Project Grant R13AG104346

T CELLS IN THE BRAIN (TCB2027): DECODING T CELL TARGETS IN NEURODEGENERATION - ABSTRACT T CELLS ARE KEY CONTRIBUTORS TO NEUROINFLAMMATION AND NEURODEGENERATION, YET IDENTIFYING THEIR TARGETS AND ANTIGEN SPECIFICITIES IN HUMAN NEUROLOGICAL DISEASE REMAINS A MAJOR CHALLENGE. RAPID ADVANCES IN NEUROIMMUNOLOGY, INCLUDING SINGLE-CELL MULTIOMICS, TCR REPERTOIRE SEQUENCING, AND ANTIGEN-DISCOVERY PLATFORMS, HAVE BEGUN TO RESHAPE OUR UNDERSTANDING OF T CELL BIOLOGY IN THE CNS. BUILDING ON THE SUCCESS OF TCB2024 AND TCB2025, WHICH EACH CONVENED OVER 200 NATIONAL AND INTERNATIONAL ATTENDEES, THE T CELLS IN THE BRAIN SERIES HAS ESTABLISHED ITSELF AS THE PREMIER FORUM FOR INTEGRATING T CELL BIOLOGY WITH HUMAN NEURODEGENERATION. THESE MEETINGS GENERATED NEW MULTI-INSTITUTIONAL COLLABORATIONS, FOSTERED TECHNOLOGY EXCHANGE AMONG IMMUNOLOGISTS, NEUROPATHOLOGISTS, T CELL ENGINEERS, AND COMPUTATIONAL BIOLOGISTS, AND SUPPORTED SEVERAL EMERGING JOINT GRANT APPLICATIONS AND SHARED DATASETS. "T CELLS IN THE BRAIN (TCB2027): DECODING T CELL TARGETS IN NEURODEGENERATION" WILL ADVANCE THIS MOMENTUM BY CONSOLIDATING RECENT PROGRESS AND PROMOTING INTERDISCIPLINARY DISCUSSION TOWARD PRECISION T-CELL-BASED THERAPIES. TCB REMAINS COMMITTED TO ACTIVE EFFORTS TO ENGAGE TRAINEES, AND JUNIOR RESEARCHERS. BY UNITING INTERDISCIPLINARY EXPERTISE AND STRENGTHENING COLLABORATIVE NETWORKS, TCB2027 AIMS TO ACCELERATE THE DEVELOPMENT OF EFFECTIVE T CELL-BASED INTERVENTIONS FOR NEURODEGENERATIVE DISORDERS.