Attachment 007 Batch 3 SDSs.pdf
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About this file
This document is a Safety Data Sheet (SDS) for Sodium Chlorite, a chemical product manufactured by MilliporeSigma. The SDS provides comprehensive technical and safety information about the substance, including its chemical properties, potential hazards, and handling guidelines.
Sodium Chlorite (CAS No. 7758-19-2) is classified as a highly hazardous substance with multiple serious risk categories, including being an oxidizing solid, acutely toxic (oral and dermal), corrosive to skin, and very toxic to aquatic life. The product is a white powder with a molecular formula of ClNaO2 and a molecular weight of 90.44 g/mol. Safety precautions include avoiding contact with skin and eyes, preventing dust formation, using appropriate personal protective equipment, and ensuring proper ventilation when handling. In case of exposure, immediate medical attention is recommended, with specific first aid instructions provided for different types of contact (inhalation, skin, eye, ingestion).
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SIGALD - 244155
The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada
SAFETY DATA SHEET
Version 6.4 Revision Date 02/25/2021
Print Date 01/13/2024
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers
Product name : Sodium chlorite
Product Number : 244155
Brand : SIGALD
CAS-No. : 7758-19-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Synthesis of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Inc.
3050 SPRUCE ST
ST. LOUIS MO 63103
UNITED STATES
Telephone : +1 314 771-5765
Fax : +1 800 325-5052
1.4 Emergency telephone
Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-
527-3887 CHEMTREC (International) 24
Hours/day; 7 Days/week
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Oxidizing solids (Category 1), H271
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Dermal (Category 2), H310
Skin corrosion (Category 1B), H314
Serious eye damage (Category 1), H318
Specific target organ toxicity - repeated exposure (Category 2), spleen, H373
Short-term (acute) aquatic hazard (Category 1), H400
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 GHS Label elements, including precautionary statements
Pictogram
Signal word Danger
Hazard statement(s)
H271 May cause fire or explosion; strong oxidizer.
H302 Harmful if swallowed.
H310 Fatal in contact with skin.
H314 Causes severe skin burns and eye damage.
H373 May cause damage to organs (spleen) through prolonged or repeated exposure.
H400 Very toxic to aquatic life.
Precautionary statement(s)
P210 Keep away from heat.
P220 Keep/Store away from clothing/ combustible materials.
P221 Take any precaution to avoid mixing with combustibles.
P260 Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P283 Wear fire/ flame resistant/ retardant clothing.
P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P350 + P310 IF ON SKIN: Gently wash with plenty of soap and water.
Immediately call a POISON CENTER or doctor/ physician.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor.
P305 + P351 + P338 +
P310
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.
P306 + P360 IF ON CLOTHING: rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P314 Get medical advice/ attention if you feel unwell.
P362 Take off contaminated clothing and wash before reuse.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P371 + P380 + P375 In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
2.3 Hazards not otherwise classified (HNOC) or not covered by GHS
Contact with acids liberates very toxic gas., Corrosive to the respiratory tract.
SECTION 3: Composition/information on ingredients
3.1 Substances
Formula : ClNaO2
Molecular weight : 90.44 g/mol
CAS-No. : 7758-19-2
Component Classification Concentration sodium chlorite
Ox. Sol. 1; Acute Tox. 3;
Acute Tox. 2; Skin Corr.
1B; Eye Dam. 1; STOT RE
2; Aquatic Acute 1; H271, H301, H310, H314, H318, H373, H400
>= 70 - < 90 sodium carbonate
Eye Irrit. 2A; H319 >= 1 - < 5 %
For the full text of the H-Statements mentioned in this Section, see Section 16.
SECTION 4: First aid measures
4.1 Description of first-aid measures
General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.Continue rinsing eyes during transport to hospital.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Dry powder Dry sand
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Hydrogen chloride gas
Sodium oxides
Carbon oxides
Hydrogen chloride gas
Sodium oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas.
Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Sweep up and shovel. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Do not flush with water. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs.Advice on safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Advice on protection against fire and explosion
Provide appropriate exhaust ventilation at places where dust is formed.Keep away from sources of ignition - No smoking.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place.
Never allow product to get in contact with water during storage. Do not store near acids.
Keep in a dry place.
