MagnetomVida Tech Specs 1.pdf

Siemens Medical Solutions USA, Inc.

40 Liberty Boulevard, Malvern, PA 19355

SIEMENS REPRESENTATIVE

Haig Tellalian - +1 617-584-1746 haig.tellalian@siemens-healthineers.com

Created: 05/22/2023 04:29:44 PM Siemens Medical Solutions USA, Inc. Confidential Page 26 of 75

P-CPQ-581405-3-3

Detailed Technical Specifications

MAGNETOM Vida (DE)

Part No./Product Description

14456200 MAGNETOM Vida - System

MAGNETOM Vida – the first BioMatrix system – leverages the intelligent combination of Tim 4G and the Siemens unique BioMatrix technology to be ready to embrace the unique set of challenges that each and every patient brings to the MRI exam.

System Design

- Short and open appearance (186 cm total system length cover-to-cover and 70 cm Open Bore Design) to reduce patient anxiety and claustrophobia

- Whole-body superconductive Zero Helium Boil-Off 3T magnet

- Weight-optimized magnet technology based on high performance 7T magnet design

- Actively Shielded water-cooled Siemens gradient system for maximum performance

Evolving from Total imaging matrix, MAGNETOM Vida comprises a new technology that addresses the intrinsic biovariability in humans - BioMatrix Technology.

Tim 4G (Total imaging matrix in the 4th generation) for excellent image quality and speed

- Siemens unique DirectRX technology enabling all digital-in/digital-out design

- Dual-Density Signal Transfer Technology

Push-button exams with GO technologies Select&GO DotGO/ myExam Companion Recon&GO MR View&GO

Tim Application Suite allowing excellent head-to-toe imaging for

- Neuro

- Angio

- Cardiac

- Body

- Onco

- Breast

- Ortho

- Pediatric

- Scientific

Further included

- High performance host computer and measurement and reconstruction system

- Patient communication including headphones

- syngo MR software including

- Turbo Suite Essential

- 1D/2D PACE

- BLADE

- Phoenix

- Inline Diffusion

- MDDW (Multiple Direction Diffusion Weighting)

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- CISS

- DESS

- TGSE

- Offline Composing MAGNETOM Vida – the first BioMatrix system – leverages the intelligent combination of Tim 4G and the Siemens unique BioMatrix technology to be ready to embrace the unique set of challenges that each and every patient brings to the MRI exam.

The system includes:

BioMatrix Technology

In order to meet the requirements of the changing healthcare market, Tim® is now further enhanced with the ability to address patient biovariablity: Evolving from Total imaging matrix, BioMatrix® technology addresses the intrinsic biovariability in humans.

BioMatrix can anticipate challenges in MR examinations, for example, the limited ability to hold one’s breath, to manage growing patient populations and increasing exam complexity in MRI.

BioMatrix can adapt to all patients and their anatomic individuality, even the critical ones, to make MRI more predictable and consistent for all patients, even critical ones.

BioMatrix can accelerate the workflow, without compromising quality of care by assisting interactions between the patient and the user, to improve MRI cost-effectiveness and patient outcomes.

BioMatrix anticipates, adapts and accelerates to embrace human nature.

Tim 4G Tim 4G provides excellent image quality and speed in MRI combined with increased patient comfort and optimized workflow efficiency. Only one patient setup, no repositioning, no changing of coils.

Ultra-light-weighted coils with high density of coil elements for maximized patient comfort and increased SNR. Feet-first positioning reduces claustrophobia.

Tim 4G with its 4G flexibility, 4G accuracy and 4G speed brings image quality and acquisition speed to a new level.

Magnet:

- Short 172 cm long (186 cm with covers), whole-body superconductive 3T magnet with active shielding (AS) technology with counter coils

- External Interference Shielding (E.I.S.)

- Excellent homogeneity enabled magnet design which allows for a cylindrically optimized homogeneity volume resulting in higher image quality (55 × 55 × 50 cm³ DEV, typ. 4.3 ppm based on the 24-plane plot method)

- Temperature sensors with real time correction algorithm for unmatched long-term stability at 70 cm

- The magnet has a typical Helium boil-off rate of 0 l/yr during typical, undisturbed clinical operation depending on the sequences used and examination time, and provided the system is serviced in regular intervals.

- It has an integrated magnet cooling system.

- The combination of standard active shim with 3 linear channels (1st order) and 5 nonlinear channels (2nd order) and passive shim allows for maximized magnetic field homogeneity and consistent high image quality for a wide range of applications

- Integrated Eco-Power technology to save around 30% of energy during standby of the system.

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Gradient system:

- Actively shielded water-cooled world-class gradient system

- All axes force compensated for lowest vibrations and acoustic performance

DirectRF - RF Transmit/Receive System:

- Fully integrated Transmit- and Receive path in the magnet housing including extremely compact water-cooled solid state amplifier with 37.5 kW peak power

- High dynamic range

- Immediate feedback loop for real-time sequence adaptation

- Integrated no tune transmit/receive Body Coil

- TimTX TrueForm includes innovative techniques in the RF excitation hardware as well as application and processing features to guarantee uniform RF distribution in all body regions.

- TimTX TrueForm for MAGNETOM Vida consists of TrueForm excitation, which uses amplitude and phase transmission settings optimized for dedicated body regions. Feeding the 4 ports of the integrated body coil with an optimized weighting yields a homogeneous B1 distribution.

- The revolutionary Tim 4G technology allows connecting up to 228 channels (coil elements) simultaneously enabling higher SNR and iPAT in all directions. No repositioning of patients is needed even for large Field of View examinations.

