Attachment 007 Batch 3 SDSs.pdf

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This document is a Safety Data Sheet (SDS) for Sodium Chlorite, a chemical product manufactured by MilliporeSigma. The SDS provides comprehensive technical and safety information about the substance, including its chemical properties, potential hazards, and handling guidelines.

Sodium Chlorite (CAS No. 7758-19-2) is classified as a highly hazardous substance with multiple serious risk categories, including being an oxidizing solid, acutely toxic (oral and dermal), corrosive to skin, and very toxic to aquatic life. The product is a white powder with a molecular formula of ClNaO2 and a molecular weight of 90.44 g/mol. Safety precautions include avoiding contact with skin and eyes, preventing dust formation, using appropriate personal protective equipment, and ensuring proper ventilation when handling. In case of exposure, immediate medical attention is recommended, with specific first aid instructions provided for different types of contact (inhalation, skin, eye, ingestion).

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SIGALD - 244155

The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

Version 6.4 Revision Date 02/25/2021

Print Date 01/13/2024

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name : Sodium chlorite

Product Number : 244155

Brand : SIGALD

CAS-No. : 7758-19-2

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Synthesis of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Inc.

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Oxidizing solids (Category 1), H271

Acute toxicity, Oral (Category 4), H302

Acute toxicity, Dermal (Category 2), H310

Skin corrosion (Category 1B), H314

Serious eye damage (Category 1), H318

Specific target organ toxicity - repeated exposure (Category 2), spleen, H373

Short-term (acute) aquatic hazard (Category 1), H400

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 GHS Label elements, including precautionary statements

Pictogram

Signal word Danger

Hazard statement(s)

H271 May cause fire or explosion; strong oxidizer.

H302 Harmful if swallowed.

H310 Fatal in contact with skin.

H314 Causes severe skin burns and eye damage.

H373 May cause damage to organs (spleen) through prolonged or repeated exposure.

H400 Very toxic to aquatic life.

Precautionary statement(s)

P210 Keep away from heat.

P220 Keep/Store away from clothing/ combustible materials.

P221 Take any precaution to avoid mixing with combustibles.

P260 Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.

P262 Do not get in eyes, on skin, or on clothing.

P264 Wash skin thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

P283 Wear fire/ flame resistant/ retardant clothing.

P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.

P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302 + P350 + P310 IF ON SKIN: Gently wash with plenty of soap and water.

Immediately call a POISON CENTER or doctor/ physician.

P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.

P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor.

P305 + P351 + P338 +

P310

IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.

P306 + P360 IF ON CLOTHING: rinse immediately contaminated clothing and skin with plenty of water before removing clothes.

P314 Get medical advice/ attention if you feel unwell.

P362 Take off contaminated clothing and wash before reuse.

P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.

P371 + P380 + P375 In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.

P391 Collect spillage.

P405 Store locked up.

P501 Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS

Contact with acids liberates very toxic gas., Corrosive to the respiratory tract.

SECTION 3: Composition/information on ingredients

3.1 Substances

Formula : ClNaO2

Molecular weight : 90.44 g/mol

CAS-No. : 7758-19-2

Component Classification Concentration sodium chlorite

Ox. Sol. 1; Acute Tox. 3;

Acute Tox. 2; Skin Corr.

1B; Eye Dam. 1; STOT RE

2; Aquatic Acute 1; H271, H301, H310, H314, H318, H373, H400

>= 70 - < 90 sodium carbonate

Eye Irrit. 2A; H319 >= 1 - < 5 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.Move out of dangerous area.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration.

Consult a physician.

In case of skin contact

Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.Continue rinsing eyes during transport to hospital.

If swallowed

Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section

2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Dry powder Dry sand

5.2 Special hazards arising from the substance or mixture

Carbon oxides

Hydrogen chloride gas

Sodium oxides

Carbon oxides

Hydrogen chloride gas

Sodium oxides

5.3 Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas.

Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Sweep up and shovel. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Do not flush with water. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs.Advice on safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.