Storage class (TRGS 510): 5.1A: Strongly oxidizing hazardous materials
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN
(EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: powder
Color: white
b) Odor No data available
c) Odor Threshold No data available
d) pH 10.0 - 11.0 at 100 g/l at 20 °C (68 °F)
e) Melting point/freezing point
No data available
f) Initial boiling point and boiling range
No data available
g) Flash point ()Not applicable
h) Evaporation rate No data available
i) Flammability (solid, gas)
No data available
j) Upper/lower flammability or explosive limits
Lower explosion limit: 7 %(V)
k) Vapor pressure No data available
l) Vapor density No data available
m) Relative density 2.432 at 20 °C (68 °F) - OECD Test Guideline 109
n) Water solubility 545 g/l at 20 °C (68 °F) - OECD Test Guideline 105
o) Partition coefficient:
n-octanol/water log Pow: < -2.7
p) Autoignition temperature
q) Decomposition No data available temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties The substance or mixture is classified as oxidizing with the category 1.
9.2 Other safety information
SECTION 10: Stability and reactivity
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong reducing agents, Powdered metals, Phosphorus, Sulfur compounds, Zinc, Ammonia, Organic materials, acids, Amines
10.6 Hazardous decomposition products
In the event of fire: see section 5
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
No data available
Inhalation: No data available
Dermal: No data available
No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
11.2 Additional Information
RTECS: VZ4800000
SECTION 12: Ecological information
12.1 Toxicity
No data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
Very toxic to aquatic life.
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product
Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable.
Contaminated packaging
Dispose of as unused product.
SECTION 14: Transport information
DOT (US)
UN number: 1496 Class: 5.1 Packing group: II
Proper shipping name: Sodium chlorite
Reportable Quantity (RQ):
Poison Inhalation Hazard: No
IMDG
UN number: 1496 Class: 5.1 Packing group: II EMS-No: F-
H, S-Q
Proper shipping name: SODIUM CHLORITE
Marine pollutant : yes
IATA
UN number: 1496 Class: 5.1 Packing group: II
Proper shipping name: Sodium chlorite
SECTION 15: Regulatory information
SARA 302 Components
This material does not contain any components with a section 302 EHS TPQ.
SARA 313 Components
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section
313.
SARA 311/312 Hazards
Reactivity Hazard, Acute Health Hazard
Massachusetts Right To Know Components
No components are subject to the Massachusetts Right to Know Act.
SECTION 16: Other information
Further information
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
The branding on the header and/or footer of this document may temporarily not visually match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered. For further information please contact mlsbranding@sial.com.
Version: 6.4 Revision Date: 02/25/2021 Print Date: 01/13/2024
Sigma - R5886
Version 6.8 Revision Date 05/05/2025
Print Date 05/06/2025
SECTION 1. IDENTIFICATION
Product name : RPMI-1640 Medium
Product Number : R5886
Brand : Sigma
Uses advised against : The product is being supplied under the TSCA R&D Exemption
(40 CFR Section 720.36). It is the recipient’s responsibility to comply with the requirements of the R&D exemption. The product may not be used for a non-exempt commercial purpose under TSCA unless appropriate consent is granted in writing by
MilliporeSigma.
3050 SPRUCE ST
ST. LOUIS MO 63103
UNITED STATES
Telephone : +1 314 771-5765
Fax : +1 800 325-5052
1.4 Emergency telephone
Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-
527-3887 CHEMTREC (International) 24
Hours/day; 7 Days/week
SECTION 2. HAZARDS IDENTIFICATION
GHS classification in accordance with the OSHA Hazard Communication Standard
(29 CFR 1910.1200)
Not a hazardous substance or mixture.
Other hazards
None known.
GHS label elements
Not a hazardous substance or mixture.
SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance / Mixture
: Mixture
Components
No hazardous ingredients
SECTION 4. FIRST AID MEASURES
If inhaled
: After inhalation: fresh air.
In case of skin contact
: In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
: After eye contact: rinse out with plenty of water.
Remove contact lenses.
If swallowed
: After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
Most important symptoms and effects, both acute and delayed
: The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
Protection of first-aiders
: For personal protection see section 8.
Notes to physician
: No data available
SECTION 5. FIRE-FIGHTING MEASURES
Suitable extinguishing media
: Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable extinguishing
: For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
: Not combustible.
Ambient fire may liberate hazardous vapours.
Hazardous combustion : Carbon oxides products
Sodium oxides
Nitrogen oxides (NOx)
Sulfur oxides
Hazardous combustion
Carbon oxides
Specific extinguishing methods
: Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
: In the event of fire, wear self-contained breathing apparatus.
