Attachment 005 Batch 1 SDSs.pdf

SAFETY DATA SHEET

1. Identification

(S)-NicotineProduct identifier

Other means of identification

N-12655Item

54-11-5CAS number

(S)-3-(1-Methyl-2-pyrrolidinyl)pyridineSynonyms

For Laboratory Use OnlyRecommended use

None known.Recommended restrictions

Manufacturer/Importer/Supplier/Distributor information

Manufacturer

Chem Service, Inc.

Address 660 Tower Lane

Company name

Website

Telephone Toll Free 800-452-9994

Direct 610-692-3026

Emergency phone number Chemtrec US 800-424-9300

Chemtrec outside US +1 703-527-3887

E-mail

United States www.chemservice.com info@chemservice.com

West Chester, PA 19380

2. Hazard(s) identification

Not classified.Physical hazards

Category 2Acute toxicity, oralHealth hazards

Category 1Acute toxicity, dermal

Category 2Acute toxicity, inhalation

Category 2Skin corrosion/irritation

Category 2BSerious eye damage/eye irritation

Category 2Reproductive toxicity

Category 1Specific target organ toxicity, single exposure

Category 1Hazardous to the aquatic environment, acute hazard

Environmental hazards

Category 1Hazardous to the aquatic environment, long-term hazard

Not classified.OSHA defined hazards

Label elements

Signal word Danger

Hazard statement Fatal if swallowed. Fatal in contact with skin. Causes skin irritation. Causes eye irritation. Fatal if inhaled. Suspected of damaging fertility or the unborn child. Causes damage to organs. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects.

Precautionary statement

Prevention Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe vapor. Do not get in eyes, on skin, or on clothing. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection.

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Material name: (S)-Nicotine

N-12655 Version #: 03 Revision date: 04-02-2020 Issue date: 10-01-2015

SDS US

Response If swallowed: Immediately call a poison center/doctor. Rinse mouth. If on skin: Wash with plenty of water. If inhaled: Remove person to fresh air and keep comfortable for breathing. If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.

Continue rinsing. Immediately call a poison center/doctor. Specific treatment is urgent (see this label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Get medical advice/attention. Take off immediately all contaminated clothing and wash it before reuse. Collect spillage.

Storage Store in a well-ventilated place. Keep container tightly closed. Store locked up.

Disposal Dispose of contents/container in accordance with local/regional/national/international regulations.

Hazard(s) not otherwise classified (HNOC) None known.

Supplemental information None.

3. Composition/information on ingredients

Substances

CAS number %Chemical name Common name and synonyms

(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine 54-11-5(S)-Nicotine 100

4. First-aid measures

Remove victim to fresh air and keep at rest in a position comfortable for breathing. Oxygen or artificial respiration if needed. Do not use mouth-to-mouth method if victim inhaled the substance.

Induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Call a physician or poison control center immediately.

Inhalation

Take off immediately all contaminated clothing. Wash with plenty of soap and water. Call a physician or poison control center immediately. Wash contaminated clothing before reuse.

Skin contact

Immediately flush eyes with plenty of water for at least 15 minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a physician or poison control center immediately.

Eye contact

Call a physician or poison control center immediately. Rinse mouth. Do not induce vomiting without advice from poison control center. If vomiting occurs, keep head low so that stomach content doesn't get into the lungs. Do not use mouth-to-mouth method if victim ingested the substance.

Induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Ingestion

Convulsions. Headache. Dizziness. Nausea, vomiting. Abdominal pain. Diarrhea. Irritation of eyes.

Exposed individuals may experience eye tearing, redness, and discomfort. Skin irritation. May cause redness and pain.

Most important symptoms/effects, acute and delayed

Provide general supportive measures and treat symptomatically. Keep victim warm. Keep victim under observation. Symptoms may be delayed.

Indication of immediate medical attention and special treatment needed

Take off immediately all contaminated clothing. IF exposed or concerned: Get medical advice/attention. If you feel unwell, seek medical advice (show the label where possible). Ensure that medical personnel are aware of the material(s) involved, and take precautions to protect themselves. Show this safety data sheet to the doctor in attendance. Discard any shoes or clothing items that cannot be decontaminated.

General information

5. Fire-fighting measures

Water fog. Foam. Dry chemical powder. Carbon dioxide (CO2).Suitable extinguishing media

Do not use water jet as an extinguisher, as this will spread the fire.Unsuitable extinguishing media

During fire, gases hazardous to health may be formed.Specific hazards arising from the chemical

Self-contained breathing apparatus and full protective clothing must be worn in case of fire.Special protective equipment and precautions for firefighters

Move containers from fire area if you can do so without risk.Fire fighting equipment/instructions

Use standard firefighting procedures and consider the hazards of other involved materials.Specific methods

No unusual fire or explosion hazards noted.General fire hazards

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Material name: (S)-Nicotine

6. Accidental release measures

Keep unnecessary personnel away. Keep people away from and upwind of spill/leak. Wear appropriate protective equipment and clothing during clean-up. Do not breathe vapors or spray mist. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Ensure adequate ventilation. Local authorities should be advised if significant spillages cannot be contained. For personal protection, see section 8 of the SDS.

