Attachment 3A SaRPS Grant Coding Booklet_4_17_19_formatted.pdf

Attachment 3A Grant Categorization Tags

LOOKUP_NAME LOOKUP_VALUE

SECTION 1 -----> Approach, Exposures, and Outcomes

Focus Focus

Environmental Matrix (Non-Biomedical Focus)

Human Health (Biomedical Focus)

Science Type Science Type

Data Science

Human Health (Biomedical)

--Basic in vitro (e.g. cell culture; biochemistry)

--Basic in vivo (model organisms)

--Epidemiological / Clinical

--Statistical Approaches

Environmental Matrix (Non-Biomedical)

--Modeling (e.g. Pollutant Modeling)

--Laboratory / Bench scale

--In situ (field studies)

Social Sciences

Education/ Training

Environmental Exposure Agent Environmental Exposure Agent

EA: Other

EA: Not Relevant

EA: Relevant but Not Specified

Air Pollutants

--Acrolein

--CO / CO2

--E-cigarettes

--NO / NO2

--Ozone

--PAHs (Air) incl BaP

--Particulates (incl diesel)

--Sulfur oxides

--Tobacco smoke

--Traffic pollutants

--VOCs

Allergens

--Cockroach allergen

--Dust mite allergen

--Food-based

--Mold

--Pollen

Asbestos

Brominated Compounds

--MTBE

--PBDEs

Chemical Weapons

Chlorinated Compounds

--Carbon tetrachloride

--Dioxins

--Furans

--Hexachlorobenzene

--MPTP

--PCBs

--PCE

--PCNs

--Perchlorates

--TCE

--Triclosan

Chlorine Gas

DNA Damaging Agent

--Alkylating agents

--Methylating agents

--Mutagens

Disinfection By-Products

ENM

--Carbon nanotubes

--Nanometals

--Silica

Extreme Weather / Climate Change

Flame Retardants

Fluorinated Compounds

--PFCs

--PFOA

--PFOS

Herbicides / Fungicides

--2,4-D

--Atrazine

--Glyphosate (RoundUp)

--Maneb / Mancozeb

--Paraquat

--Vinclozolin

Hormonal Mimics / Hormones

--Androgen

--BADGE

--BPA

--DES

--Dexamethasone

--Estradiol / Estrogen

--Genistein / Phytoestrogens

Please note that the "Other" code is used to specifiy information not available in the database. If the Other tag is selected, then the term will be written in. If a write‐in item occurs more than 5 times, DERT will consider adding the term as a new option in the coding system.

--Nonylphenol

--Other EDCs

--Phthalates

--Steroids

Infectious Agents

--Aflatoxin

--Bacteria

--LPS / Endotoxin

--Other bacterial toxins

--Red tide, domoic acid

--Virus

Iodated Compounds

--Methyl Iodide

Ionizing Radiation

--Radioactive substances

--Radon

--Uranium

Metals

--Arsenic

--Cadmium

--Chromium

--Cobalt

--Copper

--Lead

--Manganese

--Mercury

--Nickel

--Zinc

Multi-Agent: Mixtures

Multi-Agent: POPs

NAPLs

--DNAPLs

--LNAPLs

Non-Ionizing Radiation

--UV

--UVA

--UVB

Nonspecific Nano

Nutrition / Diet

--High fat diet

--PUFAs

Organotins

--Tributyltin

--Triphenyltin

Other Hydrocarbons

--PAHs (all media) incl BaP

Other Organic Compounds

--Acetone

--BPDE

--Benzene / Ethylbenzene

--Formaldehyde

--Nitro Compounds / Nitrosamines

--Phenol

--Toluene/Xylene

--n-Hexane

Pesticides

--Carbamates

--Chlorinated pesticides

--Organophosphates (incl dichlorvos)

--Other pesticides

--Pyrethroids

--Rotenoids (Rotenone)