SECTION 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
: Advice for non-emergency personnel:
Do not breathe vapors, aerosols.
Evacuate the danger area, observe emergency procedures, consult an expert.
Advice for emergency responders:
For personal protection see section 8.
Environmental precautions
: Do not let product enter drains.
Methods and materials for containment and cleaning up
: Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up with liquid-absorbent material (e.g.
Chemizorb® ). Dispose of properly. Clean up affected area.
SECTION 7. HANDLING AND STORAGE
For precautions see section 2.2.
Further information on storage conditions
: Tightly closed.
Storage class
: 12, Non Combustible Liquids
Recommended storage
: 36 - 46 °F / 2 - 8 °C
SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Ingredients with workplace control parameters
Contains no substances with occupational exposure limit values.
Engineering measures : No data available
Personal protective equipment
Respiratory protection
: Not required; except in case of aerosol formation.
Hand protection
Remarks
: not required
Eye protection
: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
: Change contaminated clothing. Wash hands after working with substance.
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
: liquid
Color
Odor
Odor Threshold : No data available pH
Melting point
Boiling point/boiling range
Flash point
: Not applicable
Evaporation rate
Flammability (solid, gas)
Flammability (liquids)
: The product is not flammable.
Burning rate
Self-ignition : Not applicable
Upper explosion limit /
Upper flammability limit
Lower explosion limit /
Lower flammability limit
Vapor pressure
Relative vapor density
Relative density
Density
Solubility(ies)
Water solubility
: soluble (68 °F / 20 °C)
Partition coefficient: n-octanol/water
Autoignition temperature
Decomposition
Viscosity, dynamic
Viscosity, kinematic
Flow time
Explosive properties
: Not classified as explosive.
Oxidizing properties
: none
Particle characteristics
Particle size
SECTION 10. STABILITY AND REACTIVITY
Reactivity
Chemical stability
: The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
: Violent reactions possible with:
The generally known reaction partners of water.
Conditions to avoid
: no information available
Incompatible materials : Strong oxidizing agents
Hazardous decomposition
: In the event of fire: see section 5
SECTION 11. TOXICOLOGICAL INFORMATION
Mixture
Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately.
SECTION 12. ECOLOGICAL INFORMATION
Ecotoxicity
No data available
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Other adverse effects
No data available
SECTION 13. DISPOSAL CONSIDERATIONS
Disposal methods
Waste from residues : Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
SECTION 14. TRANSPORT INFORMATION
International Regulations
IATA-DGR
Not regulated as a dangerous good
IMDG-Code
Not regulated as a dangerous good
Transport in bulk according to IMO instruments
Not applicable for product as supplied.
National regulation
49 CFR Road
Not regulated as a dangerous good
Poison Inhalation Hazard : No
Special precautions for user
Remarks : Not classified as dangerous in the meaning of transport regulations.
SECTION 15. REGULATORY INFORMATION
CERCLA Reportable Quantity
This material does not contain any components with a CERCLA RQ.
SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.
SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.
SARA 311/312
Hazards
: No SARA Hazards
SARA 313
: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by
SARA Title III, Section 313.
US State Regulations
Massachusetts Right To Know
No components are subject to the Massachusetts Right to Know Act.
Massachusetts Right To Know water 7732-18-5
Pennsylvania Right To Know water 7732-18-5
Maine Chemicals of High Concern water 7732-18-5
Vermont Chemicals of High Concern water 7732-18-5
Washington Chemicals of High Concern water 7732-18-5
New Jersey Right To Know water 7732-18-5
RPMI-1640 high glucose Not Assigned
The ingredients of this product are reported in the following inventories:
TSCA
: Product contains substance(s) not listed on TSCA inventory.
TSCA list
No substances are subject to a Significant New Use Rule.
No substances are subject to TSCA 12(b) export notification requirements.