- Dual-Density Signal Transfer enables ultra-high density coil design by integrating key RF components into the local coil.

Select&GO The Select&GO interface enables fast and easy single-touch patient positioning. Correct positioning saves unnecessary wasted time for repositioning and additional adjustments, therefore shortening the total room time.

- The ergonomically designed Select&GO touch panels are integrated into the front cover on each side of the patient tunnel for controlling table movement, guidance for patient setup and comfort features. They are well illuminated for easy visual recognition.

- Automated table move to upmost position, to center position or Home position facilitate smooth patient preparation and will reduce table time

- Variable (6 levels) ventilation and lighting inside the magnet bore or volume adjustments are possible for increased patient comfort

- The Select&GO touch panels provide on board guidance for patient set up where it's needed -directly at the scanner. Information such as patient name or exam type or required patient position, guidance for ECG set up and immediate visualization of physiological curves will be provided for convenient operation.

- Almost all table control functions, including ventilation and illumination of the magnet bore, can be also controlled from the operator console for convenient operation.

DotGO (≤ SW syngo MR XA30/31) Go for consistent results, efficiently with Dot Engines.

Dot offers a customizable framework for patient personalization, user guidance and exam automation.

Optimized scan strategies are provided and can be selected based on patient condition, which allow for high quality exams even when conditions change. Integrated decision points allow the user to easily add or remove one or a group of protocols with one click. Step by step image and text guidance guides novice users even through the most complicated exams. Exam automation allows optimal timing for breathing, scanning, planning or contrast arrival. Dot can be easily customized to follow the individual standards of care.

Dot is personalized, guided and automated and designed to improve workflow efficiency and image consistency.

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Dot Cockpit The central tool to continuously build knowledge into standardized exams strategies and to make those available for every user in the MRI department. Dot Cockpit is the new starting point for every exam.

myExam Companion (≥ SW syngo MR XA50) myExam Companion stands for built-in expertise that works with the user to achieve consistent, reproducible results for all patients. It offers patient personalization, user guidance and process automation via myExam Assists and intuitive protocol management via myExam Cockpit. myExam Companion helps users efficiently achieve high-quality results – regardless of their experience level, the patient, or throughput.

myExam Assists myExam Assist provides guided and flexible workflows. Optimized scan strategies are provided and can be selected based on patient condition, which allows for reproducible, high image quality and time efficient exams. The built-in flexibility allows users to change predefined strategies at any time during the workflow, and to personalize to the individual patient's condition and clinical need. Integrated decision points allow the user to easily add or remove one or a group of protocols with one click. Step by step image and text guidance guides novice users even through the most complicated exams.

Exam automation allows optimal timing for breathing, scanning, planning or contrast arrival. The different myExam Assists can be easily customized to follow the individual standards of care.

myExam Cockpit myExam Cockpit allows users to customize intuitively. It provides a central workspace for protocol management. Users can set up and maintain protocols, build knowledge into standardized exams, and make those continuously available for every user in the MRI department.

Recon&GO The Recon&GO technology encompasses a wide range of in-line functionalities automizing reconstruction and post-processing steps to provide ready-to-read results for the radiologist.

Examples are Inline ADC calculation, inline subtraction of dynamic contrast-enhanced series, up to Inline Launch of advanced post-processing applications.

MR View&GO MR View&GO is MAGNETOM Vida’s all-in-one viewing and reading solution for fast and intuitive quality check and result distribution. It receives the images directly as they come on the scanner, giving the user a clear overview of the quality of images scanned, without being distracted by constant context switches. Once the images have been checked for acceptable quality, they can easily be sent to the PACS with minimal user interaction.

Beyond that, MR View&GO offers the additional advantage to perform extended post-processing, directly at the scanner. In-line launching of post-processing applications makes it possible to fully automate the evaluation of, for example, perfusion maps, permeability or cardiac function, all without additional user interaction. This makes it possible to save radiologist time by delivering quantitative, ready-to-read results, directly to the PACS.

Tim Application Suite The Tim Application Suite offers a complete range of clinically optimized examinations for all regions.

The Tim Application Suite – allowing excellent head-to-toe imaging – is provided standard on MAGNETOM Vida.

- Neuro Suite

- Angio Suite

- Cardiac Suite

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- Body Suite

- Onco Suite

- Breast Suite

- Ortho Suite

- Pediatric Suite

- Scientific Suite

Neuro Suite Comprehensive head and spine examinations can be performed with dedicated programs. High-resolution pulse sequences and motion-insensitive pulse sequences for patients which have difficulties to lay still are provided. The Neuro Suite also includes pulse sequences for diffusion imaging, perfusion imaging, and fMRI. It includes for example:

- Fast 2D imaging with SE, TSE, GRE pulse sequences for high-resolution imaging

- BLADE for motion-insensitive TSE imaging

- EPI pulse sequences and protocols for diffusion imaging, perfusion imaging, and fMRI for advanced neuro applications. Diffusion-weighted imaging is possible with up to 16 b-values in the orthogonal directions. For reduced distortions and homogeneous signal intensity even in the presence of challenging susceptibility interfaces and at station boundaries, SliceAdjust (slice-by-slice adjustments) can be selected.

