Regenstrief Institute Inc.

Regenstrief Institute Inc., an Indianapolis-based non-profit research organization established in 1969, serves as a prime contractor and sub-recipient on federal contracts and research grants, delivering health informatics, clinical data management, and biomedical research support services to HHS agencies. The organization is a 501(c)(3) tax-exempt entity, specifically a 509(a)(3) Type I organization closely affiliated with Indiana University School of Medicine, IU Health, and Eskenazi Health, and competes full-and-open across its footprint with no SBA set-aside designations.

Regenstrief's federal work splits 39% prime and 61% sub-awards across 99 total awards valued at $76.2 million combined potential value. The customer base concentrates heavily in NIH: the National Institute on Aging leads by award count with 21 awards, while the National Center for Advancing Translational Sciences (NCATS), National Institute of Environmental Health Sciences, and National Library of Medicine anchor the dollar rankings at $20.8 million, $20.4 million, and $6.9 million combined potential value respectively. These top four NIH customers account for roughly 48% of award count and 74% of combined potential value. Within the past twelve months, activity accelerated from 2 awards in 2022 to 32 in 2024, with 22 awards in 2025 and 3 year-to-date in 2026; only one award is scheduled for completion within the next twenty-four months, presenting minimal recompete exposure.

Prime-contract work clusters on the National Center for Advancing Translational Sciences' $15 million single-award Indefinite Delivery Contract for Linkage Honest Broker services supporting the National COVID Cohort Collaborative (N3C) Data Enclave, which has generated four task orders valued at $8.2 million combined potential value. Representative delivery orders include a $3.95 million firm fixed-price award (April 2025) providing de-identification and data integration for the N3C Data Enclave, a $5.114 million delivery order (March 2024) for the same LHB services, a $1.27 million award (September 2023) for N3C operations, and a $5 million sole-source purchase order from the National Institute for Minority Health and Health Disparities (June 2024) for Logical Observation Identifiers Names and Codes (LOINC) standardized-terminology maintenance and dissemination services running through June 2029. Regenstrief also holds a GSA Multiple Award Schedule contract with 4 task orders valued at $10.6 million combined potential value and active labor categories spanning Project Administrator at $60.88/hr through Subject Matter Expert I at $317.37/hr, with no security-cleared roles. SCI-reported invoicing across prime contracts totaled $5.7 million in FY2022, $5.8 million in FY2023, and $5.3 million in FY2024, supported by roughly 11–12 FTEs per year, at median government-paid rates of $221.25/hr and a 90th-percentile rate of $569.39/hr.

Sub-award work is predominantly grant sub-recipient activity under Trustees of Indiana University (26 sub-grants visible in the source, most recent March 2026), University of Florida, Mayo Clinic Jacksonville, University of Pennsylvania, Brigham & Women's Hospital, and Purdue University, spanning clinical research coordination, data extraction, natural language processing, project management, and electronic health record analysis for National Institutes of Health grants focused on Alzheimer's disease, diabetes, post-COVID surveillance, health services research, and behavioral health. Regenstrief also subcontracts to CMS on LOINC development and to NIH's National Library of Medicine on interoperability standards; across SCI-reportable prime contracts, subcontractors account for an average 9% of contractor hours, with 14 named subcontractors reported. The NAICS concentration favors Custom Computer Programming Services (14 awards) and Other Computer Related Services (9 awards), with PSC codes anchored in Support—Professional (8 awards), Platform-as-a-Service Database and Middleware (5 awards), and Web-Based Subscriptions (4 awards), reflecting Regenstrief's positioning as a specialized health data and informatics provider rather than a broad-based IT services vendor.