Cascade Biocatalysts Inc.
Denver, CO
- UEI
- CTFCBZCWLE81
- CAGE
- 9FQZ6
- SAM.gov registration
- Active through
Company facts
- Self-certified in SAM.gov
- Entity structure
- Corporate Entity (Not Tax Exempt)
- NAICS codes registered in SAM.gov
- SAM.gov registration date
- Physical address
- 3960 Niagara St b, Denver, CO 80207, USA
- Website
- cascadebio.com
- Founded
- 1992
- Employees
- 1-10
- Estimated annual revenue
- $0-$1M
- Industry
-
- Materials
- Chemicals
- SIC code
- 28 Chemical & Allied Products
- Profiles
Registration and certifications come from SAM.gov and the SBA; company details from public web sources. Updated .
Recent federal awards
| Award | Agency | Obligated | Awarded |
|---|---|---|---|
| Immobilized cofactor regeneration systems to accelerate enzymatic API manufacturing - title: immobilized cofactor… | National Center for Advancing Translational Sciences | $306,871 | |
| Sbir phase II: enzyme stabilization via immobilization for advanced chemical manufacturing -the broader/commercial… | National Science Foundation | $1,250,000 | |
| Sbir phase i: enzyme stabilization via immobilization for advanced chemical manufacturing -this small business… | National Science Foundation | $274,918 |
About Cascade Biocatalysts Inc.
Cascade Biocatalysts Inc., a Denver-based for-profit manufacturer, operates as a federal grant recipient developing enzyme immobilization technology for advanced chemical manufacturing, with all recent work funded through the National Science Foundation and routed through the SBIR program.
Cascade's federal footprint consists of two NSF SBIR prime grants and two sub-award positions under University of California Irvine as prime grantee. The vendor's core capability is proprietary polymer brush stabilization technology that extends enzyme lifespan and reduces costs in industrial biomanufacturing. The Phase I grant, awarded December 15, 2023, was a $274,918 project grant demonstrating commercial feasibility of heterogeneous polymers to stabilize enzymes through engineered polymer-enzyme interactions, with ultimate completion in May 2024. The Phase II Cooperative Agreement, awarded September 1, 2025, carries $1.25 million in funding and targets completion August 31, 2027, with deliverables centered on scaling production to 100-kilogram batch sizes, reducing unit costs through process intensification, and enabling customer enzyme process integration for pharmaceutical, flavor, and fragrance applications. Both NSF awards fall under the Technology, Innovation, and Partnerships program (CFDA 47.084), the federal mechanism for early-stage commercialization of deep-tech ventures.
The sub-award positions under UC Irvine reflect Cascade's role in a larger multi-institutional research initiative on enzyme stabilization via coacervate polymer systems. The first sub-award, dated August 6, 2025, funds process development and scale-up optimization for chiral amine synthesis; the second, dated May 11, 2026, extends that work into reactor installation and pilot-scale demonstration at the ten-liter scale. Customer concentration is absolute — all four awards originate from NSF — and activity remains sparse: one award in 2023, two in 2025, and one in 2026. The Phase I grant completed in May 2024, leaving the Phase II Cooperative Agreement as the single award facing recompete within the next twenty-four months. Cascade has no federal contracts, GWACs, or IDVs in its footprint; all federal engagement to date runs through NSF SBIR and related innovation-focused grant vehicles.
Quick answers
What is Cascade Biocatalysts Inc.'s UEI?
Cascade Biocatalysts Inc.'s Unique Entity ID (UEI) in SAM.gov is CTFCBZCWLE81.
What is Cascade Biocatalysts Inc.'s CAGE code?
Cascade Biocatalysts Inc.'s CAGE code is 9FQZ6.
What is Cascade Biocatalysts Inc.'s primary NAICS code?
Cascade Biocatalysts Inc.'s primary NAICS code is 541714 (Research and Development in Biotechnology (except Nanobiotechnology)).
Where is Cascade Biocatalysts Inc. located?
Cascade Biocatalysts Inc.'s physical address in SAM.gov is 3960 Niagara St b, Denver, CO 80207, USA.
Is Cascade Biocatalysts Inc. registered in SAM.gov?
Yes. Cascade Biocatalysts Inc.'s SAM.gov registration is active through July 29, 2027.
What is Cascade Biocatalysts Inc.'s most recent federal award?
Cascade Biocatalysts Inc.'s most recent federal grant award is Immobilized cofactor regeneration systems to accelerate enzymatic API manufacturing - title: immobilized cofactor… (R43TR006332), from National Center for Advancing Translational Sciences, on August 15, 2026.
On GovTribe
See Cascade Biocatalysts Inc.'s full federal record
- Federal grant awards
- Funding analysis by agency, NAICS and set-aside
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