Research on Healthcare Costs, Quality and Outcomes

Active

Assistance listing
93.226
Agency
Grant awards
4,058 $3,408,324,101 in federal obligations

Program facts

Assistance types
  • Project Grant
  • Cooperative Agreement
  • Block Grant
Treasury account
  • 75-1700-0-1-552
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Department of Health and Human Services Agency for Healthcare Research and Quality (AHRQ) funds health services research, evaluation projects, demonstration programs, research networks, multidisciplinary centers, and knowledge dissemination on healthcare quality, effectiveness, efficiency, and delivery systems, with the most recent grant award issued on April 1, 2026 (93.226).

Grant awards have been funded consistently over the past several years, with 155 awards in 2022, 156 in 2023, 112 in 2024, and 3 recorded through early 2026. The program operates across a 28-year funding history dating to 1998, and has obligated $3.41 billion in federal dollars across 4,058 total awards. The portfolio is dominated by Project Grants, which account for 92 percent of awards, with Block Grants and Cooperative Agreements representing 6 percent and 2 percent respectively. All top funders are within AHRQ; the leading funder accounts for 2,514 awards and $1.03 billion obligated, followed by progressively smaller tranches. The combined non-federal share brings total obligations to $3.55 billion.

Recent awards span health information technology implementation—including patient engagement tools for lab result comprehension and age-friendly learning systems in geriatric care—alongside quality improvement research in antibiotic stewardship, diagnostic safety, and health equity. Representative awards include a $1.5 million project on clinical decision support for ICU mobility interventions, a $1.6 million dissemination study on unnecessary postoperative antibiotics in pediatric hospitals, and a $2.5 million project investigating Clostridioides difficile contact precautions. Smaller awards fund conferences on opioid harm reduction and emergency medicine workforce diversity.

Multiple opportunities remain active. A March 2025 deadline solicits clinical decision support tools for disseminating Long COVID evidence into practice (RFA-HS-25-001). Standing calls for behavioral health implementation (State-based Healthcare Extension Cooperatives, January 2025), diagnostic safety improvement (multiple R01 and R18 mechanisms through March 2026), and primary care science advancement (March 2026) are available. The program maintains continuous intake under broad program announcements for R01, R03, R18, K01, and R36 mechanisms with rolling deadlines extending through March 2026, supporting health services research across all settings where applicants can demonstrate relevance to AHRQ priorities: safety, quality, access, equity, and cost.

Objective and description

Objective

To support research and evaluations, demonstration projects, research networks, and multidisciplinary centers and to disseminate information on health care and on systems for the delivery of such care involving: (1) The quality, effectiveness, effici

Description

To support research and evaluations, demonstration projects, research networks, and multidisciplinary centers and to disseminate information on health care and on systems for the delivery of such care.

Eligibility

Applicant eligibility

Federal, State or local government agencies, federally-recognized Indian Tribal Governments, U.S. Territories, non-government organizations,public or private institutions of higher education, and other public or nonprofit private agencies, institutions, or organizations. For-profit organizations are eligible to apply for these grants only if "cooperative agreement" is the designated funding mechanism. Organizations described in section 501(c)4 of the Internal Revenue Code that engage in lobbying are not eligible.

Beneficiary eligibility

Federal, State or local government agencies, federally-recognized Indian Tribal Governments, public or private nonprofit institutions, U.S. territories, Native American organizations, consumers, students, minority groups, specialized groups, health or education professionals, individuals, scientist/researchers, and the general public.

Uses of assistance

The research should contribute to the health services knowledge base from which empirically based information can be derived by policymakers, both immediately and over the coming decades. Grants include funds for direct costs (such as personnel, travel, equipment, or supplies) necessary to carry out an approved project as well as funds for the reimbursement of applicable indirect costs (also referred to as facilities and administrative costs). Unallowable costs are indicated in the HHS Grants Policy Statement.

Length and time phasing of assistance

Grants may be approved for project periods of up to 5 years, depending on the grant program and based on the availability of funding. Refer to the FOA of interest for information regarding the maximum duration of the project period. Awards are made on an annual basis and it is expected that obligations will be made within the budget period awarded. After awards are issued, funds are released in accordance with the payment procedure established by the grantee institution with DHHS, which may be an Electronic Transfer System or a Monthly Cash Request System.

How to apply

Criteria for selecting proposals

The proposals must first be reviewed by review groups of peers and recommended for approval on the basis of scientific and technical merit. This includes consideration of the qualifications of the principal investigator and staff to conduct the research using appropriate methodology and budget. Those approved proposals which are most relevant to the identified program priority issues of the AHRQ are funded to the extent that funds are available.

Award procedure

Applications are reviewed for scientific merit by a committee including nonfederal consultants who are selected from appropriate scientific fields. AHRQ considers the recommendations of the review committee, program interest, and the availability of funds in the final selection of grant applications for funding. When such decisions are made, applicants are notified and a Notice of Award is issued.

