Magnetom Sola Tech Specs 1.pdf

Siemens Medical Solutions USA, Inc.

40 Liberty Boulevard, Malvern, PA 19355

SIEMENS REPRESENTATIVE

Haig Tellalian - +1 617-584-1746 haig.tellalian@siemens-healthineers.com

Created: 05/22/2023 04:29:42 PM Siemens Medical Solutions USA, Inc. Confidential Page 25 of 79

P-CPQ-581353-1-3

Detailed Technical Specifications

MAGNETOM Sola (DE)

Part No./Product Description

14460300 MAGNETOM Sola - System

MAGNETOM Sola - the first 1.5T BioMatrix system - leverages the intelligent combination of Tim 4G and Siemens unique BioMatrix technology to embrace the unique challenges that every patient brings to the MRI exam.

System Design

- Short and open appearance (157 cm total system length cover-to-cover and 70 cm Open Bore Design) to reduce patient anxiety and claustrophobia

- Whole-body superconductive Zero Helium Boil-Off 1.5T magnet

- Weight-optimized magnet technology based on high performance 3T and 7T magnet design

- Actively Shielded water-cooled Siemens gradient system for maximum performance

BioMatrix Technology to address intrinsic biovariability in humans. Built on three technological pillars:

- BioMatrix Sensors: anticipate challenges before they happen with respiratory sensors, which measure a patient's respiratory signal as soon as the patient lies on the table.

- BioMatrix Tuners: adapt and correct field inhomogeneities induced by patient anatomy with CoilShim and SliceAdjust.

- BioMatrix Interfaces: easily manage any type of patient with intelligent interfaces like Select&GO to accelerate workflow.

Tim 4G (Total imaging matrix in the 4th generation) for excellent image quality and speed

- Siemens unique DirectRX technology enabling all digital-in/digital-out design

- Dual-Density Signal Transfer Technology

Push-button exams with GO technologies Select&GO DotGO Recon&GO MR View&GO

Tim Application Suite enabling excellent head-to-toe imaging

- Neuro Suite

- Angio Suite

- Cardiac Suite

- Body Suite

- Onco Suite

- Breast Suite

- Ortho Suite

- Pediatric Suite

- Scientific Suite

Further included:

- High performance host computer and measurement and reconstruction system

- Patient communication including headphones

SIEMENS REPRESENTATIVE

Created: 05/22/2023 04:29:42 PM Siemens Medical Solutions USA, Inc. Confidential Page 26 of 79

- Turbo Suite Essential

- syngo MR software including:

- 1D/2D PACE

- BLADE

- Phoenix

- Inline Diffusion

- MDDW (Multiple Direction Diffusion Weighting)

- CISS

- DESS

- TGSE

- Offline Composing MAGNETOM Sola - the first 1.5T BioMatrix system - leverages the intelligent combination of Tim 4G and the Siemens unique BioMatrix technology to be ready to embrace the unique set of challenges that each and every patient brings to the MRI exam.

The system includes:

BioMatrix Technology In order to meet the requirements of the changing healthcare market, Tim® is now further enhanced with the ability to address patient biovariablity: Evolving from Total imaging matrix, BioMatrix® technology addresses the intrinsic biovariability in humans.

BioMatrix can anticipate challenges in MR examinations, for example, the limited ability to hold one's breath, to manage growing patient populations and increasing exam complexity in MRI.

BioMatrix can adapt to all patients and their anatomic individuality, even the critical ones, to make MRI more predictable and consistent for all patients, even critical ones. BioMatrix can accelerate the workflow, without compromising quality of care by assisting interactions between the patient and the user, to improve MRI cost-effectiveness and patient outcomes.

BioMatrix anticipates, adapts and accelerates to embrace human nature.

Tim 4G Tim 4G provides excellent image quality and speed in MRI combined with increased patient comfort and optimized workflow efficiency. Only one patient setup, no repositioning, no changing of coils.

Ultra-light-weighted coils with high density of coil elements for maximized patient comfort and increased SNR. Feet-first positioning reduces claustrophobia.

Tim 4G with its 4G flexibility, 4G accuracy and 4G speed brings image quality and acquisition speed to a new level.

Magnet:

- Short 145 cm long (157 cm with covers), whole-body superconductive 1.5T magnet with active shielding (AS) technology with counter coils

- External Interference Shielding (E.I.S.)

- Excellent homogeneity enabled magnet design which allows for a cylindrically optimized homogeneity volume resulting in higher image quality (50 × 50 × 45 cm³ DEV, typ. 2,8 ppm based on the 24-plane plot method)

- Temperature sensors with real time correction algorithm for unmatched long-term stability at 70 cm

- The magnet has a typical Helium boil-off rate of 0 l/yr during typical, undisturbed clinical operation depending on the sequences used and examination time, and provided the system is serviced in regular intervals.

- It has an integrated magnet cooling system.

SIEMENS REPRESENTATIVE

Created: 05/22/2023 04:29:42 PM Siemens Medical Solutions USA, Inc. Confidential Page 27 of 79

- The combination of standard active shim and passive shim allows for maximized magnetic field homogeneity and consistent high image quality for a wide range of applications

- Integrated Eco-Power technology to save around 30% of energy during standby of the system.

Gradient system:

- Actively shielded water-cooled world-class gradient system

- All axes force compensated for lowest vibrations and acoustic performance

DirectRF - RF Transmit/Receive System:

- Fully integrated Transmit- and Receive path in the magnet housing including extremely compact water-cooled solid state amplifier with 37.5 kW peak power

- High dynamic range

- Immediate feedback loop for real-time sequence adaptation

- Integrated no tune transmit/receive Body Coil

- The revolutionary Tim 4G technology allows connecting 204 channels (coil elements) simultaneously enabling higher SNR and iPAT in all directions. No repositioning of patients is needed even for large Field of View examinations. Dual-Density Signal Transfer enables ultra-high density coil design by integrating key RF components into the local coil.

