Prevention of Disease, Disability, and Death by Infectious Diseases

Active

Assistance listing
93.084
Agency
Grant awards
79 $462,422,346 in federal obligations

Program facts

Assistance types
  • Cooperative Agreement
  • Project Grant
Treasury account
  • 75-0943-0-1-550

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Department of Health and Human Services Centers for Disease Control and Prevention (CDC) is issuing cooperative agreements and project grants under CFDA 93.084 to fund prevention of infectious disease, disability, and death through strengthened public health capacity, surveillance, laboratory capabilities, and disease control interventions, with the most recent award issued on September 1, 2026.

The program funds concrete infectious disease prevention and control activities spanning HIV treatment and prevention, sexually transmitted infections, vector-borne diseases, healthcare-associated infections, antimicrobial resistance, parasitic infections, rabies, fungal diseases, and travel-related illness. Recent awards exemplify this scope: a $1.2 million cooperative agreement to integrate postexposure prophylaxis packs into sexual health clinical care for gay and bisexual men and other men who have sex with men; a $6.1 million award supporting integrative care and healthy aging for adults with HIV; a $1.55 million award for enhanced surveillance and control of arboviruses in Puerto Rico; and multiple project grants supporting development of rapid diagnostic tests for hepatitis C virus and antimicrobial susceptibility testing for non-tuberculous mycobacterial infections. The program also funds regional centers of excellence for vector-borne disease control, pathogen genomics capacity-building, epidemiological and economic modeling, healthcare quality and safety infrastructure, and pre-travel health consultation networks.

The portfolio is dominated by cooperative agreements (85 percent of 79 awards) paired with a smaller share of project grants (15 percent). CDC is the sole funder across the program. Combined federal dollars obligated total $462.4 million. Award magnitudes range widely: the smallest recent project grants awarded roughly $12,700 to $614,000, while larger cooperative agreements span $1.2 million to $80.2 million for multi-year research platforms. Award cycles typically span 1 to 5 years with project periods of 1 to 5 years and annual budget periods; renewals at the end of project periods are made through new, competitive NOFOs.

Activity has been uneven in recent years, with 6 awards in 2022, 2 in 2023, 3 in 2024, 5 in 2025, and 1 through September 2026. Grant opportunities are currently open: RFA-CK-26-0107 (Building National Partnerships for Prevention of Emerging and Reemerging Infectious Diseases, due July 1, 2026); CDC-RFA-CK-26-0193 (Alpha-gal Syndrome awareness and surveillance, due July 9, 2026); CDC-RFA-CK-26-0221 (Parasitic infection prevention and control, due July 17, 2026); RFA-CK-26-035 and RFA-CK-26-036 (travel medicine research and pre-travel consultation networks, due November 5, 2026); and RFA-CK-27-106 (rabies detection and response, posted July 27, 2026). Eligibility typically spans state and local governments, higher education, nonprofits, tribal organizations, and in some cases for-profit entities and small businesses.

Objective and description

Objective

The purpose of this program is to prevent disease, disability and death by infectious diseases. The specific objectives may include, but are not limited to: strengthening public health fundamentals; increasing capacity to prevent disease, disabilit

Description

Prevention of Disease, Disability, and Death by Infectious Diseases

Eligibility

Applicant eligibility

Dependent upon the individual NOFO, eligibility may range from open competition, limited competition, single-source, domestic and/or international in accordance with the authorizing legislation.

Uses of assistance

Funds may be used in the prevention or control of disease, disability and/or death by infectious diseases. Restrictions to funding are designated in the individual Notice of Funding Opportunity (NOFO) and, for those awarded, in the Notice of Award (NoA).

Length and time phasing of assistance

Financial assistance is available for 12-month budget period (s) within a 1- to 5-year project period. After awards are issued, funds are released in accordance with the payment procedure established by the grantee institution with Department of Health and Human Services (HHS).

How to apply

Criteria for selecting proposals

Applications will be evaluated on the review criteria described in the Notice of Funding Opportunity Announcements (NOFOs). In general, the review and selection process of complete and responsive applications to the NOFO consists of determination of the scientific and technical merit by objective or peer review, availability of funds, and relevance of program priorities and the priorities of CDC.

Award procedure

Procedures are specified in the individual NOFOs.

Time to approval or disapproval

As specified in the individual NOFOs.

Renewals

Awards under this Program are typically issued for 1- to 5-year project periods. Renewals at the end of each project period are expected to be made available in a new/continuation NOFO with a complete application and review/award process as described in the NOFO. Annual renewals within an awarded multi-year project period are made via a non-competitive process and are subject to the availability of funds.

