Att2_Proposal Intent Response Sheet.pdf

This document contains a solicitation for genetic toxicology support services. The National Institute of Environmental Health Sciences intends to award a contract for up to ten years to examine a variable number of chemicals annually, ranging from 10 to 20, for their ability to induce genetic changes in cells and tissues of laboratory animals and humans. A variety of genetic toxicology assays may be conducted each year to assess endpoints such as DNA damage, mutations, chromosomal changes, and differential gene expression profiles. In addition to conducting standard assays, the contractor will engage in research and development efforts to refine existing techniques and integrate new technologies into the National Toxicology Program's testing methods.