SECTION 16. OTHER INFORMATION
Full text of other abbreviations
AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for the Testing of Materials; bw - Body weight; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN -
Standard of the German Institute for Standardisation; DOT - Department of Transportation;
DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response;
EHS - Extremely Hazardous Substance; ELx - Loading rate associated with x% response;
EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; ERG - Emergency Response Guide;
GHS - Globally Harmonized System; GLP - Good Laboratory Practice; HMIS - Hazardous
Materials Identification System; IARC - International Agency for Research on Cancer; IATA -
International Air Transport Association; IBC - International Code for the Construction and
Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing
Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO -
International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO -
International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory;
LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; MSHA - Mine Safety and Health Administration; n.o.s. - Not
Otherwise Specified; NFPA - National Fire Protection Association; NO(A)EC - No Observed
(Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No
Observable Effect Loading Rate; NTP - National Toxicology Program; NZIoC - New Zealand
Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development;
OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and
Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; RCRA -
Resource Conservation and Recovery Act; REACH - Regulation (EC) No 1907/2006 of the
European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RQ - Reportable Quantity; SADT - Self-
Accelerating Decomposition Temperature; SARA - Superfund Amendments and
Reauthorization Act; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory;
TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United
States); UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative
The information is believed to be correct but is not exhaustive and will be used solely as a guideline, which is based on current knowledge of the chemical substance or mixture and is applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
Revision Date : 05/05/2025 match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered.
For further information please contact mlsbranding@sial.com.
US / EN
Aldrich - 137502
Version 6.10 Revision Date 04/24/2025
Print Date 04/25/2025
Product name : Sodium 2-bromoethanesulfonate
Product Number : 137502
Brand : Aldrich
CAS-No. : 4263-52-9 comply with the requirements of the R&D exemption. The product may not be used for a non-exempt commercial purpose
3050 SPRUCE ST
ST. LOUIS MO 63103
UNITED STATES
Telephone : +1 314 771-5765
Fax : +1 800 325-5052
1.4 Emergency telephone
Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-
527-3887 CHEMTREC (International) 24
Hours/day; 7 Days/week
SECTION 2. HAZARDS IDENTIFICATION
GHS classification in accordance with the OSHA Hazard Communication Standard
(29 CFR 1910.1200)
Not a hazardous substance or mixture.
: Substance
: Carbon oxides
Sulfur oxides
Hydrogen bromide gas
Sodium oxides
: Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating
Avoid inhalation of dusts.
Evacuate the danger area, observe emergency procedures, consult an expert.
and 10).
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Dry.
: 13, Non Combustible Solids
: Recommended storage temperature see product label.
Ingredients with workplace control parameters
: required when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN
EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type:
: Filter type P1
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Material : Nitrile rubber
Break through time : 480 min
Glove thickness : 0.11 mm
Protective index : Full contact
Manufacturer : Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Glove thickness : 0.11 mm
Protective index : Splash contact
Manufacturer : Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Manufacturer : data source: KCL GmbH, D-36124 Eichenzell, phone
+49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
: powder
: white
: 2.48 - 2.74 (68 °F / 20 °C)
Concentration: 454 g/l
Melting point/ range
: 541 °F / 283 °C
Method: dec.
: Decomposes below the boiling point.
Method: Test N.1: Test method for readily combustible solids
GLP: yes
Self-ignition : Method: Relative self-ignition temperature for solids does not ignite
: < 0.1 hPa (68 °F / 20 °C)
Method: OECD Test Guideline 104
: 2.2327 g/cm3 (68 °F / 20 °C)
Method: OECD Test Guideline 109
: 454 g/l (68 °F / 20 °C)
Method: OECD Test Guideline 105
: log Pow: -3.26 (68 °F / 20 °C)
Method: OECD Test Guideline 107
Bioaccumulation is not expected.
: > 500 °F / > 260 °C
Molecular weight
: 211.01 g/mol
Acute toxicity
Acute toxicity estimate Oral - 2,500 mg/kg
(Calculation method)
LD50 Oral - Rat - female - > 2,000 mg/kg
(OECD Test Guideline 423)
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Skin - reconstructed human epidermis (RhE)
Result: No skin irritation - 42 min
(OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes - Bovine cornea
Result: No eye irritation - 4 h
(OECD Test Guideline 437)
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Hazardous properties cannot be excluded.
Handle in accordance with good industrial hygiene and safety practice.
No data available
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Other adverse effects
No data available
SECTION 13. DISPOSAL CONSIDERATIONS
Disposal methods
Waste from residues : Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other
IATA-DGR
Not regulated as a dangerous good
IMDG-Code
Not regulated as a dangerous good
Transport in bulk according to IMO instruments
Not applicable for product as supplied.
National regulation
This material does not contain any components with a CERCLA RQ.
SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.
SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.