Pharmaceuticals

--Anti-inflammatories / NSAIDS

--Anti-oxidants

--Chemotherapeutics

--Glucocorticoids

--Immunosuppressants

Physical Activity Level

Physical, Non-Chemical Stress

--Hypoxia

--Oxidative stress

--Reactive nitrogen species

Psychosocial Stress

Supplements

--Fish oil

--Resveratrol

--Selenium

--Vitamin E

Tox21 Panel Health Outcome Relevant Health Outcome/Disease Endpoint

HO: Other HO: Not Relevant

HO: Relevant but Not Specified

Birth Outcomes

--Birth defects

--Birthweight

--Gestational age

--Head circumference

Cancer Outcomes

--Bone cancer

--Brain cancer

--Breast cancers

--Childhood cancer

--Colon cancer

--Kidney cancer

--Leukemia/Lymphoma

--Liver cancer

--Lung cancer

--Ovarian cancer

--Pancreatic cancer

--Prostate cancer

--Skin cancer

--Testicular cancer Cardiovascular Outcomes

--Atherosclerosis

--Blood disease

--Cardiovascular disease

--Cardiovascular malformations

--Coronary artery disease

--Hypertension

--Stroke Gastrointestinal Outcomes

--Diarrhea

--Irritable bowel syndrome Immune Outcomes

--Allergic response

--Autoimmune

--Immune response to infection

--Immunosuppression

--Immunotoxicity

--Infectious disease / infection

--Other immune condition

--Vaccine response Kidney Outcomes

--Chronic kidney disease

--Renal toxicity Liver Outcomes

Mechanistic Studies

--AhR signaling

--Carcinogenesis

--Cytochrome P450

--DNA damage/ repair / replication

--Endocrine

--Epigenetics

--Inflammation

--Mitochondrial dysfunction

--Oxidative stress Metabolic Outcomes

--Diabetes

--Metabolic syndrome

--Nutrient deficiency

--Obesity / aberrant body weight Microbiome Outcomes

Morbidity / Mortality

Musculoskeletal Outcomes

--Bone disease (non-cancer)

--Muscle disorders

--Neuromuscular / Motor function

--Osteoporosis Neurological / Cognitive Outcomes

--ADHD

--ALS

--Alzheimer's

--Autism spectrum disorder

--Autonomic nervous system functions

--Dementia

--Huntington's disease

--Mental health / psychiatric disorders

--Neurobehavioral outcomes

--Neurodegeneration outcomes

--Neurodevelopmental outcomes

--Neuroinflammation

--Neurotoxicity

--Parkinson's

--Seizures Reproductive Outcomes

--Endometriosis

--Fertility

--Fibroids

--Polycystic ovarian syndrome

--Premature / delayed menopause

--Premature / delayed puberty

--Sexuality Respiratory Outcomes

--Acute lung injury/illness

--Airway inflammation / Hyperresponsiveness

--Asthma

--Chronic obstructive pulmonary disease (COPD)

--Decreased lung capacity

--Lung Fibrosis / Emphysema

--Lung inflammation

--Other respiratory condition

--Pulmonary edema Skin Outcomes

--Contact dermatitis

--Eczema

--Lesions

--Pigmentation outcomes

--Psoriasis

--Xeroderma pigmentosum Thyroid Dysfunction

Toxicity/Toxicology

SECTION 2 -----> Research Subject Information Organism Organism

OG: Other

OG: Relevant, but not specified

OG: Not Relevant

Amphibian

--African clawed frog: Xenopus laevis

Bird

--Chicken: Gallus gallus

Crustacean

--Daphnia: Daphnia pulex

Fish

--Killifish

--Zebrafish: Danio rerio

Genetically Modified Organism

--Genetically modified cells / cell lines

--Knockout (write in genes)

--Other genetic modifications

--Transgenic (write in genes)

Human (Whole Organism)

Human Cells

--Human established cell lines

--Human primary cells

--Human stem cells (includes ES cells)

Invertebrate

--Fly: Drosophila melanogaster

--Fly: Drosophila pseudoobscura

--Worm: Caenorhabditis elegans

Non-Human Cells

--Non-human established cell lines

--Non-human primary cells

--Non-319:320human stem cells (ES cells)

Other mammal

--Monkey / rhesus monkey / macaque

--Pig

--Rabbit

--Sheep

Population-based models/models of genetic diversity

--Collaborative Cross (CC)

--Diversity Outbred (DO)

--Drosophila Genetics Reference Panel (DGRP)

--Hybrid Mouse Diversity Panel (HMDP)

--Other

--Rat Hybrid Diversity Panel (RHDP)

Prokaryote

--Bacteria: Escherichia coli

Rodent

--Golden Hamster: Mesocricetus auratus

--Guinea Pig: Cavia porcellus

--Mouse: Mus musculus

--Rat: Rattus norvegius

Unicellular Eukaryote

--Yeast: Saccharomyces cerevisiae

--Yeast: Schizosaccharomyces pombe Gender Gender

GN: Other

GN: Not Relevant

Male

Female

Ambiguous / Hermaphrodite Secondary Subject Secondary Subject

SS: Other

SS: Not Relevant

Mother

Father

Twin - Identical

Twin - Fraternal

Sibling Lifestage Exposure Lifestage at Exposure

LE: Other

LE: Not Relevant

LE: Relevant but Not Specified

Prenatal / Pre-Conception Exposure

--Pre-conception exposure

--Prenatal exposure

Infant (0-1 year) Exposure

--Neonatal (0-4 weeks) exposure

--Newborn (1-3 months) exposure

--Infancy (4-12 months) exposure

Youth (1-18 years) Exposure

--Toddler (>1-3 years) exposure

--Childhood (4-12 years) exposure

--Adolescence (12-18 years) exposure

Adulthood (18 years +) Exposure

--Adult age 18-44 years

--Middle aged adult 45-64 years

--Older adult 65+ years

Adulthood (Father)

Adulthood (Mother)