Personal precautions, protective equipment and emergency procedures

This product is miscible in water. Prevent product from entering drains.

Large Spills: Stop the flow of material, if this is without risk. Dike the spilled material, where this is possible. Absorb in vermiculite, dry sand or earth and place into containers. Following product recovery, flush area with water.

Small Spills: Wipe up with absorbent material (e.g. cloth, fleece). Clean surface thoroughly to remove residual contamination.

Never return spills to original containers for re-use. For waste disposal, see section 13 of the SDS.

Methods and materials for containment and cleaning up

Avoid release to the environment. Inform appropriate managerial or supervisory personnel of all environmental releases. Prevent further leakage or spillage if safe to do so. Avoid discharge into drains, water courses or onto the ground.

Environmental precautions

7. Handling and storage

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe vapors or spray mist. Do not get in eyes, on skin, or on clothing.

Do not taste or swallow. Avoid prolonged exposure. When using, do not eat, drink or smoke.

Pregnant or breastfeeding women must not handle this product. Should be handled in closed systems, if possible. Use only outdoors or in a well-ventilated area. Wear appropriate personal protective equipment. Wash hands thoroughly after handling. Avoid release to the environment.

Wash contaminated clothing before reuse. Observe good industrial hygiene practices.

Precautions for safe handling

Store locked up. Store in original tightly closed container. Store in a well-ventilated place. Store away from incompatible materials (see Section 10 of the SDS).

Conditions for safe storage, including any incompatibilities

8. Exposure controls/personal protection

Occupational exposure limits

The following constituents are the only constituents of the product which have a PEL, TLV or other recommended exposure limit.

At this time, the other constituents have no known exposure limits.

US. OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000)

ValueMaterial Type

PEL 0.5 mg/m3(S)-Nicotine (CAS 54-11-5)

US. ACGIH Threshold Limit Values

ValueMaterial Type

TWA 0.5 mg/m3(S)-Nicotine (CAS 54-11-5)

US. NIOSH: Pocket Guide to Chemical Hazards

ValueMaterial Type

TWA 0.5 mg/m3(S)-Nicotine (CAS 54-11-5)

No biological exposure limits noted for the ingredient(s).Biological limit values

Exposure guidelines

US - California OELs: Skin designation

(S)-Nicotine (CAS 54-11-5) Can be absorbed through the skin.

US - Minnesota Haz Subs: Skin designation applies

(S)-Nicotine (CAS 54-11-5) Skin designation applies.

US - Tennessee OELs: Skin designation

(S)-Nicotine (CAS 54-11-5) Can be absorbed through the skin.

US ACGIH Threshold Limit Values: Skin designation

(S)-Nicotine (CAS 54-11-5) Can be absorbed through the skin.

US NIOSH Pocket Guide to Chemical Hazards: Skin designation

(S)-Nicotine (CAS 54-11-5) Can be absorbed through the skin.

US. OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000)

(S)-Nicotine (CAS 54-11-5) Can be absorbed through the skin.

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Material name: (S)-Nicotine

Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level. Provide eyewash station. Eye wash fountain and emergency showers are recommended.

Appropriate engineering controls

Individual protection measures, such as personal protective equipment

Chemical respirator with organic vapor cartridge and full facepiece.Eye/face protection

Skin protection

Wear appropriate chemical resistant gloves.Hand protection

Wear appropriate chemical resistant clothing. Use of an impervious apron is recommended.Other

Chemical respirator with organic vapor cartridge and full facepiece.Respiratory protection

Wear appropriate thermal protective clothing, when necessary.Thermal hazards

Observe any medical surveillance requirements. Keep away from food and drink. Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing and protective equipment to remove contaminants.

General hygiene considerations

9. Physical and chemical properties

Appearance

Liquid.Physical state

LiquidForm

Colorless to AmberColor

Not available.Odor

Odor threshold Not available.

pH 10.2 0.05 molar solution pH 10.2

Melting point/freezing point -110.2 °F (-79 °C)

Initial boiling point and boiling range

476.6 °F (247 °C)

Flash point 203.0 °F (95.0 °C)

Evaporation rate Not available.

Not applicable.Flammability (solid, gas)

Upper/lower flammability or explosive limits

Flammability limit - lower

0.7

Flammability limit - upper

Explosive limit - lower (%) Not available.

Explosive limit - upper (%) Not available.

