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All Federal Grant Programs
21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies
Posted
9/10/18
Assistance Listing Number
93.372
Overview
Grant Opportunities
Grant Awards
263
Federal Agency
National Institutes of Health
Applicant Types
Not listed
Beneficiary Types
Not listed
Additional Information
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Popular Federal Grant Opportunities
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Popular Federal Grant Awards
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Name
Description
Awardee
Assistance Type
Dollars Obligated
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Award Date
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Updated At
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K99NS112412
DECISION-RELATED INFORMATION AT SINGLE-NEURON RESOLUTION IN HUMAN MOTOR CORTEX AND ITS IMPLICATIONS FOR NEUROPROSTHETICS
The Leland Stanford Junior University
Project Grant
($242k)
5/1/20
6/3/21
F32MH120887
MAPPING CEREBELLAR GRANULE CELL FUNCTION WITH NOVEL GENETIC AND OPTICAL TOOLS
The Trustees Of Princeton University
Project Grant
$654.6k
9/17/19
7/21/23
RF1NS128897
The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded a $7.7 million Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies program to The Trustees of Columbia University in New York, New York. The grant supports research from July 15, 2022 to June 30, 2025 to reveal the computational mechanisms of primate face recognition. Columbia University will implement feedforward and recurrent neural network models of face recognition and use optimization techniques to develop sets of synthetic face stimuli designed to elicit divergent responses from the models. Rockefeller University, under a $7.7 million sub-award, will conduct fMRI and electrophysiology experiments recording neural responses in primate face patches to the synthetic stimuli. The research aims to identify the computational mechanisms of primate face recognition, develop new neural network architectures, and establish the method of using "controversial stimuli" to directly test computational theories implemented in neural networks. Insights are expected to further understanding and treatment of perceptual disorders.
The Trustees Of Columbia University In The City Of New York
Project Grant
$7.7m
7/15/22
9/17/22
R01EB026946
REAL-TIME STATISTICAL ALGORITHMS FOR CONTROLLING NEURAL DYNAMICS AND BEHAVIOR
The Research Foundation For The State University Of New York
Project Grant
$1.1m
9/20/18
5/12/23
RF1NS132047
BRAIN DYNAMICS UNDERLYING LONG-TERM MEMORY CONSOLIDATION - ABSTRACT THE HIPPOCAMPUS HAS A WELL-ESTABLISHED ROLE IN THE INITIAL FORMATION AND STORAGE OF MEMORY. HOWEVER, LITTLE IS UNDERSTOOD ABOUT BRAIN MECHANISMS THAT SUPPORT THE RE-ORGANIZATION AND TRANSFER OF MEMORIES INTO LONGER-TERM CORTICAL STORAGE. A DETAILED UNDERSTANDING OF HIPPOCAMPAL- TO-CORTICAL CONSOLIDATION IS CRITICAL TO SHED LIGHT ON THE REGULATION OF LONG-TERM MEMORIES, AND HOW THEY MAY BECOME TOO TRANSIENT (AS IN ALZHEIMER'S, PARKINSON'S, TRAUMATIC BRAIN INJURY) OR TOO PERSISTENT (AS IN PTSD). ONE CHALLENGE HAS BEEN THE DIFFICULTY INHERENT TO TRACKING THE REAL-TIME CELLULAR RESOLUTION ACTIVITY OF MULTIPLE BRAIN REGIONS THROUGHOUT THE WEEKS-TO-MONTHS LONG CONSOLIDATION WINDOW. TOWARD THIS, WE HAVE RECENTLY DEVELOPED A HEAD-FIXED BEHAVIORAL PARADIGM, COMPATIBLE WITH LONGITUDINAL IMAGING, WHERE MICE LEARN TO FORM AND MAIN CONTEXTUAL ASSOCIATIONS FOR AT LEAST ONE MONTH. WE HAVE ALSO FOUND THAT LEARNING OF THIS TASK REQUIRES THE HIPPOCAMPUS, WHILE MEMORY CONSOLIDATION REQUIRES THE ENTORHINAL AND PREFRONTAL CORTEX. USING METHODS TO PERFORM MULTI-REGION LONGITUDINAL NEURAL ACTIVITY RECORDINGS, TOGETHER WITH ANATOMICALLY-DEFINED OPTOGENETIC INHIBITION DURING IMAGING, WE PROPOSE TO DISSECT THE REAL-TIME CONTRIBUTIONS OF THE HIPPOCAMPAL-ENTORHINAL-PREFRONTAL PATHWAY IN MEMORY CONSOLIDATION. SPECIFICALLY, WE AIM TO CHARACTERIZE A NEW BEHAVIORAL MODEL OF MEMORY CONSOLIDATION (AIM 1), AND PERFORM LONGITUDINAL IMAGING TO IDENTIFY PREFRONTAL CORTEX BRAIN ACTIVITY PATTERNS UNIQUE TO CONSOLIDATED MEMORIES (AIM 2). FINALLY, WE WILL IDENTIFY HOW ENTORHINAL PROJECTIONS STABILIZE SUCH ACTIVITY PATTERNS IN PREFRONTAL CORTEX DURING CONSOLIDATION (AIM 3). TOGETHER, WE WILL CONTRIBUTE TO OUR UNDERSTANDING OF HOW SOME MEMORIES ARE PROGRESSIVELY RE-ORGANIZED AND STABILIZED ACROSS THE BRAIN FOR LONG-TERM STORAGE.
Rockefeller University
Project Grant
$1.2m
5/1/23
4/27/23