: No SARA Hazards
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know
Sodium 2-bromoethanesulphonate 4263-52-9
Maine Chemicals of High Concern
Product does not contain any listed chemicals
Vermont Chemicals of High Concern
Product does not contain any listed chemicals
Washington Chemicals of High Concern
Product does not contain any listed chemicals
California Prop. 65
This product does not contain any chemicals known to the State of California to cause cancer, birth, or any other reproductive defects.
: On TSCA Inventory
Compensation, and Liability Act; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN -
Standard of the German Institute for Standardisation; DOT - Department of Transportation;
DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response;
EHS - Extremely Hazardous Substance; ELx - Loading rate associated with x% response;
EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; ERG - Emergency Response Guide;
GHS - Globally Harmonized System; GLP - Good Laboratory Practice; HMIS - Hazardous
Materials Identification System; IARC - International Agency for Research on Cancer; IATA -
International Air Transport Association; IBC - International Code for the Construction and
Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing
Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO -
International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO -
International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory;
LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; MSHA - Mine Safety and Health Administration; n.o.s. - Not
Otherwise Specified; NFPA - National Fire Protection Association; NO(A)EC - No Observed
(Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No
Observable Effect Loading Rate; NTP - National Toxicology Program; NZIoC - New Zealand
Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development;
OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and
Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; RCRA -
Resource Conservation and Recovery Act; REACH - Regulation (EC) No 1907/2006 of the
European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RQ - Reportable Quantity; SADT - Self-
Accelerating Decomposition Temperature; SARA - Superfund Amendments and
Reauthorization Act; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory;
TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Revision Date : 04/24/2025
The branding on the header and/or footer of this document may temporarily not visually match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered. For further information please contact mlsbranding@sial.com.
Sigma - R3501
Revision Date 04/28/2025
Print Date 04/29/2025
Product name : Rifampicin
Product Number : R3501
Brand : Sigma
CAS-No. : 13292-46-1 comply with the requirements of the R&D exemption. The product may not be used for a non-exempt commercial purpose
3050 SPRUCE ST
ST. LOUIS MO 63103
UNITED STATES
Telephone : +1 314 771-5765
Fax : +1 800 325-5052
1.4 Emergency telephone
Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-
527-3887 CHEMTREC (International) 24
Hours/day; 7 Days/week
SECTION 2. HAZARDS IDENTIFICATION
GHS classification in accordance with the OSHA Hazard Communication Standard
(29 CFR 1910.1200)
Acute toxicity (Oral)
: Category 4
Hazard pictograms
Signal Word
: Warning
Hazard Statements
: H302 Harmful if swallowed.
Precautionary Statements
Prevention:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response:
P301 + P312 + P330 IF SWALLOWED: Call a POISON
CENTER/ doctor if you feel unwell. Rinse mouth.
Disposal:
P501 Dispose of contents/ container to an approved waste disposal plant.
: Substance
Chemical name CAS
No./Unique ID
Concentration (% w/w) Trade secret
Rifampicin 13292-46-1* >= 90 - <= 100 -
* Indicates that the identifier is a CAS No.
Actual concentration is withheld as a trade secret
General advice
: Show this material safety data sheet to the doctor in attendance.
: After swallowing: immediately make victim drink water (two glasses at most).
Consult a physician.
: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Water
Foam
Carbon dioxide (CO2)
Dry powder
For this substance/mixture no limitations of
: Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
: Carbon oxides
Nitrogen oxides (NOx)
: Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating
Avoid inhalation of dusts.
Avoid substance contact.
Ensure adequate ventilation.
Evacuate the danger area, observe emergency procedures, consult an expert.
and 10).
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Dry.
: 11, Combustible Solids
: -4 °F / -20 °C storage stability
: Product is sensitive to light and moisture.
Store under inert gas.
SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Ingredients with workplace control parameters
: required when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN
EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type:
: Filter type P2
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Break through time : 480 min
Glove thickness : 0.11 mm
Protective index : Full contact
Manufacturer : KCL 741 Dermatril® L
Glove thickness : 0.11 mm
Protective index : Splash contact
Manufacturer : KCL 741 Dermatril® L
: This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-
36124 Eichenzell, Internet: www.kcl.de).
Skin and body protection
: protective clothing
: Change contaminated clothing. Preventive skin protection recommended. Wash hands after working with substance.