GO technologies

Select&GO The Select&GO interface enables fast and easy single-touch patient positioning. Correct positioning saves unnecessary wasted time for repositioning and additional adjustments, therefore shortening the total room time.

- The ergonomically designed Select&GO touch panels are integrated into the front cover on each side of the patient tunnel for controlling table movement, guidance for patient setup and comfort features. They are well illuminated for easy visual recognition.

- Automated table move to upmost position, to center position or Home position facilitate smooth patient preparation and will reduce table time

- Variable (6 levels) ventilation and lighting inside the magnet bore or volume adjustments are possible for increased patient comfort The Select&GO touch panels provide on board guidance for patient set up where it's needed - directly at the scanner. Information such as patient name or exam type or required patient position, guidance for ECG set up and immediate visualization of physiological curves will be provided for convenient operation.

- Almost all table control functions, including ventilation and illumination of the magnet bore, can be also controlled from the operator console for convenient operation.

DotGO Go for consistent results, efficiently with Dot Engines.

Dot offers a customizable framework for patient personalization, user guidance and exam automation.

Optimized scan strategies are provided and can be selected based on patient condition, which allow for high quality exams even when conditions change.

Integrated decision points allow the user to easily add or remove one or a group of protocols with one click. Step by step image and text guidance guides novice users even through the most complicated exams. Exam automation allows optimal timing for breathing, scanning, planning or contrast arrival.

Dot can be easily customized to follow the individual standards of care.

Dot is personalized, guided and automated and designed to improve workflow efficiency and image consistency.

Dot Cockpit The central tool to continuously build knowledge into standardized exams strategies and to make those available for every user in the MRI department. Dot Cockpit is the new starting point for every

SIEMENS REPRESENTATIVE

Created: 05/22/2023 04:29:42 PM Siemens Medical Solutions USA, Inc. Confidential Page 28 of 79 exam.

Recon&GO The Recon&GO technology encompasses a wide range of in-line functionalities automizing reconstruction and post-processing steps to provide ready-to-read results for the radiologist.

Examples are Inline ADC calculation, inline subtraction of dynamic contrastenhanced series, up to Inline Launch of advanced post-processing applications.

MR View&GO MR View&GO is MAGNETOM Sola's all-in-one viewing and reading solution for fast and intuitive quality check and result distribution. It receives the images directly as they come on the scanner, giving the user a clear overview of the quality of images scanned, without being distracted by constant context switches. Once the images have been checked for acceptable quality, they can easily be sent to the PACS with minimal user interaction.

Beyond that, MR View&GO offers the additional advantage to perform extended post-processing, directly at the scanner. In-line launching of post-processing applications makes it possible to fully automate the evaluation of, for example, perfusion maps, permeability or cardiac function, all without additional user interaction. This makes it possible to save radiologist time by delivering quantitative, ready-to-read results, directly to the PACS.

Tim Application Suite The Tim Application Suite offers a complete range of clinically optimized examinations for all regions.

The Tim Application Suite -allowing excellent head-to-toe imaging - is provided standard on MAGNETOM Sola.

- Neuro Suite

- Angio Suite

- Cardiac Suite

- Body Suite

- Onco Suite

- Breast Suite

- Ortho Suite

- Pediatric* Suite

- Scientific Suite

* MR scanning has not been established as safe for imaging fetuses and infants less than two years of age. The responsible physician must evaluate the benefits of the MR examination compared to those of other imaging procedures.

Neuro Suite Comprehensive head and spine examinations can be performed with dedicated programs. High-resolution pulse sequences and motion-insensitive pulse sequences for patients which have difficulties to lay still are provided. The Neuro Suite also includes pulse sequences for diffusion imaging, perfusion imaging, and fMRI.

It includes for example:

- Fast 2D imaging with SE, TSE, GRE pulse sequences for high-resolution imaging

- BLADE for motion-insensitive TSE imaging EPI pulse sequences and protocols for diffusion imaging, perfusion imaging, and fMRI for advanced neuro applications. Diffusionweighted imaging is possible with up to 16 b-values in the orthogonal directions. For reduced distortions and homogeneous signal intensity even in the presence of challenging susceptibility interfaces and at station boundaries, SliceAdjust (slice-by-slice adjustments) can be selected.

- 3D TOF for non-contrast enhanced angiography

- 3D isotropic resolution volume imaging using T1 3D MPRAGE / 3D

SIEMENS REPRESENTATIVE

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- FLASH, SPACE DarkFluid, T1 SPACE and T2 SPACE pulse sequences

- High-resolution T2 SPACE pulse sequence optimized for inner ear examinations

- Double Inversion Recovery 3D pulse sequences (DIR SPACE) with two user-selectable inversion pulses for the simultaneous suppression of e.g. cerebro-spinal fluid and white matter

- MP2RAGE (Magnetization Prepared 2 Rapid Acquisition Gradient Echoes) provides homogeneous tissue contrast for segmentation and applications such as voxel-based morphometry. In combination with MapIt*, it also provides T1 mapping functionality.

- Whole-spine pulse sequences in multiple steps with software controlled table movement

- 2D and 3D MEDIC pulse sequences for T2-weighted imaging, particularly for C-spine examinations in axial orientation where reproducibility is difficult due to CSF pulsations and blood flow artifacts

- RESOLVE (Readout Segmentation Of Long Variable Echo-trains) delivers high-resolution, low-distortion diffusion-weighted imaging (DWI) for accurate depiction of lesions.

- BioMatrix's CoilShim helps to reduce patient induced strongly localized B0 inhomogeneities as may arise, e.g., in the neck region.