- 3D TOF for non-contrast-enhanced angiography

- 3D isotropic resolution volume imaging using T1 3D MPRAGE / 3D FLASH, SPACE DarkFluid, T1 SPACE and T2 SPACE pulse sequences

- High-resolution T2 SPACE pulse sequence optimized for inner ear examinations

- Double Inversion Recovery 3D pulse sequences (DIR SPACE) with two user-selectable inversion pulses for the simultaneous suppression of e.g. cerebro-spinal fluid and white matter

- MP2RAGE (Magnetization Prepared 2 Rapid Acquisition Gradient Echoes) provides homogeneous tissue contrast for segmentation and applications such as voxel-based morphometry. In combination with MapIt*, it also provides T1 mapping functionality.

- Whole-spine pulse sequences in multiple steps with software-controlled table movement

- 2D and 3D MEDIC pulse sequences for T2-weighted imaging, particularly for C-spine examinations in axial orientation where reproducibility is difficult due to CSF pulsations and blood flow artifacts

- RESOLVE (Readout Segmentation Of Long Variable Echo-trains) delivers high-resolution, low-distortion diffusion-weighted imaging (DWI) for accurate depiction of lesions.

- BioMatrix’s CoilShim helps to reduce patient induced strongly localized B0 inhomogeneities as may arise, e.g., in the neck region.

- 3D Myelo with 3D HASTE for anatomical details

- 3D CISS (Constructive Interference in Steady State) for excellent visualization of

- fine structures such as cranial nerves. High-resolution imaging of inner ear

- TGSE sequence used primarily for T2-weighted imaging for shorter measurement time, decreased RF power deposition, and high-resolution imaging of the brain

- AutoAlign Head LS providing a fast, easy, standardized, and reproducible patient scanning supporting reading by delivering a higher and more standardized image quality

Angio Suite Excellent MR Angiography can be performed to visualize arteries and veins with or without contrast agent.

- 3D MRA pulse sequences for carotid arteries, abdominal arteries, and peripheral arteries, with short TR and TE. The strong gradients make it possible to separate the arterial phase from the venous phase

- Dynamic MRA for 3D imaging over time

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- Signal from Respiratory Sensor can be selected to actively trigger MR image acquisition, e.g. with

NATIVE*

Contrast-enhanced MRA 3D contrast-enhanced MRA pulse sequences for dynamic carotid, abdominal, and peripheral arteries, shortest TR and TE. The strong gradients make it possible to separate the arterial phase from the venous phase

- TestBolus workflow for optimal bolus timing and excellent image quality

- CareBolus functionality for accurate determination of the bolus arrival time and the “Stop and

Continue” of the 3D ce-MRA pulse sequence after the 2D bolus control scan

- Dynamic ce-MRA for 3D imaging over time

Non-contrast-MRA and venography

- Time-of-Flight (ToF) pulse sequences for MRA for the Circle of Willis, carotids and neck vessels;

can be adapted for venography, and Breath-hold protocols for abdominal vessels

- Triggered 2D ToF sequences for non-contrast-MRA in the legsMR venography and arteriography with Phase-Contrast

- TONE (Tilted optimized non-saturating excitation) techniques for improved

- Contrast-to-Noise Ratio (CNR)

Image processing tools

- Inline MIP for immediate results

- Inline subtraction of pre- and post-contrast measurements

- Inline standard deviation maps of Phase-Contrast measurements for delineation of arteries and veins

Cardiac Suite The cardiac suite covers comprehensive 2D routine cardiac applications, ranging from morphology and ventricular function to tissue characterization. It moreover features BEAT 2D in conjunction with iPAT, T-PAT and e-PAT techniques.

Cardiac views

- Fast acquisition of the basic cardiac orientations for further examination planning

- Cardiac scouting provides users with a step-by-step procedure for the visualization and planning of typical cardiac views, e.g. based on TrueFISP or Dark Blood TurboFLASH: short axis, 4-chamber and 2-chamber views.

BEAT

- Unique tool for fast and easy cardiovascular MR imaging

- E.g. 1 click change from FLASH to TrueFISP for easy contrast optimization

- 1-click to switch arrhythmia rejection on / off

- 1-click change from Cartesian to radial sampling to increase effective image resolution (e.g. in pediatric patients) and avoid folding artifacts in large patients Visualization of structural cardiovascular pathologies with CMR-BEAT

- Breath-hold and free breathing techniques for strong contrast between the blood and vascular structures. Dark Blood TSE and HASTE imaging are available for the structural evaluation of the cardiothoracic anatomy, including vessels or heart valves. Cine techniques (FLASH & TrueFISP) for high-resolution valve evaluation.

- Multiple contrasts such as T1- and T2-weighted imaging for use in diseases such as myocarditis (inflammation / hyperaemia), ARVD (fibrous-fatty degeneration) or acute myocardial infarction (edema)

- Dark-blood TSE with motion compensation for high-quality vessel wall imaging in small or large vessels

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Tools for rapid evaluation of left or right ventricular function

- Acquisition of a stack of short-axis slices (standard: advanced segmented TrueFISP)

- Automatic adjustment of the acquisition window to the current heart rate

- Use of the Inline ECG for graphical ECG triggering setup

- Retrospective gating with cine sequences (TrueFISP, FLASH)

- Pulse sequences for whole-heart coverage

- Integration of Compressed Sensing Cardiac Cine (optional) for highest temporal and spatial resolution (segmented and real-time pulse sequences)

- Real-time imaging in case the patient is not able to hold his breath 4D imaging and tissue characterization with BEAT; pulse sequences for high-contrast and high-resolution tissue characterization

- Pulse sequences for stress and rest imaging with TurboFLASH contrast support the acquisition of multiple slices with high resolution and arbitrarily adjustable slice orientation for each slice

- T-PAT and e-PAT with mSENSE and GRAPPA for advanced parallel imaging provides fast high-resolution dynamic imaging

- Segmented IR TrueFISP / FLASH with TI scout for optimization of tissue contrast

- Advanced tissue characterization with 2D phase-sensitive IR (PSIR) pulse sequences with

TrueFISP and FLASH contrast. Magnitude and phase-sensitive images with one acquisition.