Vapor pressure 0.01 kPa (77 °F (25 °C))

Vapor density Not available.

Relative density 1.02

Solubility(ies)

Solubility (water) Miscible

Partition coefficient

(n-octanol/water)

1.17

Auto-ignition temperature 464 °F (240 °C)

Decomposition temperature Not available.

Viscosity Not available.

Other information

Density 1.0096 g/cm3 estimated at 20 °C

Not explosive.Explosive properties

Flammability class Combustible IIIB estimated

Molecular formula C10-H14-N2

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Material name: (S)-Nicotine

Molecular weight 162.23 g/mol

Not oxidizing.Oxidizing properties

Specific gravity 1.01 at 20 °C

Surface tension 38.61 mN/m (68 °F (20 °C))

10. Stability and reactivity

The product is stable and non-reactive under normal conditions of use, storage and transport.Reactivity

Material is stable under normal conditions.Chemical stability

Hazardous polymerization does not occur.Possibility of hazardous reactions

Avoid temperatures exceeding the flash point. Contact with incompatible materials.Conditions to avoid

Strong acids. Strong oxidizing agents.Incompatible materials

No hazardous decomposition products are known.Hazardous decomposition products

11. Toxicological information

Information on likely routes of exposure

Inhalation Fatal if inhaled. May cause damage to organs by inhalation.

Skin contact Fatal in contact with skin. Causes skin irritation.

Eye contact Causes eye irritation.

Ingestion Fatal if swallowed.

Symptoms related to the physical, chemical and toxicological characteristics

Convulsions. Headache. Dizziness. Nausea, vomiting. Abdominal pain. Diarrhea. Irritation of eyes. Exposed individuals may experience eye tearing, redness, and discomfort. Skin irritation.

May cause redness and pain.

Information on toxicological effects

Acute toxicity Fatal if inhaled. Fatal in contact with skin. Fatal if swallowed.

Test ResultsProduct Species

(S)-Nicotine (CAS 54-11-5)

Dermal

Acute

LD50 Rabbit 50 mg/kg

Oral

* Estimates for product may be based on additional component data not shown.

LD50 Rat 50 mg/kg

Causes skin irritation.Skin corrosion/irritation

Causes eye irritation.Serious eye damage/eye irritation

Respiratory or skin sensitization

Respiratory sensitization Not a respiratory sensitizer.

This product is not expected to cause skin sensitization.Skin sensitization

No data available to indicate product or any components present at greater than 0.1% are mutagenic or genotoxic.

Germ cell mutagenicity

Carcinogenicity Not classifiable as to carcinogenicity to humans.

IARC Monographs. Overall Evaluation of Carcinogenicity

Not listed.

OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050)

Not regulated.

US. National Toxicology Program (NTP) Report on Carcinogens

Not listed.

Suspected of damaging fertility or the unborn child.Reproductive toxicity

Specific target organ toxicity -single exposure

Causes damage to organs.

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Material name: (S)-Nicotine

Specific target organ toxicity -repeated exposure

Not classified.

Aspiration hazard Not an aspiration hazard.

Chronic effects Prolonged inhalation may be harmful.

12. Ecological information

Very toxic to aquatic life with long lasting effects.Ecotoxicity

Product Test ResultsSpecies

(S)-Nicotine (CAS 54-11-5)

Aquatic

EC50Crustacea 0.242 mg/l, 48 hoursWater flea (Daphnia pulex)

* Estimates for product may be based on additional component data not shown.

LC50Fish 4 mg/l, 96 hoursRainbow trout,donaldson trout (Oncorhynchus mykiss)

Persistence and degradability

Bioaccumulative potential

Partition coefficient n-octanol / water (log Kow)

1.17

No data available.Mobility in soil

Other adverse effects No other adverse environmental effects (e.g. ozone depletion, photochemical ozone creation potential, endocrine disruption, global warming potential) are expected from this component.

13. Disposal considerations

Collect and reclaim or dispose in sealed containers at licensed waste disposal site. Do not allow this material to drain into sewers/water supplies. Do not contaminate ponds, waterways or ditches with chemical or used container. Dispose of contents/container in accordance with local/regional/national/international regulations.

Disposal instructions

Dispose in accordance with all applicable regulations.Local disposal regulations

The waste code should be assigned in discussion between the user, the producer and the waste disposal company.

Hazardous waste code

US RCRA Hazardous Waste P List: Reference

(S)-Nicotine (CAS 54-11-5) P075

Dispose of in accordance with local regulations. Empty containers or liners may retain some product residues. This material and its container must be disposed of in a safe manner (see:

Disposal instructions).

Waste from residues / unused products

Since emptied containers may retain product residue, follow label warnings even after container is emptied. Empty containers should be taken to an approved waste handling site for recycling or disposal.

