Post-vent, the sequelae: personalized prognostic modeling for consequences of neonatal intermittent hypoxemia in preterm infants at pre-school age

Active Project Grant Awarded Last action

Award ID
R01HL157256
Recipient
Awarding agency
Obligated
$23,449,724

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 99% complete
Funding
  • $20,594,908.00 Federal
  • $2,854,816.00 Non-federal
Place of performance
Illinois, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
This is the application from collaborators of the prematurity-related ventilatory control (pre-VENT): role in respiratory outcomes nhlbi collaborative program. Central to this proposal is a prospective study entitled "post-VENT, the sequelae: personalized prognostic modeling for consequences of neonatal intermittent hypoxemia in preterm infants at pre-school age". This multicenter proposal innovatively combines detailed clinical phenotyping with advanced analytics of longitudinal recordings of intermittent hypoxemia (IH) events to develop personalized prognostic models of long-term outcomes that could transform clinical care by allowing for timely identification of at-risk infants and specific pathologic IH patterns for future trials of targeted intervention. Extremely premature birth and various postnatal factors can negatively affect outcome. In a significant proportion of extremely premature infants the sequelae persist beyond infancy with relatively high rates of asthma and sleep disordered breathing (SDB) in childhood and worrisome prevalence of neurodevelopmental impairment (NDI). This multicenter proposal will systematically and innovatively examine the interaction between IH during neonatal intensive care and these sequelae by means of detailed clinical phenotyping and advanced analytics. The proposed investigation will provide personalized prognosis and identification of infants at risk of poor long-term outcome that could transform clinical care and uncover targets for preventive or therapeutic strategies. The main goal of this proposal is to build prognostic models of asthma, SDB, and NDI at pre-school age in former extremely premature infants based on physiologic waveforms and clinical characteristics in the neonatal intensive care unit. To achieve this goal this time-sensitive proposal leverages the population, research structure and expertise, and analytic resources developed for the nhlbi-funded pre-VENT collaboration.

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Original award $1,485,619 $0
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Subawards

Subrecipient Amount Awarded
Case Western Reserve University Case Western Reserve University’s role will be one of four clinical sites enrolling participants and collecting clinical data. Anna Maria Hibbs, MD, MSCE,… $1,333,232
The Washington University Despite improved survival of extremely premature infants, NICU graduates are diagnosed with asthma, sleep disordered breathing (SDB), and neurodevelopmental… $102,437
Rector & Visitors Of The University Of Virginia Collaborators of the “Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program” have proposed a… $685,470
University Of Miami Collaborators of the “Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program” have proposed a… $943,006
Rhode Island Hospital Dr. Phyllis Dennery will chair the steering committee for this project. She will attend meetings as needed, throughout the 5 year period of the grant. $68,963
University Of Alabama At Birmingham Collaborators of the “Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program” have proposed a… $1,047,511
Case Western Reserve University Collaborators of the “Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program” have proposed a… $346,183
University Of Alabama At Birmingham Collaborators of the “Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program” have proposed a… $936,136
University Of Miami Collaborators of the “Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program” have proposed a… $943,006
University Of Miami Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age $302,454
Case Western Reserve University $318,943
Rector & Visitors Of The University Of Virginia $113,433
Rhode Island Hospital Dr. Phyllis Dennery will chair the steering committee for this project. She will attend meetings as needed, throughout the 5 year period of the grant. $52,733
Rhode Island Hospital Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age $15,130
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Quick answers

Who received award R01HL157256?

R01HL157256 was awarded to ANN & Robert H Lurie Childrens Hospital Of Chicago by National Heart Lung and Blood Institute (National Institutes of Health) on December 15, 2021.

How much is award R01HL157256 worth?

$23,449,724 has been obligated on R01HL157256: $20,594,908 in federal funding and $2,854,816 in non-federal funding.

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