- Simple: no adjustment of inversion time (TI) necessary with PSIR technique

- Motion correction/averaging of multiple measurements with iPAT or tPAT accelerated single-shot

TrueFISP or GRE images of the heart, for free-breathing acquisition.

Physiological Measurement Unit (PMU) - Wireless Physio Control

- Synchronizes the measurement with the physiological cycles (triggering to minimize motion artifacts caused by cardiac and respiratory movements)

- Wireless Sensors

- Wireless Vector ECG / respiration for physiologically synchronized imaging, rechargeable battery-powered - for optimized patient handling

- Physiological Signals Display

- ECG (3 channels)

- Respiration

- External Trigger Input Display

ECG Triggering:

- Acquisition of multiple slices, e.g. of the heart, at different phases of the cardiac cycle

- Excellent image quality by synchronizing data acquisition with cardiac motion

- Respiratory Triggering: Excellent image quality by synchronizing data acquisition with the respiratory motion

- External Triggering: Interface for trigger input from external sources (e.g. Patient Monitoring

System) inside the examination room

- Interface for trigger input from external sources (e.g. pulse generator, trigger sources for fMRI) outside the examination room

- Optical trigger output for fMRI

- Retrospective gating for ECG, peripheral pulse, and external trigger input

Breast Suite MR imaging provides excellent tissue contrast that may be useful in the evaluation of the breasts.

Extremely high spatial and temporal resolution can be achieved in very short acquisition times by using iPAT with GRAPPA and CAIPIRINHA.

Customized pulse sequences (e.g. with fat saturation or water excitation or silicone excitation), as well as flexible multiplanar visualization allow a fast, simple and reproducible evaluation of MR breast

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This package includes:

- High-resolution 2D pulse sequences for morphology evaluation

- High-resolution 3D pulse sequences covering both breasts simultaneously

- Pulse sequences to support interventions (fine needle and vacuum biopsies, wire localization)

- Pulse sequences for evaluating breasts with silicone implants

- Automatic and manual frequency adjustment, taking into account the silicone signal

- Detection of the silicone signal either to suppress the silicone signal, if the surrounding tissue is to be evaluated, or to suppress the tissue signal in order to detect an implant leakage

- SPAIR – robust fat sat (robust fat suppression using an adiabatic frequency selective inversion pulse)

- DIXON – 2-point Dixon with 3D VIBE, the following contrasts can be obtained: in-phase, opposed phase, fat and water image

- iPAT with GRAPPA for maximum resolution in short time

- iPAT² with CAIPIRINHA that allows state-of-the-art sagittal breast imaging and further improvement of the temporal resolution in dynamic scans while maintaining spatial resolution

- Inline subtraction and MIP display

- Offline subtraction, MPR and MIP display

- REVEAL: diffusion imaging for breast exams. In pulse sequences with multiple b-values individual numbers of averages may be specified per b-value.

- RESOLVE: Diffusion-weighted, readout-segmented (multi shot) EPI sequence for high-resolution susceptibility-insensitive DWI of the breast

- RADIANT: Ultrasound-like reconstruction around the nipple

The Breast Suite also includes:

syngo VIEWS (Volume Imaging with Enhanced Water Signal)

- Bilateral - both breasts are examined simultaneously

- Axial - the milk ducts are directly displayed

- fat-saturated or water-excited - fat complicates clinical evaluation and is suppressed

- Near-isotropic 3D measurement - the same voxel size in all three directions for reconstruction in any slice direction

- Submillimeter voxel - highest resolution for precise evaluation

Body Suite The Body Suite is dedicated to clinical body applications. Ultra-fast high-resolution 2D and 3D pulse sequences are provided for abdomen, pelvis, MR Colonography, MRCP, dynamic kidney, and MR Urography applications.

2D PACE technique makes body imaging easy, allowing for multi-breath-hold examinations as well as free breathing during the scans. Motion artifacts are greatly reduced with 2D PACE Inline technology.

This package includes:

- Free breathing 2D PACE applications with 2D HASTE (RESTORE) and 2D / 3D TSE– it is possible to use a phase navigator, which measures respiratory induced off-resonance effects.

The positioning can be done automatically for most pulse sequences.

- Optimized fast single shot HASTE pulse sequences and high-resolution 3D pulse sequences based on SPACE and TSE for MRCP and MR Urography examinations

- REVEAL: diffusion imaging for abdomen and whole body exams. For reduced distortions and homogeneous signal intensity even in the presence of challenging susceptibility interfaces and at station boundaries, SliceAdjust (slice-by-slice adjustments) can be selected.

- In pulse sequences with multiple b-values, individual numbers of averages may be specified per b-value. Inline calculation of ADC maps, exponential ADC maps and inverted b-value images can be selected. Inline calculation (extrapolation) of high b-values (up to b=5000 s/mm²) is possible.

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- Signal from Respiratory Sensor can be selected to actively trigger MR image acquisition.