Non-human Exposure

--Neonate

--Juvenile

--Adult

--Prenatal Lifestage Assessment Lifestage at Assessment

LA: Other

LA: Not Relevant

LA: Relevant but Not Specified

Prenatal / Pre-Conception Assessment

--Pre-conception assessment

--Prenatal assessment

Infant (0-1 year) Assessment

--Infancy (4-12 months) assessment

--Neonatal (0-4 weeks) assessment

--Newborn (1-3 months) assessment

Youth (1-18 years) Assessment

--Adolescence (12-18 years) assessment

--Childhood (4-12 years) assessment

--Toddler (>1-3 years) assessment

Adulthood (18 years +) Assessment

--Adult Age 18-44 years

--Middle Aged Adult 45-64 yr

--Older Adult 65+ yrs

Adulthood (Father)

Adulthood (Mother)

Transgenerational Assessment

Non-human Assessment

--Adult Non-human

--Juvenile Non-human

--Neonate Non-human

--Prenatal Non-human Biological Route Biological Route (Passive or Applied)

BR: Other

BR: Not Relevant

BR: Relevant but Not Specified

Dermal/Implant

Full Body Exposure

Immersion

Ingestion / Gavage

Inhalation --Intranasal

Injection --Intracranial

--Intradermal

--Intramuscular

--Intraperitoneal

--Intratracheal

--Intravenous

--Subcutaneous

Ocular Biological Sample Biological Sample Collected/Tested

BS: Other

BS: Not Relevant

BS: Relevant but Not Specified

Amniotic Fluid

Blood

Breast Milk

Collected Cells

--*From established cell line

--*From primary cells

Cord Blood

Fingernails / Toenails

Hair

Maternal Biosample

--*Blood

--*Hair

--*Other

--*Plasma

--*Saliva/buccal Cells

--*Serum

--*Subject-derived Cells/Tissues/Organs

--*Urine

Paternal Biosample

--*Blood

--*Hair

--*Other

--*Plasma

--*Saliva/buccal Cells

--*Serum

--*Subject-derived Cells/Tissues/Organs

--*Urine

Placenta

Plasma

Saliva / Buccal Cells

Semen

Serum

Subject-Derived Cells / Tissues / Organs

--*Brain

--*Fetal tissue

--*Liver

--*Lung / airway

Subject-Derived IPS Cells

Urine Other Sample Other Types of Collected Information and Measurements

CI: Other

CI: Not Relevant

CI: Relevant but Not Specified

Behavioral / Cognitive Tests

Diary (e.g., Food; Activities)

General Diagnostics / Medical Exam (e.g., Weight; Blood Pressure)

Questionnaire / Survey / Interview

Specific Diagnostics / Physiological Function (e.g., Lung; Heart)

SECTION 3 -----> Epidemiological or Environmental Information Exposure Source Source of Environmental Exposure

EE: Other (write in)

EE: Not Relevant

EE: Relevant but Not Specified

Abatement / Clean Up

--Asbestos abatement

--Lead abatement

--Mold clean up

--Nuclear power plant clean up / shut down Agricultural

--Fertilizer

--Herbicide

--Pesticide / insecticide Geological Resource Recovery

--Drilling

--Hydraulic fracturing

--Mining Household

--Basic materials

--Cooking fuel

--Cookstoves

--Flame retardants in furniture (also check Furniture)

--Furniture/Appliances

--Heating fuel

--Household cleaning products

--Household electronics

--Household pesticide

--Plumbing materials

--Refrigerant Industrial

--Chemical / pharmaceutical manufacturing

--Electronics manufacturing

--General manufacturing

--Metallurgy Marine

--Fish farming

--Marine drilling

--Shipping Medical

--Drugs and drug by-products

--Medical waste Methamphetamine Production

Military

--General operations

--Weapons manufacture / testing / storage Municipal

--Power plants

--Waste disposal

--Water treatment Naturally Occurring

--Bedrock

--Biological organisms

--Sunlight Occupational (write in occupation; also check other sources)

Oil / Fuel Spill

--Leaking underground storage tank (LUST)

--Oil tankers

--Pipelines Personal

--Clothing and jewelry

--Cookware

--Diet/Food additives

--Flame retardants in clothing (also check Clothing)

--Food containers, packaging, and storage

--Personal care products

--Personal electronics

--Tobacco products Traffic (Air Pollution)

Exposure Carrier Primary Contamination Carrier of Environmental Exposure

PC: Other (write in)

PC: Not Relevant

PC: Relevant but Not Specified

Air

--Indoor

--Outdoor Dust

Food

Sediment

Soil

Water (Drinking)

--Drinking water reservoir

--Municipally provided water / public well

--Private well Water (Non-Drinking)

--Groundwater

--Lake/Pond

--Ocean

--Other body of water (e.g., drainage pond)