- 3D Myelo with 3D HASTE for anatomical details

- 3D CISS (Constructive Interference in Steady State) for excellent

- visualization of fine structures such as cranial nerves. High-resolution imaging of inner ear

- TGSE sequence used primarily for T2-weighted imaging for shorter measurement time, decreased RF power deposition, and high-resolution imaging of the brain

- AutoAlign Head LS providing a fast, easy, standardized, and reproducible patient scanning supporting reading by delivering a higher and more standardized image quality.

Angio Suite Excellent MR Angiography can be performed to visualize arteries and veins with or without contrast agent.

- 3D MRA pulse sequences for carotid arteries, abdominal arteries, and peripheral arteries, with short TR and TE. The strong gradients make it possible to separate the arterial phase from the venous phase.

- Dynamic MRA for 3D imaging over time Signal from Respiratory Sensor can be selected to actively trigger MR image acquisition, e.g. with NATIVE*.

Contrast-enhanced MRA 3D contrast-enhanced MRA pulse sequences for dynamic carotid, abdominal, and peripheral arteries, shortest TR and TE. The strong gradients make it possible to separate the arterial phase from the venous phase

- TestBolus workflow for optimal bolus timing and excellent image quality

- CareBolus functionality for accurate determination of the bolus arrival time and the “Stop and

Continue” of the 3D ce-MRA pulse squenece after the 2D bolus control scan

- Dynamic ce-MRA for 3D imaging over time

Non-contrast-MRA and venography

- Time-of-Flight (ToF) pulse squeneces for MRA for the Circle of Willis, carotids and neck vessels;

can be adapted for venography, and Breath-hold protocols for abdominal vessels

- Triggered 2D ToF sequences for non-contrast MRA in the legsMR venography and arteriography with Phase-Contrast

- TONE (Tilted optimized non-saturating excitation) techniques for improved

- Contrast-to-Noise Ratio (CNR)

Image processing tools

- Inline MIP for immediate results

SIEMENS REPRESENTATIVE

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- Inline subtraction of pre- and post-contrast measurements

- Inline standard deviation maps of Phase-Contrast measurements for delineation of arteries and veins

Cardiac Suite The cardiac suite covers comprehensive 2D routine cardiac applications, ranging from morphology and ventricular function to tissue characterization. It moreover features BEAT 2D in conjunction with iPAT, T-PAT and e-PAT techniques.

Cardiac views

- Fast acquisition of the basic cardiac orientations for further examination planning

- Cardiac scouting provides users with a step-by-step procedure for the visualization and planning of typical cardiac views, e.g. based on TrueFISP or Dark Blood TurboFLASH: short axis, 4-chamber and 2-chamber views.

BEAT

- Unique tool for fast and easy cardiovascular MR imaging

- E.g. 1 click change from FLASH to TrueFISP for easy contrast optimization

- 1-click to switch arrhythmia rejection on / off

- 1-click change from Cartesian to radial sampling to increase effective image resolution (e.g. in pediatric patients) and avoid folding artifacts in large patients Visualization of structural cardiovascular pathologies with CMRBEAT

- Breath-hold and free breathing techniques for strong contrast between the blood and vascular structures. Dark Blood TSE and HASTE imaging are available for the structural evaluation of the cardiothoracic anatomy, including vessels or heart valves. Cine techniques (FLASH & TrueFISP) for high-resolution valve evaluation.

- Multiple contrasts such as T1- and T2-weighted imaging for use in diseases such as myocarditis (inflammation / hyperaemia), ARVD (fibrous-fatty degeneration) or acute myocardial infarction (edema)

- Dark-blood TSE with motion compensation for high-quality vessel wall imaging in small or large vessels

Tools for rapid evaluation of left or right ventricular function

- Acquisition of a stack of short-axis slices (standard: advanced segmented TrueFISP)

- Automatic adjustment of the acquisition window to the current heart rate

- Use of the Inline ECG for graphical ECG triggering setup

- Retrospective gating with cine sequences (TrueFISP, FLASH)

- Pulse sequences for whole-heart coverage

- Integration of Compressed Sensing Cardiac Cine (optional) for highest temporal and spatial resolution (segemented and realtime pulse sequences)

- Real-time imaging in case the patient is not able to hold his breath

4D imaging and tissue characterization with BEAT; pulse sequences for high-contrast and high-resolution tissue characterization

- Pulse sequences for stress and rest imaging with TurboFLASH contrast support the acquisition of multiple slices with high resolution and arbitrarily adjustable slice orientation for each slice T-PAT and e-PAT with mSENSE and GRAPPA for advanced parallel imaging provides fast high-resolution dynamic imaging

- Segmented IR TrueFISP / FLASH with TI scout for optimization of tissue contrast

- Advanced tissue characterization with 2D phase-sensitive IR (PSIR) pulse sequences with

TrueFISP and FLASH contrast. Magnitude and phase-sensitive images with one acquisition.

- Simple: no adjustment of inversion time (TI) necessary with PSIR technique

- Motion correction/averaging of multiple measurements with iPAT or tPAT accelerated single-shot

TrueFISP or GRE images of the heart, for free-breathing acquisition.

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Physiological Measurement Unit (PMU) - Wireless Physio Control

- Synchronizes the measurement with the physiological cycles (triggering to minimize motion artifacts caused by cardiac and respiratory movements)

- Wireless Sensors

- Wireless Vector ECG / respiration for physiologically synchronized imaging, rechargeable battery-powered - for optimized patient handling

- Physiological Signals Display

- ECG (3 channels)

- Respiration

- External Trigger Input Display

ECG Triggering:

- Acquisition of multiple slices, e.g. of the heart, at different phases of the cardiac cycle

- Excellent image quality by synchronizing data acquisition with cardiac motion

- Respiratory Triggering: Excellent image quality by synchronizing data acquisition with the respiratory motion

- External Triggering: Interface for trigger input from external sources (e.g. Patient Monitoring

System) inside the examination room

- Interface for trigger input from external sources (e.g. pulse generator, trigger sources for fMRI) outside the examination room

- Optical trigger output for fMRI

- Retrospective gating for ECG, peripheral pulse, and external trigger input

Breast Suite MR imaging provides excellent tissue contrast that may be useful in the evaluation of the breasts.