Grant opportunities

Opportunity Status Posted Applications due
Early Detection, Response, and Control of Global Rabies Outbreaks and Associated Threats to America's Dog-Rabies Free Status RFA-CK-27-106 Forecasted —
Centers of Excellence in Healthcare Quality and Safety CDC-RFA-CK-27-0007 Forecasted —
Increasing awareness and knowledge of Alpha-gal Syndrome in the United States CDC-RFA-CK-26-0193 Closed
Reducing the burden of parasitic infections in the United States through evidence-based prevention and control activities. CDC-RFA-CK-26-0221 Closed
Building National Partnerships for the Prevention of Emerging and Reemerging Infectious Diseases CDC-RFA-CK-26-0107 Closed
Emerging Infections Network - Research for Preventing, Detecting, and Managing Travel-associated Infectious Diseases RFA-CK-26-035 Open
US Travelers Health Research, Surveillance, Communication, and Outreach Network RFA-CK-26-036 Open
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) PA-27-100 Open
Enhanced Surveillance and Control of Endemic and Emerging Arboviruses in Puerto Rico RFA-CK-25-182 Closed
Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed) PA-25-212 Closed
Modeling Infectious Diseases in Healthcare (MInD Healthcare) to Improve Pathogen Prevention and Healthcare Delivery CDC-RFA-CK-25-0018 Closed
PEP Packs: Postexposure Prophylaxis Packs for Immediate Access to HIV and Sexually Transmitted Infection Prevention RFA-PS-25-112 Closed
Develop and Test HIV Prevention Interventions for Black and Hispanic Gay, Bisexual, and Other Men Who Have Sex with Men Who Use Substances RFA-PS-25-113 Closed
Understanding Infant Feeding Preferences, Practices, and Outcomes for Mothers and other Parents with HIV in the United States RFA-PS-24-040 Closed
Improving the Quality of Life of People with HIV Aged 50 Years and Older in the United States RFA-PS-24-039 Closed
A Bridge to Adherence: Long-Acting Antiretroviral Therapy for People with HIV Released from Prison RFA-PS-24-042 Closed
NCHHSTP Epidemiologic and Economic Modeling for HIV, Viral Hepatitis, STD, and TB CDC-RFA-PS-24-0028 Closed
PHS 2023-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) PA-23-230 Closed
Centers for AIDS Research (P30 Clinical Trial Not Allowed) PAR-23-116 Closed
Developmental Centers for AIDS Research (P30 Clinical Trial Not Allowed) PAR-23-117 Closed
Clinical and Applied Research Strategies for the Prevention and Control of Fungal Diseases RFA-CK-23-001 Closed
Strengthening Training, Evaluation, and Partnerships in the Prevention and Control of Vector-Borne Diseases CDC-RFA-CK-23-0005 Closed
Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART) RFA-PS-23-002 Closed
Long-Acting Injectables for the Treatment of HIV in Non-Clinic Community-Based Settings RFA-PS-23-004 Closed
Identifying and Addressing Historical and Structural Drivers of Medical Mistrust among Hispanic/Latino Gay, Bisexual and Other Men Who Have Sex with Men (HLMSM) for HIV Prevention RFA-PS-23-006 Closed
Expanding Rapid Initiation of Antiretroviral Therapy in Non-traditional Settings: Emergency Department RFA-PS-23-005 Closed
Exploring Preferences for Long-Acting Antiretroviral Therapies (LA-ART) in a Community-Based Sample of Priority Populations Living with HIV Who are Disproportionately Affected RFA-PS-23-003 Closed
Advancing Policy as a Public Health Intervention to Reduce Morbidity, Mortality and Disparities in HIV, Viral Hepatitis, STDs, and Tuberculosis CDC-RFA-PS-23-0009 Closed
PHS 2022-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) PA-22-177 Closed
PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) PA-22-176 Closed
Emerging Infections Programs CDC-RFA-CK23-2301 Past —
Building Mathematical Modeling Workforce Capacity to Support Infectious Disease and Healthcare Research RFA-CK-22-008 Past —
Investigation of Monkeypox and Other Zoonotic Diseases in the Democratic Republic of the Congo (DRC) RFA-CK-22-001 Closed
US Public Health Pathogens Genomics Centers of Excellence CDC-RFA-CK22-2204 Closed
Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed) PAR-22-073 Closed
Technological Advancement of Global Rabies Surveillance and Control RFA-CK-22-002 Closed
Clinical and Applied Research Strategies for the Prevention and Control of Fungal Diseases RFA-CK-22-006 Closed
Continuing Enhanced National Surveillance for Prion Diseases in the United States CDC-RFA-CK22-2202 Closed
Understanding HIV/STD Risk and Enhancing PrEP Implementation Messaging in a Diverse Community-Based Sample of Gay, Bisexual, and Other Men Who Have Sex with Men in a Transformational Era RFA-PS-22-004 Closed
Implementing Pre-exposure Prophylaxis for HIV Prevention in Syringe Service Programs RFA-PS-22-001 Closed
US Public Health Pathogen Genomics Centers of Excellence RFA-CK-22-007 Past —
Optimization and Standardization of Methods to Suppress Ixodes scapularis and Disrupt Enzootic Pathogen Transmission in Settings Posing an Elevated Risk to Humans RFA-CK-22-004 Closed
PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) PA-21-259 Closed
Vector-Borne Disease Regional Centers of Excellence RFA-CK-22-005 Closed
PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) PA-21-260 Closed
Enhancing Regional Capacity for Vector Surveillance and Control in the US territories in the Caribbean CDC-RFA-CK21-2103 Closed
Monitoring Cause-specific School Absenteeism for Estimating Community-wide Influenza and SARS-CoV-2 Transmission RFA-CK-21-003 Closed
US Travelers Health Research, Surveillance, Communication, and Outreach Network RFA-CK-21-001 Closed
Emerging Infections Network - Research for Preventing, Detecting, and Managing Travelers who Acquire Infectious Diseases Abroad RFA-CK-21-002 Closed
Implementation Research Consortium to Accelerate Impact of Health Department-Delivered HIV Prevention Activities RFA-PS-21-002 Closed
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Grant awards