--Pore water

--River Environmental Sample Environmental Sample Collected/Tested

ES: Other

ES: Not Relevant

ES: Relevant but Not Specified

Air Sample

--Indoor sample

--Outdoor sample Dust Sample

Food Sample

Sediment Sample

Soil Sample

Water (Drinking) Sample

--Drinking water reservoir sample

--Municipally provided / public water

--Private well sample Water (Non-Drinking) Sample

--Groundwater

--Lake / Pond sample

--Ocean sample

--Other body of water sample

--Pore water sample

--River sample

SECTION 4 -----> Environmental Approach Environmental Approach Environmental Approach

EN: Other

EN: Not Relevant

EN: Relevant, but Not Specified

Chemical Analysis

--Analytical chemistry

--Biochemistry

--Electrochemical processes

--Non-targeted chemical analysis

--Targeted chemical analysis

Ecology

--Bioaccumulation

--Ecosystem toxicity

--Ecosystem-level indicators

Engineering

--Bioengineering

--Biosensor device

--Chemosensor device

--Environmental monitoring device

--Filtration device

--Materials science

--Personal monitoring device

--Remediation device

--Remote sensor device

--Sampling device

Fate / Transport / Monitoring

--Atmospheric modeling

--Citizen Science / community-based monitoring

--Pollutant modeling

--Pollutant tracking / monitoring

--Spatio-temporal analysis

Geosciences

--Bio-geochemical interactions

--Geochemistry

--Geology

--Hydrogeology

Mechanistic Environmental Approaches

--Biological mechanisms

--Pollutant degradation / transformation

--Role of organisms studied

Remediation Approaches

--Bioremediation

--Capping / containment

--Chemical remediation

--Electrochemical remediation

--Nano-enabled remediation

--Physical remediation

--Phytoremediation / phytostabilization

--Solar / green technology

--Sorbents

--Thermal remediation

SECTION 5 -----> Study Specifics Bioavailability For Studies that Focus on Bioavailability

BV: Other

BV: Not Relevant

BV: Relevant but Not Specified

Environmental Bioavailability

Media / Receptor Interface

Within Receptor

Dose For Studies that Focus on Dose

RD: Other

RD: Not Relevant

RD: Relevant but Not Specified

Altered Dose Response Based on Window of Exposure

Below-Threshold Dose

Dose Response

Low-Dose

Physiologically or Environmentally Relevant Dose

Experimental Approach Experimental Approach: Key Mechanism, Assays, Technologies, and infrastructure

EX: Other

EX: Not Relevant

EX: Relevant, but Not Specified

*Biological Sample Collected

Analysis of gene expression (transcripts / regulatory RNA)

Analysis of gene structure (sequence / adducts / mods)

Biochemistry techniques

-- Mass Spectrometry

-- Protein binding / activity

Biomarkers /Biomonitoring

--Biol response biomarker

--Biomarker of effect

--Biomarker of exposure

--Biomarker of susceptibility

--Candidate biomarker

--Chem metabolite biomarker

--Identify new biomarker

--Known biomarker

--Primary chemical biomarker

--Validate biomarker Cell-based assays

Cellular Processes Analysis

Chemical Analysis (fate / transport / remediation)

Data Science

--Analysis /modeling methodologies

--Data Integration

--Data algorithm development

--Data mining

--Data repository development/management

--Data/metadata standards development

--Machine learning

--Other

--Tool development

--Vocabulary/ontology development Environmental sampling / detection

-- Biosensors

-- Nano-enhanced sensors

-- Other sensors

-- Remote sensors

-- Sampling technology Geographic information (GIS, GPS)

Global / bioinformatic approaches

-- Epigenomics

-- Genomics

-- Metabolomics

-- Microarrays / global gene expression

-- Microbiomics

-- Proteomics Green Chemistry

High-throughput screening / robotics

Imaging / microscopy

Immunoassays

In silico

Metal Speciation

Monitoring Devices (biomonitoring)

Monitoring devices (environment)

Monitoring devices (personal)

Nano Tools

New methods

Population Study

-- Case-Control

-- Longitudinal

-- New cohort

-- New data from previous cohort; new subcohort

-- Randomized Control Trial

-- Uses existing cohort; no new data collected Prevention/Intervention

Remediation Technologies

Risk assessment

Signaling pathways

-- AHR signaling

-- Cytochrome P450

-- Endocrine disruption

-- Other signal transduction pathways

-- Reactive oxidative species / oxidative stress Statistical and analytical approaches

Structural Analysis

-- Computational modeling

-- Cryo EM

-- NMR

-- X-ray diffraction Systems Biology

Windows of Susceptibility

Cohort Cohort

Other

Not Relevant

Relevant but Not Specified

A Study to Understand the Mechanisms of Asthma Dietary Interventions to Protect Against Environmental Triggers (Asthma-DIET) ALS and the Microbiome

Adult Lung Health Study (ALHS)

Agricultural Health Study (AHS)/Farming and Movement Evaluation (FAME) study

Air Pollution Biomarkers and CVD in Los Angeles and Beijing

Air Pollution and COPD Patients in Boston

Air Pollution and Childhood Cancers (APCC) registry study

Air Pollution and Hypertension

Air pollution and tuberculosis in Vietnam

Airborne Exposures to Persistent Organic Pollutants (AESOP)

