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This document provides instructions for submitting proposals in response to solicitation number 75N96020R00005 from the National Institute of Environmental Health Sciences. Proposals must be submitted electronically through the eCPS website by the date and time specified in the solicitation. Offerors must also submit paper copies of the technical and business proposals with specified markings and to the addresses listed. Proposals should each be a separate PDF file for the technical and business portions, with the business proposal also including a separate Excel workbook. Formatting requirements include font size, spacing, page size and margins. The technical proposal is limited to 100 pages not including specified exclusions.

The solicitation seeks services and support to examine approximately 20 chemicals or mixtures annually for up to 10 years for induction of genetic changes in cells from exposed animals and humans. Studies may include comet assays and micronucleus assays to evaluate DNA damage and chromosomal changes. The contractor will also examine chemicals for similar genetic effects in cultured cells. The contract includes a research effort to refine existing techniques and integrate new technologies to maintain scientific relevance for the National Toxicology Program's testing.

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ATTACHMENT 1

Packaging and Delivery of Proposals for Use with the NIH electronic Contract Proposal

Submission (eCPS) Website

I. PROPOSAL SUBMISSION

A. eCPS

1. Proposals must be submitted via the electronic Contract Proposal Submission (eCPS) website at https://ecps.nih.gov.

2. Proposals submitted by facsimile or e-mail will not be accepted.

3. Follow the “How to Submit an Electronic Proposal” instructions provided on the eCPS website at: https://ecps.nih.gov/home/howto. Please note that creating an account to submit may take up to three (3) business days. Please apply for a new account early to allow enough time for the registration process.

4. Offerors are solely responsible for submitting proposals and any modifications or revisions so as to reach the Government office designated above by the date and time specified in the solicitation. If your proposal is not received by the date and time specified in the solicitation, it will be considered a “late proposal,” in accordance with FAR Clause 52.215-1 Instructions to Offerors – Competitive Acquisition.

B. Hardcopy Submission

1. In addition to submission through eCPS, Offerors shall submit full paper copies of the technical proposal and the business proposal. Hardcopies must be identical to the proposals submitted through eCPS.

2. Hardcopies must be received by the date and time specified in the solicitation.

Shipment and marking shall be indicated below:

External Package Marking:

Mark each package as follows: “RFP NO: 75N96020R00005 TO BE OPENED BY

AUTHORIZED GOVERNMENT PERSONNEL ONLY”

NUMBER OF COPIES

TECHNICAL PROPOSAL: 1 ORIGINAL AND 1 COPY TO:

BUSINESS PROPOSAL: 1 ORIGINAL AND 1 COPY TO:

If hand delivered: If using U.S. Postal Service:

Julie Bardo, Contracting Officer NIEHS, Office of Acquisitions 530 Davis Drive Morrisville, NC 27560

Julie Bardo, Contracting Officer NIEHS, Office of Acquisitions P.O. Box 12874 Mail Drop K1-05

RTP, NC 27709

*THE ORIGINALS MUST BE READILY ACCESSIBLE FOR DATE STAMPING PURPOSES.

C. Creating and Naming Files for electronic submission:

1. Create one PDF file of your Technical Proposal, including all attachments. The Technical Proposal should be created in a PDF format that enables word searches to the https://ecps.nih.gov/ https://ecps.nih.gov/home/howto

ATTACHMENT 1

maximum extent practicable. Forms and/or documents requiring signature(s) may be scanned, but must be merged into the Technical Proposal PDF file.

2. Create one PDF file of your Business Proposal, including all attachments:

The Business Proposal should be created in a PDF format that enables word searches to the maximum extent practicable. Forms and/or documents requiring signature(s) may be scanned, but must be merged into the Business Proposal PDF file. Additionally, the “Breakdown of Proposed Estimated Costs (plus Fee) with Excel Spreadsheet” (http://oamp.od.nih.gov/sites/default/files/DGS/contracting-forms/spshexcl_dec2012.xlsx) must be included in the Business Proposal.

3. Create your Business Document Excel. The Excel file should be the “Breakdown of Proposed Estimated Costs (plus Fee) with Excel Spreadsheet” (http://oamp.od.nih.gov/sites/default/files/DGS/contracting-forms/spshexcl_dec2012.xlsx) included in the Business Proposal in its original Excel format, not PDF. Multiple Excel files may be included, as necessary.

4. Each of the proposals, Technical and Business, must be separate and complete in itself.

Do not reference one proposal in another.

5. File naming convention: It is requested that the filenames for your Technical Proposal, Business Proposal, and Excel Workbook include the name of the offeror, the solicitation number and the type of proposal (i.e., Technical, Business, or Excel Workbook).

Examples:

Technical Proposal: XYZ Company_NIHAI2012001_Technical.pdf Business Proposal: XYZ Company_NIHAI2012001_Business.pdf Excel Workbook: XYZ Company_NIHAI2012001_Business.xlsx

II. FORMATTING AND PAGE LIMITATIONS:

A. Formatting for proposals

1. Proposals shall not include links to internet web site addresses (URLs) or otherwise direct readers to alternate sources of information.

2. Font size must be 10 to 12 points.

3. Spacing should be no more than 15 characters per inch. Within a vertical inch, there must be no more than six lines of text.

4. Pages shall be of standard size (8.5x11). Margins must be at least one-inch on all sides.

5. Failure to adhere to the formatting requirements above may impact whether your proposal is reviewed in its entirety.

B. Page limitations:

1. The total page count of the Technical proposal shall not exceed 100 pages.

2. Total page count does not include: Title and Back Page; Table of Contents; CVs/resumes;

Appendices; and Section Dividers that do not contain information other than title of Section.

3. Pages in excess of this limitation will be removed from the proposal and will not be considered http://oamp.od.nih.gov/sites/default/files/DGS/contracting-forms/spshexcl_dec2012.xlsx

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