Extremely high spatial and temporal resolution can be achieved in very short acquisition times by using iPAT with GRAPPA and CAIPIRINHA.

Customized pulse sequences (e.g. with fat saturation or water excitation or silicone excitation), as well as flexible multiplanar visualization allow a fast, simple and reproducible evaluation of MR breast examinations.

This package includes:

- High-resolution 2D pulse sequences for morphology evaluation

- High-resolution 3D pulse sequences covering both breasts simultaneously

- Pulse sequences to support interventions (fine needle and vacuum biopsies, wire localization)

- Pulse sequences for evaluating breasts with silicone implants

- Automatic and manual frequency adjustment, taking into account the silicone signal

- Detection of the silicone signal either to suppress the silicone signal, if the surrounding tissue is to be evaluated, or to suppress the tissue signal in order to detect an implant leakage

- SPAIR - robust fat sat (robust fat suppression using an adiabatic frequency selective inversion pulse)

- DIXON - 2-point Dixon with 3D VIBE, the following contrasts can be obtained: in-phase, opposed phase, fat and water image iPAT with GRAPPA for maximum resolution in short time

- iPAT² with CAIPIRINHA that allows state-of-the-art sagittal breast imaging and further improvement of the temporal resolution in dynamic scans while maintaining spatial resolution

- Inline subtraction and MIP display

- Offline subtraction, MPR and MIP display

- REVEAL: diffusion imaging for breast exams. In pulse sequences with multiple b-values individual numbers of averages may be specified per b-value.

- RESOLVE: Diffusion-weighted, readout-segmented (multi shot) EPI sequence for high-resolution susceptibility-insensitive DWI of the breast

SIEMENS REPRESENTATIVE

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- RADIANT: Ultrasound-like reconstruction around the nipple

The Breast Suite also includes:

syngo VIEWS (Volume Imaging with Enhanced Water Signal)

- Bilateral - both breasts are examined simultaneously

- Axial - the milk ducts are directly displayed

- fat-saturated or water-excited - fat complicates clinical evaluation and is suppressed

- Near-isotropic 3D measurement - the same voxel size in all three directions for reconstruction in any slice direction

- Submillimeter voxel - highest resolution for precise evaluation

Body Suite The Body Suite is dedicated to clinical body applications. Ultra-fast high-resolution 2D and 3D pulse sequences are provided for abdomen, pelvis, MR Colonography, MRCP, dynamic kidney, and MR Urography applications.

2D PACE technique makes body imaging easy, allowing for multibreath- hold examinations as well as free breathing during the scans.

Motion artifacts are greatly reduced with 2D PACE Inline technology.

This package includes:

- Free breathing 2D PACE applications with 2D HASTE (RESTORE) and 2D / 3D TSE- it is possible to use a phase navigator, which measures respiratory induced off-resonance effects.

The positioning can be done automatically for most pulse sequences.

- Optimized fast single shot HASTE pulse sequences and high-resolution

- 3D pulse sequences based on SPACE and TSE for MRCP and MR Urography examinations

- REVEAL: diffusion imaging for abdomen and whole body exams.

- For reduced distortions and homogeneous signal intensity even in the presence of challenging susceptibility interfaces and at station boundaries, SliceAdjust (slice-by-slice adjustments) can

- be selected.

- In pulse sequences with multiple b-values, individual numbers of averages may be specified per b-value. Inline calculation of ADC maps, exponential ADC maps and inverted b-value images can be selected. Inline calculation (extrapolation) of high b-values (up to b=5000 s/mm²) is possible.

- Signal from Respiratory Sensor can be selected to actively trigger MR image acquisition.

ABDOMEN:

2D:

- T1 (FLASH) breath-hold scans with and without FatSat (SPAIR, Quick FatSat, in- / opp-phase)

- T2 (HASTE, TSE / BLADE, EPI) breath-hold scans with and without FatSat (SPAIR, FatSat, STIR)

- T1 (TFL) triggered scans (2D PACE free breathing) in- / opp-phase T2 (HASTE, TSE / BLADE, EPI) triggered scans (2D PACE free breathing) with and without FatSat (SPAIR, FatSat, STIR) as well as HASTE- and TSE-multi-echo

- Optimized fast single-shot HASTE pulse sequences and high-resolution pulse sequences based on SPACE and TSE for MRCP and MR urography examinations

3D:

- Dixon (VIBE 2pt-Dixon) breathhold scans, following contrasts can be obtained: in-phase, opposed phase, fat and water image

- Dynamic (VIBE and Quick-FatSat) pulse sequences with Inline motion correction for visualization of focal lesions with high spatial and temporal resolution

- Colonography dark lumen with T1-weighted VIBE

- REVEAL: Diffusion-weighted imaging of the prostate, cervix, rectum and other organs with multiple b-values. Inline calculation of

- ADC maps, exponential ADC maps and inverted b-value images can be selected. Inline

SIEMENS REPRESENTATIVE

Created: 05/22/2023 04:29:42 PM Siemens Medical Solutions USA, Inc. Confidential Page 33 of 79 calculation (extrapolation) of high bvalues (up to b=5000 s/mm2) is possible.