ABDOMEN:

2D:

- T1 (FLASH) breath-hold scans with and without FatSat (SPAIR, Quick FatSat, in- / opp-phase)

- T2 (HASTE, TSE / BLADE, EPI) breath-hold scans with and without FatSat (SPAIR, FatSat, STIR)

- T1 (TFL) triggered scans (2D PACE free breathing) in- / opp-phase

- T2 (HASTE, TSE / BLADE, EPI) triggered scans (2D PACE free breathing) with and without

FatSat (SPAIR, FatSat, STIR) as well as HASTE- and TSE-multi-echo

- Optimized fast single-shot HASTE pulse sequences and high-resolution pulse sequences based on SPACE and TSE for MRCP and MR urography examinations 3D:

- Dixon (VIBE 2pt-Dixon) breath-hold scans, following contrasts can be obtained: in-phase, opposed phase, fat and water image

- Dynamic (VIBE and Quick-FatSat) pulse sequences with Inline motion correction for visualization of focal lesions with high spatial and temporal resolution

- Colonography dark lumen with T1-weighted VIBE

- REVEAL: Diffusion-weighted imaging of the prostate, cervix, rectum and other organs with multiple b-values. Inline calculation of ADC maps, exponential ADC maps and inverted b-value images can be selected. Inline calculation (extrapolation) of high b-values (up to b=5000 s/mm2) is possible.

PELVIS:

- High-resolution T1, T2 pelvic imaging

- Isotropic T2 SPACE 3D pulse sequences

- Dynamic volume examinations with 3D VIBE

THORAX:

- High-resolution T1, T2 thorax imaging

- Motion-insensitive pulse sequences (BLADE, HASTE)

- TrueFISP pulse sequences for imaging of respiratory mechanics

- Dynamic imaging with TWIST (optional), TWIST-VIBE (optional)

- Non-contrast-enhanced vessel visualization with SPACE pulse sequences

- STIR pulse sequences for the evaluation of lymph nodes

- Diffusion-weighted imaging with REVEAL

Onco Suite MR imaging provides excellent soft-tissue differentiation, multi-planar capabilities, and the possibility of selectively suppressing specific tissue, e.g. fat or water. The Onco Suite features a collection of pulse sequences and evaluation tools that may be used for a detailed assessment of a variety of oncological conditions.

General features:

- STIR TSE, HASTE, and FLASH in-phase and opposed-phase pulse sequences for highly sensitive visualization of focal lesions

- Dynamic imaging pulse sequences for assessment of the kinetic behavior of tissue

- Quantitative evaluation and fast analysis of the data with colorized Wash-in, Wash-out, Time-To-

Peak, Positive-Enhancement-Integral, MIP-time and combination maps with Inline technology

- Display and analysis of the temporal behavior in selected regions of interest with the included

MeanCurve postprocessing application. This includes the capability of using additional datasets as a guide for defining regions of interest even faster and easier than before.

- REVEAL: Diffusion-weighted imaging with multiple b-values. In pulse sequences with multiple b-

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- RESOLVE: high-resolution, low-distortion diffusion-weighted imaging (DWI). In pulse sequences with multiple b-values, individual numbers of averages may be specified per b-value. Inline calculation of ADC maps, exponential ADC maps and inverted b-value images can be selected.

Inline calculation (extrapolation) of high b-values (up to b=5000 s / mm2) is possible.

Prostate:

- Dedicated prostate pulse sequences for a variety of clinical scenarios

- T1-weighted 3D VIBE pulse sequences with high temporal resolution (VIBE, TWIST (optional) and TWIST-VIBE (optional)) allow time course evaluation

- Prostate spectroscopy (3D CSI (optional) volume scan) with up to 8 sat bands (suppression of water and fat signal)

Whole-body imaging:

- TSE STIR pulse sequences for head-to-toe and head-to-pelvis imaging

- Dedicated pulse sequences for focus regions head, neck, thorax, abdomen and pelvis

- Diffusion-weighted imaging with REVEAL including SliceAdjust

OrthoSuite Ortho Suite is a comprehensive collection of pulse sequences for joint and spine imaging.

This package includes:

- 2D TSE pulse sequences for PD, T1, and T2-weighted contrast with high in-plane resolution and thin slices

- 3D MEDIC, 3D TrueFISP pulse sequences with water excitation for T2-weighted imaging with high in-plane resolution and thin slices

- High-resolution 3D VIBE pulse sequences for MR Arthrography (knee, shoulder, and hip)

- 3D MEDIC, 3D TrueFISP, 3D VIBE pulse sequences with Water Excitation having high isotropic resolution optimized for 3D post-processing

- T1 and PD SPACE 3D imaging with high isotropic resolution, optimized for post-processing

- Single-step, and multi-step pulse sequences

- Excellent fat suppression in off-center positions, e.g. in the shoulder due to high magnet homogeneity

- Dynamic TMJ pulse sequence (different joint positions)

- Multi Echo SE sequence with up to 32 echoes for T2 mapping

- High-resolution 3D DESS (Double Echo Steady State): T2 / T1-weighted imaging for excellent fluid-cartilage differentiation

- 2-point Dixon technique for fat and water separation – Turbo Spin Echo sequence

- WARP – 2D TSE sequence combining optimized high-bandwidth pulse sequences and View

Angle Tilting (VAT), tailored to reduce susceptibility artifacts caused by orthopedic MR- Conditional implants. This helps in evaluation of soft tissue in proximity of the implants. Available pulse sequences include T1-weighted, T2-weighted, proton density and STIR contrast.

- Advanced WARP enables the reduction of gross artifacts (i.e. through-plane artifacts) caused by large MR-Conditional* implants. It contains the 2D TSE based SEMAC technique and is especially useful in the case of hip and knee joint replacements. Available pulse sequences include T1-weighted, proton density and T2 TSE STIR contrast.