Advice on protection against fire and explosion

Provide appropriate exhaust ventilation at places where dust is formed.Keep away from sources of ignition - No smoking.

Hygiene measures

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place.

Never allow product to get in contact with water during storage. Do not store near acids.

Keep in a dry place.

Storage class (TRGS 510): 5.1A: Strongly oxidizing hazardous materials

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

Contains no substances with occupational exposure limit values.

8.2 Exposure controls

Appropriate engineering controls

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN

166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0.11 mm

Break through time: 480 min

Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

Splash contact

Material: Nitrile rubber

Minimum layer thickness: 0.11 mm

Break through time: 480 min

Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN

(EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: powder

Color: white

b) Odor No data available

c) Odor Threshold No data available

d) pH 10.0 - 11.0 at 100 g/l at 20 °C (68 °F)

e) Melting point/freezing point

No data available

f) Initial boiling point and boiling range

No data available

g) Flash point ()Not applicable

h) Evaporation rate No data available

i) Flammability (solid, gas)

No data available

j) Upper/lower flammability or explosive limits

Lower explosion limit: 7 %(V)

k) Vapor pressure No data available

l) Vapor density No data available

m) Relative density 2.432 at 20 °C (68 °F) - OECD Test Guideline 109

n) Water solubility 545 g/l at 20 °C (68 °F) - OECD Test Guideline 105

o) Partition coefficient:

n-octanol/water log Pow: < -2.7

p) Autoignition temperature

q) Decomposition No data available temperature

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties The substance or mixture is classified as oxidizing with the category 1.

9.2 Other safety information

SECTION 10: Stability and reactivity

10.1 Reactivity

No data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

No data available

10.4 Conditions to avoid

No data available

10.5 Incompatible materials

Strong reducing agents, Powdered metals, Phosphorus, Sulfur compounds, Zinc, Ammonia, Organic materials, acids, Amines

10.6 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

No data available

Inhalation: No data available

Dermal: No data available

No data available

Skin corrosion/irritation

No data available

Serious eye damage/eye irritation

No data available

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

11.2 Additional Information

RTECS: VZ4800000

SECTION 12: Ecological information

12.1 Toxicity

No data available

12.2 Persistence and degradability

No data available

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Other adverse effects

An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.

Very toxic to aquatic life.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product

Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

DOT (US)

UN number: 1496 Class: 5.1 Packing group: II

Proper shipping name: Sodium chlorite

Reportable Quantity (RQ):

Poison Inhalation Hazard: No

IMDG

UN number: 1496 Class: 5.1 Packing group: II EMS-No: F-

H, S-Q

Proper shipping name: SODIUM CHLORITE

Marine pollutant : yes

IATA

UN number: 1496 Class: 5.1 Packing group: II

Proper shipping name: Sodium chlorite

SECTION 15: Regulatory information

SARA 302 Components

This material does not contain any components with a section 302 EHS TPQ.

SARA 313 Components

This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section

313.

SARA 311/312 Hazards

Reactivity Hazard, Acute Health Hazard

Massachusetts Right To Know Components

No components are subject to the Massachusetts Right to Know Act.

SECTION 16: Other information

Further information

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

The branding on the header and/or footer of this document may temporarily not visually match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered. For further information please contact mlsbranding@sial.com.

Version: 6.4 Revision Date: 02/25/2021 Print Date: 01/13/2024

Sigma - R5886

Version 6.8 Revision Date 05/05/2025

Print Date 05/06/2025

SECTION 1. IDENTIFICATION

Product name : RPMI-1640 Medium

Product Number : R5886

Brand : Sigma

Uses advised against : The product is being supplied under the TSCA R&D Exemption

(40 CFR Section 720.36). It is the recipient’s responsibility to comply with the requirements of the R&D exemption. The product may not be used for a non-exempt commercial purpose under TSCA unless appropriate consent is granted in writing by

MilliporeSigma.

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2. HAZARDS IDENTIFICATION

GHS classification in accordance with the OSHA Hazard Communication Standard

(29 CFR 1910.1200)

Not a hazardous substance or mixture.

Other hazards

None known.