: powder
: red
Melting point/ range
: 363 - 365 °F / 184 - 185 °C
: 822.94 g/mol
: The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Strong oxidizing agents
: Exposure to moisture.
Light.
no information available
Incompatible materials
Acute toxicity
Acute toxicity estimate Oral - 1,570.0 mg/kg
(Calculation method)
LD50 Oral - Rat - 1,570 mg/kg
Remarks: (RTECS)
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Remarks: No data available
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
RTECS: VJ7000000
Exposure to and/or consumption of alcohol may increase toxic effects.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
We have no description of any toxic symptoms.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Liver - Irregularities - Based on Human Evidence
Liver - Irregularities - Based on Human Evidence
No data available
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Other adverse effects
No data available
SECTION 13. DISPOSAL CONSIDERATIONS
Disposal methods
Waste from residues : Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other
IATA-DGR
Not regulated as a dangerous good
IMDG-Code
Not regulated as a dangerous good
Transport in bulk according to IMO instruments
Not applicable for product as supplied.
National regulation
This material does not contain any components with a CERCLA RQ.
SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.
SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.
: Acute Health Hazard
Chronic Health Hazard
No components are subject to the Massachusetts Right to Know Act.
Maine Chemicals of High Concern
Product does not contain any listed chemicals
Vermont Chemicals of High Concern
Product does not contain any listed chemicals
Washington Chemicals of High Concern
Product does not contain any listed chemicals
California Prop. 65
WARNING: This product can expose you to chemicals including Rifampicin, which is/are known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
: Product contains substance(s) not listed on TSCA inventory.
Compensation, and Liability Act; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN -
Standard of the German Institute for Standardisation; DOT - Department of Transportation;
DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response;
EHS - Extremely Hazardous Substance; ELx - Loading rate associated with x% response;
EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; ERG - Emergency Response Guide;
GHS - Globally Harmonized System; GLP - Good Laboratory Practice; HMIS - Hazardous
Materials Identification System; IARC - International Agency for Research on Cancer; IATA -
International Air Transport Association; IBC - International Code for the Construction and
Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing
Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO -
International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO -
International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory;
LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; MSHA - Mine Safety and Health Administration; n.o.s. - Not
Otherwise Specified; NFPA - National Fire Protection Association; NO(A)EC - No Observed
(Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No
Observable Effect Loading Rate; NTP - National Toxicology Program; NZIoC - New Zealand
Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development;
OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and
Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; RCRA -
Resource Conservation and Recovery Act; REACH - Regulation (EC) No 1907/2006 of the
European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RQ - Reportable Quantity; SADT - Self-
Accelerating Decomposition Temperature; SARA - Superfund Amendments and
Reauthorization Act; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory;
TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Revision Date : 04/28/2025 match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered.
For further information please contact mlsbranding@sial.com.
Creation Date 26-Jun-2014 Revision Date 28-Dec-2021 Revision Number 4
1. Identification Product Name Buffer Solution, pH 7.00, Color-Coded Yellow, Certified
Cat No. : AC611060000; AC611060040; AC611065000
Synonyms No information available
Recommended Use Laboratory chemicals.
Uses advised against Food, drug, pesticide or biocidal product use.
Details of the supplier of the safety data sheet
Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887
2. Hazard(s) identification Classification Classification under 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Label Elements None required
Hazards not otherwise classified (HNOC) None identified
3. Composition/Information on Ingredients
Company Fisher Scientific Company One Reagent Lane Fair Lawn, NJ 07410 Tel: (201) 796-7100
Acros Organics One Reagent Lane Fair Lawn, NJ 07410
This chemical is not considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Page 1 / 7
Buffer Solution, pH 7.00, Color-Coded Yellow, Certified Revision Date 28-Dec-2021
Component CAS No Weight % Water 7732-18-5 99.18
Dihydrogen potassium phosphate 7778-77-0 0.7
Sodium hydroxide 1310-73-2 0.1
FD&C yellow No. 5 1934-21-0 0.0 - 0.02
4. First-aid measures
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention if symptoms occur.
Skin Contact Rinse skin with water. Get medical attention if symptoms occur.
Inhalation Remove to fresh air. If breathing is difficult, give oxygen. Get medical attention if symptoms occur.
Ingestion Do NOT induce vomiting. Get medical attention if symptoms occur.
Most important symptoms and effects
No information available.
Notes…
This is the start of the file's text. The full file is on GovTribe.
File details come from the government source that posted it. Updated .