Alberta Pregnancy Outcomes and Nutrition (APrON)

Allergic Airway Intervention

Arsenic Exposure and Mortality: Northern Chile

Arsenic Health Risk Assessment and Molecular Epidemiology (ASHRAM)

Arsenic and Neural Tube Defects in Bangladesh

Autism Regression

BCERP: Cohort Study of Young Girls' Nutrition, Environment, and Transitions (CYGNET)

BCERP: Growing Up Female

BCERP: Growing Up Healthy

BPA Exposure and Risk of Gestational Diabetes

Baltimore Mobility Program Study

Bangladesh Vitamin E and Selenium Trial (BEST)

Bedford VA Altzheimer's case control

Beijing Olympics 2008 Cohort

Beijing Truck Driver Air Pollution Study

Biomarkers of Exposure to Arsenic (BEAR)

Black Women's Health Study (BWHS)

Bogalusa Heart Study (BHS)

CERCH: Seveso Women’s Health Study (SWHS)

COPD and Domestic Endotoxin (CODE)

California Prenatal Screening Program (previously known as the "Expanded Alphafetoprotein (AFP) Program" California Teacher's Study (CTS)

California Twin Sun Case Study

Cancer Screening Program (CSP) cohort

Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE)

Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS)

Chicago Health and Aging Project

Childhood Autism Risks from Genetics and Environment (CHARGE)

Children with in utero Arsenic Exposure: Bangladesh

Children's Health and Air Pollution Study in the San Joaquin Valley (CHAPS-SJV)

Chronic Beryllium Disease (CBD) cohort

Chronic Kidney Disease in Children (CKiD)

Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)

Cincinnati Lead Study (CLS)

Coal Ash and Child Neurobehavior in Kentucky

Cohort of Benzene-Exposed Workers

Columbia Center for Children's Environmental Health: Mothers and Newborns in China

Columbia Center for Children's Environmental Health: Mothers and Newborns in Poland

Controlled Air Pollution Exposure Study

Cooking and Pneumonia Study (CAPS)

DNA Repair in Head and Neck Cancer

DWH: Women and Their Children's Health (WaTCH)

Danish Medical Birth Registry

Danish National Birth Cohort (DNBC)

Deep Water Horizon: Gulf Resilience on Women's Health

Deep Water Horizon: The Gulf Long-term Follow-up Study

Diabetes Prevention Program Outcomes Study (DPPOS)

Disease Investigation Through Specialized Clinically-Oriented Ventures in Environmental Research (DISCOVER) - Baltimore

ELEMENT

Early Autism Risk Longitudinal Investigation (EARLI)

Early Markers for Autism (EMA) Study

Egyptian Agricultural Workers

Environment and Reproductive Health (EARTH) Study

Environment, genetics and epigenetics in a R.I. Birth Cohort

Environmental Control Therapy for Children with Asthma

Epigenetics, Traffic Related Air Pollution, and Neonatal Health in Southern California

Faroe Islands Cohort: Adults Prenatally Exposed to Diabetic Pollutants

Faroe Islands Cohort: Immunotoxicants in Children

Faroe Islands Cohort: Immunotoxicity with Lifetime Exposure to PFCs

Fluorosis in the Main Ethiopian Rift Valley

Folic Acid and Creatine Trial

Folic Acid and Creatine Trial

Fresno Asthmatic Children's Environmental Study (FACES)

GEStation Thyroid and Environment

Gene-Environment Interaction in Prostate Cancer (GECAP)

Gene-environments and Admixture in Latino Asthmatics (GALA 2)

Generation R

Genetics of Asthma in Latino Americans (GALA I)

Ghana Cookstove Study

Great Lakes Fish Consumption and PCB Exposure

Growth and Obesity Cohort Study (GOCS)

Gulf Coast Health Alliance: Health Risks related to the Macondo Spill (GC-HARMS)

Gutenberg Health Study (GHS)

Harvard Cooperative Program on Aging

Harvard Epigenetic Birth Cohort (HEBC)

Health Effects of Arsenic Longitudinal Study (HEALS)

Health Outcomes and Measures of the Environment (HOME) Study

Health Professionals Follow-up Study (HPFS)

Healthy Start Birth Cohort

Home Observation of Periconceptional Exposures (HOPE) Study

Home-Based Asthma Support and Education for Adults (HomeBase)

Honduran Families Using Cookstoves

Hospital-Based Phthalate Exposure in Very Low Birth Weight Infants (HBPE)

Hydraulic Fracturing and Quality of Life

Illinois Kids Development Study

Infantes y Salud Ambiental (or Infants' Environmental Health Study)

International Study of Asthma and Allergies in Childhood (ISAAC)

LA Family and Neighborhood Survey

LifeCodes

Long Island Breast Cancer Study Projects (LIBCSP)