Renewals

If additional support is desired to continue a project beyond the approved project period, an application for competing continuation must be submitted for review in the same manner as a new application.

Grant opportunities

Opportunity Status Posted Applications due
Disseminating PCOR Evidence for Long COVID Care into Practice Through Up-to-Date Clinical Decision Support RFA-HS-25-001 Closed
National Coordinating Center (NCC) for AHRQs Healthcare Extension Service - State-based Solutions to Healthcare Improvement (U54) RFA-HS-24-006 Closed
National Evaluation Center (NEC) for AHRQs Healthcare Extension Service: State-based Solutions to Healthcare Improvement (U19) RFA-HS-24-005 Closed
State-based Healthcare Extension Cooperatives to Accelerate Implementation of Actionable Knowledge into Practice (U19) RFA-HS-24-004 Closed
Using Innovative Digital Healthcare Solutions to Improve Quality at the Point of Care (R21/R33 - Clinical Trial Optional) PA-24-266 Closed
Examining the Impact of Artificial Intelligence (AI) on Healthcare Safety (R18) PA-24-261 Closed
Implementing and Evaluating Patient-Centered Clinical Decision Support Strategies in Real-World Settings(U18) RFA-HS-24-003 Closed
Research to Advance the Science of Primary Care (R01) PA-24-205 Closed
AHRQ Small Health Services Research Grant Program (R03) PA-24-155 Closed
AHRQ Health Services Research Projects (R01) PA-24-154 Closed
AHRQ Health Services Research Demonstration and Dissemination Grants (R18) PA-24-156 Closed
Evaluation and Coordinating Center for the AHRQ/PCORI Learning Health System Embedded Scientist Training and Research Centers (U18) RFA-HS-24-002 Closed
Systems-Based Approaches to Improve Patient Safety by Improving Healthcare Worker Safety and Well-Being (R01 Clinical Trial Optional) PA-24-093 Closed
AHRQ Improving Diagnostic Safety in Ambulatory Care: Strategies and Interventions (R18) PA-23-290 Closed
AHRQ Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01) PA-23-291 Closed
AHRQ Health Services Research Dissertation Program (R36) PA-23-196 Closed
Implementing and Evaluating New Models for Delivering Comprehensive, Coordinated, Person-Centered Care to People with Long COVID (U18) RFA-HS-23-012 Closed
Dissemination and Implementation of Equity-Focused Evidence-Based Interventions in Healthcare Delivery Systems (R18) RFA-HS-23-002 Closed
Supporting the Management of Substance Use Disorders in Primary Care and other Ambulatory Settings (R18) RFA-HS-23-005 Closed
AHRQ Improving Diagnostic Safety in Ambulatory Care: Strategies and Preventions (R18) RFA-HS-23-011 Closed
AHRQ Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01) RFA-HS-23-010 Closed
AHRQ Small Research Projects to Advance the Science of Primary Care (R03) PA-23-115 Closed
AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30) RFA-HS-23-001 Closed
AHRQ Mentored Research Scientist Career Development Award (K01) PA-22-255 Closed
AHRQ Conference Grant Programs (R13) PA-22-238 Closed
AHRQ Mentored Clinical Scientist Research Career Development Award (K08) PA-22-232 Closed
Understanding and Improving Diagnostic Safety in Ambulatory Care: Strategies and Interventions (R18) RFA-HS-23-025 Forecasted —
Telehealth Centers of Excellence (P50) RFA-HS-23-028 Forecasted —
Long COVID Care Centers for Underserved Communities RFA-HS-23-026 Forecasted —
Dissemination and Implementation of Perinatal Safety Culture Training to Improve Equitable Maternal Healthcare Delivery and Outcomes RFA-HS-23-022 Forecasted —
Disseminating and Implementing Patient-Centered Outcomes Research (PCOR) Evidence into Practice through Interoperable Clinical Decision Support PA-23-027 Forecasted —
Primary Care Research PA-23-028 Forecasted —
Implementing Patient-centered Delivery of Clinical Preventive Services in Primary Care (PCOR TF) RFA-HS-23-030 Forecasted —
Health System Collaboratory for Chronic Disease Management (U54) RFA-HS-23-029 Forecasted —
Competitive Revision Supplements to Existing AHRQ Grants and Cooperative Agreements to Enhance Workforce Diversity in Health Services Research PA-22-175 Closed
AHRQ Administrative Supplements for Grants in Health Services Research PA-22-168 Closed
Diagnostic Centers of Excellence: Partnerships to Improve Diagnostic Safety and Quality (R18) RFA-HS-22-008 Closed
Consumer Assessment of Healthcare Providers and Systems (CAHPS) VI (U18) RFA-HS-22-007 Closed
Large Research Projects for Combating Antibiotic-Resistant Bacteria (CARB) (R01) PA-22-047 Closed
Large Health Services Research Demonstration and Dissemination Projects for Combating Antibiotic-Resistant Bacteria (CARB)(R18) PA-22-048 Closed
Making Health Care Safer in Ambulatory Care Settings and Long-term Care Facilities (R18) PA-21-267 Closed
Notice to Extend PA-16-453 " AHRQ Conference Grant Programs (R13)" NOT-HS-21-20 Past —
AHRQ PCOR Evidence Into Clinical Practice Through CDS PA-22-052 Past —
AHRQ Equity NOFO RFA-HS-22-002 Past —
Reducing Racial and Ethnic Healthcare Disparities in Chronic Conditions by Dissemination and Implementation of Patient Centered Outcomes Research (PCOR) Evidence (R18) RFA-HS-22-001 Closed
AHRQ Primary Care: Practice-Based Research Networks (PBRNs) NOFO RFA-HS-22-003 Past —
AHRQ Primary Care: Population Health NOFO RFA-HS-22-004 Past —
AHRQ Health Service Research Exploratory/Developmental (R21) NOFO PA-22-056 Past —
AHRQ Opioids/Substance Use Disorders NOFO RFA-HS-22-005 Past —
AHRQ Digital Health Care NOFO RFA-HS-22-006 Past —
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Grant awards

