmental funds supporting new investigator recruitment and feasibility studies within cancer centers. Recent awards exemplify this scope: the Emory Lung Cancer SPORE received $2.19 million to investigate immunotherapy efficacy and artificial intelligence approaches for stage III non-small cell lung cancer; the Dana-Farber/Harvard leukemia SPORE received $2.43 million to examine resistance mechanisms to menin inhibitors and test combination therapies; and the University of Florida Health Cancer Center received $15.3 million as a new basic cancer center supporting transdisciplinary programs in genetics, epigenetics, metabolism, and cancer control across a 27-county catchment area serving medically underserved populations.
Awards are predominantly Project Grants (81%), with smaller shares of Cooperative Agreements (17%) and Block Grants (2%). The National Cancer Institute dominates funding, accounting for 374 awards valued at $15.5 billion—84% of total federal dollars obligated. The broader NIH contributed 1,293 awards totaling $2.52 billion. Award magnitude varies widely, ranging from approximately $1.19 million to $15.3 million, with recent awards clustering between $2 million and $10 million.
Activity remains robust: 2025 produced 9 awards and 2026 has yielded 3 awards to date, though the 2024 pace (6 awards) signals potential fluctuation. Annual volume peaked in 2023 at 36 awards but has moderated since.
Applicants must be nonprofit institutions within the United States with a peer-reviewed cancer research base of at least $4 million in direct costs. Recent opportunities emphasize cancer health equity and disparities research, including the Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) program (PAR-23-308, due February 21, 2025) supporting partnerships between cancer centers and institutions serving underserved populations. Broader career development and investigator-focused mechanisms also remain active, including the NCI Outstanding Investigator Award (R35, multiple PAR cycles) and the Cancer Center Support Grants renewal cycle (PAR-25-444, due September 25, 2028), which permits Clinical Trial Optional approaches.
Objective and description
- Objective
To provide an organizational focus and stimulus for the highest quality cancer research that effectively promotes interdisciplinary cancer research aimed toward the ultimate goal of reducing cancer incidence, mortality and morbidity. The Cancer Cente
- Description
To provide an organizational focus and stimulus for the highest quality cancer research that effectively promotes interdisciplinary cancer research aimed toward the ultimate goal of reducing cancer incidence, mortality and morbidity. The Cancer Center Support Grant (CCSG) provides the resources and infrastructure to facilitate the coordination of interdisciplinary programs across a broad spectrum of research from basic laboratory research to clinical investigation to population science. The CCSG supports salaries for scientific leadership of the Center, shared resources for funded center investigators, certain administrative costs, planning and evaluation, and developmental funds for new recruitments and feasibility studies.
Eligibility
- Applicant eligibility
Any nonprofit institution within the United States with a peer-reviewed cancer research base of 4.0 million dollars in direct costs may apply for a Cancer Center Support Grant.
- Beneficiary eligibility
University, college, public agency or research institution in the U.S.
- Uses of assistance
In general, CCSGs do not support research projects directly but are used to enhance the ongoing cancer research and to strengthen the existing research base according to the "Policies and Guidelines Relating to the Cancer Center Support Grant."
- Length and time phasing of assistance
Up to 5 years of support may be requested. Grants may be awarded up to 5 years based on competitive peer review.
How to apply
- Criteria for selecting proposals
The major elements in evaluating applications include the following: (1) An adequate base of established programs of high quality in laboratory and clinical cancer research; (2) research activity in a variety of disciplines, and evidence of high degree of interdisciplinary coordination, interaction and cooperation among center members; (3) appropriate and adequate organization and facilities for the conduct and evaluation of center activities; (4) a qualified director with adequate authority; and (5) an adequate commitment of the parent institution or institutions to the cancer center. The center should be recognized as a major element within the organizational structure.
- Award procedure
Grant applications are evaluated by scientific authorities for scientific and technical merit. Applications must also be reviewed by the National Cancer Advisory Board. All competitive applications compete for available funds on the basis of scientific and technical merit, program relevance, and program balance, consistent with NCI and NIH priorities and strategic plans. Initial award provides funds for the first budget period (usually 12 months) and Notice of Grant Award (Form PHS 1533-2) indicates support recommended for the remainder of the project period, allocation of Federal funds by budget categories, and special conditions, if any.
