Examining the Impact of Artificial Intelligence (AI) on Healthcare Safety (R18)

Closed Posted

Opportunity number
PA-24-261
Agency
Applications due
Award size
Not on record

Opportunity facts

Funding instrument
Grant
Category
  • Health
Eligible applicants
  • Higher Education Inst. (Public)
  • Public or Indian Housing Auth.
  • Small Businesses
  • For Profit Organizations
  • Other
  • Higher Education Inst. (Private)
  • County Governments
  • State Governments
  • Special District Governments
  • City/Township Governments
  • 501(c)(3) Nonprofits
  • Tribal Organizations (Not Federally Recognized)
  • Non-501(c)(3) Nonprofits
  • Independent School Districts
  • Tribal Governments (Federally Recognized)
Points of contact
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

The Department of Health and Human Services Agency for Healthcare Research and Quality is seeking grant applications to examine the impact of Artificial Intelligence systems on healthcare safety, specifically determining whether and how breakthrough AI uses can affect patient safety and how AI systems can be safely implemented in healthcare settings. Applicants must propose research that balances the potential benefits of AI in improving healthcare safety, effectiveness, efficiency, accessibility, and affordability against identified risks of patient harm and user burden. The agency will evaluate applications based on scientific and technical merit, including the qualifications of the principal investigator and staff, appropriateness of methodology, and budget justification, with peer review conducted by committees including nonfederal consultants from relevant scientific fields. Eligible applicants include higher education institutions (public and private), state and local governments, tribal organizations, small businesses, for-profit organizations, and nonprofit entities. The application deadline is March 25, 2026, and awards are funded under the Research on Healthcare Costs, Quality and Outcomes program (CFDA 93.226).

Historical award data under the parent program indicates typical grant values ranging from $300,000 to $1,200,000, with awards spanning multi-year project periods of up to five years depending on program availability and project scope. Project Grants (R18) have demonstrated flexibility in funding levels based on research complexity and demonstration/dissemination requirements. Research will be conducted across diverse healthcare delivery settings nationwide, including hospitals, long-term care facilities, ambulatory care practices, home healthcare, and transitions between care settings. Annual funding releases will be made to grantee institutions in accordance with established payment procedures following award issuance.

Synopsis

The purpose of this NOFO is to invite grant applications that support healthcare safety by determining (1) whether and how certain breakthrough uses of Artificial Intelligence (AI) systems can affect patient safety; and (2) how AI systems can be safely implemented and used. AI has the potential to improve the safety, effectiveness, efficiency, accessibility, and affordability of healthcare. However, as with most technologies, this potential must be balanced by identifying and mitigating potential risks for patient harm and user burden.

Files

File Type Posted
PA-24-261-Full-Announcement.html HTML file

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