Award Recipient Federal obligations Awarded
Integration of PEP packs into existing sexual health clinical care for gbmsm U01PS005307 Fenway Community Health Center, Inc. $1,200,000
PS24-039 - understanding integrative care and support pathways to healthy aging for adults aging with HIV U01PS005290 The Regents Of The University Of Colorado $6,091,164
Rapid affordable aptamer-based diagnostic test for hepatitis c virus R43PS005315 Aptus Biosciences LLC $1,002,400
Development of an ultrasensitive, rapid and portable nucleic acid based test for detection of acute hepatitis c virus… R43PS005313 Cubit Diagnostics, Inc. $12,704
Ultra-rapid optical platform for antimicrobial susceptibility testing (AST) ofpulmonary non-tuberculous mycobacterial… R43JG000004 SKM Instruments, Inc. $613,744
CK25-182 - puerto rico enhanced surveillance and control of endemic and emerging arboviruses U01CK000707 Ponce Medical School Foundation Inc. $1,550,000
Hormonal contraceptive access via pharmacist-prescribing implementation package (happi) R44DP006691 Empowerx, Inc. $3,480,746
Strengthening rocky mountain spotted fever (rmsf) prevention and control in arizona tribal lands NU50CK000653 White Mountain Apache Tribe $875,331
Epidemiology and laboratory capacity for prevention and control of emerging infectiousdiseases (ELC) NU51CK000385 Arizona Department Of Health Services $1,679,491
RFA-PS-23-004, innovative administration of long-acting injectables for HIV treatment enhancement at home (invite-home) U01PS005259 The Regents Of The University Of California. San Francisco $4,000,000

Latest 10 of 79 listed here. See the rest on GovTribe.

Top recipients by federal obligations

Rank Recipient Federal obligations Share
1 Massachusetts Department Of Public Health $80,160,192 17%
2 Puerto Rico Science, Technology, And Research Trust $66,163,081 14%
3 Department Of General Services Virginia $49,346,472 11%
4 University Of Wisconsin System $29,907,032 6%
5 Emory University $21,030,402 5%
6 The General Hospital Corporation $18,405,878 4%
7 Cornell University $14,206,936 3%
8 Duke University $12,079,448 3%
9 Rush University Medical Center $10,303,448 2%
10 University Of Florida $10,241,881 2%

10 of 57 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $2,719,000
FY2025 $20,989,345
FY2024 $105,514,771
FY2023 $165,140,770
FY2022 $130,607,506
FY2021 $43,210,964
FY2020 $66,348,918
FY2019 $28,566,144
FY2018 $21,574,664
FY2017 $78,119,586
FY2016 $50,336,842
FY2015 $9,617,513
FY2014 $6,662,093
Show all 13

Quick answers

What is Assistance Listing 93.084?

Assistance Listing 93.084 is Prevention of Disease, Disability, and Death by Infectious Diseases, a federal grant program run by Centers for Disease Control and Prevention (Department of Health and Human Services).

What is the CFDA number for Prevention of Disease, Disability, and Death by Infectious Diseases?

Its CFDA number is 93.084: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 93.084 awarded?

79 grant awards under 93.084 have obligated $462,422,346 in federal funds to 57 recipients.

Who receives the most funding from 93.084?

The recipients obligated the most under Prevention of Disease, Disability, and Death by Infectious Diseases are Massachusetts Department Of Public Health ($80,160,192), Puerto Rico Science, Technology, And Research Trust ($66,163,081) and Department Of General Services Virginia ($49,346,472).

How much did 93.084 obligate in fiscal year 2025?

Grants under 93.084 obligated $20,989,345 in federal funds in fiscal year 2025.

Are there open grant opportunities under 93.084?

5 of the latest 50 opportunities under 93.084 are open or forecasted. The latest, Early Detection, Response, and Control of Global Rabies Outbreaks and Associated Threats to America's Dog-Rabies Free Status, was posted on July 27, 2026.

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