PELVIS:

- High-resolution T1, T2 pelvic imaging

- Isotropic T2 SPACE 3D pulse sequences

- Dynamic volume examinations with 3D VIBE

THORAX:

- High-resolution T1, T2 thorax imaging

- Motion-insensitve pulse sequences (BLADE, HASTE)

- TrueFISP pulse sequences for imaging of respiratory mechanics

- Dynamic imaging with TWIST (optional), TWIST-VIBE (optional)

- Non-contrast-enhanced vessel visualization with SPACE pulse

- sequences

- STIR pulse sequences for the evaluation of lymph nodes

- Diffusion-weighted imaging with REVEAL

Onco Suite MR imaging provides excellent soft-tissue differentiation, multiplanar capabilities, and the possibility of selectively suppressing specific tissue, e.g. fat or water. The Onco Suite features a collection of pulse sequences and evaluation tools that may be used for a detailed assessment of a variety of oncological conditions.

General features:

- STIR TSE, HASTE, and FLASH in-phase and opposed-phase pulse sequences for highly sensitive visualization of focal lesions

- Dynamic imaging pulse sequences for assessment of the kinetic behavior of tissue

- Quantitative evaluation and fast analysis of the data with colorized

- Wash-in, Wash-out, Time-To-Peak, Positive-Enhancement- Integral, MIP-time and combination maps with Inline technology

- Display and analysis of the temporal behavior in selected regions of interest with the included

MeanCurve postprocessing application.

- This includes the capability of using additional datasets as a guide for defining regions of interest even faster and easier than before.

- REVEAL: Diffusion-weighted imaging with multiple b-values. In pulse sequences with multiple b-values, individual numbers of averages may be specified per b-value. Inline calculation of ADC maps, exponential ADC maps and inverted b-value images can be selected. Inline calculation (extrapolation) of high b-values (up to b = 5000 s / mm2) is possible. For reduced distortions and homogeneous signal intensity even in the presence of challenging susceptibility interfaces and at station boundaries,

- SliceAdjust (slice-by-slice adjustments) can be selected.

- RESOLVE: high-resolution, low-distortion diffusion-weighted imaging (DWI). In pulse sequences with multiple b-values, individual numbers of averages may be specified per b-value. Inline calculation of ADC maps, exponential ADC maps and inverted bvalue images can be selected.

Inline calculation (extrapolation) of high b-values (up to b=5000 s / mm2) is possible.

Prostate:

- Dedicated prostate pulse sequences for a variety of clinical scenarios

- T1-weighted 3D VIBE pulse sequences with high temporal resolution (VIBE, TWIST (optional) and TWIST-VIBE (optional)) allow time course evaluation

- Prostate spectroscopy (3D CSI (optional) volume scan) with up to 8 sat bands (suppression of water and fat signal)

Whole-body imaging:

SIEMENS REPRESENTATIVE

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- TSE STIR pulse sequences for head-to-toe and head-to-pelvis imaging

- Dedicated pulse sequences for focus regions head, neck, thorax, abdomen and pelvis

- Diffusion-weighted imaging with REVEAL including SliceAdjust

OrthoSuite Ortho Suite is a comprehensive collection of pulse sequences for joint and spine imaging.

This package includes:

- 2D TSE pulse sequences for PD, T1, and T2-weighted contrast with high in-plane resolution and thin slices

- 3D MEDIC, 3D TrueFISP pulse sequences with water excitation for T2-weighted imaging with high in-plane resolution and thin slices

- High-resolution 3D VIBE pulse sequences for MR Arthrography (knee, shoulder, and hip)

- 3D MEDIC, 3D TrueFISP, 3D VIBE pulse sequences with Water Excitation having high isotropic resolution optimized for 3D postprocessing

- T1 and PD SPACE 3D imaging with high isotropic resolution, optimized for post-processing

Single-step, and multi-step pulse sequences

- Excellent fat suppression in off-center positions, e.g. in the shoulder due to high magnet homogeneity

- Dynamic TMJ pulse sequence (different joint positions)

- Multi Echo SE sequence with up to 32 echoes for T2 mapping

- High-resolution 3D DESS (Double Echo Steady State): T2 / T1- weighted imaging for excellent fluid-cartilage differentiation

- 2-point Dixon technique for fat and water separation - Turbo Spin Echo sequence

- WARP - 2D TSE sequence combining optimized high-bandwidth pulse sequences and View

Angle Tilting (VAT), tailored to reduce susceptibility artifacts caused by orthopedic MRConditional implants. This helps in evaluation of soft tissue in proximity of the implants. Available pulse sequences include T1- weighted, T2-weighted, proton density and STIR contrast.

- Advanced WARP enables the reduction of gross artifacts (i.e. through-plane artifacts) caused by large MR-Conditional* implants. It contains the 2D TSE based SEMAC technique and is especially useful in the case of hip and knee joint replacements.

- Available pulse sequences include T1-weighted, proton density and T2 TSE STIR contrast.

*Pediatric Suite Tissue relaxation times and examination conditions in pediatrics are very different compared to those of adults. The reasons for these differences range from developing tissues, body size and faster heart rates to non-compliance with breathhold commands. Pulse sequences can be easily adapted for imaging infants.

* MR scanning has not been established as safe for imaging fetuses and infants less than two years of age. The responsible physician must evaluate the benefits of the MR examination compared to those of other imaging procedures.

Scientific Suite MAGNETOM Sola - the first 1.5T BioMatrix system - leverages the intelligent combination of Tim 4G and the Siemens unique BioMatrix technology to be ready to embrace the unique set of challenges that each and every patient brings to the MRI exam.

The system includes:

BioMatrix Technology In order to meet the requirements of the changing healthcare market, Tim® is now further enhanced with the ability to address patient biovariablity: Evolving from Total imaging matrix, BioMatrix®

SIEMENS REPRESENTATIVE

Created: 05/22/2023 04:29:42 PM Siemens Medical Solutions USA, Inc. Confidential Page 35 of 79 technology addresses the intrinsic biovariability in humans.