GHS label elements

Not a hazardous substance or mixture.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Substance / Mixture

: Mixture

Components

No hazardous ingredients

SECTION 4. FIRST AID MEASURES

If inhaled

: After inhalation: fresh air.

In case of skin contact

: In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.

In case of eye contact

: After eye contact: rinse out with plenty of water.

Remove contact lenses.

If swallowed

: After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.

Most important symptoms and effects, both acute and delayed

: The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Protection of first-aiders

: For personal protection see section 8.

Notes to physician

: No data available

SECTION 5. FIRE-FIGHTING MEASURES

Suitable extinguishing media

: Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable extinguishing

: For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards during fire fighting

: Not combustible.

Ambient fire may liberate hazardous vapours.

Hazardous combustion : Carbon oxides products

Sodium oxides

Nitrogen oxides (NOx)

Sulfur oxides

Hazardous combustion

Carbon oxides

Specific extinguishing methods

: Prevent fire extinguishing water from contaminating surface water or the ground water system.

Special protective equipment for fire-fighters

: In the event of fire, wear self-contained breathing apparatus.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

: Advice for non-emergency personnel:

Do not breathe vapors, aerosols.

Evacuate the danger area, observe emergency procedures, consult an expert.

Advice for emergency responders:

For personal protection see section 8.

Environmental precautions

: Do not let product enter drains.

Methods and materials for containment and cleaning up

: Cover drains. Collect, bind, and pump off spills.

Observe possible material restrictions (see sections 7 and 10).

Take up with liquid-absorbent material (e.g.

Chemizorb® ). Dispose of properly. Clean up affected area.

SECTION 7. HANDLING AND STORAGE

For precautions see section 2.2.

Further information on storage conditions

: Tightly closed.

Storage class

: 12, Non Combustible Liquids

Recommended storage

: 36 - 46 °F / 2 - 8 °C

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Ingredients with workplace control parameters

Contains no substances with occupational exposure limit values.

Engineering measures : No data available

Personal protective equipment

Respiratory protection

: Not required; except in case of aerosol formation.

Hand protection

Remarks

: not required

Eye protection

: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Safety glasses

: Change contaminated clothing. Wash hands after working with substance.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance

: liquid

Color

Odor

Odor Threshold : No data available pH

Melting point

Boiling point/boiling range

Flash point

: Not applicable

Evaporation rate

Flammability (solid, gas)

Flammability (liquids)

: The product is not flammable.

Burning rate

Self-ignition : Not applicable

Upper explosion limit /

Upper flammability limit

Lower explosion limit /

Lower flammability limit

Vapor pressure

Relative vapor density

Relative density

Density

Solubility(ies)

Water solubility

: soluble (68 °F / 20 °C)

Partition coefficient: n-octanol/water

Autoignition temperature

Decomposition

Viscosity, dynamic

Viscosity, kinematic

Flow time

Explosive properties

: Not classified as explosive.

Oxidizing properties

: none

Particle characteristics

Particle size

SECTION 10. STABILITY AND REACTIVITY

Reactivity

Chemical stability

: The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

: Violent reactions possible with:

The generally known reaction partners of water.

Conditions to avoid

: no information available

Incompatible materials : Strong oxidizing agents

Hazardous decomposition

: In the event of fire: see section 5

SECTION 11. TOXICOLOGICAL INFORMATION

Mixture

Acute toxicity

Oral: No data available

Inhalation: No data available

Dermal: No data available

Skin corrosion/irritation

No data available

Serious eye damage/eye irritation

No data available

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

11.2 Additional Information

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately.

SECTION 12. ECOLOGICAL INFORMATION

Ecotoxicity

No data available

Persistence and degradability

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Other adverse effects

No data available

SECTION 13. DISPOSAL CONSIDERATIONS

Disposal methods

Waste from residues : Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

SECTION 14. TRANSPORT INFORMATION

International Regulations

IATA-DGR

Not regulated as a dangerous good

IMDG-Code

Not regulated as a dangerous good

Transport in bulk according to IMO instruments

Not applicable for product as supplied.

