Case Western Reserve University

Case Western Reserve University, Office of Research Administration operating in affiliation with University Hospitals of Cleveland, is a non-profit private research university receiving federal funding as a prime recipient on grants and contracts across the National Institutes of Health, National Science Foundation, Department of Veterans Affairs, and Department of Defense. The institution competes in full-and-open procurements and operates predominantly as a grant recipient rather than a federal contractor, with research activities concentrated in biomedical sciences, health services research, engineering, and basic science spanning neurodegenerative disease, oncology, immunology, cardiovascular and pulmonary research, and translational medicine.

CWRU's recent federal footprint reflects a research enterprise delivering academic research, clinical trial execution, core facility operations, and graduate education services. The top five funding sources by award count include the National Institutes of Health (645 awards), National Science Foundation (395 awards), Veterans Integrated Service Network 10 (279 awards), National Cancer Institute (240 awards), and the National Heart Lung and Blood Institute (166 awards, $60.1 million combined potential value). By potential value, the National Heart Lung and Blood Institute leads ($60.1 million across 166 awards), followed by the National Institute of Child Health and Human Development ($54.6 million across 84 awards) and the National Institute of Diabetes and Digestive and Kidney Diseases ($34.6 million across 100 awards). Across 2022–2024, the institution delivered research services at SCI-reportable rates around $33/hr median, with 31.1 federal FTEs allocated to reportable service contracts in FY2024; these figures represent a strict subset of CWRU's total federal and non-federal research enterprise revenue.

CWRU acts as prime recipient on 88% of recent federal awards (4,096 of 4,633 total). Representative prime work includes a $9.87 million Defense Health Agency grant for a pilot randomized controlled trial of sensorimotor restoration after limb loss (through June 2029), a $1.41 million National Institute of Child Health and Human Development award for immune heterogeneity research in pediatric sepsis (through April 2030), a $2.4 million National Aeronautics and Space Administration Science grant for balanced science program execution aligned with National Academies guidance (through October 2028), and numerous National Institutes of Health project grants in cancer biology, neurodegenerative disease, infectious disease, and cardiovascular research ranging from $110 thousand to $1.5 million per award. The institution holds an Indefinite Delivery Contract with Veterans Integrated Service Network 4 ($200 thousand ceiling, through April 2028) and a Basic Ordering Agreement with the Department of the Navy Bureau of Medicine and Surgery (ten-year term through July 2035, no dollar ceiling in source data) for tuition, fees, and biomedical research core facility services. Contract activity in the past five years shows 204 awards in 2022, growing to 304 awards in 2024, then declining to 112 awards in the partial 2026 year; 287 awards face ultimate completion within the next twenty-four months, representing $11 million in potential recompete opportunity.

As a subcontractor, CWRU participates in multi-institutional research consortia led by Mayo Clinic, Emory University, The Johns Hopkins University, Northwestern University, and other academic medical research centers. Named sub-award roles include collaborative work under an ARPA-H ("EASE-REACT") program led by Mayo Clinic (focused on oxygen sensing and cell cartridge integration), immunological research under a Columbia University prime grant studying HIV reservoir characterization, and genetic analysis work under East Carolina University (TOPMed-related admixture mapping and fine-mapping of disease-associated loci). CWRU's subcontractor footprint reflects its position as a specialized research capability provider embedded in large federally-funded research networks rather than as a systems integrator or service delivery subcontractor.

Place of performance is Cleveland, Ohio (10900 Euclid Avenue) and subordinate research facilities supporting University Hospitals of Cleveland affiliate operations. The institution competes for research funding through open federal grant and contract mechanisms; no set-aside designations apply to the awards in the source material.