Sigma-Aldrich, Inc.

Sigma-Aldrich, Inc., doing business as Sigma-Aldrich Sales, Inc., is a foreign-owned, for-profit manufacturer and distributor of specialized laboratory chemicals, biological materials, and research equipment to federal agencies as a prime contractor. The company operates without small-business set-asides and competes on a full-and-open basis across the federal marketplace. Sigma-Aldrich is headquartered in St. Louis, Missouri, and serves as a subsidiary of Sigma-Aldrich Corporation, with two named subsidiaries—Bioreliance Corporation and Cell Marque Corp—that carry additional capability framing in diagnostics and cell-culture products.

Sigma-Aldrich's federal footprint centers on life-science and research-support contracting. Across 466 prime awards with combined potential value of $262.2 million, the company supplies protein purification reagents, monoclonal antibodies, isotope-labeled water and compounds, fetal bovine serum, CRISPR knockout libraries, chemical libraries for mass spectrometry, water purification systems, laboratory equipment, and biologics for cell culture and clinical trials. Representative prime work includes a $500,000 purchase order from the National Institute of Standards and Technology (awarded February 2025) for manufacturing monoclonal antibody reference material from a bioreactor run, with performance in Great Britain and delivery through December 2027; a $1.249 million purchase order from the Defense Health Agency (September 2024) for manufacturing Army Liposome Formulation containing QS-21 for Phase 2 and 3 clinical trials on behalf of Walter Reed Army Institute of Research; a $201,319 purchase order from NIST (March 2024) for organic chemicals to support mass spectrometry research; and a $146,644 purchase order from the Food and Drug Administration (August 2025) for reagents and consumables for mission-critical interdisciplinary research.

Customer concentration sits heavily with civilian research agencies. The Department of Health and Human Services dominates by both award count and dollar value, with the Office of Logistics and Acquisition Operations accounting for 44 awards and $50.5 million in combined potential value—anchored by a $50 million single-award Blanket Purchase Agreement (awarded October 2024, running through October 2026) for chemicals, biological materials, and laboratory supplies. The Centers for Disease Control and Prevention Pittsburgh ranks second by potential value with 29 awards and $1.5 million combined. The National Institute of Allergy and Infectious Diseases, National Cancer Institute, and National Institute on Drug Abuse round out the top NIH-component customers by award count. Department of Commerce (NIST), the Defense Health Agency, and the Department of the Navy Office of Naval Research represent secondary customer concentration in standards development, military medical research, and naval R&D. Top five customers by potential value account for approximately 21% of combined potential value, suggesting broad federal customer dispersion.

Sigma-Aldrich holds two significant IDVs beyond the $50 million OLAO BPA. A $315,000 single-award Indefinite Delivery Contract with the Defense Health Agency Medical Command (awarded May 2023, completion May 2028) procures 18O-labeled water at 10 atom% for military nutrition division studies; this vehicle has generated two delivery orders valued at $63,000 each. A $50 million Blanket Purchase Agreement with the Office of Logistics and Acquisition Operations (awarded October 2024) remains the primary sourcing vehicle across civilian agencies. Recent task orders under these vehicles demonstrate mixed scale—the September 2025 NIEHS task order for $10,536.57 and the March 2025 Office of Logistics and Acquisition Operations call for $11,207.26 illustrate routine small-dollar ordering against the larger BPA structure. The vendor also maintains a legacy presence on the historical HHS BPA (HHSN263201600046B), which carries 75 historical task orders and $658,000 combined potential value, and holds a position on the GSA Federal Supply Schedule (GS07F068AA) with six task orders valued at $285,000.

Activity trajectory shows year-over-year decline. Awards per year dropped from 16 in 2022 to 4 in 2026 (through June), with 2025 recording only 9 awards. Seven awards with completion dates in the next twenty-four months carry combined potential value of $726,000—a modest recompete exposure relative to the vendor's overall footprint. Obligated dollars across all awards total $9 million against combined potential value of $262.2 million, indicating a typical federal contracting pattern in which many purchase orders carry value ceilings but limited invoiced spend to date.

Sigma-Aldrich operates predominantly as a prime contractor (99% of awards), with minimal subcontract exposure. The source lists two sub-awards: subcontracting work under General Atomics on inertial confinement fusion (ICF) target fabrication and R&D (awarded April 2026 and June 2025) for the Department of Energy Office of RTD&E, and a sub-grant under General Atomics in operating supplies and equipment (August 2024). Federal grant presence is limited; the source does not identify named grant-recipient awards separate from contract task orders.

NAICS concentration reflects Sigma-Aldrich's product portfolio. Biological Product Manufacturing (except Diagnostic) dominates with 161 awards, followed by All Other Basic Organic Chemical Manufacturing (67 awards), All Other Miscellaneous Chemical Product and Preparation Manufacturing (50 awards), and Analytical Laboratory Instrument Manufacturing (41 awards). PSC coding mirrors this framing: Chemicals leads with 187 awards, Laboratory Equipment and Supplies carries 111 awards, and Drugs and Biologicals account for 65 awards. This coding concentration underscores the vendor's role as a materials supplier rather than a services integrator—purchase orders from NIH institutes, the CDC, and defense agencies for specific chemical compounds, reagents, and laboratory consumables represent the typical engagement model rather than IDIQ services or integration contracts.