Pediatric Suite

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Tissue relaxation times and examination conditions in pediatrics are very different compared to those of adults. The reasons for these differences range from developing tissues, body size and faster heart rates to non-compliance with breath-hold commands. Pulse sequences can be easily adapted for imaging infants.

Scientific Suite The Scientific Suite supports scientific users by providing easy access to application-specific data for further processing and advanced image calculus.

- Support of USB Memory sticks

- Anonymization of patient data

- Easy creation of AVIs and screen snapshots to include in presentations or teaching videos

- Export of tables, statistics and signal time courses to communal exchange formats like e.g.

tabulated text files (MeanCurve, Spectroscopy evaluation, DTI evaluation)

- Advanced image calculus including, addition, subtraction, multiplication, and division of images

This syngo software version provides security settings to protect the scanner against known security threats.

- User management with authentication to prohibit unauthorized access

- Privileges to grant rights and define functionality based on user/role

- Hardened operating system and restricted network communication

- Whitelisting (Embedded Control) against manipulation of scanner software

- Security Delivery process to frequently distribute security updates

- Option to protect customer pulse sequences trees against unauthorized modifications

- Audit trail to log system and data access by the defined users and service

- Support of customers to implement their security policy including compliance with HIPAA (Health

Insurance and Accountability Act)

The sequences, features and techniques for acquisition and reconstruction included in the Tim Application Suite are described in detail below.

Sequences Spin Echo family of sequences:

- Spin Echo (SE) – Single, Double, and Multi Echo (up to 32 echoes); Inversion Recovery (IR)

- 2D / 3D Turbo Spin Echo (TSE) – Restore technique for shorter TR times while maintaining excellent T2 contrast; TurboIR: Inversion Recovery for STIR, DarkFluid, T1 and T2, TrueIR

- 2D TSE with multiple average – it is possible to acquire T2-weighted TSE images during shallow breathing, in a time efficient manner

- 2D / 3D HASTE (Half-Fourier Acquisition with Single-Shot Turbo Spin Echo) – Inversion

Recovery for STIR and DarkFluid contrast

- SPACE for 3D imaging with high isotropic resolution with T1, T2, PD, and DarkFluid Contrast

- 2D Optimized high bandwidth TSE (T1, T2, and PD weighted and STIR) with WARP for the reduction of susceptibility artifacts caused by MR Conditional metal* implants.

Gradient Echo family of sequences:

- 2D / 3D FLASH (spoiled GRE) – dual echo for in- / opposed phase imaging 3D VIBE (Volume

Interpolated Breath-hold Examination) – quick fat saturation; double echo for in-phase / opposed phase 3D imaging; DynaVIBE: Inline 3D elastic motion correction for multi-phase data sets of the abdomen; Inline Breast Evaluation

- 2D / 3D MEDIC (Multi Echo Data Image Combination) for high-resolution T2 weighted orthopedic imaging and excellent contrast

- 2D / 3D TurboFLASH – 3D MPRAGE; single shot T1 weighted imaging e.g. for abdominal imaging during free breathing

- 3D GRE for field mapping

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- 2D / 3D FISP (Fast Imaging with Steady State Precession)

- 2D / 3D PSIF – PSIF Diffusion

- Echo Planar Imaging (EPI) – diffusion-weighted; single shot SE and FID e.g. for BOLD imaging and perfusion-weighted imaging; 2D / 3D Segmented EPI (SE and FID)

- RESOLVE (Readout Segmentation Of Long Variable Echo-trains) delivers high-resolution, low-distortion diffusion-weighted imaging (DWI) for accurate depiction of lesions.

- ce-MRA sequence with Inline subtraction and Inline MIP

- 2D / 3D Time-of-Flight (ToF) Angiography – single slab and multi slab; triggered and segmented

- 2D / 3D Phase Contrast Angiography

- BEAT Tool – TrueFISP segmented; 2D FLASH segmented; Magnetization-prepared TrueFISP

(IR, SR, FS); IR TI scout; Retrogating

Standard Fat/Water Imaging

- Fat and Water Saturation. Additional frequency selective RF pulses used to suppress bright signal from fatty tissue. Two selectable modes: weak, strong

- Quick FatSat

- SPAIR: robust fat suppression for body imaging using a frequency selective inversion pulse

- Fat / Water Excitation. Spectral selective RF pulses for exclusive fat / water excitation

- Dixon technique for fat and water separation - available both based on VIBE (2 point Dixon)

Standard Techniques

- True Inversion Recovery to obtain strong T1-weighted contrast

- Dark Blood inversion recovery technique that nulls fluid blood signal

- Saturation Recovery for 2D TurboFLASH, gradient echo, and T1-weighted 3D TurboFLASH with short scan time (e.g. MPRAGE)

- Freely adjustable receiver bandwidth, permitting studies with increased signal-to-noise ratio

- Freely adjustable flip angle. Optimized RF pulses for image contrast enhancement and increased signal-to-noise ratio

- MTC (Magnetization Transfer Contrast). Off-resonance RF pulses to suppress signal from certain tissues, thus enhancing the contrast. Used e.g. in MRA

- Analysis Tools for addition, subtraction, division, multiplication, calculations of ADC maps and b-value images

- Image Filter

- 3D post-processing MPR, MIP, MinIP, VRT

- Data storage of images on CD / DVD with DICOM viewer (external CD/DVD burner required)

- Export of cine AVI files on external media

- Selectable centric elliptical phase reordering via the user interface

- Inversion Recovery to nullify the signal of fat, fluid or any other tissue

- Multiple Direction Diffusion Weighting (MDDW) – diffusion tensor imaging measurements can be done with multiple

- diffusion-weightings and up to 12 directions for generating data sets for diffusion tensor imaging.