Contaminated packaging

14. Transport information

DOT

UN1654UN number

NicotineUN proper shipping name

6.1(PGI, II)Class

Transport hazard class(es)

-Subsidiary risk

6.1Label(s)

IIPacking group

Read safety instructions, SDS and emergency procedures before handling.Special precautions for user

IB2Special provisions

153Packaging exceptions

202Packaging non bulk

243Packaging bulk

IATA

UN1654UN number

NicotineUN proper shipping name

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Material name: (S)-Nicotine

6.1(PGI, II)Class

Transport hazard class(es)

-Subsidiary risk

IIPacking group

No.Environmental hazards

6LERG Code

Read safety instructions, SDS and emergency procedures before handling.Special precautions for user

Allowed with restrictions.Passenger and cargo aircraft

Other information

Allowed with restrictions.Cargo aircraft only

IMDG

UN1654UN number

NICOTINEUN proper shipping name

6.1(PGI, II)Class

Transport hazard class(es)

-Subsidiary risk

IIPacking group

No.Marine pollutant

Environmental hazards

F-A, S-AEmS

Read safety instructions, SDS and emergency procedures before handling.Special precautions for user

Not established.Transport in bulk according to

Annex II of MARPOL 73/78 and the IBC Code

DOT

IATA; IMDG

15. Regulatory information

This product is a "Hazardous Chemical" as defined by the OSHA Hazard Communication Standard, 29 CFR 1910.1200.

US federal regulations

TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D)

Not regulated.

CERCLA Hazardous Substance List (40 CFR 302.4)

(S)-Nicotine (CAS 54-11-5) Listed.

SARA 304 Emergency release notification

(S)-Nicotine (CAS 54-11-5) 100 LBS

OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050)

Not regulated.

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Material name: (S)-Nicotine

Superfund Amendments and Reauthorization Act of 1986 (SARA)

Immediate Hazard - Yes Delayed Hazard - Yes Fire Hazard - No Pressure Hazard - No Reactivity Hazard - No

Hazard categories

SARA 302 Extremely hazardous substance

Chemical name CAS number Reportable quantity

(pounds)

Threshold planning quantity

(pounds)

Threshold planning quantity, lower value

(pounds)

Threshold planning quantity, upper value

(pounds)

(S)-Nicotine 54-11-5 100 100

YesSARA 311/312 Hazardous chemical

SARA 313 (TRI reporting)

Chemical name % by wt.CAS number

(S)-Nicotine 10054-11-5

Other federal regulations

Clean Air Act (CAA) Section 112 Hazardous Air Pollutants (HAPs) List

Not regulated.

Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130)

Not regulated.

Not regulated.Safe Drinking Water Act

(SDWA)

WARNING: This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

US state regulations

US - California Proposition 65 - CRT: Listed date/Developmental toxin

(S)-Nicotine (CAS 54-11-5) Listed: April 1, 1990

US. California. Candidate Chemicals List. Safer Consumer Products Regulations (Cal. Code Regs, tit. 22, 69502.3, subd. (a))

(S)-Nicotine (CAS 54-11-5)

International Inventories

Country(s) or region Inventory name On inventory (yes/no)*

YesAustralia Australian Inventory of Chemical Substances (AICS)

YesCanada Domestic Substances List (DSL)

NoCanada Non-Domestic Substances List (NDSL)

YesChina Inventory of Existing Chemical Substances in China (IECSC)

YesEurope European Inventory of Existing Commercial Chemical Substances (EINECS)

NoEurope European List of Notified Chemical Substances (ELINCS)

YesJapan Inventory of Existing and New Chemical Substances (ENCS)

YesKorea Existing Chemicals List (ECL)

YesNew Zealand New Zealand Inventory

YesPhilippines Philippine Inventory of Chemicals and Chemical Substances

(PICCS)

YesUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory

*A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s) A "No" indicates that one or more components of the product are not listed or exempt from listing on the inventory administered by the governing country(s).

16. Other information, including date of preparation or last revision

10-01-2015Issue date

04-02-2020Revision date

Version # 03

Health: 4 Flammability: 0 Instability: 0

NFPA ratings

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Material name: (S)-Nicotine

Chem Service, Inc. cannot anticipate all conditions under which this information and its product, or the products of other manufacturers in combination with its product, may be used. It is the user’s responsibility to ensure safe conditions for handling, storage and disposal of the product, and to assume liability for loss, injury, damage or expense due to improper use. The above information is believed to be correct on the date it was last revised and must not be considered all inclusive. The information has been obtained only by a search of available literature and is only a guide for handling the chemicals. OSHA regulations require that if other hazards become evident, an upgraded SDS must be made available to the employee within three months. RESPONSIBILITY for updates lies with the employer and not with CHEM SERVICE, Inc.

