Project Grant R61AG104103
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $691,306 to Trustees of Indiana University (Indiana University Indianapolis) on August 15, 2026, under the Aging Research program (CFDA 93.866). The award funds research integrating real-world evidence from electronic medical records, cell line assays, and single-cell omics via deep reinforcement learning to identify repurposable drugs for Alzheimer's disease treatment. The project applies deep transfer...
- The National Institute on Aging awarded Trustees of Indiana University (doing business as Indiana University Indianapolis) $791,039 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational methods enabling patient-centered prognostic profiling for Alzheimer's disease and related dementias that accounts for individual cognitive resilience in response to neuropathological changes. The work will model each patient's distinct connectome architecture and cognitive...
- The National Institute on Aging awarded Clemson University $412,078 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop and evaluate large language model chatbots designed to enhance older adults' engagement in medical consultations about Alzheimer's disease and related dementias. The project will assess how LLM-based generative chatbots can provide personalized patient education about dementia, improve patient knowledge of ADRD, and augment patient-physician...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded The University of Chicago $597,239 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support investigation of inpatient rehabilitation facility (IRF) utilization and outcomes for older adult patients with and without Alzheimer's disease or other dementias (ADRD). The research examines comparative value and appropriateness of care delivery across post-acute care settings, specifically comparing higher-cost IRF care—which provides acute...
- The National Institute on Aging awarded the Trustees of Indiana University $1.232 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop AI-driven virtual screening pipelines and computational tools for identifying blood-brain-barrier-penetrant drug candidates against Alzheimer's disease and related dementias. The funded research encompasses three interconnected aims: developing AI-driven virtual screening pipelines incorporating small-molecule foundation...
- The National Institute on Aging, part of the National Institutes of Health, awarded $1,250,191 to the University of North Carolina at Chapel Hill on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop an integrated artificial intelligence and experimental workflow for accelerating discovery of small-molecule modulators that influence Alzheimer's disease through microglial phagocytosis regulation. The funded work combines AI-driven computational methods with...
- The National Institute on Aging awarded Carevirtue Technologies, Inc. $1.717 million on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop an AI-enabled dementia care agent for rural Alzheimer's disease and related dementia (ADRD) care partners. Carevirtue will develop a 24/7 AI-enabled dementia care agent that integrates vetted ADRD caregiving education and support content from the National Institute on Aging, AgeUcate, and other authoritative sources into a large...
- The National Institute on Aging awarded Duke University $4.899 million on August 15, 2026, under the Aging Research program (CFDA 93.866) to establish the Duke Artificial Intelligence and Technology Collaboratory for Aging: Governance and Evaluation (DUKE AITC-AIGE), a national initiative bridging the implementation gap between artificial intelligence research and its application in care for older adults and individuals with Alzheimer's disease and related dementias. The collaboratory operates...
- The National Institute on Aging awarded Trustees of Indiana University $674,455 on September 3, 2026, under the Aging Research program (CFDA 93.866) to create the first longitudinal platform tracking home health agency ownership linked to health outcomes for people living with Alzheimer's disease and related dementias. The project will build a data infrastructure addressing a documented research gap: while six million Medicare beneficiaries rely on home health agencies annually and people living...
The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of Notre Dame $582,492 on September 1, 2026, under the Aging Research program (CFDA 93.866) for Project Grant R61AG104103, OPENCARE: Open-Source Infrastructure for Evaluating Conversational AI in Dementia Care. The recipient will develop and deliver two open-source research infrastructures to address the absence of technical evaluation standards for conversational AI in Alzheimer's disease and related dementias care. Specific Aim 1 delivers a validated large language model benchmarking dataset focused on ADRD care, along with a scoring protocol serving as a technical checkpoint. Specific Aim 2 delivers AICareNexus, a functional prototype collaboration software platform designed to support agile, closed-loop communication among AI developers, clinicians, designers, patients, and care partners. The project runs from September 1, 2026, through August 31, 2028, with performance in Indiana. This represents the initial R61 phase (Years 1–2) of a planned two-phase effort; a subsequent R33 phase covering Years 3–5 follows completion of these development milestones. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $582.5k | 8/26/26 |