- WARP – 2D TSE sequence combining optimized high-bandwidth protocols and View Angle Tilting

(VAT), tailored to

- reduce susceptibility artifacts caused by orthopedic MR-Conditional* implants.

- Advanced WARP - 2D TSE based Slice Encoding for Metal Artifact Correction (SEMAC) technique for the reduction of through-plane distortions from large MR conditional* implants.

Standard techniques for Flow Artifact reductions

- LOTA (Long-Term Data Averaging) technique to reduce motion and flow artifacts

- Pre-saturation techniques using RF saturation pulses to suppress flow and motion artifacts

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- Tracking SAT bands maintain constant saturation of venous and/or arterial blood flow e.g. for 2D/3D sequential MRA

- TONE (Tilted Optimized Non-saturating Excitation - variable excitation flip angle to compensate inflow saturation effects in 3D MRA - selectable on desired flow direction and speed

- GMR (Gradient Motion Rephasing). Sequences with additional bipolar gradient pulses, permitting effective reduction of flow artifacts

Standard Motion Correction

- BLADE - improves image quality by minimizing and correcting for the effects of motion during an

MR sequence acquisition. e.g. head, spine, orthopedic imaging and the abdomen

- 1D PACE (Prospective Acquisition CorrEction) allows examination of patients with free breathing

- 2D PACE (Precise Motion Correction) detects and corrects respiratory motion eg of the heart or liver

- PSIR HeartFreeze (Phase-Sensitive Inversion Recovery) - Motion correction/averaging of multiple measurements with iPAT or tPAT accelerated single-shot TrueFISP or GRE images of the heart, for free-breathing acquisition

MAGNETOM Vida runs on syngo MR XA software line that offers an acquisition workplace with one large 16:10 24” monitor, included (second 24" monitor optional), one keyboard and one mouse.

In dual monitor setup, one monitor is used for scanning and the other for viewing. This makes for a more natural working environment in which the technologist can scan and process in parallel and has a complete overview of the examination and the results. Constant context switches are reduced, enabling multitasking for increased quality and productivity.

In the single monitor setup, all functionality is available on one monitor, allowing for full scanner operation in space-constrained control rooms.

The MR acquisition workplace provides environments for scheduling, scanning and basic quality assurance as well as viewing, basic and advanced post-processing, and data handling (Export, Import, Transfer, Record to media). The acquisition workplace can host one MR View&GO for viewing, basic post-processing, and data distribution and up to three post-processing applications in parallel.

For faster data transfer and reduced storage demand syngo MR XA software line uses the DICOM Enhanced MR Image format for its scanning result.

Features like Online Help, DICOM MPPS autocomplete, inline technologies, and scan@center additionally support the workflow.

Patient Communication

- The intercom system includes an ergonomically designed patient communication unit for desktop positioning on the syngo Acquisition Workplace and pneumatic headphones for the patient.

- It controls emergency table stop, volume control of speaker and headphones in the examination room, volume control of speaker in the control room, response to the patient's activation of the assistance-call button and provides a connection to an external audio system (external audio system is not included in the basic unit) for music playback.

Computer System The PC-based computer system uses the intuitive syngo MR user interface and allows the usage of up to 3 advanced syngo.via applications at the scanner workplace.

High-performance host computer:

- Intel Xeon processor ≥ E5-1650 (6 core)

- Clock rate ≥ 3.5 GHz

- Main Memory (RAM) ≥ 64 GB

- SSD ≥ 480GB

- Electronic mouse

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- Up to two high-resolution 24” color LCD flatscreen monitors with 1920 x 1200 pixel display, integrated gamma correction for optimum display of radiographic grayscale images and automatic backlight control for long-term brightness stability.

Installation

- The relatively light-weight design of MAGNETOM Vida eliminates in most cases the need for structural building reinforcements and also facilitates installation in upper floors.

- The compact integrated design allows for short installation times and reduces the required space to less than 31 sqm (334 sq. ft.) for the entire installation. The minimum room height clearance is only 2.40 m (7' 10").

- MAGNETOM Vida allows siting of the system without a dedicated computer room - no additional cooling or floor requirements.

- MAGNETOM Vida combines state-of-the-art performance with peace of mind. High system availability is ensured by the expert - highly trained Siemens MR service engineers

- Your Siemens service contract (not included in the basic unit) offers a comprehensive range of benefits such as Uptime Remote Diagnostics for improved productivity and maximum uptime.

14460161 MR General Engine #Vi syngo.MR General Engine extends Numaris/X by adding dedicated workflows and tools for routine and advanced reading of MR examinations.

A generic MR Basic workflow is provided, as well as specific MR Neurology, MR Prostate Reading, MR Breast Reading, and MR Cardio-Vascular workflows.

Main functionalities of syngo.MR General Engine:

- MR Basic workflow with Easy Reading mode for easy, fast, and intuitive MR reading, based on single-click and drag&drop interactions:

- single-click interaction to navigate through the series

- intelligent layout adaptation to compare series together

- single-click fusion between different contrasts

- MR Cardio-Vascular Workflows: Cardiac Reading, Angio Single Station, Angio Multi Station, Angio TimCT and Angio TWIST

- MR Evaluation tools: Subtraction, MeanCurve, Image Filter, 2D/3D Distortion Correction. ADC and b-value tool (for extrapolated b-values), Multiplication, Division, Addition, Elastic Motion Correction. Workflow optimized report templates.

