Project Grant R34NS148215
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Utah $616,000 on August 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (Assistance Listing 93.372) to develop a high-throughput computational pipeline for rapid design of photocaged neuropeptides. The project addresses the NIH BRAIN Initiative goal to enable precise modulation of neural circuit components by creating a generalizable, open-source...
- The National Eye Institute awarded Neuromatch, Inc. $118,488 on September 15, 2025, to deliver a multi-week intensive summer research education program in computational neuroscience under the Vision Research program (CFDA 93.867). The award funds a national, hands-on short-course training experience designed to equip neuroscientists with skills to access, analyze, and integrate Brain Initiative data. The program operates through collaborative learning environments in which experienced faculty...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Yale University $272,970 under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative on September 30, 2025. The award funds research on neural circuits regulating arousal and behavioral responses to visual threats. The project employs a virtual visual cliff task in mice to study the relationship between neuromodulators (norepinephrine and acetylcholine), attention, arousal, sensory...
- The National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) awarded $361,125 to the University of California, Berkeley on September 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) as a project grant. The award funds a targeted planning project to establish a functional connectomics paradigm combining ultra-fast two-photon voltage imaging (2P-FACED) with two-photon optogenetic...
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University $557,161 on July 10, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to develop a novel bioluminescence resonance energy transfer (BRET) system for optimizing and imaging in vivo recording of neural activity in freely behaving animals. The project runs through June 30, 2029, with performance in Nashville, Tennessee. The award supports...
- The National Institute of Neurological Disorders and Stroke awarded Cornell University a $686,023 Cooperative Agreement on July 8, 2026, to develop non-invasive optical imaging technology for visualizing brain structure and function at the cellular level. Cornell will advance three-photon microscopy (3PM) imaging techniques and develop new lasers to increase three-photon fluorescence signal by approximately 10,000 times. This advancement will enable visualization of mouse brain activity with...
- The National Institute of Neurological Disorders and Stroke awarded $250,000 to Trustees of Boston University on February 23, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to deliver a two-week summer school program in neurovascular imaging across scales in animals and humans. Boston University's Neurophotonics Center will provide hands-on, practical training in optical imaging technologies applicable to in vivo studies in...
- The National Institute of Neurological Disorders and Stroke awarded the University of Illinois $599,169 on September 1, 2026, under the 21st Century Cures Act — Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, CFDA 93.372, to develop and validate contrast-free super-resolution ultrasound imaging techniques for functional imaging of neural circuits in the spinal cord. The research demonstrates phase subtraction imaging (PSI) and null subtraction imaging (NSI) as...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- The National Institute of Neurological Disorders and Stroke awarded Trustees of Dartmouth College $1,010,880 on May 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to translate a novel carbon-coated neurochemical sensor technology toward integrated neurotransmitter sensing in humans. Dartmouth will develop designs to integrate fast-scan cyclic voltammetry (FSCV)-based dopamine and neuromodulator sensing capabilities into...
The National Institute of Neurological Disorders and Stroke awarded the University of New England $319,500 on September 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to establish the feasibility of applying CAMPARI3, a validated neuroscience tool that enables permanent labeling of activated neurons through green-to-red photoconversion, to corneal primary afferent neurons and to integrate the tool into broader neuroscience research at UNE. Aim 1 will determine whether CAMPARI3 can label physiologically distinct subpopulations of corneal-projecting trigeminal neurons in both healthy and dry eye conditions. Photoconverted neurons, activated via thermal and chemical stimulation, will be probed using multiplex RNAscope to map functional responses with molecular profiles. This proof-of-concept study will generate preliminary data for future R01 applications aimed at uncovering mechanisms of chronic corneal pain and identifying novel treatment targets. Aim 2 will expand CAMPARI utilization across UNE through annual summer courses, targeted virtual trainings, and creation of online educational resources. Working with BRAIN disseminators Drs. Marie-Eve Paquet and Hod Dana and in partnership with the Canadian Optogenetics and Vectorology Foundry, UNE will develop infrastructure and expertise to support widespread CAMPARI implementation for both in vitro and in vivo studies. The period of performance runs from September 1, 2026, through August 31, 2028. Work is performed in Biddeford, Maine.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $319.5k | 8/26/26 |