Persons not specifically and properly trained should not handle this chemical or its container. This product is furnished FOR LABORATORY USE ONLY! Our products may NOT BE USED as drugs, cosmetics, agricultural or pesticide products, food additives or as household chemicals.

This Safety Data Sheet (SDS) is intended only for use with Chem Service, Inc. products and should not be relied on for use with materials from any other supplier even if the chemical name(s) on the product are identical! Whenever using an SDS for a solution or mixture the user should refer to the SDS for every component of the solution or mixture. Chem Service warrants that this SDS is based upon the most current information available to Chem Service at the time it was last revised. THIS WARRANTY IS EXCLUSIVE, AND CHEM SERVICE, INC. MAKES NO OTHER

WARRANTY, EXPRESSED OR IMPLIED, INCLUDING ANY IMPLIED WARRANTY OF

MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE. This SDS is provided gratis and CHEM SERVICE, INC. SHALL NOT BE LIABLE FOR ANY INCIDENTAL, CONSEQUENTIAL OR CONTINGENT DAMAGES.

Copyright © 2000-2014 Chem Service, Inc. All rights reserved except that this SDS may be printed for the use of a customer or prospective customer of Chem Service, Inc provided the entire SDS is printed. The SDS may not be placed in any database or otherwise stored or distributed in electronic or any other form.

This product is furnished FOR LABORATORY USE ONLY.

Disclaimer

This document has undergone significant changes and should be reviewed in its entirety.Revision information

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Material name: (S)-Nicotine

Revision Date 20-Feb-2020 Revision Number 2

1. Identification Product Name 2-Methylanthraquinone

Cat No. : A14502

CAS-No 84-54-8 Synonyms No information available

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Emergency Telephone Number During normal business hours (Monday-Friday, 8am-7pm EST), call (800) 343-0660.

After normal business hours, call Carechem 24 at (866) 928-0789.

2. Hazard(s) identification Classification Classification under 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements None required

Hazards not otherwise classified (HNOC) None identified

3. Composition/Information on Ingredients

Component CAS-No Weight % 9,10-Anthracenedione, 2-methyl- 84-54-8 <=100

Company Alfa Aesar Thermo Fisher Scientific Chemicals, Inc.

30 Bond Street Ward Hill, MA 01835-8099 Tel: 800-343-0660 Fax: 800-322-4757 Email: tech@alfa.com www.alfa.com

Based on available data, the classification criteria are not met

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2-Methylanthraquinone Revision Date 20-Feb-2020

4. First-aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention immediately if symptoms occur.

Inhalation Remove to fresh air. Get medical attention immediately if symptoms occur.

Ingestion Clean mouth with water and drink afterwards plenty of water. Get medical attention if symptoms occur.

Most important symptoms and effects

None reasonably foreseeable.

Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Carbon dioxide (CO 2). Powder. Water spray. In case of major fire and large quantities:

Evacuate area. Fight fire remotely due to the risk of explosion.

Unsuitable Extinguishing Media No information available

Flash Point 209 °C / 408.2 °F

Method - No information available

Autoignition Temperature No information available Explosion Limits

Upper No data available Lower No data available Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical Keep product and empty container away from heat and sources of ignition.

Hazardous Combustion Products Carbon monoxide (CO). Carbon dioxide (CO2).

Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

NFPA

6. Accidental release measures Personal Precautions Ensure adequate ventilation. Use personal protective equipment as required. Avoid dust formation.

Environmental Precautions Should not be released into the environment. See Section 12 for additional Ecological

Information.

Methods for Containment and Clean Up

Sweep up and shovel into suitable containers for disposal. Avoid dust formation.

Health

Flammability

Instability

Physical hazards

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7. Handling and storage Handling Wear personal protective equipment/face protection. Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Avoid ingestion and inhalation. Avoid dust formation.

Storage Protect from moisture.

8. Exposure controls / personal protection Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.

9. Physical and chemical properties Physical State Solid Appearance No information available Odor No information available Odor Threshold No information available pH No information available Melting Point/Range 170 - 174 °C / 338 - 345.2 °F Boiling Point/Range No information available Flash Point 209 °C / 408.2 °F Evaporation Rate Not applicable Flammability (solid,gas) No information available Flammability or explosive limits

Upper No data available Lower No data available

Vapor Pressure No information available Vapor Density Not applicable Specific Gravity No information available Solubility No information available Partition coefficient; n-octanol/water No data available Autoignition Temperature No information available Decomposition Temperature No information available Viscosity Not applicable Molecular Formula C15 H10 O2 Molecular Weight 222.24

10. Stability and reactivity

Reactive Hazard None known, based on information available

Engineering Measures Ensure adequate ventilation, especially in confined areas.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard

EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures

Page 3 / 6

Handle in accordance with good industrial hygiene and safety practice.

Stability Moisture sensitive.