- Time to approval or disapproval
Core Grants: Approximately 10 months.
- Renewals
Same procedure as new applications.
- Appeals
A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-064.html and NIH Policy Manual Release date: February 7, 2012 http://oma.od.nih.gov/manualchapters/grants/54513/index.html).
Grant opportunities
Show 40 more
Latest 50 listed here. See the rest on GovTribe.
Grant awards
Latest 10 of 1,707 listed here. See the rest on GovTribe.
Top recipients by federal obligations
| Rank | Recipient | Federal obligations | Share |
|---|---|---|---|
| 1 | Dana-Farber Cancer Institute, Inc. | $955,897,350 | 5% |
| 2 | Sloan-Kettering Institute For Cancer Research | $794,428,192 | 4% |
| 3 | The Univeristy Of Texas M.d. Anderson Cancer Center | $704,386,146 | 4% |
| 4 | Fred Hutchinson Cancer Center | $648,542,227 | 4% |
| 5 | The Johns Hopkins University | $612,922,880 | 3% |
| 6 | University Of North Carolina At Chapel Hill | $523,972,101 | 3% |
| 7 | The Trustees Of The University Of Pennsylvania | $461,182,573 | 2% |
| 8 | Mayo Clinic | $378,837,165 | 2% |
| 9 | University Of Alabama At Birmingham | $353,452,113 | 2% |
| 10 | The Regents Of The University Of California. San Francisco | $350,685,991 | 2% |
10 of 180 recipients listed here. See the rest on GovTribe.
Federal obligations by fiscal year
| Fiscal year | Federal obligations |
|---|---|
| FY2026 | $550,730,128 |
| FY2025 | $1,679,353,653 |
| FY2024 | $1,936,789,342 |
| FY2023 | $2,320,631,584 |
| FY2022 | $1,976,083,462 |
| FY2021 | $1,058,455,569 |
| FY2020 | $567,943,534 |
| FY2019 | $538,836,383 |
| FY2018 | $537,133,743 |
| FY2017 | $512,811,634 |
| FY2016 | $520,014,368 |
| FY2015 | $476,774,126 |
| FY2014 | $498,637,273 |
| FY2013 | $479,818,574 |
| FY2012 | $519,312,324 |
| FY2011 | $527,424,393 |
| FY2010 | $534,612,025 |
| FY2009 | $458,161,685 |
| FY2008 | $198,668,367 |
| FY2007 | $282,170,627 |
| FY2006 | $346,100,270 |
| FY2005 | $395,590,503 |
| FY2004 | $376,784,213 |
| FY2003 | $299,330,805 |
| FY2002 | $263,891,747 |
| FY2001 | $102,914,321 |
Show all 26
Quick answers
What is Assistance Listing 93.397?
Assistance Listing 93.397 is Cancer Centers Support Grants, a federal grant program run by National Institutes of Health (Department of Health and Human Services).
What is the CFDA number for Cancer Centers Support Grants?
Its CFDA number is 93.397: Assistance Listing numbers were called CFDA numbers before 2018.
How much funding has Assistance Listing 93.397 awarded?
1,707 grant awards under 93.397 have obligated $18,466,139,389 in federal funds to 180 recipients.
Who receives the most funding from 93.397?
The recipients obligated the most under Cancer Centers Support Grants are Dana-Farber Cancer Institute, Inc. ($955,897,350), Sloan-Kettering Institute For Cancer Research ($794,428,192) and The Univeristy Of Texas M.d. Anderson Cancer Center ($704,386,146).
How much did 93.397 obligate in fiscal year 2025?
Grants under 93.397 obligated $1,679,353,653 in federal funds in fiscal year 2025.
Are there open grant opportunities under 93.397?
10 of the latest 50 opportunities under 93.397 are open or forecasted. The latest, Investigator-Focused Award (Parent R35), was posted on July 30, 2026.
On GovTribe
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