National regulation

49 CFR Road

Not regulated as a dangerous good

Poison Inhalation Hazard : No

Special precautions for user

Remarks : Not classified as dangerous in the meaning of transport regulations.

SECTION 15. REGULATORY INFORMATION

CERCLA Reportable Quantity

This material does not contain any components with a CERCLA RQ.

SARA 304 Extremely Hazardous Substances Reportable Quantity

This material does not contain any components with a section 304 EHS RQ.

SARA 302 Extremely Hazardous Substances Threshold Planning Quantity

This material does not contain any components with a section 302 EHS TPQ.

SARA 311/312

Hazards

: No SARA Hazards

SARA 313

: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by

SARA Title III, Section 313.

US State Regulations

Massachusetts Right To Know

No components are subject to the Massachusetts Right to Know Act.

Massachusetts Right To Know water 7732-18-5

Pennsylvania Right To Know water 7732-18-5

Maine Chemicals of High Concern water 7732-18-5

Vermont Chemicals of High Concern water 7732-18-5

Washington Chemicals of High Concern water 7732-18-5

New Jersey Right To Know water 7732-18-5

RPMI-1640 high glucose Not Assigned

The ingredients of this product are reported in the following inventories:

TSCA

: Product contains substance(s) not listed on TSCA inventory.

TSCA list

No substances are subject to a Significant New Use Rule.

No substances are subject to TSCA 12(b) export notification requirements.

SECTION 16. OTHER INFORMATION

Full text of other abbreviations

AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for the Testing of Materials; bw - Body weight; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN -

Standard of the German Institute for Standardisation; DOT - Department of Transportation;

DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response;

EHS - Extremely Hazardous Substance; ELx - Loading rate associated with x% response;

EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -

Concentration associated with x% growth rate response; ERG - Emergency Response Guide;

GHS - Globally Harmonized System; GLP - Good Laboratory Practice; HMIS - Hazardous

Materials Identification System; IARC - International Agency for Research on Cancer; IATA -

International Air Transport Association; IBC - International Code for the Construction and

Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing

Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO -

International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO -

International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory;

LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; MSHA - Mine Safety and Health Administration; n.o.s. - Not

Otherwise Specified; NFPA - National Fire Protection Association; NO(A)EC - No Observed

(Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No

Observable Effect Loading Rate; NTP - National Toxicology Program; NZIoC - New Zealand

Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development;

OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and

Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; RCRA -

Resource Conservation and Recovery Act; REACH - Regulation (EC) No 1907/2006 of the

European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RQ - Reportable Quantity; SADT - Self-

Accelerating Decomposition Temperature; SARA - Superfund Amendments and

Reauthorization Act; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory;

TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United

States); UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

The information is believed to be correct but is not exhaustive and will be used solely as a guideline, which is based on current knowledge of the chemical substance or mixture and is applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.

Revision Date : 05/05/2025 match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered.

For further information please contact mlsbranding@sial.com.

US / EN

Aldrich - 137502

Version 6.10 Revision Date 04/24/2025

Print Date 04/25/2025

Product name : Sodium 2-bromoethanesulfonate

Product Number : 137502

Brand : Aldrich

CAS-No. : 4263-52-9 comply with the requirements of the R&D exemption. The product may not be used for a non-exempt commercial purpose

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2. HAZARDS IDENTIFICATION

GHS classification in accordance with the OSHA Hazard Communication Standard

(29 CFR 1910.1200)

Not a hazardous substance or mixture.

: Substance

: Carbon oxides

Sulfur oxides

Hydrogen bromide gas

Sodium oxides

: Suppress (knock down) gases/vapors/mists with a water spray jet.

Prevent fire extinguishing water from contaminating

Avoid inhalation of dusts.

Evacuate the danger area, observe emergency procedures, consult an expert.

and 10).

Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

Dry.

: 13, Non Combustible Solids

: Recommended storage temperature see product label.