Conditions to Avoid Incompatible products.

Incompatible Materials Oxidizing agent

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2)

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information Acute Toxicity

Product Information Component Information Toxicologically Synergistic Products

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation No information available

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA Mexico 9,10-Anthracenedione, 2-methyl- 84-54-8 Not listed Not listed Not listed Not listed Not listed

Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure None known STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and delayed

No information available

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information Ecotoxicity Do not empty into drains.

Persistence and Degradability No information available

Bioaccumulation/ Accumulation No information available.

Mobility No information available.

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13. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

14. Transport information DOT Not regulated TDG Not regulated IATA Not regulated IMDG/IMO Not regulated

15. Regulatory information

United States of America Inventory

Component CAS-No TSCA TSCA Inventory notification - Active/Inactive

TSCA - EPA Regulatory Flags

9,10-Anthracenedione, 2-methyl- 84-54-8 X ACTIVE -

Legend:

TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed

TSCA 12(b) - Notices of Export Not applicable

International Inventories Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Australia (AICS), China (IECSC), Korea (ECL).

Component CAS-No DSL NDSL EINECS PICCS ENCS AICS IECSC KECL 9,10-Anthracenedione, 2-methyl- 84-54-8 X - 201-539-6 - X X - -

U.S. Federal Regulations

SARA 313 Not applicable

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Not applicable

Clean Air Act Not applicable

OSHA - Occupational Safety and Health Administration

Not applicable

CERCLA Not applicable

California Proposition 65 This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know Regulations

Not applicable

U.S. Department of Transportation Reportable Quantity (RQ): N DOT Marine Pollutant N DOT Severe Marine Pollutant N

U.S. Department of Homeland Security

This product does not contain any DHS chemicals.

Page 5 / 6

Other International Regulations

Mexico - Grade No information available

16. Other information Prepared By Health, Safety and Environmental Department

Email: tech@alfa.com www.alfa.com

Revision Date 20-Feb-2020 Print Date 20-Feb-2020 Revision Summary SDS authoring systems update, replaces ChemGes SDS No. 84-54-8/2.

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

End of SDS

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Creation Date 10-May-2010 Revision Date 24-Dec-2021 Revision Number 8

1. Identification Product Name 2-Mercaptoethanol (Reagent)

Cat No. : O3446I-100

CAS No 60-24-2 Synonyms 2-Hydroxy-1-ethanethiol; Thioglycol

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, Outside the USA: 001-703-527-3887

2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements

Signal Word Danger

Company Fisher Scientific Company One Reagent Lane Fair Lawn, NJ 07410 Tel: (201) 796-7100

Acute oral toxicity Category 3 Acute dermal toxicity Category 2 Acute Inhalation Toxicity - Vapors Category 3 Skin Corrosion/Irritation Category 2 Serious Eye Damage/Eye Irritation Category 1 Skin Sensitization Category 1A Reproductive Toxicity Category 2 Specific target organ toxicity - (repeated exposure) Category 2 Target Organs - Liver, Heart.

Flammable liquids Category 4

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2-Mercaptoethanol (Reagent) Revision Date 24-Dec-2021

Hazard Statements Combustible liquid Fatal in contact with skin Causes skin irritation May cause an allergic skin reaction Causes serious eye damage Suspected of damaging fertility May cause damage to organs through prolonged or repeated exposure Toxic if swallowed or if inhaled

Precautionary Statements Prevention Obtain special instructions before use Do not handle until all safety precautions have been read and understood Use personal protective equipment as required Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Do not get in eyes, on skin, or on clothing Use only outdoors or in a well-ventilated area Contaminated work clothing should not be allowed out of the workplace Wear protective gloves Do not breathe dust/fume/gas/mist/vapors/spray Keep away from heat/sparks/open flames/hot surfaces. - No smoking Keep cool Response IF exposed or concerned: Get medical attention/advice Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Call a POISON CENTER or doctor/physician Skin Immediately call a POISON CENTER or doctor/physician IF ON SKIN: Gently wash with plenty of soap and water Remove/Take off immediately all contaminated clothing Wash contaminated clothing before reuse If skin irritation or rash occurs: Get medical advice/attention Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing Immediately call a POISON CENTER or doctor/physician Ingestion IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician Rinse mouth Fire In case of fire: Use CO2, dry chemical, or foam for extinction Storage Store locked up Store in a well-ventilated place. Keep container tightly closed Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) Very toxic to aquatic life Toxic to aquatic life with long lasting effects

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Other hazards Stench.

3. Composition/Information on Ingredients

Component CAS No Weight % 2-Mercaptoethanol 60-24-2 <100

Ethanol, 2,2'-dithiobis- 1892-29-1 <0.25

4. First-aid measures

General Advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is required.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.