Scope of delivery:

syngo.MR General Engine software package with MR Radiology workflows, MR Cardio-Vascular workflows and MR Evaluation for a workstation-based server.

14456321 Brain Dot Engine #Se

The Brain Dot Engine provides guided and automated workflows customizable to the site specific standards of care for general brain examinations. The Brain Dot Engine supports the user in achieving reproducible image quality with increased ease of use and time efficient exams.

The brain workflow can be personalized to the individual patient condition and clinical need. Several predefined strategies are included, which can be easily selected with one click. They can be changed at any time during the brain workflow.

Protocols tailored for use of contrast media are integrated.

- Standard: Standard examination with 2D protocols

- Resolution focus: Examination with 3D protocols (with e.g. SPACE) for detailed views

- Speed focus: Examination with fast 2D protocols (with e.g. HASTE) for further speeding up the exam

- Motion insensitive: Examination with syngo BLADE protocols

- to minimize and correct for the effects of motion automatically

Step-by-step user guidance is seamlessly integrated. Example images and guidance text are displayed for each individual step of the scanning workflow. Both - images and text - are easily

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Easy positioning of the patient with AutoPosition. The patient is automatically placed at the isocenter without any laser marking required.

AutoAlign Head provides automated, positioning and alignment of slice groups to the anatomy, relying on multiple anatomical landmarks. Besides basic brain positioning, AutoAlign Head computes reference position for several other brain structures such as the inner ear, the orbits and the optic nerve.

Automatic real-time calculation of trace-weighted images and ADC maps with Inline Diffusion Technology.

Easy rerun or repeat with functionality allows for reduced table time. Alternatively an exam can be repeated with a changed strategy.

The Brain Dot Engine as all Dot engines can be modified by the user to their individual standard of care.

14461775 DotGO Routine Package #BM

The DotGO Routine Package includes both:

- Spine Dot Engine and

- Large Joint Dot Engine.

As a package they offer a comprehensive set of workflows with guidance and automation, for standardized image quality in Spine and MSK MR imaging.

The Spine Dot Engine provides the functionality of Inline Composing and Tim Planning Suite for streamlining workflows in all spine imaging. Tools, such as auto-positioning and vertebral recognition with AutoAlign Spine, AutoCoverage and Spine Labelling support and optimize reproducibility for your cervical, thoracic and lumbar spine imaging for all clinical indications.

The Large Joint Dot Engine enhances standardization of the knee, hip and shoulder workflows and optimizes reproducible image quality by incorporating automation tools, such as anatomically based auto-positioning (AutoAlign). Dedicated imaging techniques, such as Advanced WARP, are included and can help to expand the access of diagnostic MRI to a broader range of patient types.

Spine Dot Engine:

The Spine Dot Engine provides optimized cervical, thoracic and lumbar spine imaging for patients of all conditions.

Spine Dot Engine provides the functionality to simplify your spine workflow by providing tools to reduce examination times, achieve optimal image quality, and assist you during reading.

- User guidance step-by-step

- AutoPosition

- AutoAlign Spine with intervertebral disc detection

- AutoCoverage

- AutoSatPosition

- Initial and interactive snapping

- AutoLabeling of vertebrae

- Automatic curved multiplanar reconstructions of 3D datasets

The Spine Dot Engine includes:

- Tim Planning Suite

- Inline Composing

- syngo WARP Susceptibility Artifact Reduction syngo WARP integrates different techniques tailored to reduce susceptibility artifacts caused by orthopedic MR-conditional metal implants. 2D TSE sequence combining optimized high-

SIEMENS REPRESENTATIVE

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Large Joint Dot Engine:

Large Joint Dot Engine optimizes image quality of knee, hip and shoulder scans by proposing the most appropriate protocols according to the examination strategy chosen for the specific patient. It ensures reproducible image quality and streamlines large joint examinations to the greatest extent.

Dot Exam Strategies The workflow can be personalized to the individual patient condition and clinical need. The Large Joint Dot Engine comes with the following predefined strategies, which the user can select according to patient conditions or change at any time during the workflow, when conditions change:

- Image quality: Achieve highest image quality in a reasonable scan time with 2D and 3D protocols.

- Speed focus: Examine patients in the shortest possible time with protocols being accelerated to the maximal extent.

- Motion artifact reduction: Compensate for the effects of motion, e.g. with motion insensitive syngo BLADE protocols.

- Artifacts reduction: Reduce susceptibility artifacts, using syngo WARP.

AutoAlign

- Automated, localizer based positioning and alignment of slice groups to the anatomy, relying on anatomical landmarks. Providing fast, easy, and reproducible patient scanning and supporting the reading by consistently delivering high image quality with a standardized slice orientation.

Inline MPRs - Automatic multiplanar reconstruction for 3D datasets

- The Multi Planar Reconstruction (MPR) tool uses the position information from the AutoAlign algorithm and can be easily configured to automatically generate any required 2D images from high-resolution 3D acquisitions.

Guidance View

- Step-by-step user guidance is seamlessly integrated.

- Example images and guidance text are displayed for each individual step of the scanning workflow.

- Both images and text are easily configurable by the user syngo WARP - Susceptibility Artifact Reduction

- syngo WARP integrates different techniques tailored to reduce susceptibility artifacts caused by orthopedic MR-conditional metal implants. 2D TSE sequence combining optimized high-bandwidth protocols and View Angle Tilting (VAT) techniques. This helps in evaluation of soft tissue in proximity of the implant. Available protocols include T1- weighted, T2-weighted, proton density and STIR contrast.

Advanced WARP:

- Advanced WARP application…