Ingredients with workplace control parameters

: required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN

EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Recommended Filter type:

: Filter type P1

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Material : Nitrile rubber

Break through time : 480 min

Glove thickness : 0.11 mm

Protective index : Full contact

Manufacturer : Dermatril® (KCL 740 / Aldrich Z677272, Size M)

Glove thickness : 0.11 mm

Protective index : Splash contact

Manufacturer : Dermatril® (KCL 740 / Aldrich Z677272, Size M)

Manufacturer : data source: KCL GmbH, D-36124 Eichenzell, phone

+49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

: powder

: white

: 2.48 - 2.74 (68 °F / 20 °C)

Concentration: 454 g/l

Melting point/ range

: 541 °F / 283 °C

Method: dec.

: Decomposes below the boiling point.

Method: Test N.1: Test method for readily combustible solids

GLP: yes

Self-ignition : Method: Relative self-ignition temperature for solids does not ignite

: < 0.1 hPa (68 °F / 20 °C)

Method: OECD Test Guideline 104

: 2.2327 g/cm3 (68 °F / 20 °C)

Method: OECD Test Guideline 109

: 454 g/l (68 °F / 20 °C)

Method: OECD Test Guideline 105

: log Pow: -3.26 (68 °F / 20 °C)

Method: OECD Test Guideline 107

Bioaccumulation is not expected.

: > 500 °F / > 260 °C

Molecular weight

: 211.01 g/mol

Acute toxicity

Acute toxicity estimate Oral - 2,500 mg/kg

(Calculation method)

LD50 Oral - Rat - female - > 2,000 mg/kg

(OECD Test Guideline 423)

Inhalation: No data available

Dermal: No data available

Skin corrosion/irritation

Skin - reconstructed human epidermis (RhE)

Result: No skin irritation - 42 min

(OECD Test Guideline 439)

Serious eye damage/eye irritation

Eyes - Bovine cornea

Result: No eye irritation - 4 h

(OECD Test Guideline 437)

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

Test Type: Ames test

Test system: Escherichia coli/Salmonella typhimurium

Metabolic activation: with and without metabolic activation

Method: OECD Test Guideline 471

Result: negative

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

11.2 Additional Information

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Hazardous properties cannot be excluded.

Handle in accordance with good industrial hygiene and safety practice.

No data available

Persistence and degradability

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Other adverse effects

No data available

SECTION 13. DISPOSAL CONSIDERATIONS

Disposal methods

Waste from residues : Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other

IATA-DGR

Not regulated as a dangerous good

IMDG-Code

Not regulated as a dangerous good

Transport in bulk according to IMO instruments

Not applicable for product as supplied.

National regulation

This material does not contain any components with a CERCLA RQ.

SARA 304 Extremely Hazardous Substances Reportable Quantity

This material does not contain any components with a section 304 EHS RQ.

SARA 302 Extremely Hazardous Substances Threshold Planning Quantity

This material does not contain any components with a section 302 EHS TPQ.

: No SARA Hazards

No components are subject to the Massachusetts Right to Know Act.

Pennsylvania Right To Know

Sodium 2-bromoethanesulphonate 4263-52-9

Maine Chemicals of High Concern

Product does not contain any listed chemicals

Vermont Chemicals of High Concern

Product does not contain any listed chemicals

Washington Chemicals of High Concern

Product does not contain any listed chemicals

California Prop. 65

This product does not contain any chemicals known to the State of California to cause cancer, birth, or any other reproductive defects.

: On TSCA Inventory

Compensation, and Liability Act; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN -

Standard of the German Institute for Standardisation; DOT - Department of Transportation;

DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response;

EHS - Extremely Hazardous Substance; ELx - Loading rate associated with x% response;

EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -

Concentration associated with x% growth rate response; ERG - Emergency Response Guide;

GHS - Globally Harmonized System; GLP - Good Laboratory Practice; HMIS - Hazardous

Materials Identification System; IARC - International Agency for Research on Cancer; IATA -

International Air Transport Association; IBC - International Code for the Construction and

Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing

Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO -

International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO -

International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory;

LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; MSHA - Mine Safety and Health Administration; n.o.s. - Not