Inhalation Remove to fresh air. If not breathing, give artificial respiration. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Immediate medical attention is required.

Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and effects

None reasonably foreseeable. Causes severe eye damage. May cause allergic skin reaction. Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting

Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may be used to cool closed containers.

Unsuitable Extinguishing Media No information available

Flash Point 73 °C / 163.4 °F

Method - No information available

Autoignition Temperature 295 °C / 563 °F

Explosion Limits Upper 2.7 vol % Lower 1.1 vol % Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available

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Specific Hazards Arising from the Chemical Combustible material. Containers may explode when heated. Keep product and empty container away from heat and sources of ignition. Thermal decomposition can lead to release of irritating gases and vapors. Do not allow run-off from fire-fighting to enter drains or water courses.

Hazardous Combustion Products Sulfur oxides. Sulfides.

Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA

6. Accidental release measures Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary measures against static discharges.

Environmental Precautions Do not flush into surface water or sanitary sewer system. Do not allow material to contaminate ground water system. Prevent product from entering drains. Local authorities should be advised if significant spillages cannot be contained.

Methods for Containment and Clean Up

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Remove all sources of ignition.

7. Handling and storage Handling Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on clothing. Use only under a chemical fume hood. Do not breathe mist/vapors/spray. Do not ingest. If swallowed then seek immediate medical assistance. Keep away from open flames, hot surfaces and sources of ignition.

Storage. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat, sparks and flame. Incompatible Materials. Oxidizing agent. Acids. Strong bases.

8. Exposure controls / personal protection Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.

9. Physical and chemical properties Physical State Liquid Appearance Light yellow

Health

Flammability

Instability

Physical hazards N/A

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard

EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures

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Handle in accordance with good industrial hygiene and safety practice.

Odor Stench Odor Threshold No information available pH 5.2 (0.1M) Melting Point/Range -100 °C / -148 °F Boiling Point/Range 157 - 158 °C / 314.6 - 316.4 °F Flash Point 73 °C / 163.4 °F Evaporation Rate No information available Flammability (solid,gas) Not applicable Flammability or explosive limits

Upper 2.7 vol % Lower 1.1 vol %

Vapor Pressure 1 mmHg @ 20 °C Vapor Density 2.69 Specific Gravity 1.110 Solubility Soluble in water Partition coefficient; n-octanol/water No data available Autoignition Temperature 295 °C / 563 °F Decomposition Temperature > 157°C Viscosity 3.43 cP at 20 °C Molecular Formula C2 H6 O S Molecular Weight 78.13

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions. Water reactive.

Conditions to Avoid Incompatible products. Heat, flames and sparks. Excess heat. Exposure to moist air or water. Keep away from open flames, hot surfaces and sources of ignition.

Incompatible Materials Oxidizing agent, Acids, Strong bases

Hazardous Decomposition Products Sulfur oxides, Sulfides

Hazardous Polymerization No information available.

Hazardous Reactions None under normal processing.

11. Toxicological information Acute Toxicity

Product Information Component Information

Component LD50 Oral LD50 Dermal LC50 Inhalation 2-Mercaptoethanol LD50 = 244 mg/kg ( Rat ) 150 µL/kg ( Rabbit )

112 - 224 mg/kg ( Rabbit ) Not listed

Ethanol, 2,2'-dithiobis- LD50 = 173 mg/kg ( Rat ) Not listed Not listed

Toxicologically Synergistic Products

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes, respiratory system and skin

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

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2-Mercaptoethanol 60-24-2 Not listed Not listed Not listed Not listed Not listed Ethanol, 2,2'-dithiobis- 1892-29-1 Not listed Not listed Not listed Not listed Not listed Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure None known STOT - repeated exposure Liver Heart

Aspiration hazard No information available

Symptoms / effects,both acute and delayed

Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing:

Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information Ecotoxicity The product contains following substances which are hazardous for the environment. Very toxic to aquatic organisms.

Component Freshwater Algae Freshwater Fish Microtox Water Flea 2-Mercaptoethanol EC50: = 12 mg/L, 72h

(Desmodesmus subspicatus)

Not listed = 125 mg/L EC50 Pseudomonas putida 17 h

EC50: = 1.52 mg/L, 48h (Daphnia magna)

Persistence and Degradability Persistence is unlikely

Bioaccumulation/ Accumulation No information available.

Mobility . Will likely be mobile in the environment due to its water solubility.