Long Island WTC Responders cohort

Manganese and Neurological Outcomes in South Africa

Marietta Community Actively Researching Exposure Study (CARES)

Markers of Autism Risk in Babies-Learning Early Signs (MARBLES)

Maternal Residential Proximity to Shale Gas Extraction and Pregnancy Outcomes

Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) - Childhood Obesity Study Memory and Aging Project (MAP)

Metal mixtures in Montevideo Children

Metropolitan Study of Chemicals and Pregnancy Health (The Parent Study)

Mexico City Air Pollution and Birth Outcomes

Mexico City Childhood Asthma Study (MCCAS)

Michigan PBB Cohort

Mother-Offspring Neurodevelopment Cohort in Wanshan, China

Mountain Air Project (MAP)

Multi-Ethnic Study of Atherosclerosis (MESA)

Mycotoxin Biomarkers and Childrens Health in Africa

NYC Air Pollution and Pregnancy Outcomes Cohort

National Birth Defects Prevention Study

National Farmworker Clinical Research Database

National Health and Nutrition Examination Surveys (NHANES) Continuous

National Health and Nutrition Examination Surveys (NHANES) Hispanic: 1982-1984

National Health and Nutrition Examination Surveys (NHANES) I: 1971-1974

National Health and Nutrition Examination Surveys (NHANES) II: 1976-1980

National Health and Nutrition Examination Surveys (NHANES) III: 1988-1994

Native American Wood Stove Study

Navajo Birth Cohort Study

Navajo Uranium Assessment and Kidney Health Project (NUAKHP)

New Bedford Cohort

New England Children's Amalgam Trial (NECAT)

New York City Mothers & Newborns Study

Newborn Epigenetics Study Cohort (NEST)

Northern California Childhood Leukemia Study (NCCLS)

Norwegian Mother and Child Cohort Study (MoBa)

Nurses' Health Studies (NHS) I

Nurses' Health Studies (NHS) II

Nurses' Health Studies (NHS) III

Parkinson's Disease, Environment, and Genes (PEG)

Parkinsonism and Metal Exposures Among Welders

Parkinsonism in Welders

Particulate Reduction Education in City Homes (PREACH)

Pediatric Brain Imaging Project

Pediatric Imaging, Neurocognition, and Genetics (PING)

Peru Two Cities Asthma Study

Pesticide Exposure and Cerebral Palsy

Pesticide Exposure and Childhood Autism

Pesticide Exposure in Yakima Valley

Philadelphia Neurodevelopment Cohort (PNC)

Pregnancy Infection and Nutrition (PIN) cohort

Pregnancy to Early Life Longitudinal data system (PELL)

Prenatal Endocrine Disruption and Social Stress

Prenatal Environmental Determinants of InterGenerational Risk (PEDIGREE)

Prenatal Exposure to BPA/Phthalates: Infant Physical and Behavioral Development

Prenatal PCEs in New Bedford

Prental Exposures and the Fetal Brain (Detroit)

Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST)

Programming Research in Environment and Social Stressors (PROGRESS)

Programming of Intergenerational Stress Mechanisms (PRISM)

Project VIVA cohort

Promoting Activity and Changes in Eating (PACE)

Public Health Impact of Mixed element Exposure in susceptible populations

Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) Cohort

Reasons for Geographic and Racial Differences in Stroke Study (REGARDS)

Residents of Ambler, PA exposed to asbestos

Risk Factors for Antisocial Behavior (RFAB) Study

Russian Children's Study

Rwandan Cookstove Study

SPIROMICS - Air Pollution Study

Sacramento Area Latino Study on Aging Cohort

Sanitation Hygiene Infant Nutrition Efficacy (SHINE)

School Inner City Asthma Study (SICAS)

Seafood Choice in Asian Communities

Secondary Pesticide Exposure on Children and Adolescents

Seveso Women’s Health Study Follow Up

Seychelles Child Development and Nutrition Study (SCDNS)

Shanghai Textile Worker Study (STWS)

Sister Study

Southern Center on Environmentally Driven Disparities in Birth Outcomes (SCEDDBO)

Sperm Environmental Epigenetics and Deveelopment Study (SEEDS)

Stockholm Youth Cohort (SYC)

Strong Heart Family Study (SHFS)

Strong Heart Water Study

Study of African Americans, Asthma, Genes and Environments (SAGE I)

Study of African Americans, Asthma, Genes and Environments (SAGE II)

Study of Environment Lifestyle and Fibroids

Study of Metals and Assisted Reproductive Technologies

Study of Traffic, Air Quality and Respiratory health (STAR)

Swedish Twin Study

The C8 (PFOA) Health Project: Neurobehavioral Development

The C8 (PFOA) Health Project: Reproductive Health

The C8 (PFOA) Health Project: Study of Exposure Response

The Chihuahua Cohort

The Child Health and Development Studies Cohort (CHDS)

The Children's Health Study (CHS)

The Infant Development and Environment Study (TIDES)

The New Hampshire Birth Cohort Study

The Normative Aging Study (NAS)