Award Recipient Federal obligations Awarded
An age-friendly learning healthcare system: a transformative digital solution for geriatrics clinics R33HS029982 University Of Utah $248,956
Labgenie: a patient-engagement tool to aid older adults' understanding of lab test results R33HS029969 Florida State University $295,823
Improving identification and coordination of mobility interventions in the ICU using clinical decision support R33HS029959 The University Of Iowa $245,311
Scale-LHS: synthesize, coordinate, amplify, learn, and evaluate the ahrq/pcor LHS network U18HS030335 The Trustees Of The University Of Pennsylvania $1,581,298
Improving pediatric donor heart utilization with predictive analytics R21HS029548 Rector & Visitors Of The University Of Virginia $276,018
Reducing variance in diagnosis of mental disorders to improve patient safety R18HS030218 The Rand Corporation $957,640
Disseminating and implementing medsma℞t families in emergency departments: a randomized control trial to assess… R18HS030202 The University Of Kentucky Research Foundation $1,572,997
Addressing variability and inequities via systematic evidence-based recommendations (adviser) for head and neck imaging R18HS029839 Brigham & Womens Hospital Inc. $795,826
Artificial intelligence and human factors in healthcare quality & safety R13HS030350 Pennsylvania State University $33,371
Annual UAB methods symposium R13HS030349 University Of Alabama At Birmingham $50,000

Latest 10 of 4,058 listed here. See the rest on GovTribe.

Top recipients by federal obligations

10 of 479 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $28,275,155
FY2025 $102,830,922
FY2024 $263,488,082
FY2023 $273,449,619
FY2022 $292,921,023
FY2021 $275,995,037
FY2020 $129,612,776
FY2019 $150,978,504
FY2018 $173,113,586
FY2017 $156,259,557
FY2016 $191,473,832
FY2015 $204,747,830
FY2014 $166,963,688
FY2013 $156,408,155
FY2012 $130,497,522
FY2011 $130,003,386
FY2010 $135,572,786
FY2009 $89,821,843
FY2008 $37,840,324
FY2007 $60,900,882
FY2006 $26,737,031
FY2005 $71,239,141
FY2004 $34,688,469
FY2003 $32,026,715
FY2002 $54,212,721
FY2001 $37,152,612
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Quick answers

What is Assistance Listing 93.226?

Assistance Listing 93.226 is Research on Healthcare Costs, Quality and Outcomes, a federal grant program run by Agency for Healthcare Research and Quality (Department of Health and Human Services).

What is the CFDA number for Research on Healthcare Costs, Quality and Outcomes?

Its CFDA number is 93.226: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 93.226 awarded?

4,058 grant awards under 93.226 have obligated $3,408,324,101 in federal funds to 479 recipients.

Who receives the most funding from 93.226?

The recipients obligated the most under Research on Healthcare Costs, Quality and Outcomes are Regents Of The University Of Michigan ($163,968,779), The Johns Hopkins University ($94,916,641) and Northwestern University ($85,369,480).

How much did 93.226 obligate in fiscal year 2025?

Grants under 93.226 obligated $102,830,922 in federal funds in fiscal year 2025.

Are there open grant opportunities under 93.226?

8 of the latest 50 opportunities under 93.226 are open or forecasted. The latest, Disseminating PCOR Evidence for Long COVID Care into Practice Through Up-to-Date Clinical Decision Support, was posted on January 10, 2025.

On GovTribe

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