BioMatrix can anticipate challenges in MR examinations, for example, the limited ability to hold one's breath, to manage growing patient populations and increasing exam complexity in MRI.

BioMatrix can adapt to all patients and their anatomic individuality, even the critical ones, to make MRI more predictable and consistent for all patients, even critical ones. BioMatrix can accelerate the workflow, without compromising quality of care by assisting interactions between the patient and the user, to improve MRI cost-effectiveness and patient outcomes.

BioMatrix anticipates, adapts and accelerates to embrace human nature.

Tim 4G Tim 4G provides excellent image quality and speed in MRI combined with increased patient comfort and optimized workflow efficiency. Only one patient setup, no repositioning, no changing of coils.

Ultra-light-weighted coils with high density of coil elements for maximized patient comfort and increased SNR. Feet-first positioning reduces claustrophobia.

Tim 4G with its 4G flexibility, 4G accuracy and 4G speed brings image quality and acquisition speed to a new level.

Magnet:

- Short 145 cm long (157 cm with covers), whole-body superconductive 1.5T magnet with active shielding (AS) technology with counter coils

- External Interference Shielding (E.I.S.)

- Excellent homogeneity enabled magnet design which allows for a cylindrically optimized homogeneity volume resulting in higher image quality (50 × 50 × 45 cm³ DEV, typ. 2,8 ppm based on the 24-plane plot method)

- Temperature sensors with real time correction algorithm for unmatched long-term stability at 70 cm

- The magnet has a typical Helium boil-off rate of 0 l/yr during typical, undisturbed clinical operation depending on the sequences used and examination time, and provided the system is serviced in regular intervals.

- It has an integrated magnet cooling system.

- The combination of standard active shim and passive shim allows for maximized magnetic field homogeneity and consistent high image quality for a wide range of applications

- Integrated Eco-Power technology to save around 30% of energy during standby of the system.

Gradient system:

- Actively shielded water-cooled world-class gradient system

- All axes force compensated for lowest vibrations and acoustic performance

DirectRF - RF Transmit/Receive System:

- Fully integrated Transmit- and Receive path in the magnet housing including extremely compact water-cooled solid state amplifier with 37.5 kW peak power

- High dynamic range

- Immediate feedback loop for real-time sequence adaptation

- Integrated no tune transmit/receive Body Coil

- The revolutionary Tim 4G technology allows connecting 204 channels (coil elements) simultaneously enabling higher SNR and iPAT in all directions. No repositioning of patients is needed even for large Field of View examinations. Dual-Density Signal Transfer enables ultra-high density coil design by integrating key RF components into the local coil.

SIEMENS REPRESENTATIVE

Created: 05/22/2023 04:29:42 PM Siemens Medical Solutions USA, Inc. Confidential Page 36 of 79

GO technologies

Select&GO The Select&GO interface enables fast and easy single-touch patient positioning. Correct positioning saves unnecessary wasted time for repositioning and additional adjustments, therefore shortening the total room time.

- The ergonomically designed Select&GO touch panels are integrated into the front cover on each side of the patient tunnel for controlling table movement, guidance for patient setup and comfort features. They are well illuminated for easy visual recognition.

- Automated table move to upmost position, to center position or Home position facilitate smooth patient preparation and will reduce table time

- Variable (6 levels) ventilation and lighting inside the magnet bore or volume adjustments are possible for increased patient comfort The Select&GO touch panels provide on board guidance for patient set up where it's needed - directly at the scanner. Information such as patient name or exam type or required patient position, guidance for ECG set up and immediate visualization of physiological curves will be provided for convenient operation.

- Almost all table control functions, including ventilation and illumination of the magnet bore, can be also controlled from the operator console for convenient operation.

DotGO Go for consistent results, efficiently with Dot Engines.

Dot offers a customizable framework for patient personalization, user guidance and exam automation.

Optimized scan strategies are provided and can be selected based on patient condition, which allow for high quality exams even when conditions change.

Integrated decision points allow the user to easily add or remove one or a group of protocols with one click. Step by step image and text guidance guides novice users even through the most complicated exams. Exam automation allows optimal timing for breathing, scanning, planning or contrast arrival.

Dot can be easily customized to follow the individual standards of care.

Dot is personalized, guided and automated and designed to improve workflow efficiency and image consistency.

Dot Cockpit The central tool to continuously build knowledge into standardized exams strategies and to make those available for every user in the MRI department. Dot Cockpit is the new starting point for every exam.

Recon&GO The Recon&GO technology encompasses a wide range of in-line functionalities automizing reconstruction and post-processing steps to provide ready-to-read results for the radiologist.

Examples are Inline ADC calculation, inline subtraction of dynamic contrastenhanced series, up to Inline Launch of advanced post-processing applications.

MR View&GO MR View&GO is MAGNETOM Sola's all-in-one viewing and reading solution for fast and intuitive quality check and result distribution. It receives the images directly as they come on the scanner, giving the user a clear overview of the quality of images scanned, without being distracted by constant context switches. Once the images have been checked for acceptable quality, they can easily be sent to the PACS with minimal user interaction.

Beyond that, MR View&GO offers the additional advantage to perform extended post-processing, directly at the scanner. In-line launching of post-processing applications makes it possible to fully automate the evaluation of, for example, perfusion maps, permeability or cardiac function, all without additional user interaction. This makes it possible to save radiologist time by delivering quantitative, ready-to-read results, directly to the PACS.

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Tim Application Suite The Tim Application Suite offers a complete range of clinically optimized examinations for all regions.

The Tim Application Suite -allowing excellent head-to-toe imaging - is provided standard on MAGNETOM Sola.