Otherwise Specified; NFPA - National Fire Protection Association; NO(A)EC - No Observed

(Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No

Observable Effect Loading Rate; NTP - National Toxicology Program; NZIoC - New Zealand

Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development;

OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and

Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; RCRA -

Resource Conservation and Recovery Act; REACH - Regulation (EC) No 1907/2006 of the

European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RQ - Reportable Quantity; SADT - Self-

Accelerating Decomposition Temperature; SARA - Superfund Amendments and

Reauthorization Act; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory;

TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Revision Date : 04/24/2025

The branding on the header and/or footer of this document may temporarily not visually match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered. For further information please contact mlsbranding@sial.com.

Sigma - R3501

Revision Date 04/28/2025

Print Date 04/29/2025

Product name : Rifampicin

Product Number : R3501

Brand : Sigma

CAS-No. : 13292-46-1 comply with the requirements of the R&D exemption. The product may not be used for a non-exempt commercial purpose

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2. HAZARDS IDENTIFICATION

GHS classification in accordance with the OSHA Hazard Communication Standard

(29 CFR 1910.1200)

Acute toxicity (Oral)

: Category 4

Hazard pictograms

Signal Word

: Warning

Hazard Statements

: H302 Harmful if swallowed.

Precautionary Statements

Prevention:

P264 Wash skin thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Response:

P301 + P312 + P330 IF SWALLOWED: Call a POISON

CENTER/ doctor if you feel unwell. Rinse mouth.

Disposal:

P501 Dispose of contents/ container to an approved waste disposal plant.

: Substance

Chemical name CAS

No./Unique ID

Concentration (% w/w) Trade secret

Rifampicin 13292-46-1* >= 90 - <= 100 -

* Indicates that the identifier is a CAS No.

Actual concentration is withheld as a trade secret

General advice

: Show this material safety data sheet to the doctor in attendance.

: After swallowing: immediately make victim drink water (two glasses at most).

Consult a physician.

: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Water

Foam

Carbon dioxide (CO2)

Dry powder

For this substance/mixture no limitations of

: Combustible.

Development of hazardous combustion gases or vapours possible in the event of fire.

: Carbon oxides

Nitrogen oxides (NOx)

: Suppress (knock down) gases/vapors/mists with a water spray jet.

Prevent fire extinguishing water from contaminating

Avoid inhalation of dusts.

Avoid substance contact.

Ensure adequate ventilation.

Evacuate the danger area, observe emergency procedures, consult an expert.

and 10).

Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

Dry.

: 11, Combustible Solids

: -4 °F / -20 °C storage stability

: Product is sensitive to light and moisture.

Store under inert gas.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Ingredients with workplace control parameters

: required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN

EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Recommended Filter type:

: Filter type P2

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Break through time : 480 min

Glove thickness : 0.11 mm

Protective index : Full contact

Manufacturer : KCL 741 Dermatril® L

Glove thickness : 0.11 mm

Protective index : Splash contact

Manufacturer : KCL 741 Dermatril® L

: This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-

36124 Eichenzell, Internet: www.kcl.de).

Skin and body protection

: protective clothing

: Change contaminated clothing. Preventive skin protection recommended. Wash hands after working with substance.

: powder

: red

Melting point/ range

: 363 - 365 °F / 184 - 185 °C

: 822.94 g/mol

: The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Strong oxidizing agents

: Exposure to moisture.

Light.

no information available

Incompatible materials

Acute toxicity

Acute toxicity estimate Oral - 1,570.0 mg/kg

(Calculation method)

LD50 Oral - Rat - 1,570 mg/kg

Remarks: (RTECS)

Inhalation: No data available

Dermal: No data available

Skin corrosion/irritation

Remarks: No data available

Serious eye damage/eye irritation

Remarks: No data available

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

11.2 Additional Information

RTECS: VJ7000000

Exposure to and/or consumption of alcohol may increase toxic effects.

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

After absorption:

We have no description of any toxic symptoms.

Other dangerous properties can not be excluded.

Handle in accordance with good industrial hygiene and safety practice.