The San Francisco Bay Area Lung Cancer Study

The San Francisco Bay Area Lung Cancer Study

The Treatment of Lead-Exposed Children (TLC) Trial

US West Coast Childhood Brain Tumors (WCCBT) Study

University of Washington Twin Registry

Venda Health Examination of Mothers, Babies, and Their Environment

Washington State Pesticide Handlers

Wayne County Health, Environment, Allergy and Disease: Asthma Longitudinal Study (WHEALS)

Woburn Childhood Leukemia Follow-Up Study

Women's Health Initiative (WHI)

Women's Health Study (WHS) Harvard

Women's Risk of Endometriosis (WREN) study

World Trade Center Pregnancy Cohort

Cohort Focus Cohort Focus

Cohort Details Provided

Cohort Relationship Cohort Relationship

GC: Not Relevant

GC: Relevant But Not Specified

New Cohort

New Information

New Analysis Only

Data Only

Broader Applications Broader Applications of research

BA: Other

BA: Not Relevant

Anticipated Commercial Use

Social / Behavioral

Translational - Policy

Translational - Therapeutics/Diagnostics

Chromatin/Epigenetics Chromatin/Epigenetics

CE: Other

CE: Not Relevant

CE: Relevant but Not Specified

Chromatin Remodeling

DNA Methylation

Histone Marks

--Acetylation [Archive]

--Methylation [Archive]

--Ubiquitination [Archive] RNA Regulation / Metabolism

Transgenerational Modifications

SECTION 6 -----> Training Activities Training Level Training Level

TL: Other

TL: Not Relevant

TL: Relevant but Not Specified

High School

Undergraduate

Post-Baccalaureate

Masters

PhD (Pre-Doctoral)

Postdoctoral Trainees

Current Investigator

--Junior investigators

--Mid-career investigators

Medical Students

Dual Degree Student: MD / PhD or DVM / PhD

Practicing Medical Professionals

Occupational / Employees

Science Teachers

Target Populations Target Populations

TP: Other

TP: Not Relevant

TP: Relevant but Not Specified

Under-Represented Ethnic/Racial Group

Low SES Groups

Women

Required by Grant

Trainee Activities Trainee Activities

TA: Other

TA: Not Relevant

TA: Relevant but Not Specified

Capacity Building

Continuing Education

Coursework

EHS Career Exploration

Formal Certification

Interdisciplinary/Cross-Disciplinary Training

International Training

Mentorship

Outside the Lab

--Community outreach

--Educational outreach

--Field experiences

--Field trips

--Patient-oriented activities

--Training exercises / simulations

Professional / Career Development

Projects / Presentations

Research / Lab Rotations

Responsible Conduct of Research / Ethics

Science Communication

Seminar / Journal Clubs

Teacher Training

Train-the-Trainer

Worker Training

Suppport Duration Duration of Support

SD: Other

SD: Not Relevant

SD: Relevant but Not Specified

1-5 Months

6 Months -12 Months

1-3 Years

4+ Years

SECTION 7 -----> Administrative and Program Information Site Specific Study Site-specific Study

Within US

Outside US

Both Within and Outside US

ST: Not Relevant

Knowledge Management Knowledge Management

KM: Not Relevant

KM: Other

Data Sharing

--Other cohort (write in name)

--Other data source (write in source)

--Sharing data and using shared data

Large-scale Data Collection Effort

--Animal model data

--Environmental Data

--Epidemiological data

--Epigenomic Data

--Exposure/biomonitoring/biomarker data

--Genomic Data

--Imaging data

--Other Data

--Other clinical data

--Proteomic and protein sequence/structure data

--RNA/transcriptome gene expression data

--Social and demographic data

Specimen / Sample Sharing

--Biological samples

--Model organisms

Social Science Social Science Issues

SI: Other

SI: Not Relevant

Border / Immigrant Communities

Community Engagement

--Community education

--Community web tools

--Community-based participatory research

--Partnerships with federal / state / local / tribal representatives

--Partnerships with schools / teachers / museums

--Research translation

--Risk communication

Community Resilience

Community-Based Prevention / Interventions

ELSI (Ethical Legal Social Issues)

Economics / Cost Benefit

Environmental Justice

Policy and Health

Social Determinants of Health

--Built environment and health

Vulnerable Populations / Health Disparities

--Gender based

--Low-income / low-SES populations

--Native populations

--Racial / ethnic minorities

--Rural populations

--Urban populations

Landmark Program Landmark Program

LP: Not Relevant

LP: Autism Research

LP: Bisphenol A (BPA) Research Program

LP: Climate Change

LP: DNA Repair Research

LP: DOHaD

LP: Environmental Epigenetics

LP: Exposure Biology Research Program

LP: Global Environmental Health

LP: Gulf Oil

LP: Nanotechnology

LP: Oceans / Human Health

LP: PEPH

LP: Worker Training / Occupations

MDB: Inflammation for Sri

MDB: Superfund with Children's Health

^LP: Breast Cancer & the Environment Research Program

^LP: Centers for Neurodegeneration Science

^LP: Children's Env Health Centers (Centers Grants Only)

