ADAPT Contract Research Organization Support Services
Closed Solicitation Posted
This opportunity was awarded. See the award notice from .
- Solicitation number
- 75N992-25-SN-104
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Place of performance
- Washington, District of Columbia 20005, United States
- Points of contact
Notice details come from SAM.gov. Updated .
About this opportunity
The Advanced Research Projects Agency for Health (ARPA-H) is seeking a Contract Research Organization (CRO) to support the ADvanced Analysis for Precision Therapy (ADAPT) program, a groundbreaking clinical research initiative focused on improving cancer treatment strategies. The solicitation, issued by the Department of Health and Human Services National Institutes of Health, requires a contractor to manage complex clinical trial data, conduct advanced biological specimen testing, and support regulatory submissions across breast, colon, and lung cancer research. Evaluation criteria will include past performance, assay testing verification, narrative responses, and pricing, with factors B and C (assay testing and narrative responses) considered more important than price. Key proposal deadlines include a questions submission deadline of April 3, 2025, and a proposal submission deadline of April 21, 2025 at 10:00 AM ET. The government will assess proposals using a comprehensive rating scale ranging from "Outstanding" to "Unacceptable" across multiple technical and performance dimensions.
The contract is set aside for small businesses with no more than 1,000 employees in the Research and Development in Physical, Engineering, and Life Sciences industry (NAICS 541715). The solicitation anticipates a single award contract with a five-year performance period from July 1, 2025 to June 30, 2030, covering a base year and four option years. The total project scope includes approximately 1,700 patients and up to 17,000 molecular and genetic tests, including whole exome and transcriptome sequencing, ctDNA sequencing, and optional cfMeDIP-seq assays. The contract will be structured as a hybrid Firm Fixed Price and Time and Materials arrangement, with an estimated total potential value that suggests significant investment in precision cancer research. Performance will occur in Washington, DC 20005, with the contractor responsible for managing serial clinical trial data, developing regulatory strategies for in vitro diagnostic tests, and supporting ARPA-H's interconnected technical areas focused on innovative cancer therapy research.
Notice text
4 versions
Update #4 · Latest ·
This is a combined synopsis/solicitation for commercial products or commercial services prepared in accordance with the format in subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.
The Advanced Research Projects Agency for Health (ARPA-H) is providing the formal Request for Proposals (RFP) for the ADvanced Analysis for Precision Therapy (ADAPT) Contact Research Organization (CRO) Support Services Requirement. ARPA-H anticipates a single award contract resulting from this announcement.
Please review the solicitation thoroughly and in its entirety. All necessary information to submit a proposal is included in the RFP and its attachments.
Questions Due Date: April 3, 2025 1:00PM ET
Proposals Due Date: April 21, 2025 10:00AM ET
Amendment 0001 provided on 03/28/2025.
Amendment 0002 provided on 04/07/2025. Amendment 0002 extends the proposal submission deadline to 1:00PM ET on April 18, 2025. This amendment does not include responses to the question period. Responses to the question period will be posted via amendment at a later date.
Amendment 0003 provided on 04/15/2025. Amendment 0003 extends the proposal submission deadline to 10:00AM ET on April 21, 2025. This amendment incorporates responses to the question period into the solicitation. All changes to the documentation are highlighted in the Conformed Copy in red text.
Update #3 ·
This is a combined synopsis/solicitation for commercial products or commercial services prepared in accordance with the format in subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.
The Advanced Research Projects Agency for Health (ARPA-H) is providing the formal Request for Proposals (RFP) for the ADvanced Analysis for Precision Therapy (ADAPT) Contact Research Organization (CRO) Support Services Requirement. ARPA-H anticipates a single award contract resulting from this announcement.
Please review the solicitation thoroughly and in its entirety. All necessary information to submit a proposal is included in the RFP and its attachments.
Questions Due Date: April 3, 2025 1:00 ET
Proposals Due Date: April 18, 2025 1:00 ET
Amendment 0001 provided on 03/28/2025.
Amendment 0002 provided on 04/07/2025. Amendment 0002 extends the proposal submission deadline to 1:00PM ET on April 18, 2025. This amendment does not include responses to the question period. Responses to the question period will be posted via amendment at a later date.
Update #2 ·
This is a combined synopsis/solicitation for commercial products or commercial services prepared in accordance with the format in subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.
The Advanced Research Projects Agency for Health (ARPA-H) is providing the formal Request for Proposals (RFP) for the ADvanced Analysis for Precision Therapy (ADAPT) Contact Research Organization (CRO) Support Services Requirement. ARPA-H anticipates a single award contract resulting from this announcement.
Please review the solicitation thoroughly and in its entirety. All necessary information to submit a proposal is included in the RFP and its attachments.
Questions Due Date: April 3, 2025 1:00 ET
Proposals Due Date: April 11, 2025 1:00 ET
Amendment 0001 provided on 03/28/2025.
Update #1 ·
This is a combined synopsis/solicitation for commercial products or commercial services prepared in accordance with the format in subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.
The Advanced Research Projects Agency for Health (ARPA-H) is providing the formal Request for Proposals (RFP) for the ADvanced Analysis for Precision Therapy (ADAPT) Contact Research Organization (CRO) Support Services Requirement. ARPA-H anticipates a single award contract resulting from this announcement.
Please review the solicitation thoroughly and in its entirety. All necessary information to submit a proposal is included in the RFP and its attachments.
Questions Due Date: April 3, 2025 1:00 ET
Proposals Due Date: April 11, 2025 1:00 ET
Files
| File | Type | Posted |
|---|---|---|
| A23 75N99225R00005 AMD 0003.pdf | ||
| A23 Attachment 2a Assay Testing Requirements.xlsx | XLSX spreadsheet | |
| A23 Attachment 1 Price Template.xlsx | XLSX spreadsheet | |
| A23 75N99225R00005 Conformed 041525.pdf | ||
| A23 Attachment 2 Assay Testing Worksheet.xlsx | XLSX spreadsheet | |
| A24 Q_A Consolidated List 75N99225R00005 FINAL.xlsx | XLSX spreadsheet | |
| A23 75N99225R00005 AMD 0002.pdf | ||
| A23 75N99225R00005 Conformed 040725.pdf | ||
| A23 Attachment ARPA-H-MAI-24-01-03 AMD 02.pdf | ||
| A23 75N99225R00005 AMD 0001.pdf | ||
| A23 75N99225R00005 Conformed AMD 0001 032825.pdf | ||
| A23 Attachment 3 HHS Subcontracting Plan Template.docx | DOCX document | |
| A23 Attachment 2 Assay Testing Worksheet.xlsx | XLSX spreadsheet | |
| A23 75N99225R00002 Final.pdf | ||
| A23 Attachment 2a Assay Testing Requirements.xlsx | XLSX spreadsheet | |
| A23 Attachment 1 Price Template.xlsx | XLSX spreadsheet |
Show all 16
Notice history
| Notice | Type | Posted |
|---|---|---|
| ADAPT Contract Research Organization Support Services | Award Notice | |
| This notice | Solicitation | |
| ADAPT Contract Research Organization Support Services | Special Notice |
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