- Neuro Suite

- Angio Suite

- Cardiac Suite

- Body Suite

- Onco Suite

- Breast Suite

- Ortho Suite

- Pediatric* Suite

- Scientific Suite

* MR scanning has not been established as safe for imaging fetuses and infants less than two years of age. The responsible physician must evaluate the benefits of the MR examination compared to those of other imaging procedures.

Neuro Suite Comprehensive head and spine examinations can be performed with dedicated programs. High-resolution pulse sequences and motion-insensitive pulse sequences for patients which have difficulties to lay still are provided. The Neuro Suite also includes pulse sequences for diffusion imaging, perfusion imaging, and fMRI.

It includes for example:

- Fast 2D imaging with SE, TSE, GRE pulse sequences for high-resolution imaging

- BLADE for motion-insensitive TSE imaging EPI pulse sequences and protocols for diffusion imaging, perfusion imaging, and fMRI for advanced neuro applications. Diffusionweighted imaging is possible with up to 16 b-values in the orthogonal directions. For reduced distortions and homogeneous signal intensity even in the presence of challenging susceptibility interfaces and at station boundaries, SliceAdjust (slice-by-slice adjustments) can be selected.

- 3D TOF for non-contrast enhanced angiography

- 3D isotropic resolution volume imaging using T1 3D MPRAGE / 3D

- FLASH, SPACE DarkFluid, T1 SPACE and T2 SPACE pulse sequences

- High-resolution T2 SPACE pulse sequence optimized for inner ear examinations

- Double Inversion Recovery 3D pulse sequences (DIR SPACE) with two user-selectable inversion pulses for the simultaneous suppression of e.g. cerebro-spinal fluid and white matter

- MP2RAGE (Magnetization Prepared 2 Rapid Acquisition Gradient Echoes) provides homogeneous tissue contrast for segmentation and applications such as voxel-based morphometry. In combination with MapIt*, it also provides T1 mapping functionality.

- Whole-spine pulse sequences in multiple steps with software controlled table movement

- 2D and 3D MEDIC pulse sequences for T2-weighted imaging, particularly for C-spine examinations in axial orientation where reproducibility is difficult due to CSF pulsations and blood flow artifacts

- RESOLVE (Readout Segmentation Of Long Variable Echo-trains) delivers high-resolution, low-distortion diffusion-weighted imaging (DWI) for accurate depiction of lesions.

- BioMatrix's CoilShim helps to reduce patient induced strongly localized B0 inhomogeneities as may arise, e.g., in the neck region.

- 3D Myelo with 3D HASTE for anatomical details

- 3D CISS (Constructive Interference in Steady State) for excellent

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- visualization of fine structures such as cranial nerves. High-resolution imaging of inner ear

- TGSE sequence used primarily for T2-weighted imaging for shorter measurement time, decreased RF power deposition, and high-resolution imaging of the brain

- AutoAlign Head LS providing a fast, easy, standardized, and reproducible patient scanning supporting reading by delivering a higher and more standardized image quality.

Angio Suite Excellent MR Angiography can be performed to visualize arteries and veins with or without contrast agent.

- 3D MRA pulse sequences for carotid arteries, abdominal arteries, and peripheral arteries, with short TR and TE. The strong gradients make it possible to separate the arterial phase from the venous phase.

- Dynamic MRA for 3D imaging over time Signal from Respiratory Sensor can be selected to actively trigger MR image acquisition, e.g. with NATIVE*.

Contrast-enhanced MRA 3D contrast-enhanced MRA pulse sequences for dynamic carotid, abdominal, and peripheral arteries, shortest TR and TE. The strong gradients make it possible to separate the arterial phase from the venous phase

- TestBolus workflow for optimal bolus timing and excellent image quality

- CareBolus functionality for accurate determination of the bolus arrival time and the “Stop and

Continue” of the 3D ce-MRA pulse squenece after the 2D bolus control scan

- Dynamic ce-MRA for 3D imaging over time

Non-contrast-MRA and venography

- Time-of-Flight (ToF) pulse squeneces for MRA for the Circle of Willis, carotids and neck vessels;

can be adapted for venography, and Breath-hold protocols for abdominal vessels

- Triggered 2D ToF sequences for non-contrast MRA in the legsMR venography and arteriography with Phase-Contrast

- TONE (Tilted optimized non-saturating excitation) techniques for improved

- Contrast-to-Noise Ratio (CNR)

Image processing tools

- Inline MIP for immediate results

- Inline subtraction of pre- and post-contrast measurements

- Inline standard deviation maps of Phase-Contrast measurements for delineation of arteries and veins

Cardiac Suite The cardiac suite covers comprehensive 2D routine cardiac applications, ranging from morphology and ventricular function to tissue characterization. It moreover features BEAT 2D in conjunction with iPAT, T-PAT and e-PAT techniques.

Cardiac views

- Fast acquisition of the basic cardiac orientations for further examination planning

- Cardiac scouting provides users with a step-by-step procedure for the visualization and planning of typical cardiac views, e.g. based on TrueFISP or Dark Blood TurboFLASH: short axis, 4-chamber and 2-chamber views.

BEAT

- Unique tool for fast and easy cardiovascular MR imaging

- E.g. 1 click change from FLASH to TrueFISP for easy contrast optimization

- 1-click to switch arrhythmia rejection on / off

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- 1-click change from Cartesian to radial sampling to increase effective image resolution (e.g. in pediatric patients) and avoid folding artifacts in large patients

Visualization of structural cardiovascular pathologies with CMRBEAT

- Breath-hold and free breathing techniques for strong contrast between the blood and vascular structures. Dark Blood TSE and HASTE imaging are available for the structural evaluation of the cardiothoracic anatomy, including vessels or heart valves. Cine techniques (FLASH & TrueFISP) for high-resolution valve evaluation.