^LP: Core Centers

^LP: Outstanding New Environmental Scientist Award (ONES)

^LP: Superfund Research Program

^LP: Training (T grants only)

^LP: WTP

Scientific Focus Group Scientific Focus Group assignment

SFG: Not Relevant

SFG Recommendation Made (do not use, add all checks here)

AhR / Cytochrome P450

Air Pollution SFG

Autism SFG

Breast Cancer SFG

Cancer and the Environment SFG

Cardiovascular Health

Children's Environmental Health SFG

Climate Change SFG

DNA Repair SFG

DOHAD SFG

Deep Water Horizon SFG

Endocrine Disruptors/BPA SFG

Endocrine Disruptors/Gen SFG

Epigenetics (CCT)

Epigenetics/Epigenomics SFG

Exposome (CCT)

Exposure Biology SFG

Global Environmental Health (CCT)

GxE SFG

Health Disparities (CCT)

Immunology/Microbiome SFG

Inflammation (CCT)

Knowledge Management and e-Science (CCT)

Metabolic Disorders SFG

Mitochondrial Dysfunction

Nanotechnology/Nanotoxicology SFG

Neurodegeneration SFG

Neurodevelopment SFG

Nutrition SFG

Oceans/Human Health SFG

Oxidative Stress

Predictive Toxicology and Disease (CCT)

Reproductive Health: Female SFG

Reproductive Health: Male SFG

Resistance and Susceptibility

Stem Cells (CCT)

Training SFG

Website and Social Media (CCT)

^Children's Environmental Health Centers SFG

^Core Centers SFG

^SBIR/STTR SFG

please use LP: ^Superfund SFG

Strategic Plan Themes Relevant Themes: NIEHS Strategic Plan (primary, secondary, and special mention)

Theme 1: Fundamental Research

Theme 2: Exposure Research

Theme 3: Translational Science

Theme 4: Health Disparities and GEH

Theme 5: Training and Education

Theme 6: Communications and Engagement

Subproject has no relevant theme

Cross-cutting theme: Knowledge Management

Strategic Plan Goals Relevant NIEHS Strategic Plan Goals and Subgoals (primary, secondary, and special mention)

1. Fundamental mechanisms

--1a. Effects on genome structure / function

--1b. Effects on epigenetic program

--1c. ID mechanisms of resistance vs. susceptibility

--1d. Development and aging

--1e. Integrate HTS, cell system, and/or model organisms

2. Individual susceptibility

--2a. ID critical windows of susceptibility

--2b. Deepen understanding of dose-response relationships

--2c. Study factors that determine individual susceptibility

3. Exposure science

--3a. Improve exposure assessment - populations and individuals

--3b. Exposome - define and communicate the concept

--3c. Create tools and technologies to characterize the exposome

4. Combined environmental exposures

--4a. Assess joint actions of multiple environmental insults on toxicity and disease

--4b. Study role of microbiome in response to environmental agents

--4c. Study interactions of infectious agents combined with environmental exposures

--4d. Assess role of non-chemical exposures and ID possible preventative measures

5. Emerging health threats

--5a. Use EHS data to elucidate information, determine public health approach

--5b. Cooperate with public health partners

--5c. Focus on research needs to inform policy

6. Health disparities

--6a. Conduct community based, culturally aware, participatory research

--6b. Conduct research and education on ELSI

--6c. Develop, implement interventions to reduce exposures for affected populations

7. Knowledge management

--7a. Develop bioinformatics, biostatistics, and data integration tools

--7b. Develop publicly available (Web) resources / tools for integration / analysis of data

8. Teaching, education, and training

--8a. Educate all to improve health decisions

--8b. Leadership, partnership, strategies, and mechanisms to promote EHS education

--8c. Develop training programs (students; postdocs; teachers; foreign students)

--8d. Foster EHS training to medical education (health care professionals)

9. Training new research scientists

--9a. Foster cross-disciplinary training - esp. informatics / engineering / behavioral

--9b. Recruit from other disciplines to diversify skill sets

--9c. Consider full career trajectory of scientist and provide opportunities

--9d. Promote integration of EHS into medical training, doctors and nurses

--9e. Build EHS research capacity in countries with biggest EH problems

--9f. Increase diversity within training programs

10. Minimize economic impacts

--10a. Train in EH Economics to evaluate cost / benefits of exposures, interventions

--10b. Measure econ benefits of NIEHS investments

--10c. Assist policymakers with state-of-science assessments

11. Bidirectional communication

--11a. Public image - promote NIEHS as trusted source

--11b. Identify and expand stakeholder community and enhance engagement

--11c. Build and lead long-term partnerships with federal and nonfederal groups

--11d. Research in effective communication

--11e. Develop integrated, searchable knowledge base of EH information

Admin and support

--No Subgoal