Component log Pow 2-Mercaptoethanol -0.056

13. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

14. Transport information

DOT

UN-No UN2966 Proper Shipping Name THIOGLYCOL Hazard Class 6.1 Packing Group II

TDG

UN-No UN2966 Proper Shipping Name THIOGLYCOL Hazard Class 6.1 Packing Group II

IATA

UN-No UN2966

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Proper Shipping Name THIOGLYCOL Hazard Class 6.1 Packing Group II

IMDG/IMO

UN-No UN2966 Proper Shipping Name THIOGLYCOL Hazard Class 6.1 Packing Group II

15. Regulatory information

United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - Active-Inactive

TSCA - EPA Regulatory Flags

2-Mercaptoethanol 60-24-2 X ACTIVE - Ethanol, 2,2'-dithiobis- 1892-29-1 X ACTIVE -

Legend:

TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed

TSCA 12(b) - Notices of Export Not applicable

International Inventories Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea

(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL 2-Mercaptoethanol 60-24-2 X - 200-464-6 X X X X X KE-23095

Ethanol, 2,2'-dithiobis- 1892-29-1 - X 217-576-6 X - X X KE-12729

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313 Not applicable

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Not applicable

Clean Air Act Not applicable

OSHA - Occupational Safety and Health Administration

Not applicable

CERCLA Not applicable

California Proposition 65 This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

2-Mercaptoethanol X X X - -

U.S. Department of Transportation Reportable Quantity (RQ): N

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DOT Marine Pollutant N DOT Severe Marine Pollutant N

U.S. Department of Homeland Security

This product does not contain any DHS chemicals.

Other International Regulations

Mexico - Grade No information available

Authorisation/Restrictions according to EU REACH

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Pollutant

Ozone Depletion Potential

Restriction of Hazardous

Substances (RoHS) 2-Mercaptoethanol 60-24-2 Listed Not applicable Not applicable Not applicable

Ethanol, 2,2'-dithiobis- 1892-29-1 Not applicable Not applicable Not applicable Not applicable

Component CAS No Seveso III Directive

(2012/18/EC) -

Qualifying Quantities for Major Accident

Notification

Seveso III Directive

(2012/18/EC) -

Qualifying Quantities for Safety Report

Requirements

Rotterdam Convention (PIC)

Basel Convention (Hazardous Waste)

2-Mercaptoethanol 60-24-2 Not applicable Not applicable Not applicable Not applicable Ethanol, 2,2'-dithiobis- 1892-29-1 Not applicable Not applicable Not applicable Not applicable

16. Other information Prepared By Regulatory Affairs

Thermo Fisher Scientific Email: EMSDS.RA@thermofisher.com

Creation Date 10-May-2010 Revision Date 24-Dec-2021 Print Date 24-Dec-2021 Revision Summary SDS sections updated. 2. 3. 16.

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

End of SDS

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1. Identification

Product identifier Amitraz

Other means of identification

Product code N-11068

Synonym(s) N,N-bis(2,4-xylyliminomethyl)methylamine

Recommended use For Laboratory Use Only

Recommended restrictions None known.

Manufacturer/Importer/Supplier/Distributor information

Manufacturer

Chem Service, Inc.

Address 660 Tower Lane

Company name

Website

Telephone Toll Free 800-452-9994

Direct 610-692-3026

Emergency phone number Chemtrec US 800-424-9300

Chemtrec outside US +1 703-527-3887

E-mail

United States www.chemservice.com info@chemservice.com

West Chester, PA 19380

2. Hazard(s) identification

Not classified.Physical hazards

Category 4Acute toxicity, oralHealth hazards

Category 3Acute toxicity, dermal

Category 1Sensitization, skin

Category 2Specific target organ toxicity, repeated exposure

Category 1Hazardous to the aquatic environment, acute hazard

Environmental hazards

Category 1Hazardous to the aquatic environment, long-term hazard

Not classified.OSHA defined hazards

Label elements

Signal word Danger

Hazard statement Harmful if swallowed. Toxic in contact with skin. May cause an allergic skin reaction. May cause damage to organs through prolonged or repeated exposure. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects.

Precautionary statement

Prevention Wash thoroughly after handling. Do not eat, drink or smoke when using this product.

Contaminated work clothing must not be allowed out of the workplace. Avoid release to the environment. Wear protective gloves/protective clothing.

Response If swallowed: Call a poison center/doctor if you feel unwell. If on skin: Wash with plenty of water.

Call a poison center/doctor if you feel unwell. Specific treatment (see this label). Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. Take off immediately all contaminated clothing and wash it before reuse. Collect spillage.

Storage Store locked up.

Disposal Dispose of contents/container in accordance with local/regional/national/international regulations.

Hazard(s) not otherwise classified (HNOC) None known.

Supplemental information Not applicable.

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Material name: Amitraz

12844 Version #: 01 Issue date: 10-27-2014

3. Composition/information on ingredients

Substances

CAS number %Chemical name Common name and synonyms

N,N-bis(2,4-xylyliminomethyl)methylamine 33089-61-1Amitraz 100

*Designates that a specific chemical identity and/or percentage of composition has been withheld as a trade secret.

4. First-aid measures

Inhalation Move to fresh air.