- Multiple contrasts such as T1- and T2-weighted imaging for use in diseases such as myocarditis (inflammation / hyperaemia), ARVD (fibrous-fatty degeneration) or acute myocardial infarction (edema)

- Dark-blood TSE with motion compensation for high-quality vessel wall imaging in small or large vessels

Tools for rapid evaluation of left or right ventricular function

- Acquisition of a stack of short-axis slices (standard: advanced segmented TrueFISP)

- Automatic adjustment of the acquisition window to the current heart rate

- Use of the Inline ECG for graphical ECG triggering setup

- Retrospective gating with cine sequences (TrueFISP, FLASH)

- Pulse sequences for whole-heart coverage

- Integration of Compressed Sensing Cardiac Cine (optional) for highest temporal and spatial resolution (segemented and realtime pulse sequences)

- Real-time imaging in case the patient is not able to hold his breath

4D imaging and tissue characterization with BEAT; pulse sequences for high-contrast and high-resolution tissue characterization

- Pulse sequences for stress and rest imaging with TurboFLASH contrast support the acquisition of multiple slices with high resolution and arbitrarily adjustable slice orientation for each slice T-PAT and e-PAT with mSENSE and GRAPPA for advanced parallel imaging provides fast high-resolution dynamic imaging

- Segmented IR TrueFISP / FLASH with TI scout for optimization of tissue contrast

- Advanced tissue characterization with 2D phase-sensitive IR (PSIR) pulse sequences with

TrueFISP and FLASH contrast. Magnitude and phase-sensitive images with one acquisition.

- Simple: no adjustment of inversion time (TI) necessary with PSIR technique

- Motion correction/averaging of multiple measurements with iPAT or tPAT accelerated single-shot

TrueFISP or GRE images of the heart, for free-breathing acquisition.

Physiological Measurement Unit (PMU) - Wireless Physio Control

- Synchronizes the measurement with the physiological cycles (triggering to minimize motion artifacts caused by cardiac and respiratory movements)

- Wireless Sensors

- Wireless Vector ECG / respiration for physiologically synchronized imaging, rechargeable battery-powered - for optimized patient handling

- Physiological Signals Display

- ECG (3 channels)

- Respiration

- External Trigger Input Display

ECG Triggering:

- Acquisition of multiple slices, e.g. of the heart, at different phases of the cardiac cycle

- Excellent image quality by synchronizing data acquisition with cardiac motion

- Respiratory Triggering: Excellent image quality by synchronizing data acquisition with the respiratory motion

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- External Triggering: Interface for trigger input from external sources (e.g. Patient Monitoring System) inside the examination room

- Interface for trigger input from external sources (e.g. pulse generator, trigger sources for fMRI) outside the examination room

- Optical trigger output for fMRI

- Retrospective gating for ECG, peripheral pulse, and external trigger input

Breast Suite MR imaging provides excellent tissue contrast that may be useful in the evaluation of the breasts.

Extremely high spatial and temporal resolution can be achieved in very short acquisition times by using iPAT with GRAPPA and CAIPIRINHA.

Customized pulse sequences (e.g. with fat saturation or water excitation or silicone excitation), as well as flexible multiplanar visualization allow a fast, simple and reproducible evaluation of MR breast examinations.

This package includes:

- High-resolution 2D pulse sequences for morphology evaluation

- High-resolution 3D pulse sequences covering both breasts simultaneously

- Pulse sequences to support interventions (fine needle and vacuum biopsies, wire localization)

- Pulse sequences for evaluating breasts with silicone implants

- Automatic and manual frequency adjustment, taking into account the silicone signal

- Detection of the silicone signal either to suppress the silicone signal, if the surrounding tissue is to be evaluated, or to suppress the tissue signal in order to detect an implant leakage

- SPAIR - robust fat sat (robust fat suppression using an adiabatic frequency selective inversion pulse)

- DIXON - 2-point Dixon with 3D VIBE, the following contrasts can be obtained: in-phase, opposed phase, fat and water image iPAT with GRAPPA for maximum resolution in short time

- iPAT² with CAIPIRINHA that allows state-of-the-art sagittal breast imaging and further improvement of the temporal resolution in dynamic scans while maintaining spatial resolution

- Inline subtraction and MIP display

- Offline subtraction, MPR and MIP display

- REVEAL: diffusion imaging for breast exams. In pulse sequences with multiple b-values individual numbers of averages may be specified per b-value.

- RESOLVE: Diffusion-weighted, readout-segmented (multi shot) EPI sequence for high-resolution susceptibility-insensitive DWI of the breast

- RADIANT: Ultrasound-like reconstruction around the nipple

The Breast Suite also includes:

syngo VIEWS (Volume Imaging with Enhanced Water Signal)

- Bilateral - both breasts are examined simultaneously

- Axial - the milk ducts are directly displayed

- fat-saturated or water-excited - fat complicates clinical evaluation and is suppressed

- Near-isotropic 3D measurement - the same voxel size in all three directions for reconstruction in any slice direction

- Submillimeter voxel - highest resolution for precise evaluation

Body Suite The Body Suite is dedicated to clinical body applications. Ultra-fast high-resolution 2D and 3D pulse sequences are provided for abdomen, pelvis, MR Colonography, MRCP, dynamic kidney, and MR Urography applications.

2D PACE technique makes body imaging easy, allowing for multibreath- hold examinations as well as free breathing during the scans.

Motion artifacts are greatly reduced with 2D PACE Inline technology.

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This package includes:

- Free breathing 2D PACE applications with 2D HASTE (RESTORE) and 2D / 3D TSE- it is possible to use a phase navigator, which measures respiratory induced off-resonance effects.

The positioning…