Case Western Reserve University

Case Western Reserve University, Office of Research Administration, operating in affiliation with University Hospitals of Cleveland, is a tax-exempt private research university receiving federal awards as a prime grant and contract recipient across biomedical sciences, health services research, translational medicine, clinical research, engineering, and materials science. The institution does not compete under small-business set-asides and operates in full-and-open competition across federal sources.

The institution's recent federal footprint centers on research grants from the National Institutes of Health, National Science Foundation, Department of Veterans Affairs, and Department of Defense. Representative work includes a $4.3 million NHLBI grant to investigate phosphorylation-based mechanisms of cardiac myosin binding protein C in contractile function (prime recipient, award date July 15, 2026); a $7.5 million NSF Cooperative Agreement to establish NEO-SMART, a regional innovation hub for advanced materials and manufacturing in Northeast Ohio (prime recipient, award date August 1, 2026); a $3.8 million NINDS grant to develop and validate transient selective neural inhibition via photobiomodulation for chronic knee pain treatment (prime recipient, award date August 1, 2026); and a $1.5 million NHLBI grant to develop an artificial intelligence-based decision-support tool for myocardial ischemia risk stratification using low-cost screening data (prime recipient, award date July 15, 2026). The institution also holds a single-award indefinite-delivery contract with Veterans Integrated Service Network 4 valued at $200,000 (ceiling), from which eight delivery orders totaling $376,056 in obligated value were issued between April and July 2026 for academic affiliate research cores and biomedical research support.

Customer concentration is broad across 173 distinct federal agencies. The Department of Health and Human Services National Institutes of Health dominates by award count (645 awards, 37% of total), with the National Heart Lung and Blood Institute, National Institute of Child Health and Human Development, and National Institute of Diabetes and Digestive and Kidney Diseases leading by combined potential value. The National Science Foundation accounts for 398 awards; the Department of Veterans Affairs Veterans Health Administration, Veterans Integrated Service Network 10, for 281 awards with $19.9 million in combined potential value. These three sources represent 37% of all awards. Potential-value rankings show NHLBI anchoring the largest award concentration at $60.1 million across 172 grants, followed by NICHD at $54.6 million across 90 awards and NIDDK at $34.6 million across 104 awards, indicating that smaller award counts often carry larger individual grant values characteristic of NIH research funding.

The institution's named parent vehicles are limited in the source; the largest is Navy Indefinite Delivery Contract N0014098G2427 with 119 task orders valued at $8.9 million in combined potential value, suggesting naval research collaborations. The institution's activity trajectory shows awards per year ranging from 201 in 2026 to 303 in 2024, with 231 in 2025, indicating stable federal engagement. Recompete exposure in the next 24 months totals 289 awards with $9 million in combined potential value—a manageable renewal pipeline relative to the institution's scale.

The Service Contract Inventory dataset covers 19 records (11 as prime, 8 as subcontractor) across FY2022–FY2025, representing a partial view of the institution's federal services activity. SCI-reported invoicing of federal service contracts above the $150,000 threshold totaled approximately $4 million across the four-year window, with FY2024 and FY2025 each representing roughly $1.4 million to $1.7 million in invoiced revenue. The SCI dataset reflects workforce scale of approximately 20–30 FTEs on reportable service contracts, with FY2024 and FY2025 showing roughly 21–23 FTEs. Government-paid hourly rates on federal services contracts captured in SCI ran consistently near $32–$33 per hour across the 10th, median, and 90th percentiles, characteristic of academic research support labor. Sub-engagement across SCI-prime contracts averaged zero percent, indicating that on reportable federal service contracts, the institution delivers work primarily through its own personnel rather than subcontractors.

The institution operates 88% of its awards as prime (4,155 prime awards) and 12% as subcontractor (568 sub-awards), with subcontracting roles including research contributions to Mayo Clinic on the EASE-REACT Program (organ-on-chip oxygen monitoring), subcontracts under Honeywell Federal Manufacturing for National Security Campus operations support, and research collaborations with the Children's Hospital of Philadelphia, Johns Hopkins University, and Northwestern University on NIH-funded projects. Recent grant sub-recipient work includes investigator support for the REVERSE-Long COVID clinical trial at Vanderbilt University Medical Center and biospecimen processing and transcriptomic analysis for the Rapid AD cohort expansion under the Alzheimer Disease Genetics Consortium at University of Pennsylvania. The institution's teaming posture is predominantly prime-driven, with sub-relationships anchored to research collaborations rather than service delivery subcontracting.