Liver - Irregularities - Based on Human Evidence

Liver - Irregularities - Based on Human Evidence

No data available

Persistence and degradability

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Other adverse effects

No data available

SECTION 13. DISPOSAL CONSIDERATIONS

Disposal methods

Waste from residues : Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other

IATA-DGR

Not regulated as a dangerous good

IMDG-Code

Not regulated as a dangerous good

Transport in bulk according to IMO instruments

Not applicable for product as supplied.

National regulation

This material does not contain any components with a CERCLA RQ.

SARA 304 Extremely Hazardous Substances Reportable Quantity

This material does not contain any components with a section 304 EHS RQ.

SARA 302 Extremely Hazardous Substances Threshold Planning Quantity

This material does not contain any components with a section 302 EHS TPQ.

: Acute Health Hazard

Chronic Health Hazard

No components are subject to the Massachusetts Right to Know Act.

Maine Chemicals of High Concern

Product does not contain any listed chemicals

Vermont Chemicals of High Concern

Product does not contain any listed chemicals

Washington Chemicals of High Concern

Product does not contain any listed chemicals

California Prop. 65

WARNING: This product can expose you to chemicals including Rifampicin, which is/are known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

: Product contains substance(s) not listed on TSCA inventory.

Compensation, and Liability Act; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN -

Standard of the German Institute for Standardisation; DOT - Department of Transportation;

DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response;

EHS - Extremely Hazardous Substance; ELx - Loading rate associated with x% response;

EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -

Concentration associated with x% growth rate response; ERG - Emergency Response Guide;

GHS - Globally Harmonized System; GLP - Good Laboratory Practice; HMIS - Hazardous

Materials Identification System; IARC - International Agency for Research on Cancer; IATA -

International Air Transport Association; IBC - International Code for the Construction and

Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing

Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO -

International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO -

International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory;

LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; MSHA - Mine Safety and Health Administration; n.o.s. - Not

Otherwise Specified; NFPA - National Fire Protection Association; NO(A)EC - No Observed

(Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No

Observable Effect Loading Rate; NTP - National Toxicology Program; NZIoC - New Zealand

Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development;

OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and

Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; RCRA -

Resource Conservation and Recovery Act; REACH - Regulation (EC) No 1907/2006 of the

European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RQ - Reportable Quantity; SADT - Self-

Accelerating Decomposition Temperature; SARA - Superfund Amendments and

Reauthorization Act; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory;

TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Revision Date : 04/28/2025 match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered.

For further information please contact mlsbranding@sial.com.

Creation Date 26-Jun-2014 Revision Date 28-Dec-2021 Revision Number 4

1. Identification Product Name Buffer Solution, pH 7.00, Color-Coded Yellow, Certified

Cat No. : AC611060000; AC611060040; AC611065000

Synonyms No information available

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11

Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99

CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887

2. Hazard(s) identification Classification Classification under 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements None required

Hazards not otherwise classified (HNOC) None identified

3. Composition/Information on Ingredients

Company Fisher Scientific Company One Reagent Lane Fair Lawn, NJ 07410 Tel: (201) 796-7100

Acros Organics One Reagent Lane Fair Lawn, NJ 07410

This chemical is not considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Page 1 / 7

Buffer Solution, pH 7.00, Color-Coded Yellow, Certified Revision Date 28-Dec-2021

Component CAS No Weight % Water 7732-18-5 99.18

Dihydrogen potassium phosphate 7778-77-0 0.7

Sodium hydroxide 1310-73-2 0.1

FD&C yellow No. 5 1934-21-0 0.0 - 0.02

4. First-aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention if symptoms occur.

Skin Contact Rinse skin with water. Get medical attention if symptoms occur.

Inhalation Remove to fresh air. If breathing is difficult, give oxygen. Get medical attention if symptoms occur.

Ingestion Do NOT induce vomiting. Get medical attention if symptoms occur.

Most important symptoms and effects

No information available.

Notes…

This is the start of the file's text. The full file is on GovTribe.

File details come from the government source that posted it. Updated .